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1.发明授权Infectious cDNA clone of north american porcine reproductive and respiratory syndrome (PPRS) virus and uses thereof 有权北美猪繁殖与呼吸综合征（PPRS）病毒感染性cDNA克隆及其用途公开(公告)号：US08492132B2
公开(公告)日：2013-07-23
申请号：US12607358
申请日：2009-10-28
Applicant: Jay G. Calvert , Michael G. Shepard , Siao-Kun W. Welch
Inventor： Jay G. Calvert , Michael G. Shepard , Siao-Kun W. Welch
CPC classification number: C07K14/005 , A61K2039/525 , A61K2039/53 , C12N15/86 , C12N2770/10022 , C12N2770/10043
Abstract: The invention provides isolated polynucleotide molecules, plasmids, viral vectors, and transfected host cells that comprise a DNA molecule encoding an infectious RNA molecule that encode a PRRS (Porcine Reproductive and Respiratory Syndrome) virus, and further provides the PRRS virus encoded thereby. The invention also provides isolated infectious RNA molecules encoding PRRS virus.
Abstract translation: 本发明提供分离的多核苷酸分子，质粒，病毒载体和转染的宿主细胞，其包含编码编码PRRS（猪繁殖和呼吸综合征）病毒的感染性RNA分子的DNA分子，并进一步提供由其编码的PRRS病毒。 本发明还提供编码PRRS病毒的分离的感染性RNA分子。
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2.发明申请Infectious cDNA Clone of North American Porcine reproductive and Respiratory Syndrome (PRRS) Virus and Uses Thereof 有权北美猪繁殖与呼吸综合征（PRRS）病毒及其用途的传染性cDNA克隆公开(公告)号：US20110040079A1
公开(公告)日：2011-02-17
申请号：US12615504
申请日：2009-11-10
Applicant: JAY GREGORY CALVERT , MICHAEL G. SHEPPARD , SIAO-KUN W. WELCH , RAYMOND R.R. ROWLAND , DAL-YOUNG KIM
Inventor： JAY GREGORY CALVERT , MICHAEL G. SHEPPARD , SIAO-KUN W. WELCH , RAYMOND R.R. ROWLAND , DAL-YOUNG KIM
IPC: C07H21/04
CPC classification number: C07K14/005 , A61K39/00 , A61K2039/525 , A61K2039/5254 , A61K2039/53 , A61K2039/552 , A61K2039/55544 , A61K2039/55566 , A61K2039/55577 , C07K2319/42 , C07K2319/60 , C12N7/00 , C12N15/86 , C12N2770/10021 , C12N2770/10022 , C12N2770/10034 , C12N2770/10043 , C12N2770/10061 , G01N33/56983 , G01N2333/08
Abstract: The invention provides isolated polynucleotide molecules that comprise a DNA sequence encoding an infectious RNA sequence encoding a genetically-modified North American PRRS virus, wherein the polynucleotide molecule lacks at least one detectable antigenic epitope of North American PRRS virus. The invention also provides vaccines comprising genetically modified North American PRRS virus, RNA molecules, plasmids and viral vectors comprising the isolated polynucleotide molecules. Also provided are isolated polynucleotide molecules further comprising at least one nucleotide sequence that encodes a detectable heterologous antigenic epitope, and vaccines comprising North American PRRS virus, RNA molecules, plasmids and viral vectors comprising such isolated polynucleotide molecules.
Abstract translation: 本发明提供了分离的多核苷酸分子，其包含编码编码经遗传修饰的北美PRRS病毒的感染性RNA序列的DNA序列，其中多核苷酸分子缺少至少一种可检测的北美PRRS病毒抗原表位。 本发明还提供包含经遗传修饰的北美PRRS病毒，RNA分子，质粒和包含分离的多核苷酸分子的病毒载体的疫苗。 还提供了进一步包含编码可检测的异源抗原表位的至少一个核苷酸序列的分离的多核苷酸分子，以及包含北美PRRS病毒，RNA分子，质粒和包含这种分离的多核苷酸分子的病毒载体的疫苗。
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3.发明授权North American porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof 有权北美猪繁殖与呼吸综合征（PRRS）病毒及其用途公开(公告)号：US09566324B2
公开(公告)日：2017-02-14
申请号：US13884077
申请日：2011-11-09
Applicant: Jay Gregory Calvert , David Ewell Slade , Siao-Kun W. Welch
Inventor： Jay Gregory Calvert , David Ewell Slade , Siao-Kun W. Welch
IPC: A61K39/12 , C07K16/08 , C07K14/005 , C12N7/00 , A61K39/00
CPC classification number: A61K39/12 , A61K2039/5254 , A61K2039/552 , A61K2039/57 , C07K14/005 , C07K16/08 , C12N7/00 , C12N15/86 , C12N2770/10022 , C12N2770/10034 , C12N2770/10043 , C12N2770/10051 , C12N2770/10062 , C12N2770/10064 , C12N2770/10071
Abstract: The invention provides isolated polynucleotide molecules that comprise a DNA sequence encoding an infectious RNA sequence encoding a genetically-modified North American PRRS virus, methods to make it and related polypeptides, polynucleotides, and various components. Vaccines comprising the genetically modified virus and polynucleotides and a diagnostic kit to distinguish between naturally infected and vaccinated animals are also provided.
