公开(公告)号：US06307094B1

公开(公告)日：2001-10-23

申请号：US09564656

申请日：2000-05-02

申请人： Joshua Anthony Chong ,  Fereydon Abdesaken ,  Lori Ann Spangler ,  Renee Caroline Roemmele ,  Randall Wayne Stephens ,  Peter David Nightingale ,  David John Hartley

发明人： Joshua Anthony Chong ,  Fereydon Abdesaken ,  Lori Ann Spangler ,  Renee Caroline Roemmele ,  Randall Wayne Stephens ,  Peter David Nightingale ,  David John Hartley

IPC分类号： C07C6963

CPC分类号： C07C67/31 ,  C07C69/675

摘要： The present invention provides a solventless process for the catalytic hydrogenation of esters of 4,4,4-trihaloacetoacetic acid using a platinum catalyst in the presence of an acid or base co-catalyst to provide the analagous 3-hydroxybutyrate ester. Such 3-hydroxybutyrate esters are useful as solvents, cleaners or fine chemical intermediates.

摘要翻译： 本发明提供了一种在酸或碱助催化剂存在下使用铂催化剂催化氢化4,4,4-三卤乙酰乙酸酯的无溶剂方法，以提供分离的3-羟基丁酸酯。 这种3-羟基丁酸酯可用作溶剂，清洁剂或精细化学中间体。

公开(公告)号：US06437174B1

公开(公告)日：2002-08-20

申请号：US09214219

申请日：1999-03-29

申请人： Wolfgang Appel ,  Sergej Pasenok

发明人： Wolfgang Appel ,  Sergej Pasenok

IPC分类号： C07C6963

CPC分类号： C07C67/307 ,  C07C69/63

摘要： The present invention concerns a method for producing esters of 2-fluoro-iso butyric acid in which the corresponding 2-hydroxyisobutyric acid ester is reacted with hydrofluoric acid.

摘要翻译： 本发明涉及一种生产2-氟异丁酸的酯的方法，其中相应的2-羟基异丁酸酯与氢氟酸反应。

公开(公告)号：US06255524B1

公开(公告)日：2001-07-03

申请号：US09331785

申请日：1999-06-25

申请人： Hirokazu Aoyama ,  Shoji Takagi ,  Shinichi Matsumura ,  Yoshinori Tanaka

发明人： Hirokazu Aoyama ,  Shoji Takagi ,  Shinichi Matsumura ,  Yoshinori Tanaka

IPC分类号： C07C6963

CPC分类号： C07C45/30 ,  C07C51/58 ,  C07C51/60 ,  C07C67/00 ,  C07C47/14 ,  C07C53/50 ,  C07C69/63

摘要： An acid chloride can be produced at a high yield from a primary alcohol having a polyfluoroalkyl group and one methylene group by (1) a method in which RfCH2OH (wherein Rf is a polyfluoroalkyl group) is reacted with chlorine to produce RfCOCl, (2) a method in which RfCHO is reacted with chlorine to produce RfCOCl, and (3) a method for producing an acid chloride comprising (a) a step in which an aldehyde (RfCHO) is formed from an alcohol (RfCH2OH), (b) a step in which a monochloroester (RfCOOCHClRf) is formed from the aldehyde and an acid chloride (RfCOCl), and (c) a step in which the acid chloride (RfCOCl) is formed from the monochloroester.

摘要翻译： （1）RfCH 2 OH（其中Rf为多氟烷基）与氯反应生成RfCOCl的方法可以高产率地由具有多氟烷基和一个亚甲基的伯醇生产酰氯，（2） 其中RfCHO与氯反应生成RfCOCl的方法，和（3）生产酰氯的方法，包括（a）其中由醇形成醛（RfCHO）的步骤（RfCH 2 OH），（b） 从醛和酰氯（RfCOCl）形成单氯酸酯（RfCOOCHClRf）的步骤，和（c）由单氯酸酯形成酰氯（RfCOCl）的步骤。

公开(公告)号：US06278015B1

公开(公告)日：2001-08-21

申请号：US09617381

申请日：2000-07-17

申请人： Lori Ann Spangler ,  Fereydon Abdesaken ,  Joshua Anthony Chong

发明人： Lori Ann Spangler ,  Fereydon Abdesaken ,  Joshua Anthony Chong

IPC分类号： C07C6963

CPC分类号： C07C327/22 ,  C07C67/14 ,  C07C69/63

摘要： The present invention provides a process for preparing esters or thioesters of trifluoroacetic acid from trifluoroacetyl chloride and an alcohol or a thiol with the ester or thioester being present as the solvent. Esters and thioesters of trifluoroacetic acid are fine chemical intermediates which can be used in the manufacture of pharmaceuticals, agricultural chemicals, liquid crystals, dyes and industrial chemicals. Trifluoroacetate esters and thioesters can also be used as solvents in the manufacture of other fine chemicals, pharmaceuticals, agricultural chemicals, liquid crystals, industrial chemicals and dyes.

