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    Method for identifying autoimmune disease, method for detecting anti-Reg protein autoantibody and diagnostics for autoimmune disease
    1.
    发明授权
    Method for identifying autoimmune disease, method for detecting anti-Reg protein autoantibody and diagnostics for autoimmune disease 失效
    用于鉴定自身免疫性疾病的方法，用于检测抗Reg蛋白自身抗体的方法和用于自身免疫性疾病的诊断

    公开(公告)号：US06919210B1

    公开(公告)日：2005-07-19

    申请号：US09958447

    申请日：2000-04-06

    申请人： Hiroshi Okamoto

    发明人： Hiroshi Okamoto

    IPC分类号： G01N33/564 ,  C07K14/475 ,  G01N33/546

    CPC分类号： G01N33/564 ,  G01N2800/24 ,  Y10S435/975 ,  Y10S436/811 ,  Y10S530/806 ,  Y10S530/845

    摘要： A method for judging an autoimmune disease by detecting the existence of an anti-Reg protein autoantibody in a specimen; and a method for judging insulin-dependent or non-insulin-dependent diabetes mellitus.A method for detecting an anti-Reg protein autoantibody by bringing into a specimen into contact with an antigen component and detecting the formation of an immune complex.A reagent for diagnosing autoimmune disease which contain an antigen component capable of binding specifically to the anti-Reg protein autoantibody; and a reagent for diagnosing insulin-dependent or non-insulin-dependent diabetes mellitus.

    摘要翻译： 一种通过检测样品中抗-RF蛋白自身抗体的存在来判断自身免疫疾病的方法; 以及用于判断胰岛素依赖型或非胰岛素依赖性糖尿病的方法。 通过将样品与抗原成分接触并检测免疫复合物的形成来检测抗Reg蛋白自身抗体的方法。 一种用于诊断自身免疫疾病的试剂，其含有能够特异性结合抗Reg蛋白自身抗体的抗原成分; 以及用于诊断胰岛素依赖性或非胰岛素依赖性糖尿病的试剂。

    Endorphins having placental or pancreatic origin
    2.
    发明授权
    Endorphins having placental or pancreatic origin 失效
    内啡肽具有胎盘或胰腺起源

    公开(公告)号：US4438104A

    公开(公告)日：1984-03-20

    申请号：US394340

    申请日：1982-07-01

    申请人： Charles D. Kimball ,  John C. Houck

    发明人： Charles D. Kimball ,  John C. Houck

    IPC分类号： A61K38/00 ,  C07K14/665 ,  A61K37/00 ,  C07C103/52

    CPC分类号： C07K14/665 ,  A61K38/00 ,  Y10S514/809 ,  Y10S530/845 ,  Y10S530/851

    摘要： An endorphin peptide is described that has a molecular weight by amino acid analysis of about 14,000 daltons, an infrared spectrum substantially as shown in FIG. 5, and an amino acid analysis substantially as follows:______________________________________ Amino Acid Nanomoles ______________________________________ Aspartic acid 9.4 Threonine 6.2 Serine 10.1 Glutamic acid 16.0 Proline 6.3 Glycine 18.6 Alanine 12.5 Valine 6.0 Methionine 1.0 Isoleucine 2.6 Leucine 7.1 Tyrosine 1.1 Phenylalanine 4.3 Histidine 3.6 Lysine 7.8 Arginine 2.8 Total 115.4 ______________________________________ The peptide is immunoreactive against .beta.-endorfin rabbit antisera and displaces Naloxone from opiate receptors in brain tissue.

