METHOD OF SYNTHESIS OF CDL2 COMPLEX WITH HIGH BIOLOGICAL ACTIVITY AGAINST AT LEAST CHLOROQUINE RESISTANT STRAIN OF THE MALARIA PARASITE PLASMODIUM FALCIPARUM
    2.
    发明申请
    METHOD OF SYNTHESIS OF CDL2 COMPLEX WITH HIGH BIOLOGICAL ACTIVITY AGAINST AT LEAST CHLOROQUINE RESISTANT STRAIN OF THE MALARIA PARASITE PLASMODIUM FALCIPARUM 审中-公开
    合成具有高生物活性的CDL2复合物的方法,用于疟原虫PLASMODIUM FALCIPARUM的最低氯霉素抗性菌株

    公开(公告)号:US20130109857A1

    公开(公告)日:2013-05-02

    申请号:US13642692

    申请日:2010-11-19

    Applicant: Enos Kiremire

    Inventor: Enos Kiremire

    CPC classification number: C07F3/08 C07D213/53

    Abstract: Metal complex of Nickel (II) containing a dithio-based ligand have been synthesized and characterized by elemental analysis, mass spectrometry, Proton NMR and FT-IR spectrometry. A single crystal X-ray structure of the cadmium complex has been analyzed. The metal complex was subjected to biological tests on falcipain-2 (FP-2) and falcipain-3 (FP-3) cysteine protease enzymes from the malaria parasite Plasmodium falciparum. They were further tested in vitro against chloroquine resistant strain (W2). Whereas the potency of the metal complexes was weaker than the control regarding the FP-2 and FP-3, the potency of metal complexes was found to be exceedingly greater than the control when tested against the chloroquine resistant strain (W2) with a strength ratio of (1.4). This paper describes the synthesis, characterization and biological results of the said metal complex containing deprotonated 3-[1-(2-pyridyl) ethylidene] hydrazinecarbodithioate ligand.

    Abstract translation: 已经通过元素分析,质谱,质子核磁共振和FT-IR光谱法合成了含有二硫基配位体的镍(II)金属络合物。 已经分析了镉络合物的单晶X射线结构。 对来自疟原虫恶性疟原虫的疟原虫-2(FP-2)和镰刀菌素-3(FP-3)半胱氨酸蛋白酶进行生物试验。 他们进一步体外抗氯喹抗性菌株(W2)。 虽然金属络合物的效力弱于对FP-2和FP-3的对照,但是发现金属络合物的效力远高于对抗氯喹抗性菌株(W2)时的对照,强度比 (1.4)。 本文介绍了含有去质子化的3- [1-(2-吡啶基)亚乙基]肼碳二硫酸酯配体的所述金属络合物的合成,表征和生物学结果。

    WATER SOLUBLE QUANTUM DOTS
    6.
    发明申请
    WATER SOLUBLE QUANTUM DOTS 有权
    水可溶量子

    公开(公告)号:US20100008861A1

    公开(公告)日:2010-01-14

    申请号:US12552970

    申请日:2009-09-02

    Abstract: An economic, direct synthetic method for producing water soluble QDs that are ready for bioconjugation is provided. The method can produce aqueous QDs with emission wavelengths varying from 400 nm to 700 nm Highly luminescent metal sulfide (MS) QDs are produced via an aqueous synthesis route. MS QDs are capped with thiol-containing charged molecules in a single step. The resultant MS QDs exhibit the distinctive excitonic photoluminescence desired of QDs and can be fabricated to avoid undesirable broadband emissions at higher wavelengths. This provides a significant improvement over the present complex and expensive commercial processes for the production of QDs. The aqueous QDs are stable in biological fluids over a long period of time. In addition, nontoxic ZnS QDs have been produced with good photoluminescence properties by refluxing the ZnS QD suspensions over a period of time.

    Abstract translation: 提供了一种用于生产水溶性量子点的经济,直接的合成方法,可用于生物共轭。 该方法可以产生发射波长从400nm到700nm变化的含水量子点。高发光金属硫化物(MS)量子点通过水性合成途径产生。 在一个步骤中,MS量子点被含硫醇的带电分子封盖。 所得的MS量子点显示量子点所需的独特的激子光致发光,并且可以被制造以避免在较高波长处的不期望的宽带发射。 这提供了相对于目前用于生产量子点的复杂和昂贵的商业过程的显着改进。 水质量子在长时间内在生物体液中是稳定的。 此外,通过在一段时间内回流ZnS QD悬浮液,已经生产出具有良好光致发光性质的无毒ZnS量子点。

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