Abstract translation: 本发明提供了分离的多核苷酸分子，其包含编码编码经遗传修饰的北美PRRS病毒的感染性RNA序列的DNA序列，其制备方法和相关多肽，多核苷酸和各种成分。 还提供了包含经遗传修饰的病毒和多核苷酸的疫苗和用于区分天然感染和接种疫苗的动物的诊断试剂盒。
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4.发明申请公开(公告)号：US20160317642A1
公开(公告)日：2016-11-03
申请号：US15105760
申请日：2014-12-19
Applicant: BOEHRINGER INGELHEIM VETMEDICA GMBH
Inventor： Andreas GALLEI , Christoph KELLER , Erik SCHACHT , Marieke HERREL
IPC: A61K39/12 , C07K14/005 , C12Q1/02 , C12N7/00
CPC classification number: A61K39/12 , A61K2039/5254 , A61K2039/552 , C07K14/005 , C12N7/00 , C12N15/86 , C12N2770/10021 , C12N2770/10034 , C12N2770/10043 , C12Q1/02 , G01N2333/08
Abstract: The present invention belongs to the field of animal health and provides means to study Porcine Reproductive and Respiratory Syndrome (PRRS), a viral disease affecting swine, and for the development of vaccines, therapeutics and diagnostics for the prophylaxis, treatment and diagnosis of PRRS. in a first consideration, the invention relates to a new PRRS virus variant, and, in a second consideration, to a nucleic acid sequence which comprises the genome of an infectious genotype I (EU) PRRS virus clone. Based on this, new PRRS vaccine candidates with improved properties are provided.
Abstract translation: 本发明属于动物健康领域，并提供了研究猪繁殖与呼吸综合征（PRRS），一种影响猪的病毒性疾病以及开发用于预防，治疗和诊断PRRS的疫苗，治疗和诊断的方法。 在第一个考虑中，本发明涉及新的PRRS病毒变体，并且在第二个考虑中涉及包含感染性基因型I（EU）PRRS病毒克隆的基因组的核酸序列。 基于此，提供了具有改进性质的新型PRRS疫苗候选物。
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5.发明授权Infectious cDNA of north american porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof 有权北美猪繁殖与呼吸综合征（PRRS）病毒的感染性cDNA克隆及其用途公开(公告)号：US08895025B2
公开(公告)日：2014-11-25
申请号：US12608305
申请日：2009-10-29
Applicant: Jay Gregory Calvert , Michael G. Sheppard , Siao-Kun W. Welch , Raymond R. R. Rowland , Dal-Young Kim
Inventor： Jay Gregory Calvert , Michael G. Sheppard , Siao-Kun W. Welch , Raymond R. R. Rowland , Dal-Young Kim
IPC: A61K39/00 , C12N15/86 , C07K14/005 , C12N7/00
CPC classification number: C07K14/005 , A61K39/00 , A61K2039/525 , A61K2039/5254 , A61K2039/53 , A61K2039/552 , A61K2039/55544 , A61K2039/55566 , A61K2039/55577 , C07K2319/42 , C07K2319/60 , C12N7/00 , C12N15/86 , C12N2770/10021 , C12N2770/10022 , C12N2770/10034 , C12N2770/10043 , C12N2770/10061 , G01N33/56983 , G01N2333/08
Abstract: The invention provides isolated polynucleotide molecules that comprise a DNA sequence encoding an infectious RNA sequence encoding a genetically-modified North American PRRS virus, wherein the polynucleotide molecule lacks at least one detectable antigenic epitope of North American PRRS virus. The invention also provides vaccines comprising genetically modified North American PRRS virus, RNA molecules, plasmids and viral vectors comprising the isolated polynucleotide molecules. Also provided are isolated polynucleotide molecules further comprising at least one nucleotide sequence that encodes a detectable heterologous antigenic epitope, and vaccines comprising North American PRRS virus, RNA molecules, plasmids and viral vectors comprising such isolated polynucleotide molecules.
