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1.发明申请公开(公告)号：US20140154744A1
公开(公告)日：2014-06-05
申请号：US14131382
申请日：2012-07-11
Applicant: Dieter Soll , Caroline Aldag , Michael Hohn
Inventor： Dieter Soll , Caroline Aldag , Michael Hohn
IPC: C12N15/113 , C12N9/10 , A61K47/48 , C12N9/02
CPC classification number: C12P21/00 , C07K14/47 , C12N9/0004 , C12N9/0008 , C12N9/10 , C12N9/1007 , C12N9/14 , C12N9/93 , C12N15/11 , C12N15/113 , C12N2310/531 , C12P21/02 , C12Y209/01001 , C12Y306/05003 , C12Y601/01011
Abstract: Non-naturally occurring tRNASec and methods of using them for recombinant expression of proteins engineered to include one or more selenocysteine residues are disclosed. The non-naturally occurring tRNASec can be used for recombinant manufacture of selenocysteine containing polypeptides encoded by mRNA without the requirement of an SECIS element. In some embodiments, selenocysteine containing polypeptides are manufactured by co-expressing a non-naturally occurring tRNASec a recombinant expression system, such as E. coli, with SerRS, EF-Tu, SelA, or PSTK and SepSecS, and an mRNA with at least one codon that recognizes the anticodon of the non-naturally occurring tRNASec.
Abstract translation: 公开了非天然存在的tRNASec以及将其用于重组表达工程改造为包含一个或多个硒代半胱氨酸残基的蛋白质的方法。 非天然存在的tRNASec可用于重组制备由mRNA编码的含硒半胱氨酸的多肽，而不需要SECIS元件。 在一些实施方案中，含硒代半胱氨酸的多肽通过用SerRS，EF-Tu，SelA或PSTK和SepSecS共表达非天然存在的tRNASec重组表达系统（例如大肠杆菌）和至少具有mRNA 一个识别非天然存在的tRNASec的反密码子的密码子。
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公开(公告)号：US09340780B2
公开(公告)日：2016-05-17
申请号：US14575421
申请日：2014-12-18
Applicant: aTyr Pharma Inc. , Pangu Biopharma Limited
Inventor： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain P. Vasserot , Wing-Sze Lo , Jeffry D. Watkins , Cheryl L. Quinn , John D. Mendlein
IPC: C12N9/00 , C12N15/00 , G01N33/573 , A61K38/00
CPC classification number: C07K16/40 , A61K9/0019 , A61K38/00 , C07K2317/24 , C12N9/93 , C12Y601/01011 , G01N33/573 , G01N2333/9015
Abstract: Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
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3.发明申请INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF SERYL-TRNA SYNTHETASES 有权与SERLL-TRNA合成蛋白质蛋白相关的治疗，诊断和抗体组合物的创新发现公开(公告)号：US20150240227A1
公开(公告)日：2015-08-27
申请号：US14575421
申请日：2014-12-18
Applicant: aTyr Pharma Inc. , Pangu Biopharma Limited
Inventor： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain P. Vasserot , Wing-Sze Lo , Jeffry D. Watkins , Cheryl L. Quinn , John D. Mendlein
IPC: C12N9/00 , G01N33/573
CPC classification number: C07K16/40 , A61K9/0019 , A61K38/00 , C07K2317/24 , C12N9/93 , C12Y601/01011 , G01N33/573 , G01N2333/9015
Abstract: Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
Abstract translation: 提供了包含新确定的氨酰-tRNA合成酶的蛋白质片段的组合物，编码它们的多核苷酸及其补体，相关试剂及其在诊断，药物发现，研究和治疗应用中的使用方法。
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Patent Agency Ranking
4.发明授权Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of seryl-tRNA synthetases 有权与丝氨酰-tRNA合成酶的蛋白质片段相关的治疗，诊断和抗体组合物的创新发现公开(公告)号：US08946157B2
公开(公告)日：2015-02-03
申请号：US13696047
申请日：2011-05-02
Applicant: Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain Philippe Vasserot , Jeffry D. Watkins , Cheryl L. Quinn , Wing-Sze Lo , John D. Mendlein
Inventor： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain Philippe Vasserot , Jeffry D. Watkins , Cheryl L. Quinn , Wing-Sze Lo , John D. Mendlein
CPC classification number: C07K16/40 , A61K9/0019 , A61K38/00 , C07K2317/24 , C12N9/93 , C12Y601/01011 , G01N33/573 , G01N2333/9015
Abstract: Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
Abstract translation: 提供了包含新确定的氨酰-tRNA合成酶的蛋白质片段的组合物，编码它们的多核苷酸及其补体，相关试剂及其在诊断，药物发现，研究和治疗应用中的使用方法。
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公开(公告)号：US20130315887A1
公开(公告)日：2013-11-28
申请号：US13696047
申请日：2011-05-02
Applicant: Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain Philippe Vasserot , Jeffry D. Watkins , Cheryl L. Quinn , Wing-Sze Lo , John D. Mendlein
