公开(公告)号：US20240315250A1

公开(公告)日：2024-09-26

申请号：US18734194

申请日：2024-06-05

申请人： Nevada Naturals Inc.

发明人： Anthony J. Sawyer ,  Richard F. Stockel

IPC分类号： A01N47/44 ,  A01N37/36 ,  A01N43/16 ,  A61L15/20 ,  A61L15/46 ,  A61L15/60 ,  A61L17/00 ,  A61L26/00 ,  A61L27/34 ,  A61L27/52 ,  A61L27/54 ,  A61L29/08 ,  A61L29/14 ,  A61L29/16 ,  A61L31/10 ,  A61L31/14 ,  A61L31/16

CPC分类号： A01N47/44 ,  A01N37/36 ,  A01N43/16 ,  A61L15/20 ,  A61L15/46 ,  A61L15/60 ,  A61L17/005 ,  A61L27/34 ,  A61L27/52 ,  A61L27/54 ,  A61L29/085 ,  A61L29/145 ,  A61L29/16 ,  A61L31/10 ,  A61L31/145 ,  A61L31/16 ,  A01N2300/00 ,  A61L26/0066 ,  A61L2300/406 ,  A61L2400/04

摘要： Compositions are provided that have at least two of three active ingredients. The active ingredients maybe a salt having a cation NαC8-C16 alkanoyl-L di-basic amino acid —C1-C4 alkyl ester, a glycerol monoester of a fatty acid and a sugar ester of a fatty acid. The compositions are useful in methods of killing or inhibiting planktonic bacteria or fungi and bacteria or fungi embedded in a biofilm and prevention of biofilm formation on surfaces. The composition may further comprise a hydrogel and a benefit agent such as an antibiotic that can be solubilized by the hydrogel and supplied to the biofilm matrix by the active ingredients of the composition. Devices such as chronic wound coverings coated with the composition are also provided. Methods of preserving products with the composition are also provided.

公开(公告)号：US12097300B2

公开(公告)日：2024-09-24

申请号：US17167568

申请日：2021-02-04

申请人： Nanyang Technological University

发明人： Bee Eng Mary Chan ,  Chun Kiat Yeo ,  Nguan Soon Tan ,  Surendra Hittanahalli Mahadevegowda

IPC分类号： A61L26/00 ,  B82Y5/00 ,  C08L79/04 ,  C08L81/02

CPC分类号： A61L26/008 ,  A61L26/0052 ,  A61L26/0066 ,  C08L79/04 ,  C08L81/02 ,  A61L2400/12 ,  B82Y5/00

摘要： Disclosed herein is a hydrogel that eradicates biofilm bacteria from wounds and accelerates diabetic wound healing. Also disclosed herein are methods of manufacture and use of said hydrogel.

公开(公告)号：US20240299351A1

公开(公告)日：2024-09-12

申请号：US18288473

申请日：2022-04-28

申请人： Northwestern University

发明人： Nathan C. GIANNESCHI ,  Kurt Q. LU ,  Zofia Elzbieta SIWICKA ,  Naneki Chelsea COLLINS-MCCALLUM ,  Dauren BIYASHEV ,  Ummiye Venus ONAY ,  Michael Mark DEMCZUK

IPC分类号： A61K31/404 ,  A61K9/00 ,  A61K9/14 ,  A61L26/00 ,  A61P17/02

CPC分类号： A61K31/404 ,  A61K9/0014 ,  A61K9/14 ,  A61L26/0052 ,  A61P17/02

摘要： Aspects disclosed herein include a method for treatment of a subject, the method comprising: topically administering a melanin formulation having an artificial melanin material (thereby administering artificial melanin material) to (or, to a site of) damaged skin of the subject; wherein the administered artificial melanin material comprises extracellular artificial melanin material at (or, at the site of) the damaged skin; and facilitating skin healing in the wound via at least the extracellular artificial melanin material; wherein the step of facilitating skin healing comprises at least a portion of the extracellular artificial melanin material performing a therapeutic extracellular activity.

