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公开(公告)号：US08834891B2
公开(公告)日：2014-09-16
申请号：US11374350
申请日：2006-03-13
Applicant: Jeremy Kroll , Mike Roof
Inventor： Jeremy Kroll , Mike Roof
IPC: A61K39/116 , A61K39/00 , A61K45/00 , A61K39/112 , A01N63/00 , A01N65/00 , A61K39/02
CPC classification number: A61K39/105 , A61K35/74 , A61K39/0241 , A61K39/0275 , A61K39/12 , A61K39/295 , A61K39/39 , A61K2039/521 , A61K2039/522 , A61K2039/525 , A61K2039/542 , A61K2039/55 , A61K2039/552 , A61K2039/55566 , A61K2039/70 , C12N7/00 , C12N2750/10034 , Y02A50/482 , Y10S424/825
Abstract: The present invention provides combination vaccines that comprise an immunological agent effective for reducing the incidence of or lessening the severity of PPE caused by L. intracellularis, and one or more immunological active components effective in treatment and/or prophylaxis of at least one further disease-causing organism for swine. Moreover, the present invention also relates to a kit that comprises an immunological agent effective for reducing the incidence of or lessening the severity of PPE caused by L. intracellularis, and one or more immunological active components effective in treatment and/or prophylaxis of at least one further disease-causing organism for swine.
Abstract translation: 本发明提供了组合疫苗，其包含有效降低由细胞内源性细胞因子引起的PPE的严重程度的发生率或降低的免疫学试剂，以及一种或多种有效治疗和/或预防至少一种其它疾病的免疫活性成分， 引起猪的生物体。 此外，本发明还涉及一种试剂盒，其包含有效降低由细胞内源性细胞因子引起的PPE的严重程度的发生率或降低的免疫学试剂，以及一种或多种有效治疗和/或预防的免疫活性成分 一种另外一种导致猪致病的生物体。
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公开(公告)号：US08563005B2
公开(公告)日：2013-10-22
申请号：US12942579
申请日：2010-11-09
Applicant: Jeremy Kroll , Philip Utley , Dianna Murphy Jordan
Inventor： Jeremy Kroll , Philip Utley , Dianna Murphy Jordan
CPC classification number: G01N33/56911 , A61K39/102 , A61K2039/552
Abstract: The invention provides immunogenic compositions useful for inhibiting, treating, protecting, or preventing infection by Actinobacillus suis. These immunogenic compositions are demonstrated to usefully stimulate immunogenic responses in treated pigs. Some vaccines stimulated reactions sufficient to be protective against A. suis. In addition, the invention provides kits comprising the immunogenic compositions; as well as, methods of using the compositions and kits.
Abstract translation: 本发明提供了可用于抑制，治疗，保护或预防由放线杆菌感染的免疫原性组合物。 证明这些免疫原性组合物有效刺激处理的猪的免疫原性反应。 一些疫苗刺激的反应足以防止A. suis。 此外，本发明提供了包含免疫原性组合物的试剂盒; 以及使用组合物和试剂盒的方法。
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公开(公告)号：US20120213810A1
公开(公告)日：2012-08-23
申请号：US13396298
申请日：2012-02-14
Applicant: Kim BURGARD , Jeremy KROLL , Sarah M. LAYTON , Volker OHLINGER , Francois-Xavier ORVEILLON , Stefan PESCH , Michael Dennis PIONTKOWSKI , Michael B. ROOF , Philip UTLEY , Eric Martin VAUGHN
Inventor： Kim BURGARD , Jeremy KROLL , Sarah M. LAYTON , Volker OHLINGER , Francois-Xavier ORVEILLON , Stefan PESCH , Michael Dennis PIONTKOWSKI , Michael B. ROOF , Philip UTLEY , Eric Martin VAUGHN
CPC classification number: A61K39/12 , A61K2039/5254 , A61K2039/53 , A61K2039/552 , A61K2039/575 , C12N7/00 , C12N2770/10021 , C12N2770/10034 , C12N2770/10064 , C12N2770/10071
Abstract: The present invention is related to improved modified live PRRS vaccines containing new PRRSV European strains of PRRSV and methods of use and manufacture of such vaccines.
Abstract translation: 本发明涉及包含新的PRRSV欧洲PRRSV菌株的改良的活的PRRS疫苗，以及使用和制造这种疫苗的方法。
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公开(公告)号：US20060035287A1
公开(公告)日：2006-02-16
申请号：US10918006
申请日：2004-08-13
Applicant: Jeremy Kroll , Michael Roof , Marc Eichmeyer
Inventor： Jeremy Kroll , Michael Roof , Marc Eichmeyer
IPC: G01N33/567 , G01N33/554 , G01N33/53 , G01N33/569
CPC classification number: G01N33/56911 , G01N2469/20
Abstract: Improved immunoassays for the protection of antibodies against Lawsonia intracellularis are provided which permit rapid, easy detection of low concentrations of anti-Lawsonia antibodies in animal-derived specimens. The preferred assay is an ELISA assay employing an antigenic extract of L. intracellularis lipopolysaccharide.
