公开(公告)号：US11498907B2

公开(公告)日：2022-11-15

申请号：US17015450

申请日：2020-09-09

申请人： KEZAR LIFE SCIENCES

发明人： Henry Johnson ,  Sean Dalziel ,  Dustin McMinn

IPC分类号： C07D303/12 ,  C07D295/13 ,  C07D303/46 ,  C07D295/15 ,  C07C229/36 ,  C07D301/02 ,  C07D303/32

摘要： Disclosed herein are methods for preparing [(2S,3R)-N-[(2S)-3-(cyclopent-1-en-1-yl)-1-[(2R)-2-methyloxiran-2-yl]-1-oxopropan-2-yl]-3-hydroxy-3-(4-methoxyphenyl)-2-[(2S)-2-[2-(morpholin-4-yl)acetamido]propanamido]propanamide (compound “G”): and precursors thereof.

公开(公告)号：US20210284935A1

公开(公告)日：2021-09-16

申请号：US17303614

申请日：2021-06-03

申请人： ECOLAB USA INC.

发明人： DAVID DOTZAUER ,  KRISTA KUTZ OTTING

IPC分类号： C11D3/395 ,  C11D1/22 ,  C11D3/04 ,  C11D3/22 ,  C11D3/33 ,  C11D3/36 ,  C11D3/39 ,  C11D17/00 ,  A47L15/00 ,  A61L2/18 ,  C02F1/72 ,  C07D301/02 ,  D06F35/00 ,  D21C9/10 ,  D21C9/16 ,  D21H21/32

摘要： Stabilized compositions employing a sequestrant system and a binding system for improving shelf stability and dispensing stability of a solid activated bleach composition are disclosed. The compositions contain a peroxygen source and a catalyst activator which require generation of a peroxycarboxylic acid or other active oxygen sanitizing agent at a point of use. Stabilized compositions employ a sequestrant system including a phosphonic acid and/or dipicolinic acid sequestrant and a binding system comprising an anionic surfactant for a solid formulation of a catalyst activator and peroxygen source to provide shelf stability and dispensing stability for a activated bleach composition. Methods of formulating and use are further disclosed.

公开(公告)号：US10981883B2

公开(公告)日：2021-04-20

申请号：US16694296

申请日：2019-11-25

申请人： BASF Agro B.V.

发明人： Thomas Zierke ,  Joachim Gebhardt ,  Peter Schaefer ,  Uwe Josef Vogelbacher ,  Michael Rack ,  Jan Klaas Lohmann

IPC分类号： C07D301/02 ,  C07D249/08 ,  A01N43/653

摘要： The present invention relates to a process for the preparation of the compounds II from the respective oxo compounds. Furthermore, the invention relates to a process for the preparation of triazole compounds from oxiranes II.

公开(公告)号：US20210039074A1

公开(公告)日：2021-02-11

申请号：US16968548

申请日：2019-02-06

申请人： BASF SE

发明人： Andrey KARPOV ,  Andreas LEHR ,  Daniela RIECK ,  Holger BORCHERT ,  Tobias WEINLAND ,  Marco BOSCH ,  Christian WALSDORFF ,  Christian BARTOSCH ,  Juergen ZUEHLKE

IPC分类号： B01J23/50 ,  B01J35/10 ,  B01J35/02 ,  B01J37/02 ,  B01J37/08 ,  C07D301/02

摘要： A method for preparing a silver impregnation solution comprises (a) charging a neutralization reactor R1 with an aqueous organic amine; (b) adding oxalic acid powder through a first feeding conduit to the neutralization reactor R1 to obtain an aqueous oxalic acid-organic amine solution; (c) directing the aqueous oxalic acid-organic amine solution from the neutralization reactor to a complexation reactor R2; (d) adding particulate silver oxide through a second feeding conduit to the complexation reactor R2 to obtain a silver impregnation solution; and, optionally, (e) subjecting the silver impregnation solution to filtration. The silver impregnation solution is used for producing a catalyst effective in the oxidative conversion of ethylene to ethylene oxide. The method allows for the preparation of a silver impregnation solution in an efficient and occupationally and environmentally safe way. Security hazards which can occur when oxalic acid and silver oxide are added to an aqueous amine solution using the same powder feeding equipment or the same reactor are avoided.

公开(公告)号：US10781192B2

公开(公告)日：2020-09-22

申请号：US16312688

申请日：2017-06-29

申请人： KEZAR LIFE SCIENCES

发明人： Henry Johnson ,  Sean Dalziel ,  Dustin McMinn

IPC分类号： C07D295/15 ,  C07D295/13 ,  C07D303/46 ,  C07D303/12 ,  C07C229/36 ,  C07D301/02 ,  C07D303/32

摘要： Disclosed herein are methods for preparing [(2S,3R)—N-[(2S)-3-(cyclopent-1-en-1-yl)-1-[(2R)-2-methyloxiran-2-yl]-1-oxopropan-2-yl]-3-hydroxy-3-(4-methoxyphenyl)-2-[(2S)-2-[2-(morpholin-4-yl)acetamido]propanamido]propanamide (compound “G”): and precursors thereof.

