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公开(公告)号：US20250041391A1
公开(公告)日：2025-02-06
申请号：US18927301
申请日：2024-10-25
Applicant: Endo Biologics Limited
Inventor： Wayne K. HERBER
Abstract: The invention relates to recombinant nucleic acid and polypeptides encoding collagenase I and collagenase II, methods for the preparation thereof and methods for the use thereof. The invention also encompasses methods related to releasing a composition comprising collagenase prior to therapeutic administration.
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公开(公告)号：US12173350B2
公开(公告)日：2024-12-24
申请号：US16616356
申请日：2018-05-23
Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.
Inventor： Doron Shabat , Michal Eli Roth-Konforti
Abstract: The present invention provides turn-ON dioxetane-based chemiluminescence probes based on the Schapp's adamantylidene-dioxetane probe, which are capable of detecting or imaging, more specifically, determining the presence, or measuring the level, of proteases, as well as compositions and uses thereof.
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公开(公告)号：US20240418729A1
公开(公告)日：2024-12-19
申请号：US18704616
申请日：2023-06-16
Applicant: Rapid Novor, Inc.
Inventor： Mariya LIYASOVA , Bin MA
Abstract: Some pathological conditions are accompanied by the increase in dimers of free light chains (FLCs) kappa and/or lambda. For instance, high levels of FLC dimers are found in AL amyloidosis, multiple myeloma, and multiple sclerosis. There is thus a need for sensitive methods that could specifically and quantitatively measure the amount of FLC dimers in a sample. The present application relates to a method for detecting and quantifying immunoglobulin FLC dimers in a sample that comprises subjecting the sample to proteolytic digestion under non-reducing conditions and subjecting the digested sample to mass spectrometry analysis to detect immunoglobulin free light chain dimer peptides. The method may be useful for diagnosis and monitoring of diseases characterized by the aberrant production of FLCs, such as plasma cell discrasias. Light-chain deposition disease (LCDD), autoimmune diseases, chronic kidney disease (CKD), and inflammatory conditions.
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公开(公告)号：US20240417807A1
公开(公告)日：2024-12-19
申请号：US18746198
申请日：2024-06-18
Inventor： William R. Taylor , Jonathan J. Harrington , Patrick S. Quint , Hongzhi Zou , Harold R. Bergen, III , David I. Smith , David A. Ahlquist
IPC: C12Q1/6886 , C12Q1/37 , C12Q1/40 , G01N33/574
Abstract: This document relates to methods and materials for detecting premalignant and malignant neoplasms. For example, methods and materials for determining whether or not a stool sample from a mammal contains nucleic acid markers or polypeptide markers of a neoplasm are provided.
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公开(公告)号：US20240385137A1
公开(公告)日：2024-11-21
申请号：US18199845
申请日：2023-05-19
Applicant: Ellen Tuanying Chen
Inventor： Ellen Tuanying Chen
IPC: G01N27/327 , C12Q1/00 , C12Q1/37 , G01N27/30 , G01N27/447
Abstract: The present invention provides a multiple functioning system for quantum sensing, scalable long time energy storage and quantum computing, as well as providing a dielectric insulator coating method, a solid-state component approach, and a delocalized direct-electron transfer relay in the nanopores “Five-petal Starflower”-like structured membrane to overcome the d-wave Pi JJ ground energy instability, and enables to act as a gate-controlled diode bridge suppressing supercurrent at a low scan rate. The system comprises multiple-layer organo-metallic cross-linked polymers forming various superlattice nanostructured “Five-petal Starflower”-like toroidal nano array membranes based on for sensing Cooper-pair wave transmissions causing intrinsic magnetic flux quantum observed based on a Josephson junction toroidal array, an insulator coating material and method, and a long JJ tunneling in the membranes promoted Cooper-pairs cross the Josephson toroidal junction barriers at zero-bias, and magnifying the quantum conductance. The One-Device-Assembly system enables a pj energy consumption for quantum qubits; or acting as a long-time energy storage device with high energy density; also acted as a quantum sensor sensing the presence of sub-nanogram per mL to 50 μg/mL level collagen that is inversely proportional to the supercurrent at zero bias under a media-free and electrolyte-free condition at room-temperature without an external magnetic field applied.