Abstract translation: 本发明提供了分离的多核苷酸分子，其包含编码编码经遗传修饰的北美PRRS病毒的感染性RNA序列的DNA序列，其中多核苷酸分子缺少至少一种可检测的北美PRRS病毒抗原表位。 本发明还提供包含经遗传修饰的北美PRRS病毒，RNA分子，质粒和包含分离的多核苷酸分子的病毒载体的疫苗。 还提供了进一步包含编码可检测的异源抗原表位的至少一个核苷酸序列的分离的多核苷酸分子，以及包含北美PRRS病毒，RNA分子，质粒和包含这种分离的多核苷酸分子的病毒载体的疫苗。
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Patent Agency Ranking
公开(公告)号：US08790656B2
公开(公告)日：2014-07-29
申请号：US11422970
申请日：2006-06-08
Applicant: Johanna Jacoba Maria Meulenberg , Monique Helene Verheije
IPC: C12N15/86 , A61K39/12 , C07K14/005 , C12N7/00 , A61K39/00
CPC classification number: C07K14/005 , A61K39/00 , A61K2039/51 , A61K2039/5256 , C12N7/00 , C12N15/86 , C12N2770/10022 , C12N2770/10034 , C12N2770/10043 , C12N2770/10061
Abstract: The invention relates to the field of PRRS viruses and infectious clones obtained from PRRS viruses. Furthermore, the invention relates to vaccines and diagnostic assays obtainable by using and modifying such infectious clones of PRRS viruses. The invention provides a porcine reproductive and respiratory syndrome virus (PRRSV) replicon having at least some of its original PRRSV nucleic acid deleted, said replicon capable of in vivo RNA replication, said replicon further having been deprived of at least some of its original PRRSV nucleic acid and/or having been supplemented with nucleic acid derived from a heterologous microorganism.
Abstract translation: 本发明涉及从PRRS病毒获得的PRRS病毒和感染性克隆的领域。 此外，本发明涉及通过使用和修饰PRRS病毒感染性克隆而获得的疫苗和诊断测定法。 本发明提供了具有其原始PRRSV核酸的至少一些缺失的猪繁殖和呼吸综合征病毒（PRRSV）复制子，所述复制子能够进行体内RNA复制，所述复制子还被剥夺了其原始PRRSV核酸的至少一些 酸和/或已经补充有源自异源微生物的核酸。
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7.发明申请公开(公告)号：US20120149096A1
公开(公告)日：2012-06-14
申请号：US13276671
申请日：2011-10-19
Applicant: Kay S. Faaberg , Jun Han , Gongping Liu , Yue Wang
Inventor： Kay S. Faaberg , Jun Han , Gongping Liu , Yue Wang
CPC classification number: C12N7/00 , C07K14/005 , C12N2770/10021 , C12N2770/10022 , C12N2770/10043
Abstract: The present invention provides isolated infectious polynucleotides, such as infectious clones, having a nucleotide sequence with identity to PRRS viruses such as VR-2332, Lelystad, or others, and optionally further including a deletion in a region of ORF1 that encodes the nsp2 polypeptide.
Abstract translation: 本发明提供了分离的感染性多核苷酸，例如具有与PRRS病毒（例如VR-2332，Lelystad等）同一性的核苷酸序列的感染性克隆，并且还任选地在编码nsp2多肽的ORF1区域中进一步包括缺失。
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8.发明申请Infectious cDNA Clone of North American Porcine Reproductive and Respiratory Syndrome (PRRS) Virus and Uses Thereof 有权北美猪繁殖与呼吸综合征（PRRS）病毒及其用途的传染性cDNA克隆公开(公告)号：US20110040080A1
公开(公告)日：2011-02-17
申请号：US12619880
申请日：2009-11-17
Applicant: Jay Gregory Calvert , Michael G. Sheppard , Siao-Kun W. Welch , Raymond R.R. Rowland , Dal-Young Kim
Inventor： Jay Gregory Calvert , Michael G. Sheppard , Siao-Kun W. Welch , Raymond R.R. Rowland , Dal-Young Kim
IPC: C07H21/04
CPC classification number: C07K14/005 , A61K2039/525 , A61K2039/53 , C12N15/86 , C12N2770/10022 , C12N2770/10043
Abstract: The invention provides isolated polynucleotide molecules, including plasmids; viral vectors; and transfected host cells that comprise a DNA sequence encoding an infectious RNA sequence encoding a North American PRRS virus; and also North American PRRS viruses encoded thereby. The invention further provides isolated infectious RNA molecules encoding a North American PRRS virus. The invention also provides isolated polynucleotide molecules, infectious RNA molecules, viral vectors, and transfected host cells encoding genetically-modified North American PRRS viruses; and genetically-modified North American PRRS viruses encoded thereby. The invention also provides vaccines comprising such plasmids, RNA molecules, viral vectors, and North American PRRS viruses, and methods of using these vaccines in swine and in other animals. Also provided are isolated polynucleotide molecules, viral vectors, and transfected host cells that comprise a nucleotide sequence encoding a peptide of a North American PRRS virus. These viral vectors and transfected host cell lines are useful in providing peptides to compensate for mutated peptide coding sequences of DNA sequences encoding genetically-modified North American PRRS viruses so that functional virions can be generated.