公开(公告)号：US10738065B2

公开(公告)日：2020-08-11

申请号：US16404740

申请日：2019-05-07

申请人： KOREA INSTITUTE OF INDUSTRIAL TECHNOLOGY

发明人： Yun Ju Kim ,  Hyun Aee Chun ,  Su Jin Park ,  Sook Yeon Park

IPC分类号： C07D301/02 ,  C07F7/08 ,  B01J31/02

摘要： Provided is a method for preparing an epoxy compound having an alkoxysilyl group effectively by using a mild catalyst as well as an aromatic alcohol ring-opening agent. The preparation method for an epoxy compound having an alkoxysilyl group includes: performing a ring opening step by reacting an epoxy compound having an epoxide group, which is a starting material, with an aromatic alcohol ring-opening agent in the presence of a phosphine-based catalyst and an optional solvent so as to obtain an intermediate having a partially ring-opened epoxide group; and performing an alkoxysilylation step by reacting the intermediate having a partially ring-opened epoxide with isocyanate alkoxysilane.

公开(公告)号：US10053436B2

公开(公告)日：2018-08-21

申请号：US15324312

申请日：2015-06-26

申请人： BASF Agro B.V.

发明人： Joachim Gebhardt ,  Manfred Ehresmann ,  Tiziana Chiodo ,  Martin Viertelhaus ,  Roland Goetz

IPC分类号： C07D295/096 ,  C07D249/08 ,  C07D301/02 ,  C07D303/38

CPC分类号： C07D295/096 ,  C07D249/08 ,  C07D301/02 ,  C07D303/38

摘要： The present invention relates to a process for the preparation of oxirane compounds of formula II from keto compounds III using dimethyl sulfide (CH3)2S and dimethylsulfate (CH3)2SO4, forming the reagent IV, trimethylsulfonium methylsulfate [(CH3)3S+ CH3SO4−], in aqueous solution in the presence of potassium hydroxide (KOH).

公开(公告)号：US09988388B2

公开(公告)日：2018-06-05

申请号：US15092689

申请日：2016-04-07

申请人： UNIVERSITE DE BOURGOGNE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)

发明人： Franck Denat ,  Pauline Desogere ,  Claire Bernhard ,  Yoann Rousselin ,  Frederic Boschetti

IPC分类号： C07D487/04 ,  C07D255/02 ,  C07D401/14 ,  C07F9/6515 ,  C07D401/06 ,  C07D301/02 ,  A61K49/00 ,  A61K49/10 ,  A61K51/04 ,  B01J31/18

CPC分类号： C07D487/04 ,  A61K49/0002 ,  A61K49/0021 ,  A61K49/0052 ,  A61K49/106 ,  A61K51/0482 ,  B01J31/182 ,  B01J2231/72 ,  C07D255/02 ,  C07D301/02 ,  C07D401/06 ,  C07D401/14 ,  C07F9/6515

摘要： A compound with formula (V′) the synthesis method for compound (V′), and its use for the preparation of 1,4,7-triazacyclononane (tacn) and N- and/or C-functionalized derivatives thereof, particularly compounds with formula (I) Also, metallic complexes comprising a ligand with formula (I) and a metal and their use for imaging.

公开(公告)号：US09981967B2

公开(公告)日：2018-05-29

申请号：US14079530

申请日：2013-11-13

申请人： UNIVERSITE DE BOURGOGNE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)

发明人： Franck Denat ,  Pauline Desogere ,  Claire Bernhard ,  Yoann Rousselin ,  Frederic Boschetti

IPC分类号： C07D255/02 ,  C07D487/04 ,  C07D401/14 ,  C07F9/6515 ,  C07D401/06 ,  C07D301/02 ,  A61K49/00 ,  A61K49/10 ,  A61K51/04 ,  B01J31/18

CPC分类号： C07D487/04 ,  A61K49/0002 ,  A61K49/0021 ,  A61K49/0052 ,  A61K49/106 ,  A61K51/0482 ,  B01J31/182 ,  B01J2231/72 ,  C07D255/02 ,  C07D301/02 ,  C07D401/06 ,  C07D401/14 ,  C07F9/6515

摘要： The present invention embodiments relate to a compound with formula (V′) The invention also relates in certain embodiments to the synthesis method for compound (V′) and its use for the preparation of 1,4,7-triazacyclononane (tacn) and N- and/or C-functionalized derivatives thereof, particularly compounds with formula (I) The invention also relates in certain embodiments to metallic complexes comprising a ligand with formula (I) and a metal and their use for imaging.

公开(公告)号：US20180118701A1

公开(公告)日：2018-05-03

申请号：US15805679

申请日：2017-11-07

申请人： BASF Agro B.V.

发明人： Thomas ZIERKE ,  Joachim GEBHARDT ,  Peter SCHAEFER ,  Uwe Josef VOGELBACHER ,  Michael RACK ,  Jan Klaas LOHMANN

IPC分类号： C07D301/02 ,  C07D249/08 ,  A01N43/653

摘要： The present invention relates to a process for the preparation of the compounds II from the respective oxo compounds. Furthermore, he invention relates to a process for the preparation of triazole compounds from oxiranes II.