公开(公告)号：US20240344087A1

公开(公告)日：2024-10-17

申请号：US18518831

申请日：2023-11-24

Applicant: Amber Bio Inc.

Inventor： Basem AL-SHAYEB ,  Jacob BORRAJO ,  Mohammad Kamyab JAVANMARDI ,  Kushagra SHARMA

IPC: C12N15/90 ,  C12N9/22 ,  C12N15/11

CPC classification number: C12N15/907 ,  C12N9/22 ,  C12N15/11 ,  C12N15/111 ,  C12N2310/20

Abstract: The disclosure relates to compositions and methods that modify target nucleic acids, as well as methods of detecting nucleic acids. Various compositions are described herein, including compositions comprising endonucleases, endonuclease systems, and chimeric proteins having the endonuclease and a nucleic-acid modulating domain or a nucleic acid modifying domain.

公开(公告)号：US20250059543A1

公开(公告)日：2025-02-20

申请号：US18938195

申请日：2024-11-05

Applicant: Amber Bio Inc.

Inventor： Jacob BORRAJO ,  Basem AL-SHAYEB

IPC: C12N15/113 ,  C12N15/85

Abstract: The present disclosure provides compositions and methods of use thereof for targeting trans-splicing of a pre-mRNA in a cell.