Inventor： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain Philippe Vasserot , Jeffry D. Watkins , Cheryl L. Quinn , Wing-Sze Lo , John D. Mendlein
IPC: C12N9/00
CPC classification number: C07K16/40 , A61K9/0019 , A61K38/00 , C07K2317/24 , C12N9/93 , C12Y601/01011 , G01N33/573 , G01N2333/9015
Abstract: Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
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6.发明申请COMPOSITIONS AND METHODS FOR MAKING SELENOCYSTEINE CONTAINING POLYPEPTIDES 有权用于制备含多糖的SELENOCYSTEINE的组合物和方法公开(公告)号：US20170029858A1
公开(公告)日：2017-02-02
申请号：US15274541
申请日：2016-09-23
Applicant: Yale University
Inventor： Dieter Soll , Caroline Aldag , Michael Hohn
IPC: C12P21/00 , C12N9/00 , C12N9/14 , C12N15/113 , C12N9/10
CPC classification number: C12P21/00 , C07K14/47 , C12N9/0004 , C12N9/0008 , C12N9/10 , C12N9/1007 , C12N9/14 , C12N9/93 , C12N15/11 , C12N15/113 , C12N2310/531 , C12P21/02 , C12Y209/01001 , C12Y306/05003 , C12Y601/01011
Abstract: Non-naturally occurring tRNASec and methods of using them for recombinant expression of proteins engineered to include one or more selenocysteine residues are disclosed. The non-naturally occurring tRNASec can be used for recombinant manufacture of selenocysteine containing polypeptides encoded by mRNA without the requirement of an SECIS element. In some embodiments, selenocysteine containing polypeptides are manufactured by co-expressing a non-naturally occurring tRNASec a recombinant expression system, such as E. coli, with SerRS, EF-Tu, SelA, or PSTK and SepSecS, and an mRNA with at least one codon that recognizes the anticodon of the non-naturally occurring tRNASec.
Abstract translation: 公开了非天然存在的tRNASec以及将其用于重组表达工程改造为包含一个或多个硒代半胱氨酸残基的蛋白质的方法。 非天然存在的tRNASec可用于重组制备由mRNA编码的含硒半胱氨酸的多肽，而不需要SECIS元件。 在一些实施方案中，含硒代半胱氨酸的多肽通过用SerRS，EF-Tu，SelA或PSTK和SepSecS共表达非天然存在的tRNASec重组表达系统（例如大肠杆菌）和至少具有mRNA 一个识别非天然存在的tRNASec的反密码子的密码子。
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7.发明申请INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF SERYL-TRNA SYNTHETASES 审中-公开与SERLL-TRNA合成蛋白质蛋白相关的治疗，诊断和抗体组合物的创新发现公开(公告)号：US20170002092A1
公开(公告)日：2017-01-05
申请号：US15099103
申请日：2016-04-14
Applicant: aTyr Pharma, Inc. , Pangu BioPharma Limited
Inventor： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain P. Vasserot , Wing-Sze Lo , Jeffry D. Watkins , Cheryl L. Quinn , John D. Mendlein
CPC classification number: C07K16/40 , A61K9/0019 , A61K38/00 , C07K2317/24 , C12N9/93 , C12Y601/01011 , G01N33/573 , G01N2333/9015
Abstract: Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
Abstract translation: 提供了包含新确定的氨酰-tRNA合成酶的蛋白质片段的组合物，编码它们的多核苷酸及其补体，相关试剂及其在诊断，药物发现，研究和治疗应用中的使用方法。
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8.发明授权公开(公告)号：US09464288B2
公开(公告)日：2016-10-11
申请号：US14131382
申请日：2012-07-11
Applicant: Dieter Soll , Caroline Aldag , Michael Hohn
Inventor： Dieter Soll , Caroline Aldag , Michael Hohn
CPC classification number: C12P21/00 , C07K14/47 , C12N9/0004 , C12N9/0008 , C12N9/10 , C12N9/1007 , C12N9/14 , C12N9/93 , C12N15/11 , C12N15/113 , C12N2310/531 , C12P21/02 , C12Y209/01001 , C12Y306/05003 , C12Y601/01011
Abstract: Non-naturally occurring tRNASec and methods of using them for recombinant expression of proteins engineered to include one or more selenocysteine residues are disclosed. The non-naturally occurring tRNASec can be used for recombinant manufacture of selenocysteine containing polypeptides encoded by mRNA without the requirement of an SECIS element. In some embodiments, selenocysteine containing polypeptides are manufactured by co-expressing a non-naturally occurring tRNASec a recombinant expression system, such as E. coli, with SerRS, EF-Tu, SelA, or PSTK and SepSecS, and an mRNA with at least one codon that recognizes the anticodon of the non-naturally occurring tRNASec.
Abstract translation: 公开了非天然存在的tRNASec以及将其用于重组表达工程改造为包含一个或多个硒代半胱氨酸残基的蛋白质的方法。 非天然存在的tRNASec可用于重组制备由mRNA编码的含硒半胱氨酸的多肽，而不需要SECIS元件。 在一些实施方案中，含硒代半胱氨酸的多肽通过用SerRS，EF-Tu，SelA或PSTK和SepSecS共表达非天然存在的tRNASec重组表达系统（例如大肠杆菌）和至少具有mRNA 一个识别非天然存在的tRNASec的反密码子的密码子。
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