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335 条记录 (耗时 0.032 秒)

    Monocyte locomotion inhibitory factor
    1.
    发明申请
    Monocyte locomotion inhibitory factor 失效
    单核细胞运动抑制因子

    公开(公告)号：US20040259807A1

    公开(公告)日：2004-12-23

    申请号：US10861123

    申请日：2004-06-04

    发明人： Roberto Rodolfo Kretschmer Schmid

    IPC分类号： A61K038/05 ,  C07K005/06

    CPC分类号： C07K5/081 ,  A61K38/00 ,  C07K7/06 ,  C07K14/44 ,  C12N2799/021

    摘要： The invention relates to an anti-inflammatory oligopeptides which contain the terminal pharmacophore Cys-Asn-Ser which is capable of inhibiting the NF-nullnull signaling pathway. The oligopeptides are useful in stimulating the in vivo production of IL-10, and for treating inflammatory diseases and scarring when formulated in pharmaceutical compositions for administration to patients.

    摘要翻译： 本发明涉及含有能够抑制NF-κB信号通路的末端药效团Cys-Asn-Ser的抗炎性寡肽。 寡肽可用于刺激IL-10的体内产生，并且在用于给予患者的药物组合物中配制时用于治疗炎性疾病和瘢痕形成。

    Composition and methods for treatment of HIV infection
    2.
    发明申请
    Composition and methods for treatment of HIV infection 审中-公开

    公开(公告)号：US20040228839A1

    公开(公告)日：2004-11-18

    申请号：US10760729

    申请日：2004-01-20

    发明人： Vassilios I. Avramis ,  Lewis Cohen

    IPC分类号： A61K038/21 ,  A61K031/551 ,  A61K038/05

    CPC分类号： A61K38/50 ,  A61K2300/00

    摘要： Method of inhibiting or treating Human Immunodeficiency Virus (HIV) infection, comprising administering to a patient in need thereof an effective amount of a pharmaceutically acceptable composition comprising a PEG-ASNase compound or asparaginase, and optionally at least one compound selected from the group consisting of protease inhibitor compounds, ribonucleotide reductase inhibitor compounds and HIV reverse transcriptase inhibitor compounds.

    Compositions and methods for treatment of psoriasis
    4.
    发明申请
    Compositions and methods for treatment of psoriasis 有权
    用于治疗牛皮癣的组合物和方法

    公开(公告)号：US20040214749A1

    公开(公告)日：2004-10-28

    申请号：US10426239

    申请日：2003-04-28

    申请人： ProCyte Corporation

    发明人： Leonard M. Patt

    IPC分类号： A61K038/05

    CPC分类号： A61K47/42 ,  A61K33/34 ,  A61K38/06 ,  A61K47/02 ,  A61K47/34 ,  A61K2300/00

    摘要： A method for treating psoriasis of the skin of a patient employs topically applying to the affected skin a composition comprising at least one peptide copper complex. In other embodiments, the present invention is directed to such a method where the composition used therefor further comprises certain disclosed active agents, including active drug and active cosmetic substances. In a related aspect, further embodiments of the present invention are directed to compositions comprising at least one peptide copper complex and certain active drug and active cosmetic substances that render the compositions particularly effective in treating psoriasis.

    摘要翻译： 用于治疗患者皮肤的银屑病的方法采用向受影响的皮肤局部施用包含至少一种肽铜络合物的组合物。 在其它实施方案中，本发明涉及这样的方法，其中用于其的组合物还包含某些公开的活性剂，包括活性药物和活性化妆品物质。 在相关方面，本发明的其它实施方案涉及包含至少一种肽铜络合物和某些活性药物和活性化妆品物质的组合物，其使组合物在治疗牛皮癣方面特别有效。

    Presbyopia treatment by lens alteration
    5.
    发明申请
    Presbyopia treatment by lens alteration 有权
    老花眼治疗透镜改变

    公开(公告)号：US20040213774A9

    公开(公告)日：2004-10-28

    申请号：US10050879

    申请日：2002-01-18

    发明人： Jonathan S. Till

    IPC分类号： A61K038/44 ,  A61K038/05 ,  A61K031/095 ,  A61F002/00

    CPC分类号： A61K38/063 ,  A61K38/45 ,  A61K41/00

    摘要： This invention effects a change in the accommodation of the human lens affected by presbyopia through the use of various reducing agents that change accommodative abilities of the human lens, and/or by applying energy to affect a change in the accommodative abilities of the human lens. This invention both prevents the onset of presbyopia as well as treats it. By breaking and/or preventing the formation of bonds that adhere lens fibers together causing hardening of the lens, the present invention increases the elasticity and distensibility of the lens and/or lens capsule.