摘要翻译： 本发明提供从三氟乙酰氯和醇或硫醇制备三氟乙酸的酯或硫酯的方法，其中酯或硫酯作为溶剂存在。 三氟乙酸的酯和硫酯是精细化学中间体，可用于制药，农药，液晶，染料和工业化学品的制造。 三氟乙酸酯和硫酯也可用作制造其他精细化学品，药物，农药，液晶，工业化学品和染料的溶剂。

公开(公告)号：US06262299B1

公开(公告)日：2001-07-17

申请号：US09348085

申请日：1999-07-06

申请人： John Tsai ,  Sirisoma Wanigatunga

发明人： John Tsai ,  Sirisoma Wanigatunga

IPC分类号： C07C6963

CPC分类号： C08F20/60 ,  A61K8/8158 ,  A61K2800/5428 ,  A61Q5/06 ,  C04B24/123 ,  C04B24/2652 ,  C07C229/16 ,  C07C233/38 ,  C08F20/36 ,  C08F2220/1825 ,  C08F2220/387 ,  C08F220/14 ,  C08F2220/603 ,  C08F220/06

摘要： A zwitterionic monomer having amino-multicarboxylic acid functionality having Structure (I) wherein R1 is selected from the group consisting of H, an alkyl group having 1 to 6 carbon atoms; R2 is (CH2)n where n is 2 to 12; R3 and R4 are independently an alkyl group having 1 to 6 carbon atoms; R5 is (CH2)m where m is 2 or 3; R6 and R7 are independently selected from wherein R20 is selected from the group consisting of H, CH3, and COOY; R21 is selected from H or CH3; X is oxygen or nitrogen; A is a halide; and Y is independently a cation. The zwitterionic monomer is the reaction product of an amino-multicarboxylic acid and an amine containing monomer. Polymers prepared with the zwitterionic monomer are especially useful in hair treatment compositions to provide increased stiffness to hair, in coating formulations to increase the impact resistance, wet adhesion, and flexibility of the coating, especially wood coatings, and in mortar compositions to improve mortar compatibility, especially with redispersible powders.

摘要翻译： 具有结构（I）的氨基 - 多元羧酸官能团的两性离子单体，其中R 1选自H，具有1至6个碳原子的烷基; R2是（CH2）n，其中n是2到12; R3和R4独立地为具有1至6个碳原子的烷基; R5是（CH2）m，其中m是2或3; R 6和R 7独立地选自其中R 20选自H，CH 3和COOY; R 21选自H或CH 3; X是氧或氮; A是卤化物; Y独立地为阳离子。 两性离子单体是氨基 - 多元羧酸和含胺单体的反应产物。 用两性离子单体制备的聚合物在头发处理组合物中特别有用，以提供增加的毛发刚度，在涂层配方中增加涂层的抗冲击性，湿粘合性和柔韧性，特别是木材涂层，以及用于改善砂浆相容性的砂浆组合物 ，特别是可再分散的粉末。

公开(公告)号：US06376705B1

公开(公告)日：2002-04-23

申请号：US09576375

申请日：2000-05-22

申请人： Weiming Qiu

发明人： Weiming Qiu

IPC分类号： C07C6963

CPC分类号： C07C67/343 ,  C07C69/65 ,  C07C69/63

摘要： Esters and other carboxylic acid derivatives of 3,3,4,4-tetrahydroperfluoroalkylcarboxylic acids are made by the iron promoted reaction of an ester of bromodifluoroacetic acid or other carboxylic acid derivatives and a (perfluoroalkyl)ethylene. The resulting products may be converted to the corresponding alkali metal or ammonium carboxylate slits which are useful as surfactants in fluoroolefin polymerizations.

