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公开(公告)号：US12098135B2
公开(公告)日：2024-09-24
申请号：US18075646
申请日：2022-12-06
IPC分类号： C07D263/52 , C07D209/96 , C07D235/02
CPC分类号： C07D263/52 , C07D209/96 , C07D235/02
摘要： Aldoketo reductase (AKR) inhibitors having formulas I-III are used to treat disorders associated with NO/SNO deficiency.
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公开(公告)号：US20220315532A1
公开(公告)日：2022-10-06
申请号：US17596714
申请日：2020-06-22
发明人： Yining ZHANG , Lei YIN , Zhenglin YAO
IPC分类号： C07D209/96 , C07D401/04 , C07F5/02 , C07D403/04 , C07D401/14
摘要： The present invention relates to methods for preparing 5-fluoro-4-(7′-fluoro-2′-methylspiro[cyclopentane-1,3′-indol]-5′-yl)-N-(5-(1-methylpiperidin-4-yl)pyridin-2-yl)pyrimidin-2-amine and a salt and an intermediate thereof The methods provided herein have improved the existing synthesis methods, simplified the preparation process and increased the yield and purity, and can well meet the requirement of large-scale industrial manufacture.
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公开(公告)号：US20220281831A1
公开(公告)日：2022-09-08
申请号：US17597628
申请日：2020-07-15
发明人： Nan JI , Michael d. SINTCHAK , Li ZHANG , Xiaozhang ZHENG
IPC分类号： C07D265/26 , C07D401/06 , C07D217/24 , C07D413/06 , C07D471/04 , C07D498/04 , C07D239/96 , C07D471/10 , C07D209/96 , C07D223/16 , C07D487/04 , C07D519/00
摘要： The present invention provides compounds, compositions thereof, and methods of using the same. The present invention also relates to compounds and methods useful for binding and modulating the activity of cereblon (CRBN), especially for the inhibition of CRBN, and the treatment of CRBN-mediated disorders.
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公开(公告)号：US20220213034A1
公开(公告)日：2022-07-07
申请号：US17306390
申请日：2021-05-03
IPC分类号： C07D207/14 , C07D401/08 , C07D403/04 , C07D471/10 , C07D243/08 , C07D409/08 , C07D413/14 , C07D471/04 , C07D487/04 , C07D413/12 , C07D271/06 , C07D413/04 , C07D487/10 , C07D209/96 , C07D295/205 , C07D213/57
摘要： This invention relates to compounds that are agonists of the muscarinic M1 receptor or M1 and M4 receptors and which are useful in the treatment of muscarinic M1 or M1/M4 receptor mediated diseases. Also provided are pharmaceutical compositions containing the compounds and the therapeutic uses of the compounds. Compounds provided are of formula wherein Q4, Q5, R5, p, V, Q1, Q2, X1, X2 and W are defined herein.
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公开(公告)号：US11245079B2
公开(公告)日：2022-02-08
申请号：US16390675
申请日：2019-04-22
申请人： Merck Patent GmbH
发明人： Anja Jatsch , Tobias Grossmann , Amir Hossain Parham , Thomas Eberle , Christof Pflumm , Jonas Kroeber , Philipp Stoessel , Elvira Montenegro , Rouven Linge
IPC分类号： H01L51/00 , C09K11/06 , C07D405/04 , C07D417/10 , C07D209/96 , C07D401/04 , C07D405/10 , C07D409/04 , C07D413/04 , C07D413/10 , C07D487/10 , C07D491/20 , C07D491/22 , C09B11/00 , C09B21/00 , C09B57/00 , H05B33/20 , C07D209/94 , C07D491/107 , H01L51/50
摘要： The invention relates to compounds which are suitable for use in electronic devices, and electronic devices, in particular organic electroluminescent devices, containing said compounds.
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公开(公告)号：US11014880B2
公开(公告)日：2021-05-25
申请号：US16890581
申请日：2020-06-02
IPC分类号： A61K31/015 , C07C211/35 , C07D207/14 , C07D401/08 , C07D403/04 , C07D471/10 , C07D243/08 , C07D409/08 , C07D413/14 , C07D471/04 , C07D487/04 , C07D413/12 , C07D271/06 , C07D413/04 , C07D487/10 , C07D209/96 , C07D295/205 , C07D213/57
摘要： This invention relates to compounds that are agonists of the muscarinic M1 receptor or M1 and M4 receptors and which are useful in the treatment of muscarinic M1 or M1/M4 receptor mediated diseases. Also provided are pharmaceutical compositions containing the compounds and the therapeutic uses of the compounds. Compounds provided are of formula wherein Q4, Q5, R5, p, V, Q1, Q2, X1, X2 and W are defined herein.
