公开(公告)号：US20240360427A1

公开(公告)日：2024-10-31

申请号：US18473042

申请日：2023-09-22

申请人： SPECIFIC BIOLOGICS INC.

发明人： Brent E. STEAD

IPC分类号： C12N9/22 ,  A61K48/00 ,  A61P35/00 ,  C12N15/10 ,  C12N15/11

CPC分类号： C12N9/22 ,  A61K48/0066 ,  A61P35/00 ,  C12N15/102 ,  C12N15/111 ,  C12N2310/20

摘要： Provided herein are compositions and methods of using chimeric nucleases comprising an I-TevI nuclease domain and a Cas domain for the targeting of oncogenes.

公开(公告)号：US20240358721A1

公开(公告)日：2024-10-31

申请号：US18688496

申请日：2022-09-01

申请人： UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

发明人： Prithu SUNDD

IPC分类号： A61K31/635 ,  A61K31/145 ,  A61K31/553 ,  A61K31/713 ,  A61K39/00 ,  A61P9/12 ,  C07K16/28 ,  C12N9/22 ,  C12N15/11

CPC分类号： A61K31/635 ,  A61K31/145 ,  A61K31/553 ,  A61K31/713 ,  A61P9/12 ,  C07K16/2854 ,  C12N9/22 ,  C12N15/111 ,  A61K2039/505 ,  C12N2310/122 ,  C12N2310/14 ,  C12N2310/20

摘要： The present disclosure relates to methods for treating pulmonary vaso-occlusion in a subject comprising administering to the subject a gasdermin-D inhibitor. In some examples. the disclosed methods are effective at treating subjects resistant to P-selectin-based therapy.

公开(公告)号：US20240352495A1

公开(公告)日：2024-10-24

申请号：US18685259

申请日：2022-09-13

申请人： Moderna Enzymatics Co., Ltd.

发明人： Masayuki Suetsugu ,  Seia Nara

IPC分类号： C12P19/34 ,  C12N9/12 ,  C12N15/11

CPC分类号： C12P19/34 ,  C12N9/1205 ,  C12N9/1217 ,  C12N9/1223 ,  C12N9/1229 ,  C12N15/11 ,  C12Y207/0104 ,  C12Y207/02001 ,  C12Y207/03002 ,  C12Y207/04001 ,  C12Y207/04006

摘要： Provided is a method for producing circular DNA in which a region that is sandwiched by a region Ha and a region Hb in circular double-stranded DNA is substituted with the entirety or a portion of a linear-DNA fragment, wherein the region Hb is located downstream of the region Ha in the circular double-stranded DNA; the linear-DNA fragment is single-stranded or double-stranded linear DNA that has a homologous region that corresponds to the region Ha and a homologous region that corresponds to the region Hb, the latter homologous region being positioned downstream of the former homologous region; and the method comprising: preparing a reaction solution that contains the circular double-stranded DNA, the linear-DNA fragment, and a protein that has RecA-family-recombinase activity, and performing homologous recombination reaction by incubating the reaction solution for a predetermined period of time, thereby producing circular DNA in which the region that is from the region Ha to the region Hb in the circular double-stranded DNA is substituted with the region that is from the homologous region that corresponds to the region Ha to the homologous region that corresponds to the region Hb in the linear-DNA fragment.

公开(公告)号：US20240352473A1

公开(公告)日：2024-10-24

申请号：US18685643

申请日：2022-08-23

申请人： Futuragene Israel Ltd.

发明人： Dror Avisar ,  Shelly Azulay

IPC分类号： C12N15/82 ,  C12N9/22 ,  C12N15/11

CPC分类号： C12N15/8216 ,  C12N9/22 ,  C12N15/11 ,  C12N15/8203 ,  C12N2310/20 ,  C12N2710/00043

摘要： The present disclosure is directed to a novel sequence constructed from viral elements for use as a transgenic promoter; for example, in transgenic plants. More specifically, the present disclosure is directed to a chimeric transgenic promoter sequence comprising a portion derived from the Figwort Mosaic Vims (FMV/FiMV) genome and a portion derived from the Cassava Vein Mosaic Virus (CsVMV) genome. The present disclosure provides methods and compositions for the making and using such a transgenic promoter.

公开(公告)号：US20240352453A1

公开(公告)日：2024-10-24

申请号：US18584538

申请日：2024-02-22

申请人： Prime Medicine, Inc.

发明人： Wei Hsi YEH ,  Dewi HARJANTO

IPC分类号： C12N15/11 ,  C12N9/12 ,  C12N9/22

CPC分类号： C12N15/111 ,  C12N9/1276 ,  C12N9/22 ,  C12N2310/20

摘要： Provided herein are compositions and methods of using prime editing systems comprising prime editors and prime editing guide RNAs for treatment of genetic disorders.