Abstract translation: 本发明提供分离的多核苷酸分子，包括质粒; 病毒载体; 和包含编码编码北美PRRS病毒的感染性RNA序列的DNA序列的转染宿主细胞; 以及由此编码的北美PRRS病毒。 本发明还提供编码北美PRRS病毒的分离的感染性RNA分子。 本发明还提供分离的多核苷酸分子，感染性RNA分子，病毒载体和编码经遗传修饰的北美PRRS病毒的转染宿主细胞; 和由此编码的转基因北美PRRS病毒。 本发明还提供包含这样的质粒，RNA分子，病毒载体和北美PRRS病毒的疫苗，以及在猪和其他动物中使用这些疫苗的方法。 还提供了分离的多核苷酸分子，病毒载体和包含编码北美PRRS病毒的肽的核苷酸序列的转染宿主细胞。 这些病毒载体和转染的宿主细胞系可用于提供肽以补偿编码经遗传修饰的北美PRRS病毒的DNA序列的突变的肽编码序列，从而可以产生功能性病毒体。
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9.发明申请RECOMBINANT NORTH AMERICAN TYPE 1 PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS AND METHODS OF USE 有权重组北美1型PORCINE生殖和呼吸综合征病毒及其使用方法公开(公告)号：US20100136047A1
公开(公告)日：2010-06-03
申请号：US12145231
申请日：2008-06-24
Applicant: Ying Fang , Eric A. Nelson , Jane Hennings
Inventor： Ying Fang , Eric A. Nelson , Jane Hennings
CPC classification number: C07K14/005 , A61K2039/5254 , A61K2039/5256 , C12N7/00 , C12N15/86 , C12N2770/10021 , C12N2770/10022 , C12N2770/10034 , C12N2770/10043 , C12N2770/10061
Abstract: Porcine reproductive and respiratory syndrome virus (PRRSV) is a major problem in the pork industry worldwide. The inclusion of markers in vaccines will allow for diagnostic differentiation of vaccinated animals from those naturally infected with wild-type virus. Using a cDNA infectious clone of North American Type 1 PRRSV, a recombinant green fluorescent protein (GFP) tagged PRRSV has been made, containing deletion of an immunogenic epitope, ES4, in the nsp2 region. GFP and ES4 epitope-based ELISAs compliment the marker identification.
Abstract translation: 猪繁殖与呼吸综合征病毒（PRRSV）是全球猪肉行业的主要问题。 在疫苗中包含标记将允许接种动物与野生型病毒天然感染的动物进行诊断分化。 使用北美1型PRRSV的cDNA感染性克隆，已经制备了重组绿色荧光蛋白（GFP）标记的PRRSV，其在nsp2区域中含有免疫原性表位ES4的缺失。 GFP和ES4基于表位的ELISA证明了标记鉴定。
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公开(公告)号：US10010601B2
公开(公告)日：2018-07-03
申请号：US15105760
申请日：2014-12-19
Applicant: Boehringer Ingelheim Vetmedica GmbH
Inventor： Andreas Gallei , Christoph Keller , Erik Schacht , Marieke Herrel
CPC classification number: A61K39/12 , A61K2039/5254 , A61K2039/552 , C07K14/005 , C12N7/00 , C12N15/86 , C12N2770/10021 , C12N2770/10034 , C12N2770/10043 , C12Q1/02 , G01N2333/08
Abstract: The present invention belongs to the field of animal health and provides means to study Porcine Reproductive and Respiratory Syndrome (PRRS), a viral disease affecting swine, and for the development of vaccines, therapeutics and diagnostics for the prophylaxis, treatment and diagnosis of PRRS. In a first consideration, the invention relates to a new PRRS virus variant, and, in a second consideration, to a nucleic acid sequence which comprises the genome of an infectious genotype I (EU) PRRS virus clone. Based on this, new PRRS vaccine candidates with improved properties are provided.
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