-
1.发明申请公开(公告)号：US20180185469A1
公开(公告)日：2018-07-05
申请号：US15841928
申请日：2017-12-14
Applicant: OHIO STATE INNOVATION FOUNDATION
IPC: A61K39/12 , C07K16/10 , A61K35/74 , A61K35/76 , A61K39/385 , A61K39/39 , C12N7/00 , A61K9/14 , A61K39/00 , A61K9/51 , B82Y5/00
CPC classification number: A61K39/12 , A61K9/0019 , A61K9/14 , A61K9/5153 , A61K35/74 , A61K35/76 , A61K39/385 , A61K39/39 , A61K2039/5252 , A61K2039/5258 , A61K2039/541 , A61K2039/543 , A61K2039/545 , A61K2039/552 , A61K2039/55544 , A61K2039/55555 , A61K2039/55566 , A61K2039/55594 , A61K2039/57 , A61K2039/572 , A61K2039/58 , A61K2039/6018 , A61K2039/6087 , A61K2039/6093 , B82Y5/00 , C07K14/005 , C07K16/10 , C07K2317/76 , C12N7/00 , C12N2770/10021 , C12N2770/10023 , C12N2770/10034 , C12N2770/10061 , C12N2770/10063 , C12N2770/10071
Abstract: Disclosed herein are methods and compositions for treating or preventing Porcine reproductive and respiratory syndrome (PRRS) infection in a subject.
-
公开(公告)号：US20160256536A1
公开(公告)日：2016-09-08
申请号：US15160832
申请日：2016-05-20
Applicant: MJ BIOLOGICS, INC.
Inventor： BYOUNG-KWAN KIM
CPC classification number: A61K39/12 , A61K39/39 , A61K2039/5254 , C12N7/00 , C12N2770/10034 , C12N2770/10071
Abstract: The disclosure includes compositions and methods for the production of an immune response against porcine reproductive and respiratory syndrome (PRRS) virus, or PRRSV. The disclosure is based in part on the use of two or more peptide domains, each with a different sequence, from the PRRSV GP5 protein ectodomain. Compositions and methods comprising polypeptides containing the two or more domains, or nucleic acids encoding them, are described.
-
3.发明申请公开(公告)号：US20180111964A1
公开(公告)日：2018-04-26
申请号：US15794211
申请日：2017-10-26
Applicant: Chao-Wei LIAO , Chung-Chin CHEN
Inventor： Chao-Wei LIAO , Ting-Kai LIAO
IPC: C07K7/08 , C12N9/10 , C07K14/005 , C07K14/475 , A61K39/12 , A61K39/00
CPC classification number: C07K7/08 , A61K39/0005 , A61K39/00113 , A61K39/12 , A61K2039/542 , A61K2039/55544 , A61K2039/55555 , A61K2039/57 , A61K2039/6037 , A61K2039/70 , A61P31/14 , A61P31/20 , C07K14/005 , C07K14/21 , C07K14/475 , C07K2319/01 , C07K2319/10 , C07K2319/33 , C07K2319/40 , C12N9/1077 , C12N2710/20034 , C12N2710/20071 , C12N2770/10034 , C12N2770/10071 , C12Y204/02036
Abstract: A fusion polypeptide is disclosed, which includes: (a) a mucosa targeting polypeptide; (b) a translocating peptide for translocation; and (c) a antigenic epitope. In addition, a method for enhancing a stimulation of an immune response using the aforementioned fusion polypeptide is also disclosed.
-
4.发明申请公开(公告)号：US20170080078A1
公开(公告)日：2017-03-23
申请号：US15284290
申请日：2016-10-03
Applicant: OHIO STATE INNOVATION FOUNDATION
CPC classification number: A61K39/12 , A61K9/14 , A61K9/5153 , A61K35/74 , A61K35/76 , A61K39/385 , A61K39/39 , A61K2039/5252 , A61K2039/5258 , A61K2039/541 , A61K2039/543 , A61K2039/545 , A61K2039/552 , A61K2039/55544 , A61K2039/55555 , A61K2039/55566 , A61K2039/55594 , A61K2039/57 , A61K2039/572 , A61K2039/58 , A61K2039/6018 , A61K2039/6087 , A61K2039/6093 , B82Y5/00 , C07K16/10 , C12N7/00 , C12N2770/10021 , C12N2770/10023 , C12N2770/10034 , C12N2770/10061 , C12N2770/10071
Abstract: Disclosed herein are methods and compositions for treating or preventing Porcine reproductive and respiratory syndrome (PRRS) infection in a subject.