公开(公告)号：US20240277894A1

公开(公告)日：2024-08-22

申请号：US18648498

申请日：2024-04-29

申请人： Guangdong Ocean University

发明人： Zhang Hu ,  Lefan Li ,  Mingneng Liao

IPC分类号： A61L26/00 ,  C08L5/08

CPC分类号： A61L26/0095 ,  A61L26/0004 ,  A61L26/0023 ,  A61L26/0052 ,  A61L26/0066 ,  A61L26/008 ,  C08L5/08 ,  A61L2300/106 ,  A61L2300/406

摘要： A composite antibacterial hydrogel dressing, a preparation method and an application method thereof are provided, which relate to the field of biomedical technologies. The composite antibacterial hydrogel dressing is made from the following raw materials in parts by weight: 8 to 22 parts of chitosan, 12 to 36 parts of carrageenan, 9 to 25 parts of 2-aminoisonicotinic acid, 3 to 8 parts of lactic acid, 4 to 10 parts of iodine and 6 to 15 parts of potassium iodide. The composite antibacterial hydrogel dressing has a good flexibility, a strong antibacterial effect, a long antibacterial time, no skin irritation, good application prospect in the field of medical wound repair, simple preparation process and easy industrial production.

公开(公告)号：US20240277893A1

公开(公告)日：2024-08-22

申请号：US18644676

申请日：2024-04-24

申请人： UAB Bioremedium

发明人： Šiurkus Juozas

IPC分类号： A61L26/00

CPC分类号： A61L26/008 ,  A61L26/0052 ,  A61L26/0066 ,  A61L26/0076 ,  A61L2300/252 ,  A61L2300/254 ,  A61L2300/402 ,  A61L2300/406 ,  A61L2300/41 ,  A61L2300/414 ,  A61L2300/418 ,  A61L2300/802

摘要： Stabilized pharmaceutical wound dressing compositions comprising calreticulin protein for use in medical treatment, in particular for topical treatment of acute and chronic wounds, are provided. Pharmaceutical compositions of the present invention comprise calreticulin protein or a functional fragment or derivative thereof and one or more of pharmaceutically acceptable polymeric materials that form hydrogel. More specifically, compositions of present invention can be sprayed onto a wound as a liquid or applied topically in the form of gel. Compositions of the present invention may further comprise serum albumins, preservatives and additional biologically active molecules.

公开(公告)号：US20240277891A1

公开(公告)日：2024-08-22

申请号：US18571487

申请日：2022-06-27

申请人： Yoshiyuki Koyama ,  TOAGOSEI CO., LTD.

发明人： Yoshiyuki Koyama ,  Tomoko Ito ,  Kenichi Nakamura ,  Ayaka Ouchi

IPC分类号： A61L26/00 ,  C08J5/18

CPC分类号： A61L26/008 ,  A61L26/0052 ,  C08J5/18 ,  C08J2333/02 ,  C08J2333/10 ,  C08J2433/02 ,  C08J2439/06

摘要： A medical treatment material that forms a hydrogel upon contact with water contains a polymer (A) including a structural unit derived from an ethylenic unsaturated monomer (ma) which has a carboxyl group and a molecular weight of 115 or less, and a polymer (B) including a structural unit derived from an ethylenic unsaturated monomer (mb) which has a functional group E that is capable of forming a hydrogen bond with a carboxyl group, the polymer (B) not being the polymer (A). At least one of the polymer (A) and the polymer (B) includes a structural unit derived from an ethylenic unsaturated monomer (mc) differing from the ethylenic unsaturated monomers (ma) and (mb), and the monomer (mc) is not an ethylenic unsaturated monomer having a cross-linkable functional group.

