知搜-全球专利检索

  1. Login
  2. Sign Up

Search Results

6 records (took 0.024 seconds)

    IN VITRO METHOD OF PREDICTING RUMEN DIGESTIBLE PROTEIN
    2.
    发明公开
    IN VITRO METHOD OF PREDICTING RUMEN DIGESTIBLE PROTEIN 审中-公开

    公开(公告)号：US20240255516A1

    公开(公告)日：2024-08-01

    申请号：US18561078

    申请日：2022-05-12

    Applicant: CAN TECHNOLOGIES, INC.

    Inventor： Jeremy Chignell ,  Cathy Staloch Hass ,  Gladys Ethel Margaria ,  Gregory Michael Poynter ,  Michael Telander ,  Stephanie Zebro ,  Alessandro Zontini

    IPC: G01N33/68

    CPC classification number: G01N33/6803 ,  G01N2333/962

    Abstract: The present disclosure relates to in vitro methods of predicting rumen digestible protein of a feed sample. An in vitro method of predicting rumen digestible protein of a feed sample includes forming an aqueous test composition including the feed sample, a buffer, and one or more digestive enzymes. The method includes incubating the test composition. The method includes removing one or more test samples of the test composition at time points during the incubating, the time points including about 0 h and at least one time point after about 0 h. The method includes measuring soluble protein content of the one or more test samples. The method includes using the measured soluble protein content of the one or more test samples to predict a rate and/or extent of rumen protein digestion of the feed sample.

    METHODS, COMPOSITIONS, AND KITS FOR DETECTION OF ASPERGILLOSIS
    3.
    发明申请
    METHODS, COMPOSITIONS, AND KITS FOR DETECTION OF ASPERGILLOSIS 审中-公开
    方法，组合物和用于检测ASPERGILLOSIS的试剂盒

    公开(公告)号：US20170038383A1

    公开(公告)日：2017-02-09

    申请号：US15236988

    申请日：2016-08-15

    Applicant: CITY OF HOPE

    Inventor： Markus KALKUM ,  Karine BAGRAMYAN ,  Diana DIAZ-AREVALO ,  James I. ITO ,  Sanjeet DADWAL

    IPC: G01N33/573 ,  G01N33/577 ,  G01N33/543

    CPC classification number: G01N33/573 ,  A61K38/00 ,  A61K39/0002 ,  C07K16/14 ,  C07K16/40 ,  C07K2317/622 ,  C07K2317/92 ,  C12Q1/37 ,  G01N33/54313 ,  G01N33/56961 ,  G01N33/577 ,  G01N2333/38 ,  G01N2333/962

    Abstract: Provided herein are methods for detecting an Aspergillus protease in a sample, diagnosing a subject with aspergillosis caused by an Aspergillus infection based on the presence of an Aspergillus protease in a sample, and methods of aspergillosis treatment that incorporate these diagnostic methods. In certain embodiments, the Aspergillus protease is Asp f2, and the Aspergillus infection is caused A. fumigatus, A. flavus, A. versicolor, A. niger, or A. terreus. Also provided herein are antibodies and kits for use in these methods, including novel antibodies specific for Asp f2.

    Abstract translation: 本文提供了用于检测样品中的曲霉菌蛋白酶的方法，基于样品中曲霉菌蛋白酶的存在来诊断由曲霉菌感染引起的曲霉病的受试者以及包含这些诊断方法的曲霉菌病治疗方法。 在某些实施方案中，曲霉属蛋白酶为Asp f2，曲霉属感染引起烟曲霉（A. fumigatus），黄曲霉（A. flavus），槐花（A. versicolor），黑曲霉（A.niger）或土曲霉（A. terreus）。 本文还提供了用于这些方法的抗体和试剂盒，包括对Asp f2特异性的新型抗体。

    METHODS, COMPOSITIONS, AND KITS FOR DETECTION OF ASPERGILLOSIS
    5.
    发明申请
    METHODS, COMPOSITIONS, AND KITS FOR DETECTION OF ASPERGILLOSIS 有权
    方法，组合物和用于检测ASPERGILLOSIS的试剂盒