    摘要翻译： 本发明通过使用改变人体晶状体的调节能力的各种还原剂和/或通过施加能量来影响人体晶状体的调节能力的变化来影响受到老花眼影响的人体晶状体的调节的变化。 本发明既防止了老花眼的发生，又能够治疗老花眼。 通过破坏和/或防止粘附透镜纤维在一起引起透镜硬化的粘结，本发明增加了透镜和/或透镜胶囊的弹性和透光性。

    Method for treating conditions associated with the Metabolic Syndrome (Syndrome X)
    6.
    发明申请
    Method for treating conditions associated with the Metabolic Syndrome (Syndrome X) 有权
    治疗与代谢综合征相关的病症的方法（综合征X）

    公开(公告)号：US20040186059A1

    公开(公告)日：2004-09-23

    申请号：US10804954

    申请日：2004-03-19

    发明人： Marise S. Gottlieb

    IPC分类号： A61K038/05

    CPC分类号： A61K38/06 ,  A61K35/16 ,  A61K38/05 ,  A61K2300/00

    摘要： The present invention is directed to a method for treating individuals having inflammation or preventing inflammation in individuals at risk for inflammation, more specifically individuals with chronic inflammation as evidenced by elevated C-reactive protein, serum fibrinogen, elevated platelet count and platelet activity, elevated blood glucose, any component or combination of components of the metabolic syndrome by using the selected immunoregulators. The present invention also includes a method for preventing the development of inflammation in individuals at risk for inflammation by using the selected immunoregulators, and for deferring progression of the inflammatory state to the more specific outcomes of the Metabolic Syndrome including diabetes mellitus, coronary heart disease, and cancer.

    摘要翻译： 本发明涉及用于治疗患有炎症的个体具有炎症或预防炎症的个体的方法，更具体地说是具有慢性炎症的个体，如C反应蛋白升高，血清纤维蛋白原，升高的血小板计数和血小板活性，升高的血液 葡萄糖，任何组分或代谢综合征组分的组合，通过使用选定的免疫调节剂。 本发明还包括通过使用选择的免疫调节剂来预防炎症风险的个体发炎的方法，并且将炎性状态的进展推迟到代谢综合征的更具体的结果，包括糖尿病，冠心病， 和癌症。

    Cosmetic or dermatological use of peptides for promoting adhesion between skin cells
    9.
    发明申请
    Cosmetic or dermatological use of peptides for promoting adhesion between skin cells 有权
    用于促进皮肤细胞之间粘附的肽的化妆品或皮肤病学用途

    公开(公告)号：US20040142873A1

    公开(公告)日：2004-07-22

    申请号：US10755277

    申请日：2004-01-13

    发明人： Claude Dal Farra ,  Nouha Domloge

    IPC分类号： A61K038/08 ,  A61K038/06 ,  A61K038/05 ,  A61K007/11

    CPC分类号： A61Q5/00 ,  A61K8/64 ,  A61Q19/00 ,  A61Q19/08

    摘要： Method for preparing a cosmetic or dermatological composition, of a sufficient amount of peptides of sequence (Gly-Pro-Gln)n-NH2, wherein: n ranges between 1 and 3, and the amino acids can be in the form L, D or DL; the peptides or the composition being designed to: promote adhesion between skin cells, promote cell adhesion, to provide curative and/or preventive treatment for ageing skin symptoms (of physiological or solar origin) and to enhance skin appearance. In a preferred embodiment, the peptide is of sequence (Gly-Pro-Gln)2-NH2.

    摘要翻译： 用于制备足量的序列肽（Gly-Pro-Gln）n-NH 2的化妆品或皮肤病学组合物的方法，其中n在1和3之间，氨基酸可以是L，D或 DL; 肽或组合物被设计为：促进皮肤细胞之间的粘附，促进细胞粘附，为老化的皮肤症状（生理或太阳能来源）提供治疗和/或预防治疗，并增强皮肤外观。 在优选的实施方案中，肽是序列（Gly-Pro-Gln）2-NH 2。