公开(公告)号：US20240285767A1

公开(公告)日：2024-08-29

申请号：US18589636

申请日：2024-02-28

申请人： Alnylam Pharmaceuticals, Inc.

发明人： Martin MAIER ,  Muthusamy JAYARAMAN ,  Akin AKINC ,  Shigeo MATSUDA ,  Pachamuthu KANDASAMY ,  Kallanthottathil G. RAJEEV ,  Muthiah MANOHARAN ,  Jayaprakash K. NAIR ,  Thomas A. BAILLIE

IPC分类号： A61K47/18 ,  A61K9/127 ,  A61K9/51 ,  A61K31/7088 ,  A61K31/7105 ,  A61K31/713 ,  C07C31/125 ,  C07C211/09 ,  C07C211/10 ,  C07C211/11 ,  C07C217/08 ,  C07C229/12 ,  C07C235/06 ,  C07C251/38 ,  C07C323/12 ,  C07C323/58 ,  C07C327/22 ,  C07C327/28 ,  C07C327/32 ,  C07D207/32 ,  C07D233/54 ,  C07D295/08 ,  C07D295/12 ,  C07D295/14 ,  C07D317/30 ,  C07F5/02

CPC分类号： A61K47/18 ,  A61K9/1272 ,  A61K9/5123 ,  A61K31/7088 ,  A61K31/7105 ,  A61K31/713 ,  C07C31/125 ,  C07C211/09 ,  C07C211/10 ,  C07C211/11 ,  C07C217/08 ,  C07C229/12 ,  C07C235/06 ,  C07C251/38 ,  C07C323/12 ,  C07C323/58 ,  C07C327/22 ,  C07C327/28 ,  C07C327/32 ,  C07D207/32 ,  C07D233/54 ,  C07D295/08 ,  C07D295/12 ,  C07D295/14 ,  C07D317/30 ,  C07F5/022

摘要： The present invention relates to a cationic lipid having one or more biodegradable groups located in a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.

公开(公告)号：US11943999B2

公开(公告)日：2024-03-26

申请号：US17208662

申请日：2021-03-22

申请人： UNIVERSAL DISPLAY CORPORATION

发明人： Chun Lin ,  Chuanjun Xia ,  Jui-Yi Tsai

IPC分类号： H10K85/30 ,  C07D209/82 ,  C07D213/69 ,  C07D233/54 ,  C07D235/04 ,  C07D401/12 ,  C07F7/08 ,  C07F15/00 ,  C09K11/06 ,  H10K50/11 ,  H10K101/10

CPC分类号： H10K85/346 ,  C07D209/82 ,  C07D213/69 ,  C07D233/54 ,  C07D235/04 ,  C07D401/12 ,  C07F7/0814 ,  C07F15/0086 ,  C07F15/0093 ,  C09K11/06 ,  H10K50/11 ,  C09K2211/1007 ,  C09K2211/1029 ,  C09K2211/1044 ,  C09K2211/185 ,  H10K2101/10

摘要： Novel Pt tetradentate complexes having Pt—O bond is disclosed. These complexes are useful as emitters in phosphorescent OLEDs.

公开(公告)号：US11919867B1

公开(公告)日：2024-03-05

申请号：US18384013

申请日：2023-10-26

申请人： KING FAISAL UNIVERSITY

发明人： Hany Mohamed Abd El-Lateef Ahmed ,  Mai Mostafa Khalaf Ali ,  Antar Ahmed Abdelhamid Ahmed ,  Amer A. Amer

IPC分类号： C07D233/54 ,  A61K31/4172 ,  A61P31/04 ,  A61P31/10 ,  C07D233/64

CPC分类号： C07D233/64 ,  A61P31/04 ,  A61P31/10

摘要： An 5-(4,5-bis(4-bromophenyl)-2-(4-methoxyphenyl)-1H-imidazol-1-yl)pentanoic compound, its synthesis, and its use as an antimicrobial agent.

公开(公告)号：US20220175930A1

公开(公告)日：2022-06-09

申请号：US17651038

申请日：2022-02-14

申请人： ALNYLAM PHARMACEUTICALS, INC.

发明人： Martin Maier ,  Muthusamy Jayaraman ,  Akin Akinc ,  Shigeo Matsuda ,  Pachamuthu Kandasamy ,  Kallanthottathil G. Rajeev ,  Muthiah Manoharan

IPC分类号： A61K47/18 ,  A61K9/127 ,  A61K9/51 ,  A61K31/713 ,  C07D317/30 ,  C07C211/09 ,  C07C211/10 ,  C07C211/11 ,  C07C217/08 ,  C07C229/12 ,  C07C327/22 ,  C07C327/28 ,  C07C327/32 ,  C07C235/06 ,  C07C251/38 ,  C07F5/02 ,  C07D233/54 ,  C07D207/32 ,  C07D295/08 ,  C07D295/12 ,  C07D295/14 ,  C07C323/12 ,  C07C323/58 ,  C07C31/125 ,  A61K31/7088 ,  A61K31/7105

摘要： The present invention relates to a cationic lipid having one or more biodegradable groups located in a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.

公开(公告)号：US20220175928A1

公开(公告)日：2022-06-09

申请号：US17651023

申请日：2022-02-14

申请人： ALNYLAM PHARMACEUTICALS, INC.