-
公开(公告)号：US09534207B2
公开(公告)日：2017-01-03
申请号：US14281287
申请日：2014-05-19
Applicant: Kim Burgard , Jeremy Kroll , Sarah M. Layton , Volker Ohlinger , Francois-Xavier Orveillon , Stefan Pesch , Michael Dennis Piontkowski , Michael B. Roof , Philip Utley , Eric Martin Vaughn
Inventor： Kim Burgard , Jeremy Kroll , Sarah M. Layton , Volker Ohlinger , Francois-Xavier Orveillon , Stefan Pesch , Michael Dennis Piontkowski , Michael B. Roof , Philip Utley , Eric Martin Vaughn
IPC: A61K39/225 , C12N7/00 , A61K39/12 , A61K38/00 , A61K39/00
CPC classification number: A61K39/12 , A61K2039/5254 , A61K2039/53 , A61K2039/552 , A61K2039/575 , C12N7/00 , C12N2770/10021 , C12N2770/10034 , C12N2770/10064 , C12N2770/10071
Abstract: The present invention is related to improved modified live PRRS vaccines containing new PRRSV European strains of PRRSV and methods of use and manufacture of such vaccines.
Abstract translation: 本发明涉及包含新的PRRSV欧洲PRRSV菌株的改良的活的PRRS疫苗，以及使用和制造这种疫苗的方法。
-
Patent Agency Ranking
6.发明授权Recombinant fusion antigen gene, recombinant fusion antigen protein and subunit vaccine composition having the same against infection of porcine reproductive and respiratory syndrome virus 有权重组融合抗原基因，与猪繁殖与呼吸综合征病毒感染相同的重组融合抗原蛋白和亚单位疫苗组合物公开(公告)号：US09441015B2
公开(公告)日：2016-09-13
申请号：US14667697
申请日：2015-03-25
Inventor： Mei-Li Wu , Hso-Chi Chaung , Guan-Ming Ke
IPC: C07K14/005 , C12N7/00 , A61K39/39 , A61K39/12 , A61K39/00
CPC classification number: C07K14/005 , A61K39/12 , A61K2039/55561 , A61K2039/70 , C07K2319/00 , C12N2770/10022 , C12N2770/10034 , C12N2770/10071 , C12N2799/026
Abstract: The present invention is directed to a recombinant fusion antigen gene, a recombinant fusion antigen protein and a subunit vaccine composition having the same against infection of porcine reproductive and respiratory syndrome virus (PRRSV). A recombinant fusion antigen gene, which encodes glycoprotein GP5 with truncated N′-terminal decoy epitope, a linker sequence and membrane protein M, followed by codon optimization, is expressed by a baculovirus expression system in vitro, thereby enhancing a yield of the recombinant fusion antigen protein. The recombinant fusion antigen protein can be applied in a subunit vaccine composition, for providing vaccinated animals with better protection ability without the risks of virulent spread and virulent recovery.
Abstract translation: 本发明涉及重组融合抗原基因，重组融合抗原蛋白和与猪繁殖与呼吸综合征病毒（PRRSV）感染相同的亚单位疫苗组合物。 编码具有截短的N末端诱饵表位的糖蛋白GP5，接头序列和膜蛋白M，然后密码子优化的重组融合抗原基因在体外由杆状病毒表达系统表达，从而提高重组融合物的产量 抗原蛋白。 重组融合抗原蛋白可以应用于亚单位疫苗组合物中，为疫苗接种的动物提供更好的保护能力，而不会产生毒性扩散和毒性恢复的风险。
-
公开(公告)号：US20170065709A1
公开(公告)日：2017-03-09
申请号：US15358288
申请日：2016-11-22
Applicant: Boehringer Ingelheim Vetmedica GmbH
Inventor： Kim BURGARD , Jeremy KROLL , Sarah M. LAYTON , Volker OHLINGER , Francois-Xavier ORVEILLON , Stefan PESCH , Michael Dennis PIONTKOWSKI , Michael B. ROOF , Philip UTLEY , Eric Martin VAUGHN
CPC classification number: A61K39/12 , A61K2039/5254 , A61K2039/53 , A61K2039/552 , A61K2039/575 , C12N7/00 , C12N2770/10021 , C12N2770/10034 , C12N2770/10064 , C12N2770/10071
Abstract: The present invention is related to improved modified live PRRS vaccines containing new PRRSV European strains of PRRSV and methods of use and manufacture of such vaccines.