公开(公告)号：US20240277890A1

公开(公告)日：2024-08-22

申请号：US18568478

申请日：2022-06-14

申请人： Amicoat AS

发明人： Andreas Spiegelberg ,  Wenche Stensen ,  John Sigurd Svendsen

IPC分类号： A61L26/00

CPC分类号： A61L26/0019 ,  A61L26/0028

摘要： The present invention provides an antimicrobial article comprising polyurethane, wherein said polyurethane is impregnated with a compound of Formula (I)


AA-AA-AA-X—Y   (I)

The invention also provides polyurethane impregnated with a compound of Formula (I). The invention also provides compositions comprising at least one organic solvent, a thermoplastic polyurethane and a compound of Formula (I), and coatings produced using such compositions. The invention also provides methods of producing polyurethane impregnated with a compound of Formula (I), medical devices incorporating polyurethane impregnated with a compound of Formula (I), and medical uses of polyurethane impregnated with a compound of Formula (I).

公开(公告)号：US20240277887A1

公开(公告)日：2024-08-22

申请号：US18639137

申请日：2024-04-18

申请人： Cook Medical Technologies LLC

发明人： Shaun D. Gittard ,  John Crowder Sigmon, Jr. ,  Vihar C. Surti

IPC分类号： A61L15/58 ,  A61L24/00 ,  A61L26/00

CPC分类号： A61L15/58 ,  A61L24/001 ,  A61L26/0061 ,  A61L2400/06

摘要： The present invention relates to a long-lasting medical product for protecting or treating a lesion in the gastrointestinal tract. The medical product includes a protective covering, wherein the medical product upon application at and about the site of the lesion adheres to the gastrointestinal tissue and is capable of remaining at and about the site of the lesion for a time sufficient to allow the lesion to heal or be treated.

公开(公告)号：US20240270942A1

公开(公告)日：2024-08-15

申请号：US18568137

申请日：2022-06-17

申请人： UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED

发明人： Mei HE

IPC分类号： C08L3/02 ,  A61L26/00 ,  B33Y70/00

CPC分类号： C08L3/02 ,  A61L26/0023 ,  A61L26/0033 ,  A61L26/0038 ,  A61L26/008 ,  B33Y70/00 ,  A61L2400/12

摘要： Described herein are biocompatible nanocomposite hydrogel compositions for three-dimensional printing, comprising: collagen, starch, and gelatin nanoparticles. Additionally described are methods of using three-dimensional objects printed from the a nanocomposite hydrogel compositions for healing wounds and regenerating tissue.

公开(公告)号：US20240252520A1

公开(公告)日：2024-08-01

申请号：US18408546

申请日：2024-01-09

申请人： Beth Israel Deaconess Medical Center, Inc. ,  President and Fellows of Harvard College

发明人： Aristidis Veves ,  George Theocharidis ,  Zhuqing Li ,  Ioannis Vlachos ,  David J. Mooney ,  Sangmin Lee

IPC分类号： A61K31/662 ,  A61K9/06 ,  A61K9/70 ,  A61K31/27 ,  A61K31/445 ,  A61K31/473 ,  A61K31/55 ,  A61K47/02 ,  A61K47/36 ,  A61L26/00 ,  A61P17/02

CPC分类号： A61K31/662 ,  A61K9/06 ,  A61K9/7023 ,  A61K31/27 ,  A61K31/445 ,  A61K31/473 ,  A61K31/55 ,  A61K47/02 ,  A61K47/36 ,  A61L26/0023 ,  A61L26/0066 ,  A61L26/008 ,  A61P17/02 ,  A61L2300/102 ,  A61L2300/216 ,  A61L2300/258 ,  A61L2300/622

摘要： In certain aspects, the disclosure relates to devices and methods for treating wounds wherein an acetylcholinesterase inhibitor is delivered to a wound to promote wound healing. In further aspects, metrifonate can be delivered to the wound by time release from a wound dressing. In further aspects a sequence of wound dressings can be applied to the wound to treat different phases of wound healing.