公开(公告)号：US20240350666A1

公开(公告)日：2024-10-24

申请号：US18685599

申请日：2022-08-23

申请人： Children`s Medical Center Corporation

发明人： William Pu ,  Nathan VanDusen ,  Suya Wang ,  Mason Eric Sweat

IPC分类号： A61K48/00 ,  A61P9/00 ,  A61P21/00 ,  C12N9/22 ,  C12N15/11 ,  C12N15/86

CPC分类号： A61K48/005 ,  A61P9/00 ,  A61P21/00 ,  C12N9/22 ,  C12N15/111 ,  C12N15/86 ,  C12N2310/20 ,  C12N2740/15043 ,  C12N2750/14143

摘要： Provided herein are compositions and methods for high efficiency genome editing by targeting novel genetic loci.

公开(公告)号：US20240350619A1

公开(公告)日：2024-10-24

申请号：US18027132

申请日：2022-05-10

申请人： GUANGZHOU RIBOBIO CO., LTD. ,  ARGORNA PHARMACEUTICALS CO., LTD.

发明人： Bill Biliang ZHANG ,  Lin MA ,  Jian WEN ,  Hong ZHANG ,  Huiling ZHONG

IPC分类号： A61K39/215 ,  A61K39/00 ,  A61P31/14 ,  C07K14/005 ,  C12N7/00 ,  C12N15/11 ,  C12N15/85

CPC分类号： A61K39/215 ,  A61P31/14 ,  C07K14/005 ,  C12N7/00 ,  C12N15/11 ,  C12N15/85 ,  A61K2039/53 ,  A61K2039/55555 ,  A61K2039/70 ,  C12N2770/20022 ,  C12N2770/20034 ,  C12N2830/50

摘要： This disclosure provides vaccines and compositions based on SARS-COV-2 S protein, and specifically relates to recombinant SARS-COV-2 spike protein (Sprotein) and mRNA and DNA coding thereof. This disclosure also relates to recombinant plasmid comprising DNA sequence encoding recombinant S protein. This disclosure further relates to composition comprising the recombinant S protein and/or mRNA mentioned above, mRNA-carrier particle such as lipid nanoparticle (LNP), and composition such as a vaccine composition.

公开(公告)号：US12121524B2

公开(公告)日：2024-10-22

申请号：US16962441

申请日：2019-01-16

申请人： VERTEX PHARMACEUTICALS INCORPORATED

发明人： Marc Saul Weinberg ,  Diego Sebastian D'Astolfo ,  Sudipta Mahajan

IPC分类号： A61K31/5377 ,  A61K9/00 ,  A61K31/498 ,  A61K31/501 ,  A61K31/506 ,  A61K31/5375 ,  A61K31/7088 ,  A61K38/46 ,  A61P43/00 ,  C07D413/12 ,  C12N9/22 ,  C12N15/11

CPC分类号： A61K31/5377 ,  A61K9/0019 ,  A61K9/0053 ,  A61K31/498 ,  A61K31/501 ,  A61K31/506 ,  A61K31/5375 ,  A61K31/7088 ,  A61K38/465 ,  A61P43/00 ,  C07D413/12 ,  C12N9/22 ,  C12N15/11 ,  C12N2310/20 ,  C12N2320/31 ,  C12N2320/32 ,  C12N2320/35 ,  C12N2800/80

摘要： The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various diseases, conditions, or disorders.

公开(公告)号：US20240344087A1

公开(公告)日：2024-10-17

申请号：US18518831

申请日：2023-11-24

申请人： Amber Bio Inc.

发明人： Basem AL-SHAYEB ,  Jacob BORRAJO ,  Mohammad Kamyab JAVANMARDI ,  Kushagra SHARMA

IPC分类号： C12N15/90 ,  C12N9/22 ,  C12N15/11

CPC分类号： C12N15/907 ,  C12N9/22 ,  C12N15/11 ,  C12N15/111 ,  C12N2310/20

摘要： The disclosure relates to compositions and methods that modify target nucleic acids, as well as methods of detecting nucleic acids. Various compositions are described herein, including compositions comprising endonucleases, endonuclease systems, and chimeric proteins having the endonuclease and a nucleic-acid modulating domain or a nucleic acid modifying domain.

公开(公告)号：US20240343790A1

公开(公告)日：2024-10-17

申请号：US18627131

申请日：2024-04-04

申请人： Genzyme Corporation

发明人： Huawei Qiu ,  Clark Pan ,  Julie Bird

IPC分类号： C07K16/22 ,  A61K39/00 ,  A61K39/395 ,  C07K16/00 ,  C07K16/46 ,  C12N15/11 ,  C12N15/62

CPC分类号： C07K16/22 ,  A61K39/395 ,  A61K39/3955 ,  C07K16/00 ,  C07K16/46 ,  C12N15/11 ,  C12N15/62 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/35 ,  C07K2317/52 ,  C07K2317/53 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/626 ,  C07K2317/64 ,  C07K2317/70 ,  C07K2317/72 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2319/00 ,  C07K2319/23 ,  C07K2319/73

摘要： An scFv-Fc dimer binds and neutralizes TGFβ1 selectively and with high affinity and avidity. The scFv region may comprise the same VH and VL domains or CDR regions as metelimumab. The unique combination of their smaller size, high selectivity, potency against TGFβ1, and long in vivo half-life makes the scFv-Fc dimers ideal candidates for therapeutic applications.