Abstract translation: 本发明涉及包含新的PRRSV欧洲PRRSV菌株的改良的活的PRRS疫苗，以及使用和制造这种疫苗的方法。
-
8.发明授权North American porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof 有权北美猪繁殖与呼吸综合征（PRRS）病毒及其用途公开(公告)号：US09566324B2
公开(公告)日：2017-02-14
申请号：US13884077
申请日：2011-11-09
Applicant: Jay Gregory Calvert , David Ewell Slade , Siao-Kun W. Welch
Inventor： Jay Gregory Calvert , David Ewell Slade , Siao-Kun W. Welch
IPC: A61K39/12 , C07K16/08 , C07K14/005 , C12N7/00 , A61K39/00
CPC classification number: A61K39/12 , A61K2039/5254 , A61K2039/552 , A61K2039/57 , C07K14/005 , C07K16/08 , C12N7/00 , C12N15/86 , C12N2770/10022 , C12N2770/10034 , C12N2770/10043 , C12N2770/10051 , C12N2770/10062 , C12N2770/10064 , C12N2770/10071
Abstract: The invention provides isolated polynucleotide molecules that comprise a DNA sequence encoding an infectious RNA sequence encoding a genetically-modified North American PRRS virus, methods to make it and related polypeptides, polynucleotides, and various components. Vaccines comprising the genetically modified virus and polynucleotides and a diagnostic kit to distinguish between naturally infected and vaccinated animals are also provided.
Abstract translation: 本发明提供了分离的多核苷酸分子，其包含编码编码经遗传修饰的北美PRRS病毒的感染性RNA序列的DNA序列，其制备方法和相关多肽，多核苷酸和各种成分。 还提供了包含经遗传修饰的病毒和多核苷酸的疫苗和用于区分天然感染和接种疫苗的动物的诊断试剂盒。
-
公开(公告)号：US20140255442A1
公开(公告)日：2014-09-11
申请号：US14281287
申请日：2014-05-19
Applicant: Kim BURGARD , Jeremy KROLL , Sarah M. LAYTON , Volker OHLINGER , Francois-Xavier ORVEILLON , Stefan PESCH , Michael Dennis PIONTKOWSKI , Michael B. ROOF , Philip UTLEY , Eric Martin VAUGHN
Inventor： Kim BURGARD , Jeremy KROLL , Sarah M. LAYTON , Volker OHLINGER , Francois-Xavier ORVEILLON , Stefan PESCH , Michael Dennis PIONTKOWSKI , Michael B. ROOF , Philip UTLEY , Eric Martin VAUGHN
IPC: C12N7/00
CPC classification number: A61K39/12 , A61K2039/5254 , A61K2039/53 , A61K2039/552 , A61K2039/575 , C12N7/00 , C12N2770/10021 , C12N2770/10034 , C12N2770/10064 , C12N2770/10071
Abstract: The present invention is related to improved modified live PRRS vaccines containing new PRRSV European strains of PRRSV and methods of use and manufacture of such vaccines.
Abstract translation: 本发明涉及包含新的PRRSV欧洲PRRSV菌株的改良的活的PRRS疫苗，以及使用和制造这种疫苗的方法。
-
公开(公告)号：US08765142B2
公开(公告)日：2014-07-01
申请号：US13396298
申请日：2012-02-14
Applicant: Kim Burgard , Jeremy Kroll , Sarah M. Layton , Volker Ohlinger , Francois-Xavier Orveillon , Stefan Pesch , Michael Dennis Piontkowski , Michael B. Roof , Philip Utley , Eric Martin Vaughn
Inventor： Kim Burgard , Jeremy Kroll , Sarah M. Layton , Volker Ohlinger , Francois-Xavier Orveillon , Stefan Pesch , Michael Dennis Piontkowski , Michael B. Roof , Philip Utley , Eric Martin Vaughn
IPC: A61K39/225 , A61K38/00
CPC classification number: A61K39/12 , A61K2039/5254 , A61K2039/53 , A61K2039/552 , A61K2039/575 , C12N7/00 , C12N2770/10021 , C12N2770/10034 , C12N2770/10064 , C12N2770/10071
Abstract: The present invention is related to improved modified live PRRS vaccines containing new PRRSV European strains of PRRSV and methods of use and manufacture of such vaccines.
Abstract translation: 本发明涉及包含新的PRRSV欧洲PRRSV菌株的改良的活的PRRS疫苗，以及使用和制造这种疫苗的方法。
-
-
-
-
-
-
-
-
-
Search Results
27
records
(took 0.043 seconds)
