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公开(公告)号：US20240358645A1
公开(公告)日：2024-10-31
申请号：US18652504
申请日：2024-05-01
发明人： Yeon-Sun HONG , Yoo Soo YANG , In-San KIM
IPC分类号： A61K9/48 , A61K31/337 , A61K31/407 , A61K31/704 , A61K38/47 , A61K39/395 , A61K41/00 , A61K45/06 , A61N5/10 , A61P35/00
CPC分类号： A61K9/48 , A61K31/337 , A61K31/407 , A61K31/704 , A61K38/47 , A61K39/3955 , A61K41/0057 , A61K45/06 , A61P35/00 , C12Y302/01035 , A61N5/10 , A61N2005/1098
摘要： The present invention relates to a recombinant exosome containing hyaluronidase and a use thereof, and more particularly to a recombinant exosome that presents hyaluronidase on its surface and use thereof as an anticancer agent.
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2.发明公开公开(公告)号：US20240325505A1
公开(公告)日：2024-10-03
申请号：US18288797
申请日：2022-09-08
发明人： Qipeng YUAN , Li CHENG , Pengtao LIU
IPC分类号： A61K38/47 , A61K31/7028 , A61P17/00 , A61P17/14
CPC分类号： A61K38/47 , A61K31/7028 , A61P17/00 , A61P17/14 , C12Y302/01147
摘要： The present disclosure relates to a pharmaceutical composition for improving and treating leukotrichia and/or alopecia and a preparation method thereof. In the present disclosure, the pharmaceutical composition includes glucoraphanin and myrosinase as active ingredients, where the glucoraphanin has a content of 0.1% to 50% and the myrosinase has a total enzyme activity of 0.1 mU to 10 U based on a total weight of the pharmaceutical composition. The pharmaceutical composition shows safety, rapidity, effective improvement and treatment of leukotrichia and/or alopecia, and wide application range for subjects.
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公开(公告)号：US12102667B2
公开(公告)日：2024-10-01
申请号：US17820316
申请日：2022-08-17
发明人： Heejoon Myung , Min Soo Kim , Hye-Won Hong , Young Deuk Kim , Jaeyeon Jang
CPC分类号： A61K38/47 , A61K38/12 , A61P31/04 , C12N7/00 , C12N9/2462 , C12Y302/01017 , C12N2795/00042
摘要： Provided are a novel polypeptide having endolysin activity, a fusion protein comprising the polypeptide and an antibiotic active protein, and an antibiotic use against a gram-negative pathogen of the polypeptide and/or fusion protein and/or a use for prevention and/or treatment of gram-negative pathogen infection and/or disease or symptoms related to gram negative pathogen infection.
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公开(公告)号：US20240318158A1
公开(公告)日：2024-09-26
申请号：US18659215
申请日：2024-05-09
申请人： Halozyme, Inc,
发明人： Ge WEI , H. Michael SHEPARD , Qiping Zhao , Robert James CONNOR
IPC分类号： C12N9/26 , A61K9/00 , A61K38/00 , A61K38/28 , A61K38/47 , A61K45/06 , A61K47/10 , A61P35/00 , C07K14/47 , C12Q1/34
CPC分类号： C12N9/2474 , A61K9/0019 , A61K38/28 , A61K38/47 , A61K45/06 , A61K47/10 , A61P35/00 , C07K14/47 , C12Q1/34 , C12Y302/01035 , A61K38/00 , C07K2319/30 , G01N2333/926 , G01N2333/928 , Y02A50/30
摘要： Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided are compositions and formulations and uses thereof.
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5.发明公开公开(公告)号：US20240316217A1
公开(公告)日：2024-09-26
申请号：US18264364
申请日：2022-02-04
发明人： R. Scott McIvor , Nicholas Alexander Piers Sascha Buss , Troy C. Lund , Elizabeth Braunlin , Lalitha R. Belur , Carolyn Fairbanks , Marie-Laure Nevoret
CPC分类号： A61K48/005 , A61K9/0019 , A61K9/0085 , A61K38/47 , A61K48/0075 , A61K48/0083 , A61P3/06 , A61P9/00 , A61P19/00 , C12N15/86 , C12Y302/01076 , C12N2750/14143
摘要： A method to prevent, inhibit the progression of, reduce the severity of, or treat cardiac, vascular or skeletal dysfunction or defect(s) in a human having lysosomal storage disorder, is provided.