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Patent Agency Ranking
公开(公告)号：US12134796B2
公开(公告)日：2024-11-05
申请号：US17007766
申请日：2020-08-31
Applicant: Woundchek Laboratories (US), Inc.
Inventor： Simon W. Bayliff , Patrick Brosnan
Abstract: Methods of detecting a local infection, critical colonization, or infection in a wound, predicting wound healing in a wound, and detecting bacterial pathogenesis in a wound are provided.
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公开(公告)号：US20240345091A1
公开(公告)日：2024-10-17
申请号：US18682950
申请日：2022-08-10
Applicant: The State of Israel, Ministry of Agriculture & Rural Development, Agriculture research Organization
Inventor： Giorgi SHTENBERG , Nanda KUMAR , Shlomo BLUM
IPC: G01N33/573 , B01L3/00 , C12Q1/37 , G01N33/543
CPC classification number: G01N33/573 , B01L3/502715 , C12Q1/37 , G01N33/54386 , B01L2200/16 , B01L2300/0654 , B01L2300/0809
Abstract: A label-free optical biosensing system and method provide high sensitivity and specificity for in situ detection and activity estimation of serotypes, such as Botulinum Neurotoxins (BoNT). Pre-fabricated thin-film support structures are treated with a competitive immunoassay coupled to a biochemical cascade reaction, which provides optical signal amplification. When the thin-film support structures receive a target analyte and are exposed to polychromatic light, reaction products cause a change in average refractive index which appears in reflectivity spectra measured by an optical interferometer. Optical signal amplification enables a linear response for serotype concentrations of only a few picograms per millilitre, as well as a level-of-detection threshold of 5.0 picograms per millilitre or less. The specificity and selectivity of the method have been verified in studies using various combinations of different serotypes as a target analyte. Similarly, the serotype activity is estimated by an adjunct sensing platform.
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8.发明公开公开(公告)号：US20240287106A1
公开(公告)日：2024-08-29
申请号：US18568401
申请日：2022-06-09
Applicant: The University of Tokyo , RIKEN
Inventor： Toru Komatsu , Yasuteru Urano , Shingo Sakamoto , Rikiya Watanabe , Yu Kagami
Abstract: To provide a synthesis scheme capable of easily synthesizing various kinds of fluorescent probes. A method for preparing a compound represented by Formula (III) below, the method including steps (1) to (5).
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公开(公告)号：US20240264163A1
公开(公告)日：2024-08-08
申请号：US18415295
申请日：2024-01-17
Applicant: Massachusetts Institute of Technology
Inventor： Edward BOYDEN , Adam Henry MARBLESTONE , Samuel Gordon RODRIQUES
CPC classification number: G01N33/6824 , C12Q1/37 , G01N21/6428 , G01N21/6458 , G01N21/76 , G01N2333/948
Abstract: The invention, in part, includes methods of single molecule protein sequencing that include using weak binding spectra in the amino acid identification.
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公开(公告)号：US12054516B2
公开(公告)日：2024-08-06
申请号：US18137604
申请日：2023-04-21
Applicant: BIOMADISON, INC
Inventor： Ward C Tucker , Francis Mark Dunning
IPC: C07K14/00 , C12N9/52 , C12Q1/37 , G01N33/542
CPC classification number: C07K14/00 , C12N9/52 , C12Q1/37 , G01N33/542 , G01N2333/33
Abstract: Recombinant nucleic acids encoding reporting constructs for characterizing botulinum neurotoxin protease activity and cells that incorporate such recombinant nucleic acids and that are suitable for use in cell-based assays for the neurotoxin are provided. The encoded reporting constructs are a pair of recombinant hybrid proteins that act in concert. The reporting constructs are a pair of recombinant hybrid proteins that act in concert, and that include a botulinum neurotoxin protease recognition and cleavage sequence positioned to release a fluorophore upon cleavage.
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