发明人： Martin Maier ,  Muthusamy Jayaraman ,  Akin Akinc ,  Shigeo Matsuda ,  Pachamuthu Kandasamy ,  Kallanthottathil G. Rajeev ,  Muthiah Manoharan

IPC分类号： A61K47/18 ,  A61K9/127 ,  A61K9/51 ,  A61K31/713 ,  C07D317/30 ,  C07C211/09 ,  C07C211/10 ,  C07C211/11 ,  C07C217/08 ,  C07C229/12 ,  C07C327/22 ,  C07C327/28 ,  C07C327/32 ,  C07C235/06 ,  C07C251/38 ,  C07F5/02 ,  C07D233/54 ,  C07D207/32 ,  C07D295/08 ,  C07D295/12 ,  C07D295/14 ,  C07C323/12 ,  C07C323/58 ,  C07C31/125 ,  A61K31/7088 ,  A61K31/7105

摘要： The present invention relates to a cationic lipid having one or more biodegradable groups located in a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.

公开(公告)号：US20220125927A1

公开(公告)日：2022-04-28

申请号：US17573878

申请日：2022-01-12

申请人： ALNYLAM PHARMACEUTICALS, INC.

发明人： Martin Maier ,  Muthusamy Jayaraman ,  Akin Akinc ,  Shigeo Matsuda ,  Pachamuthu Kandasamy ,  Kallanthottathil G Rajeev ,  Muthiah Manoharan

IPC分类号： A61K47/18 ,  C07C323/58 ,  C07C327/28 ,  A61K31/713 ,  C07C323/12 ,  C07D233/54 ,  C07D295/12 ,  C07D295/14 ,  A61K9/51 ,  C07C31/125 ,  C07C211/09 ,  C07C235/06 ,  A61K31/7088 ,  C07C211/10 ,  C07C217/08 ,  C07D295/08 ,  C07D317/30 ,  A61K31/7105 ,  C07C327/22 ,  C07C327/32 ,  C07F5/02 ,  C07C211/11 ,  C07C251/38 ,  A61K9/127 ,  C07C229/12 ,  C07D207/32

摘要： The present invention relates to a cationic lipid having one or more biodegradable groups located in a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.

公开(公告)号：US10959987B2

公开(公告)日：2021-03-30

申请号：US16384472

申请日：2019-04-15

申请人： King Abdulaziz University

发明人： Moustafa E. El-Araby ,  Abdelsattar Mansour Omar ,  Mahmoud Abdelkhalek El-Faky ,  Sameh Hamdy Abdelmageed Soror ,  Maan Talaat Khayat ,  Hani Zakariah Asfour ,  Faida Hassan Bamane

IPC分类号： A61K31/4164 ,  A61K31/55 ,  C07D233/64 ,  C07D233/54 ,  C07C279/04 ,  C07C279/10 ,  C07C279/12 ,  C07C279/16 ,  A61P31/14

摘要： Imidazole-based compounds as hepatitis C virus (HCV) inhibitors. The compounds have an imidazole core that is disubstituted via amide links. Also described are a pharmaceutical composition incorporating the imidazole-based compound, a method of preparing these compounds, and a method for using the pharmaceutical composition in the treatment of HCV infection.

公开(公告)号：US20200343459A1

公开(公告)日：2020-10-29

申请号：US16927297

申请日：2020-07-13

申请人： UNIVERSAL DISPLAY CORPORATION

发明人： CHUN LIN ,  Chuanjun Xia ,  Jui-Yi Tsai

IPC分类号： H01L51/00 ,  C07D209/82 ,  C07D235/04 ,  C07D233/54 ,  C07F15/00 ,  C07D401/12 ,  C07F7/08 ,  C07D213/69 ,  C09K11/06 ,  H01L51/50

摘要： Novel Pt tetradentate complexes having Pt—O bond is disclosed. These complexes are useful as emitters in phosphorescent OLEDs.

公开(公告)号：US20190270726A1

公开(公告)日：2019-09-05

申请号：US16415862

申请日：2019-05-17

申请人： Unity Biotechnology, Inc.

发明人： Thomas W. von Geldern ,  Bradley Backes ,  Bing Chen

IPC分类号： C07D403/06 ,  C07D233/54 ,  C07D233/64

摘要： This invention provides a method for enantioselective synthesis of cis-imidazolines and related structures through chiral resolution. A chiral acid is used to separate enantiomeric precursors of the cis-imidazolines from a racemic mixture by selective crystallization. Both enantiomers can be cyclized into the desired cis-imidazoline by complementary pathways. Compounds can be synthesized according to the invention with an enantiomeric excess as high as 99%. Cis-imidazolines such as Nutlin-3a prepared according to this invention may be used for treating cancer, killing senescent cells, or treating senescence-associated conditions.

公开(公告)号：US10329279B2

公开(公告)日：2019-06-25

申请号：US15955474

申请日：2018-04-17

申请人： Unity Biotechnology, Inc.

发明人： Thomas W. von Geldern ,  Bradley Backes ,  Bing Chen

IPC分类号： C07D403/06 ,  C07D233/54 ,  C07D233/64

摘要： This invention provides a method for enantioselective synthesis of cis-imidazolines and related structures through chiral resolution. A chiral acid is used to separate enantiomeric precursors of the cis-imidazolines from a racemic mixture by selective crystallization. Both enantiomers can be cyclized into the desired cis-imidazoline by complementary pathways. Compounds can be synthesized according to the invention with an enantiomeric excess as high as 99%. Cis-imidazolines such as Nutlin-3a prepared according to this invention may be used for treating cancer, killing senescent cells, or treating senescence-associated conditions.