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公开(公告)号：US20240307511A1
公开(公告)日：2024-09-19
申请号：US18538866
申请日：2023-12-13
IPC分类号： A61K38/47 , A61K9/00 , A61K31/343 , A61K31/439 , A61K35/76 , A61K45/06 , A61K48/00 , A61P3/00 , C12N7/00 , C12N9/24 , C12N15/86
CPC分类号： A61K38/47 , A61K9/0019 , A61K31/343 , A61K31/439 , A61K35/76 , A61K45/06 , A61P3/00 , C12N7/00 , C12N9/2402 , C12N15/86 , C12Y302/01076 , A61K48/00 , A61K48/0083 , C12N2750/14121 , C12N2750/14132 , C12N2750/14143
摘要： A co-therapeutic regimen comprising AAV9-mediated intrathecal/intracisternal and/or systemic delivery of an expression cassette containing a hIDUA gene and two or more immunosuppressants is provided herein. Also provided are methods useful for treating hIDUA deficiency (MPSI) and the symptoms associated with Hurler, Hurler-Scheie and Scheie syndromes.
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公开(公告)号：US12091692B2
公开(公告)日：2024-09-17
申请号：US17327568
申请日：2021-05-21
申请人： HALOZYME, INC.
发明人： Ge Wei , H. Michael Shepard , Qiping Zhao , Robert James Connor
IPC分类号： A61K38/28 , A61K9/00 , A61K38/47 , A61K45/06 , A61K47/10 , A61P35/00 , C07K14/47 , C12N9/26 , C12Q1/34 , A61K38/00
CPC分类号： C12N9/2474 , A61K9/0019 , A61K38/28 , A61K38/47 , A61K45/06 , A61K47/10 , A61P35/00 , C07K14/47 , C12Q1/34 , C12Y302/01035 , A61K38/00 , C07K2319/30 , G01N2333/926 , G01N2333/928 , Y02A50/30 , A61K38/28 , A61K2300/00 , A61K38/47 , A61K2300/00
摘要： Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided are compositions and formulations and uses thereof.
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公开(公告)号：US12090205B2
公开(公告)日：2024-09-17
申请号：US16665236
申请日：2019-10-28
发明人： Joseph C. Salamone , Rebecca Erin McMahon , Suprena Emanuella Zariah Poleon , Ann Beal Salamone
IPC分类号： A61K33/38 , A61K9/06 , A61K31/12 , A61K31/137 , A61K31/167 , A61K31/4174 , A61K31/616 , A61K31/635 , A61K31/785 , A61K33/30 , A61K35/64 , A61K38/47 , A61K47/10 , A61K47/14 , A61K47/34
CPC分类号： A61K47/34 , A61K9/06 , A61K31/12 , A61K31/137 , A61K31/167 , A61K31/4174 , A61K31/616 , A61K31/635 , A61K31/785 , A61K33/30 , A61K33/38 , A61K35/64 , A61K38/47 , A61K47/10 , A61K47/14 , C12Y302/01
摘要： The reduction in the sol-gel temperature of aqueous poloxamer surfactant compositions by the addition of hydrophobic vicinal diols is provided. Lowering of the sol-gel temperature and the gelling efficiency of water-soluble poloxamer block copolymers of polyethylene oxide-b-polypropylene oxide-b-polyethylene oxide has been markedly improved by the addition of small amounts of at least one hydrophobic vicinal diol, such as monoalkyl glycols, monoalkyl glycerols, or monoacyl glycerols. The decrease in the sol-gel temperature facilitates gel formation, and such gels exhibit greater residence time on a surface, particularly those with biological properties.
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公开(公告)号：US20240285734A1
公开(公告)日：2024-08-29
申请号：US18518270
申请日：2024-05-14
申请人： Daniel Darvish
发明人： Daniel Darvish
IPC分类号： A61K38/47 , A61K9/00 , A61K38/17 , A61K38/45 , A61K45/06 , A61P21/04 , C12N7/00 , C12N9/12 , C12N9/24 , C12N15/86
CPC分类号： A61K38/47 , A61K9/0019 , A61K38/17 , A61K38/45 , A61K45/06 , A61P21/04 , C12N7/00 , C12N9/1205 , C12N9/2402 , C12N15/86 , C12Y207/0106 , C12Y302/01183 , C12N2750/14143
摘要： The invention relates to composition and methods for expressing UDP-GlcNAc 2-Epimerase/ManNAc Kinase enzyme (GNE) in a living organism. In preferred embodiments, the invention relates to treating disease condition that involves use of therapeutically effective amount of a composition described herein.
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公开(公告)号：US12071642B2
公开(公告)日：2024-08-27
申请号：US18462237
申请日：2023-09-06
CPC分类号： C12N9/2414 , A61K38/47 , A61P1/18 , C12Y302/01001
摘要： The present invention provides engineered amylase polypeptides and compositions thereof. The engineered amylase polypeptides have been optimized to provide improved thermostability, protease stability, and stability under a range of pH conditions, including acidic (pH
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