摘要翻译： 3,3,4,4-四氢全氟烷基羧酸的酯和其它羧酸衍生物通过溴二氟乙酸或其它羧酸衍生物和（全氟烷基）乙烯的酯促进铁的反应来制备。 所得产物可以转化为相应的碱金属或铵羧酸盐狭缝，其可用作氟烯烃聚合中的表面活性剂。

公开(公告)号：US06252105B1

公开(公告)日：2001-06-26

申请号：US09348072

申请日：1999-07-06

申请人： Max Braun ,  Johannes Eicher ,  Francine Janssens ,  Kerstin Eichholz ,  Stefan Palsherm

发明人： Max Braun ,  Johannes Eicher ,  Francine Janssens ,  Kerstin Eichholz ,  Stefan Palsherm

IPC分类号： C07C6963

CPC分类号： C07C67/56 ,  C07C51/47 ,  C07C51/64 ,  C07C53/18 ,  C07C67/14 ,  C07C67/58 ,  C07C53/48 ,  C07C59/195 ,  C07C69/63 ,  C07C69/72

摘要： Organic compounds, e.g. fluorinated organic compounds such as fluorinated carboxylic acids or fluorinated carboxylic acid chlorides, may contain small amounts of carboxylic acid fluorides, hydrogen fluoride or hydrolyzable fluoride, which during the preparation of derivatives of the fluorinated organic compounds, for example by esterification, may yield corrosive fluorides or hydrogen fluoride. The invention is a method for the synthesis and/or purification of preferably fluorinated organic compounds such as carboxylic acids, carboxylic acid chlorides and derivatives such as esters thereof, starting from corresponding carboxylic acid chlorides containing acid fluorides or hydrolyzable fluoride, and alcohols under the catalytic action of “onium” salts of carboxylic acids, to obtain products which have a low fluoride content. Alternatively, an inorganic oxide adsorbent is utilized. The method is especially suitable for the synthesis of esters of trifluoroacetic acid, chlorodifluoroacetic acid, trifluoroacetoacetic acid and/or difluoroacetoacetic acid.

摘要翻译： 有机化合物，例如 含氟有机化合物如氟化羧酸或氟化羧酸氯化物可含有少量羧酸氟化物，氟化氢或水解性氟化物，其在氟化有机化合物衍生物的制备过程中，例如通过酯化反应，可产生腐蚀性氟化物 或氟化氢。 本发明是一种合成和/或纯化优选氟化有机化合物如羧酸，羧酸氯化物及其衍生物如酯的方法，起始于含有酸性氟化物或可水解氟化物的相应的羧酸氯化物和催化剂下的醇 羧酸的“鎓”盐的作用，以获得具有低氟含量的产物。 或者，使用无机氧化物吸附剂。 该方法特别适用于三氟乙酸，氯二氟乙酸，三氟乙酰乙酸和/或二氟乙酰乙酸的酯的合成。

公开(公告)号：US06639100B2

公开(公告)日：2003-10-28

申请号：US10212840

申请日：2002-08-07

申请人： Akihiro Ishii ,  Masatomi Kanai ,  Takashi Hayami ,  Katsuyoshi Shibata ,  Masaki Matsui ,  Kazumasa Funabiki ,  Yokusu Kuriyama ,  Manabu Yasumoto

发明人： Akihiro Ishii ,  Masatomi Kanai ,  Takashi Hayami ,  Katsuyoshi Shibata ,  Masaki Matsui ,  Kazumasa Funabiki ,  Yokusu Kuriyama ,  Manabu Yasumoto

IPC分类号： C07C6963

CPC分类号： C07C69/675 ,  C07B2200/07 ,  C07C29/143 ,  C07C45/516 ,  C07C45/78 ,  C07C45/81 ,  C07C49/82 ,  C07C49/84 ,  C07C31/42

摘要： A process for producing an optically active perfluoroalkylcarbinol by reacting an optically active imine with a hemiacetal or hydrate of a perfluoroalkylaldehyde to obtain a condensate, and hydrolyzing the condensate under acidic conditions. Optical purity of optically active 4,4,4-trifluoro-3-hydroxy-1-aryl-1-butanone compounds may be increased by precipitating and removing a racemic crystal, and also recrystallizing the compound. Novel compounds include optically active and inactive 4,4,4-trifluoro-3-hydroxybutanoic aryl esters. A process for producing optically active or incactive 4,4,4-trifluoro-3-hydroxybutyric acid aryl esters includes oxidizing an optically active or inactive 4,4,4-trifluoro-3-hydroxy-1-aryl-1-butanone. Optical purity of optically active aryl esters may be increased by recrystallization. Optically active 4,4,4-trifluoro-1,3-butanediol may be produced by reducing the optically active aryl ester with a hydride. Optically active or inactive 4,4,4-trifluoro-3-hydroxybutyric acid alkyl esters are produced by reacting optically active or inactive aryl esters with lower alcohols under acid conditions.