    公开(公告)号：US20140274882A1

    公开(公告)日：2014-09-18

    申请号：US14217004

    申请日：2014-03-17

    Applicant: CITY OF HOPE

    Inventor： Markus KALKUM ,  Karine BAGRAMYAN ,  Diana DIAZ-AREVALO ,  James I. ITO ,  Sanjeet DADWAL

    IPC: C12Q1/37 ,  C07K16/40 ,  G01N33/573

    CPC classification number: G01N33/573 ,  A61K38/00 ,  A61K39/0002 ,  C07K16/14 ,  C07K16/40 ,  C07K2317/622 ,  C07K2317/92 ,  C12Q1/37 ,  G01N33/54313 ,  G01N33/56961 ,  G01N33/577 ,  G01N2333/38 ,  G01N2333/962

    Abstract: Provided herein are methods for detecting an Aspergillus protease in a sample, diagnosing a subject with aspergillosis caused by an Aspergillus infection based on the presence of an Aspergillus protease in a sample, and methods of aspergillosis treatment that incorporate these diagnostic methods. In certain embodiments, the Aspergillus protease is Asp f2, and the Aspergillus infection is caused A. fumigatus, A. flavus, A. versicolor, A. niger, or A. terreus. Also provided herein are antibodies and kits for use in these methods, including novel antibodies specific for Asp f2.

    Abstract translation: 本文提供了用于检测样品中的曲霉菌蛋白酶的方法，基于样品中曲霉菌蛋白酶的存在来诊断由曲霉菌感染引起的曲霉病的受试者以及包含这些诊断方法的曲霉菌病治疗方法。 在某些实施方案中，曲霉属蛋白酶为Asp f2，曲霉属感染引起烟曲霉（A. fumigatus），黄曲霉（A. flavus），槐花（A. versicolor），黑曲霉（A.niger）或土曲霉（A. terreus）。 本文还提供了用于这些方法的抗体和试剂盒，包括对Asp f2特异性的新型抗体。

    Prolyl Endopeptidase Probes
    6.
    发明申请
    Prolyl Endopeptidase Probes 审中-公开
    脯氨酰内肽酶探针

    公开(公告)号：US20120065103A1

    公开(公告)日：2012-03-15

    申请号：US13231146

    申请日：2011-09-13

    Applicant: Amit K. Galande ,  Douglas Stuart Watson ,  Krishna Kodukula ,  Kalyani Jambunathan

    Inventor： Amit K. Galande ,  Douglas Stuart Watson ,  Krishna Kodukula ,  Kalyani Jambunathan

    IPC: C12Q1/37 ,  C07K7/06 ,  C07K5/117 ,  C07D207/16 ,  C40B30/08 ,  C07K5/097

    CPC classification number: C07K1/13 ,  C07K7/08 ,  C12Q1/37 ,  G01N33/582 ,  G01N2333/962

    Abstract: Prolyl endopeptidase (PE) activity in lung samples is detected by contacting the lung sample with a probe comprising a —P—X— (or —X—P—, —P—X—P—) PE recognition site, wherein P is a prolyl bioisostere, X is a residue that is not a prolyl bioisostere or is a prolyl bioisostere flanked on each side by a residue that is not a prolyl bioisostere, and “-” is an amide bond, under conditions wherein PE activity of the sample specifically hydrolyzes an amide bond of the recognition site to generate an optical signal; and (b) detecting the signal.

    Abstract translation: 通过使肺样品与包含-P-X-（或-X-P-，-P-X-P-）PE识别位点的探针接触来检测肺样品中的脯氨酰内肽酶（PE）活性，其中P是 脯氨酰生物电子显微镜，X是不是脯氨酰生物电子等排体的残基，或者是侧链侧面的不是脯氨酰基生物电子等排物的脯氨酰生物电子等排体，在 - 样品的PE活性的条件下，“ - ”是酰胺键 水解识别位点的酰胺键以产生光信号; 和（b）检测信号。

Patent Agency Ranking