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    Method and apparatus for fractionation using conventional dielectrophoresis and field flow fractionation
    2.
    发明授权
    Method and apparatus for fractionation using conventional dielectrophoresis and field flow fractionation 失效
    使用常规介电电泳和场流分馏的分级方法和设备

    公开(公告)号：US5993630A

    公开(公告)日：1999-11-30

    申请号：US604779

    申请日：1996-01-31

    Applicant: Frederick F. Becker ,  Peter R. C. Gascoyne ,  Ying Huang ,  Xiao-Bo Wang

    Inventor： Frederick F. Becker ,  Peter R. C. Gascoyne ,  Ying Huang ,  Xiao-Bo Wang

    IPC: B03C5/02 ,  G01N30/00 ,  G01N27/26 ,  G01N27/447

    CPC classification number: B03C5/028 ,  G01N30/0005 ,  G01N2030/0035 ,  G01N2030/0065

    Abstract: The present disclosure is directed to a novel apparatus and novel methods for the separtion, characterization, and manipulation of matter. In particular, the invention combines the use of frequency-dependent dielectric and conductive properties of particulate matter and solubilized matter with the properties of the suspending and transporting medium to discriminate and separate such matter. The apparatus includes a chamber having at least one electrode element and at least one inlet and one output port into which cells are introduced and removed from the chamber. Matter carried through the chamber in a fluid stream is then displaced within the fluid by a dielectrophoretic (DEP) force caused by the energized electrode. Following displacement within the fluid, matter travels through the chamber at velocities according to the velocity profile of the chamber. After the matter has transitted through the chamber, it exits at the opposite end of the chamber at a characteristic position. Methods according to the invention involve using the apparatus for discriminating and separating matter for research, diagnosis of a condition, and therapeutic purposes. Examples of such methods may include separation of mixtures of cells, such as cancer cells from normal cells, separation of parasitized erythrocytes from normal erythrocytes, separation of nucleic acids, and others.

    Abstract translation: 本公开涉及用于分离，表征和操纵物质的新型装置和新颖方法。 特别地，本发明结合了使用频率依赖的电介质和颗粒物质和溶解物质的导电性质与悬浮和输送介质的性质，以区分和分离这种物质。 该装置包括具有至少一个电极元件和至少一个入口和一个输出端口的腔室，细胞从腔室中被引入和移出。 然后通过流体流中的腔室进行的物质由通电电极引起的介电电泳（DEP）力在流体内移动。 在流体内移动之后，物质按照腔室的速度分布以速度行进通过腔室。 在物体经过腔室之后，它在特定位置处在腔室的相对端处离开。 根据本发明的方法涉及使用该装置来鉴别和分离用于研究，病症诊断和治疗目的的物质。 这些方法的实例可以包括分离细胞混合物，例如来自正常细胞的癌细胞，从正常红细胞分离寄生的红细胞，分离核酸等。

    MINIATURIZED ELECTROTHERMAL FLOW INDUCED INFUSION PUMP
    4.
    发明申请
    MINIATURIZED ELECTROTHERMAL FLOW INDUCED INFUSION PUMP 有权
    微型电热流感诱导泵

    公开(公告)号：US20160235912A1

    公开(公告)日：2016-08-18

    申请号：US14971715

    申请日：2015-12-16

    Applicant: CFD Research Corporation

    Inventor： Sivaramakrishnan Krishnamoorthy ,  Guiren Wang ,  Jianjun Feng ,  Yi Wang

    IPC: A61M5/142 ,  A61M5/168

    CPC classification number: A61M5/14244 ,  A61M2205/0244 ,  B01F13/0079 ,  B01F13/0081 ,  B01L3/5027 ,  B01L99/00 ,  B01L2300/1833 ,  B01L2400/0415 ,  B01L2400/0442 ,  B01L2400/0493 ,  B01L2400/0496 ,  B08B7/0064 ,  B08B9/00 ,  F04B19/006 ,  F04B19/24 ,  G01N2030/0035 ,  G01N2030/0065

    Abstract: A micropump that pumps liquid using electrothermally-induced flow is described, along with a corresponding self-regulating pump and infusion pump. The micropump has applications in microfluidic systems, such as biochips. The self-regulating infusion pump is useful for administration of large and small volumes of liquids such as drugs to patients and can be designed for a wide range of flow rates by combining multiple micropumps in one infusion pump system. The micropump uses electrode sequences on opposing surfaces of a flow chamber that are staggered with respect to each other. The opposing surfaces include staggered electrodes that have the same phase and same electrode sequence. As such electrodes with the same phase are staggered and not eclipsed.