    摘要翻译： 描述了通过大约14,000道尔顿的氨基酸分析具有分子量的内啡肽，基本如图1所示的红外光谱。 5和基本上如下的氨基酸分析：氨基酸纳摩尔 - 阿魏酸9.4-苏氨酸6.2-丝氨酸10.1-谷氨酸16.0-脯氨酸6.3-甘氨酸18.6-丙氨酸12.5-碱性6.0-甲硫氨酸1.0-异亮氨酸2.6-亮氨酸7.1 - 酪氨酸1.1苯丙氨酸4.3 - 组氨酸3.6 -Lysine 7.8-精氨酸2.8 - 总共115.4 - 肽对β-endorfin兔抗血清有免疫反应，并从脑组织中的阿片受体中取代纳洛酮。

    Zymogen activation peptides (ZAP) in the diagnosis of disease
    8.
    发明授权
    Zymogen activation peptides (ZAP) in the diagnosis of disease 失效
    酶原激活肽（ZAP）在疾病诊断中的应用

    公开(公告)号：US5356781A

    公开(公告)日：1994-10-18

    申请号：US721234

    申请日：1991-06-26

    申请人： John Hermon-Taylor ,  Brian M. Austen

    发明人： John Hermon-Taylor ,  Brian M. Austen

    IPC分类号： G01N33/573 ,  G01N33/68 ,  G01N33/543 ,  C07K7/06 ,  C12N9/96 ,  C07K14/00

    CPC分类号： G01N33/6893 ,  G01N33/573 ,  G01N2800/067 ,  Y10S435/81 ,  Y10S530/845

    摘要： Pancreatic disease can be diagnosed by assaying a patient's body fluid such as serum or urine, for pancreatic activation peptides (PAP) released from zymogens by proteolytic activation. Particularly useful are peptides having C-terminal D.sub.4 K sequences. The method uses polyclonal or monoclonal antibodies generated and selected for C-terminal specificity on PAP so that the tests only report free PAP not parent zymogen. Also described are peptides and antibodies labelled with revealing agents and/or immobilised on solid supports and their use in diagnostic assays and kits. In pancreatic disease the tests distinguish necrotising from oedematous acute pancreatitis and permit severity prediction and monitoring as well as diagnosing chronic pancreatitis in exacerbation. Tests reporting free activation peptides from the zymogens prophospholipase A, procolipase and proelastases are also applicable in non-pancreatic diseases where activation of these zymogens, sharing sequence homology in the activation peptide C-terminal region with pancreatic isoenzymes, forms part of the molecular pathology of the condition.

    摘要翻译： 可以通过测定患者的体液如血清或尿液，通过蛋白水解活化从酶原释放的胰激活肽（PAP）来诊断胰腺疾病。 特别有用的是具有C末端D4K序列的肽。 该方法使用产生并选择用于PAP的C-末端特异性的多克隆或单克隆抗体，使得测试仅报告游离PAP不是母体酶原。 还描述了用显露剂标记和/或固定在固体支持物上的肽和抗体及其在诊断测定和试剂盒中的用途。 在胰腺疾病中，这种检测将坏死性坏死性急性胰腺炎分为坏死因子，并允许严重程度预测和监测以及诊断恶化的慢性胰腺炎。 报道酶原磷脂酶A，原纤维蛋白酶和原弹药蛋白酶的自由激活肽的测试也适用于非胰腺疾病，其中这些酶原激活在激活肽C-末端区域与胰同型酶共享序列同源性，形成分子病理学的一部分 条件。

    Pancreas specific protein systems
    9.
    发明授权
    Pancreas specific protein systems 失效
    胰腺特异性蛋白质系统

    公开(公告)号：US4446240A

    公开(公告)日：1984-05-01

    申请号：US230298

    申请日：1981-01-30

    申请人： Samuel T. Nerenberg

    发明人： Samuel T. Nerenberg

    IPC分类号： G01N33/531 ,  G01N33/56 ,  C07G7/00 ,  G01N33/60

    CPC分类号： G01N33/531 ,  Y10S436/804 ,  Y10S436/811 ,  Y10S530/845

    摘要： Pancreas specific protein systems, including Pan Ag purified antigen having molecular mass of about 2.25.times.10.sup.5 daltons and pancreas specific antibodies to such antigen, and methods for providing and utilizing such antigen and antibodies.

    摘要翻译： 胰蛋白特异性蛋白质系统，包括具有约2.25×10 5道尔顿分子量的Pan Ag纯化抗原和对这种抗原的胰腺特异性抗体，以及提供和利用此类抗原和抗体的方法。