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公开(公告)号：US20210122757A1
公开(公告)日：2021-04-29
申请号：US17042646
申请日：2019-03-29
发明人： Olaf KINZEL , Christoph STEENECK , Simon ANDERHUB , Martin HORNBERGER , Sheena PINTO , Barbara HERKERT , Thomas HOFFMANN
IPC分类号： C07D491/048 , C07D307/94 , C07D209/96 , C07D405/06
摘要： The present invention relates to novel spirocyclic compounds which act as modulators of indoleaine 2,3-dioxygenase (IDO1) and to the use of said compounds in the prophylaxis and/or treatment of diseases or conditions mediated by indoleamine 2,3-dioxygenase. The invention further relates to pharmaceutical compositions comprising the novel compounds.
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公开(公告)号：US10759751B2
公开(公告)日：2020-09-01
申请号：US16295364
申请日：2019-03-07
IPC分类号： A61K31/395 , C07D209/96 , C07D207/14 , C07D401/08 , C07D403/04 , C07D471/10 , C07D243/08 , C07D409/08 , C07D413/14 , C07D471/04 , C07D487/04 , C07D413/12 , C07D271/06 , C07D413/04 , C07D487/10 , C07D295/205 , C07D213/57
摘要： This invention relates to compounds that are agonists of the muscarinic M1 receptor or M1 and M4 receptors and which are useful in the treatment of muscarinic M1 or M1/M4 receptor mediated diseases. Also provided are pharmaceutical compositions containing the compounds and the therapeutic uses of the compounds. Compounds provided are of formula wherein Q4, Q5, R5, p, V, Q1, Q2, X1, X2 and W are defined herein.
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公开(公告)号：US09871207B2
公开(公告)日：2018-01-16
申请号：US14766183
申请日：2014-02-05
发明人： Wonsam Kim , Sunhee Lee , Hyeryeong Kim , Jaewan Jang , Yuri Kim , Junghwan Park , Seongje Park
IPC分类号： H01L51/00 , C07D495/04 , C07D409/14 , C07D209/56 , C07D209/96 , C07D487/04 , C07D493/04 , C09K11/06 , C07D403/04 , C07D403/14 , C07D491/048 , C07D307/93 , C07D333/78 , C07D209/94 , C07C13/62 , C07C13/72 , H01L51/50
CPC分类号： H01L51/0071 , C07C13/62 , C07C13/72 , C07C2603/54 , C07C2603/94 , C07D209/56 , C07D209/94 , C07D209/96 , C07D307/93 , C07D333/78 , C07D403/04 , C07D403/14 , C07D409/14 , C07D487/04 , C07D491/048 , C07D493/04 , C07D495/04 , C09K11/06 , C09K2211/1007 , C09K2211/1033 , C09K2211/1037 , C09K2211/1044 , C09K2211/1092 , H01L51/0072 , H01L51/0074 , H01L51/5016 , Y02E10/549
摘要： The present invention provides a novel compound capable of improving light emitting efficiency, stability, and lifespan of the element, an organic element using the same, and an electric device for the same.
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公开(公告)号：US09818948B2
公开(公告)日：2017-11-14
申请号：US14346187
申请日：2012-08-23
申请人： Anja Jatsch , Amir Hossain Parham , Christof Pflumm , Philipp Stoessel , Jonas Valentin Kroesser , Rémi Manouk Anémian , Thomas Eberle
发明人： Anja Jatsch , Amir Hossain Parham , Christof Pflumm , Philipp Stoessel , Jonas Valentin Kroesser , Rémi Manouk Anémian , Thomas Eberle
IPC分类号： H01L51/54 , C09K11/06 , H01L51/00 , C07D405/14 , C07F9/6568 , C07D405/04 , C07D409/04 , C07D409/14 , C07D487/04 , C07D487/10 , C07D491/04 , C07D491/14 , C07D495/04 , C07D495/14 , C07D209/86 , C07D209/88 , C07D209/96 , C07F7/08 , C09B57/00 , H01L51/50
CPC分类号： H01L51/0052 , C07D209/86 , C07D209/88 , C07D209/96 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D487/04 , C07D487/10 , C07D491/04 , C07D491/14 , C07D495/04 , C07D495/14 , C07F7/0814 , C07F9/65683 , C07F9/65685 , C09B57/00 , H01L51/0071 , H01L51/0072 , H01L51/0073 , H01L51/0074 , H01L51/5016 , Y02E10/549
摘要： The present invention describes carbazole derivatives formula (1), where the following applies to the symbols used: Y is on each occurrence, identically or differently, CR or N; X is selected from C(R1)2, O, S, PR1, P(═O)R1 or BR1; characterized in that at least one group R is present which stands, identically or differently on each occurrence, for a group of the following formula (2), and/or in that at least one group R1 is present which stands for a group of the following formula (3) or (4), in particular for use as triplet matrix materials in organic electroluminescent devices. The invention furthermore relates to a process for the preparation of the compounds according to the invention and to electronic devices comprising same.
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