    Abstract translation: 描述了使用电热诱导流体泵送液体的微型泵，以及相应的自调节泵和输液泵。 微型泵在微流体系统中具有应用，如生物芯片。 自调节输液泵可用于向患者施用大量和小体积的液体，例如药物，并且可以通过在一个输液泵系统中组合多个微泵来设计用于各种流量的流量。 微型泵使用相对于彼此交错的流动室的相对表面上的电极序列。 相对表面包括具有相同相位和相同电极序列的交错电极。 因为具有相同相位的电极是交错的并且不会被淹没。

    Methods and apparatus for electrosmear analysis
    5.
    发明申请
    Methods and apparatus for electrosmear analysis 有权
    电泳分析方法与装置

    公开(公告)号：US20040178068A1

    公开(公告)日：2004-09-16

    申请号：US10743698

    申请日：2003-12-22

    Applicant: The University of Texas System

    Inventor： Peter R.C. Gascoyne ,  Jody V. Vykoukal ,  Chandra Das ,  Frederick F. Becker

    IPC: G01N027/26

    CPC classification number: G01N30/0005 ,  B03C5/005 ,  B03C5/026 ,  B03C2201/24 ,  G01N1/2813 ,  G01N2030/0065 ,  G01N2030/007

    Abstract: Methods and apparatus for preparing a smear for cytopathology or other analysis. In a representative embodiment, cells of a sample are subjected to a dielectrophoretic force to segregate the cells into two or more zones of a surface. The particles are attached to the surface, thereby defining a nullsegregated smear.null The segregated smear is then fixed and stained for cytopathology analysis.

    Abstract translation: 用于细胞病理学或其他分析的涂片的制备方法和装置。 在代表性的实施方案中，样品的细胞经受介电电泳力以将细胞分离成表面的两个或更多个区域。 颗粒附着在表面上，从而定义了“分离的涂片”。 然后将分离的涂片固定并染色用于细胞病理学分析。

    Method and apparatus for fractionation using conventional dielectrophoresis and field flow fractionation
    6.
    发明申请
    Method and apparatus for fractionation using conventional dielectrophoresis and field flow fractionation 审中-公开
    使用常规介电电泳和场流分馏的分级方法和设备

    公开(公告)号：US20040011651A1

    公开(公告)日：2004-01-22

    申请号：US10436647

    申请日：2003-05-13

    Applicant: Board of Regents, The University of Texas System

    Inventor： Frederick Becker ,  Peter R.C. Gascoyne ,  Ying Huang ,  Xiaobo Wang ,  Jun Yang

    IPC: G01N027/27

    CPC classification number: B03C5/028 ,  B03C5/026 ,  G01N30/0005 ,  G01N2030/0035 ,  G01N2030/0065 ,  G01N2030/007

    Abstract: Methods and apparatus for discriminating matter in a chamber having an inlet port and an outlet port utilizing dielectrophoresis and field flow fractionation. A carrier medium is introduced into the inlet port and is directed from the inlet port to the outlet port according to a velocity profile. A programmed voltage signal is applied to an electrode element coupled to the chamber to form a dielectrophoretic force on the matter. The dielectrophoretic force is balanced with a gravitational force to displace the matter to positions within said velocity profile in the carrier medium to discriminate the matter. A chamber having a top and bottom outlet port may be utilized to withdraw a first portion of a carrier medium from the top outlet port at a first, controllable fluid flow rate and to withdraw a second portion of the carrier medium from the bottom outlet port at a second, controllable fluid flow rate.

    Abstract translation: 用于区分具有入口和出口的室中的物质的方法和装置，利用介电电泳和场流分级。 载体介质被引入入口并根据速度分布从入口端​​口引导到出口。 将编程的电压信号施加到耦合到腔室的电极元件以在该物质上形成介电电泳力。 介电电泳力与重力平衡以将物质移动到载体介质中的所述速度分布内的位置以区分该物质。 可以使用具有顶部和底部出口端口的腔室以第一可控流体流速从顶部出口端口抽出载体介质的第一部分，并且从底部出口端口将载体介质的第二部分从底部出口端口 第二可控流体流速。

    Analyte species separation system
    10.
    发明申请
    Analyte species separation system 有权
    分析物种分离系统

    公开(公告)号：US20030226754A1

    公开(公告)日：2003-12-11

    申请号：US10389250

    申请日：2003-03-14

    Inventor： David A. Le Febre

    IPC: G01N027/447

    CPC classification number: G01N27/44769 ,  G01N30/0005 ,  G01N2030/0025 ,  G01N2030/0065 ,  G01N2030/285

    Abstract: A analyte species separation system including a fluid flow field disposed between confining surfaces, the flow field having a first flow component flowing in a first direction and a second flow component flowing in a second, transverse, direction, and an electric field configured to cause analyte species to move in the separation flow field at least in a direction opposite to the first flow component, a analyte injection channel in fluid communication with the flow field and an analyte separation target channel or otherwise a collector in fluid communication with the flow field, the system configure so that an analyte species in an analyte sample injected into the flow field traverses at least a portion of the flow field toward the collector target channel with said second flow component, enabling analyte species separation parallel to the first direction and movement in the second direction so that analyte species having mobilities outside a selected mobility range do not enter the target channel and/or an analyte species having a selected mobility is directed into the target channel.

    Abstract translation: 一种分析物种分离系统，包括设置在限制表面之间的流体流场，所述流场具有沿第一方向流动的第一流动分量和沿第二横向方向流动的第二流动分量，以及被配置成引起分析物 物种在分离流场中至少沿与第一流动分量相反的方向移动，与流场流体连通的分析物注入通道和分析物分离目标通道或与流场流体连通的收集器， 系统配置，使得注入到流场中的分析物样品中的分析物物质通过所述第二流动分量穿过流场的至少一部分朝向收集器目标通道，使分析物物质分离平行于第一方向并且在第二方向上的运动 方向，使得具有选定移动范围之外的迁移率的分析物种不进入ta rget信道和/或具有选择的移动性的分析物种被引导到目标信道中。

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