摘要翻译： 通过使光学活性亚胺与全氟烷基醛的半缩醛或水合物反应得到缩合物，并在酸性条件下水解缩合物，制备光学活性全氟烷基甲醇的方法。 光学活性的4,4,4-三氟-3-羟基-1-芳基-1-丁酮化合物的光学纯度可以通过沉淀和除去外消旋晶体而增加，也可以使化合物重结晶。 新型化合物包括光学活性和无活性的4,4,4-三氟-3-羟基丁酸芳酯。 制备光学活性或不活泼的4,4,4-三氟-3-羟基丁酸芳基酯的方法包括氧化光学活性或无活性的4,4,4-三氟-3-羟基-1-芳基-1-丁酮。 光学活性芳基酯的光学纯度可通过重结晶而增加。 可以通过用氢化物还原光学活性芳基酯来制备光学活性的4,4,4-三氟-1,3-丁二醇。 光学活性或无活性的4,4,4-三氟-3-羟基丁酸烷基酯是通过在酸性条件下使光学活性或惰性芳基酯与低级醇反应来制备的。

公开(公告)号：US06521781B2

公开(公告)日：2003-02-18

申请号：US10003276

申请日：2001-12-06

申请人： Minoru Kakuda ,  Yoshihisa Arai ,  Kikuo Furukawa ,  Takehiko Isobe

发明人： Minoru Kakuda ,  Yoshihisa Arai ,  Kikuo Furukawa ,  Takehiko Isobe

IPC分类号： C07C6963

CPC分类号： C07C67/03 ,  C07C67/08 ,  C07C2603/74 ,  C07C69/54

摘要： A 2-hydrocarbyl-2-adamantyl acrylate compound represented by the following Formula 6: is produced easily and stably with high yields by reacting a 2-adamantanone compound represented by the following Formula 1: with at least one organometallic compound represented by the following Formula 2 or 3: R1MgX  (2) R1Li  (3) and at least one acrylic compound represented by the following Formula 4 or 5: wherein, R1, R2, R3, X, Y and n in the above formulae being as defined in the disclosure.

摘要翻译： 由下式6表示的2-烃基-2-金刚烷基丙烯酸酯化合物通过使由下式1表示的2-金刚烷酮化合物与至少一种由下式表示的有机金属化合物反应，以高收率容易且稳定地制备： 2或3：和由下式4或5表示的至少一种丙烯酸类化合物：其中，上式中的R 1，R 2，R 3，X，Y和n如本公开内容所定义。

公开(公告)号：US06369269B2

公开(公告)日：2002-04-09

申请号：US09862708

申请日：2001-05-23

申请人： Seiichi Kobayashi ,  Nobuya Kawauchi ,  Toshiyuki Suzuki ,  Masao Imai ,  Kenichi Fujii

发明人： Seiichi Kobayashi ,  Nobuya Kawauchi ,  Toshiyuki Suzuki ,  Masao Imai ,  Kenichi Fujii

IPC分类号： C07C6963

CPC分类号： C08F20/38 ,  C07C323/12 ,  C07C327/28 ,  C07C333/04 ,  C07D333/22 ,  G02B1/041 ,  C08L33/14

摘要： A sulfur-containing O-(meth)acrylate compound of the following formula (1) is useful as a starting material for a resin composition used in optical applications such as a lens; wherein R represents hydrogen atom or methyl group; 1 represents an integer from 1 to 3; B is when B is  n is 2; m is 1 or 2; A is selected from the following groups: wherein m represents 1 or 2; each ring may be substituted by one or more alkyl, alkylthio or alkoxy groups having 1 or 2 carbon atoms; p and q are 0 or 1, while m is 1 when p is 1; when B is  n is 1; m is 2 or 3; A is selected from the following groups: —(CH2)r—S—(CH2)r—, —(CH2)r—S—S—(CH2)r—.  —(CH2)r—S—(CH2)s—S—(CH2)r—and and wherein r and s are an integer from 1 to 3; when B is  n is 1; m is 2; A is selected from the following groups: —(CH2)r—S—(CH2)r—, —CH2)r—S—S—(CH2)r and —(CH2)r—S—(CH2)s—S—(CH2)r— wherein r and s are an integer from 1 to 3.

摘要翻译： 下式（1）的含硫O-（甲基）丙烯酸酯化合物可用作用于光学应用如透镜的树脂组合物的起始原料;其中R表示氢原子或甲基; 1表示1〜3的整数， B是当B是n是2时; m为1或2; A选自以下基团：其中m表示1或2; 每个环可以被一个或多个具有1或2个碳原子的烷基，烷硫基或烷氧基取代; p和q为0或1，而当p为1时，m为1; B为n时为1; m为2或3; A选自以下基团： - （CH 2）r -S-（CH 2）s -S-（CH 2）r - ，其中r和s为1至3的整数;当B为n时， m为2; A选自以下组：并且其中r和s为1至3的整数。