公开(公告)号：US20240424110A1

公开(公告)日：2024-12-26

申请号：US17912416

申请日：2021-03-19

Applicant: Kymera Therapeutics, Inc.

Inventor： Nan JI ,  Matthew M. WEISS ,  Xiaozhang ZHENG ,  Xiao ZHU

IPC: A61K47/55 ,  A61K47/54

Abstract: The present invention relates to compounds and methods useful for the modulation of mouse double minute 2 homolog (“MDM2”) protein via ubiquitination and/or degradation by compounds according to the present invention.

公开(公告)号：US20240383868A1

公开(公告)日：2024-11-21

申请号：US18547038

申请日：2022-02-18

Applicant: Kymera Therapeutics, Inc.

Inventor： Yi ZHANG

IPC: C07D277/42 ,  A61K31/382 ,  A61K31/426 ,  A61K31/428 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/444 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/5025 ,  A61K31/519 ,  C07C317/40 ,  C07C317/44 ,  C07D217/24 ,  C07D277/46 ,  C07D277/56 ,  C07D277/82 ,  C07D335/06 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.

公开(公告)号：US20240343724A1

公开(公告)日：2024-10-17

申请号：US18265595

申请日：2021-12-09

Applicant: Kymera Therapeutics, Inc.

Inventor： Yi ZHANG ,  Xiaozhang ZHENG ,  Xiao ZHU

IPC: C07D417/14 ,  A61K31/454

CPC classification number: C07D417/14 ,  A61K31/454

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.

公开(公告)号：US20240173419A1

公开(公告)日：2024-05-30

申请号：US18453156

申请日：2023-08-21

Applicant: Kymera Therapeutics, Inc.

Inventor： Philip COLLIER ,  Xiaozhang ZHENG ,  Xiao ZHU ,  Melissa FORD ,  Matthew M. WEISS ,  Robert AVERSA ,  Lewis Dale PENNINGTON ,  Eamon COMER ,  Kiran Vijayakumari MAHASENAN ,  Yi ZHANG

IPC: A61K47/55 ,  A61K47/54

CPC classification number: A61K47/55 ,  A61K47/545

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.

公开(公告)号：US20240024318A1

公开(公告)日：2024-01-25

申请号：US18313040

申请日：2023-05-05

Applicant: Kymera Therapeutics, Inc.

Inventor： Yi ZHANG ,  Paul R. Fleming ,  Xiao Zhu

IPC: A61K31/506 ,  A61K47/54 ,  A61P35/00

CPC classification number: A61K31/506 ,  A61K47/545 ,  A61P35/00

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.

公开(公告)号：US20230257399A1

公开(公告)日：2023-08-17

申请号：US18050883

申请日：2022-10-28

Applicant: Kymera Therapeutics, Inc.

Inventor： William LEONG ,  Dharyl Charles WILSON

IPC: C07D519/00

CPC classification number: C07D519/00 ,  C07B2200/07

Abstract: The present invention provides compounds, compositions thereof, and processes for preparing same.

公开(公告)号：US11723980B2

公开(公告)日：2023-08-15

申请号：US17650545

申请日：2022-02-10

Applicant: Kymera Therapeutics, Inc.

Inventor： Nello Mainolfi ,  Nan Ji ,  Arthur F. Kluge ,  Matthew M. Weiss ,  Yi Zhang

IPC: A61K47/54 ,  A61P35/00 ,  A61K31/444 ,  A61K31/454 ,  A61K31/4439 ,  A61K31/519 ,  A61K31/404 ,  A61K31/53 ,  A61K31/472 ,  A61K31/422 ,  A61K31/5377 ,  A61K31/496 ,  A61K31/427

CPC classification number: A61K47/545 ,  A61K31/404 ,  A61K31/422 ,  A61K31/427 ,  A61K31/444 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/472 ,  A61K31/496 ,  A61K31/519 ,  A61K31/53 ,  A61K31/5377 ,  A61P35/00

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.

公开(公告)号：US20230110180A1

公开(公告)日：2023-04-13

申请号：US17738556

申请日：2022-05-06

Applicant: Kymera Therapeutics, Inc.

Inventor： Xiaozhang ZHENG ,  Yi ZHANG ,  Rober AVERSA ,  Xiao ZHU ,  Philip COLLIER

IPC: A61K47/55

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.

公开(公告)号：US11623932B2

公开(公告)日：2023-04-11

申请号：US16649732

申请日：2018-09-21

Applicant: Kymera Therapeutics, Inc.

Inventor： Nello Mainolfi ,  Nan Ji ,  Yi Zhang ,  Matthew M. Weiss

IPC: C07D495/14 ,  A61K9/00 ,  A61K9/08 ,  A61K9/10 ,  A61K47/55 ,  A61P35/00 ,  C07D401/14 ,  C07D417/14 ,  C07D487/04 ,  C07D495/04

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the targeted degradation of proteins, and the treatment of target protein-mediated disorders.

公开(公告)号：US11512080B2

公开(公告)日：2022-11-29

申请号：US16961362

申请日：2019-01-14

Applicant: Kymera Therapeutics, Inc.

Inventor： Nello Mainolfi ,  Nan Ji ,  Arthur F. Kluge

IPC: C07D211/88 ,  C07D417/04 ,  C07D239/22 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D413/04 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of CRBN, and the treatment of CRBN-mediated disorders.