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5.发明申请Lawsonia intracellularis of European origin and vaccines, diagnostic agents and methods of use thereof 有权欧洲来源的细胞内劳森氏菌和疫苗，诊断剂及其使用方法公开(公告)号：US20050031647A1
公开(公告)日：2005-02-10
申请号：US10891745
申请日：2004-07-15
Applicant: Michael Roof , Jeremy Kroll , Jeffrey Knittel
Inventor： Michael Roof , Jeremy Kroll , Jeffrey Knittel
CPC classification number: A61K39/105 , A61K2039/505 , A61K2039/521 , A61K2039/522 , C07K16/1203 , G01N2333/195 , Y10S424/825
Abstract: The present invention relates to Lawsonia intracellularis vaccines and methods for protecting against and diagnosing L. intracellularis infection. The products and processes of the invention are attainable, in part, as the result of an improved method for cultivating large scale supplies of L. intracellularis, including both a novel isolate of L. intracellularis of European origin and a method of preparing a lyophilized product containing the attenuated European isolate as vaccine product.
Abstract translation: 本发明涉及细胞内劳森氏菌疫苗以及用于保护和诊断细胞内感染的方法。 本发明的产品和方法部分地可以通过用于培养大量细胞内源性物质的改进方法的结果，所述方法包括欧洲来源的细胞内分泌物的新型分离物和制备冻干产物的方法 含有减毒的欧洲分离物作为疫苗产品。
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Patent Agency Ranking
公开(公告)号：US09534207B2
公开(公告)日：2017-01-03
申请号：US14281287
申请日：2014-05-19
Applicant: Kim Burgard , Jeremy Kroll , Sarah M. Layton , Volker Ohlinger , Francois-Xavier Orveillon , Stefan Pesch , Michael Dennis Piontkowski , Michael B. Roof , Philip Utley , Eric Martin Vaughn
Inventor： Kim Burgard , Jeremy Kroll , Sarah M. Layton , Volker Ohlinger , Francois-Xavier Orveillon , Stefan Pesch , Michael Dennis Piontkowski , Michael B. Roof , Philip Utley , Eric Martin Vaughn
IPC: A61K39/225 , C12N7/00 , A61K39/12 , A61K38/00 , A61K39/00
CPC classification number: A61K39/12 , A61K2039/5254 , A61K2039/53 , A61K2039/552 , A61K2039/575 , C12N7/00 , C12N2770/10021 , C12N2770/10034 , C12N2770/10064 , C12N2770/10071
Abstract: The present invention is related to improved modified live PRRS vaccines containing new PRRSV European strains of PRRSV and methods of use and manufacture of such vaccines.
Abstract translation: 本发明涉及包含新的PRRSV欧洲PRRSV菌株的改良的活的PRRS疫苗，以及使用和制造这种疫苗的方法。
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公开(公告)号：US20110123570A1
公开(公告)日：2011-05-26
申请号：US12942579
申请日：2010-11-09
Applicant: Jeremy KROLL , Philip UTLEY , Dianna M. JORDAN
Inventor： Jeremy KROLL , Philip UTLEY , Dianna M. JORDAN
CPC classification number: G01N33/56911 , A61K39/102 , A61K2039/552
Abstract: The invention provides immunogenic compositions useful for inhibiting, treating, protecting, or preventing infection by Actinobacillus suis. These immunogenic compositions are demonstrated to usefully stimulate immunogenic responses in treated pigs. Some vaccines stimulated reactions sufficient to be protective against A. suis. In addition, the invention provides kits comprising the immunogenic compositions; as well as, methods of using the compositions and kits.
Abstract translation: 本发明提供了可用于抑制，治疗，保护或预防由放线杆菌感染的免疫原性组合物。 证明这些免疫原性组合物有效刺激处理的猪的免疫原性反应。 一些疫苗刺激的反应足以防止A. suis。 此外，本发明提供了包含免疫原性组合物的试剂盒; 以及使用组合物和试剂盒的方法。
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公开(公告)号：US20060204522A1
公开(公告)日：2006-09-14
申请号：US11374350
申请日：2006-03-13
Applicant: Jeremy Kroll , Mike Roof
Inventor： Jeremy Kroll , Mike Roof
IPC: A61K39/295 , A61K39/116
CPC classification number: A61K39/105 , A61K35/74 , A61K39/0241 , A61K39/0275 , A61K39/12 , A61K39/295 , A61K39/39 , A61K2039/521 , A61K2039/522 , A61K2039/525 , A61K2039/542 , A61K2039/55 , A61K2039/552 , A61K2039/55566 , A61K2039/70 , C12N7/00 , C12N2750/10034 , Y02A50/482 , Y10S424/825
Abstract: The present invention provides combination vaccines that comprise an immunological agent effective for reducing the incidence of or lessening the severity of PPE caused by L. intracellularis, and one or more immunological active components effective in treatment and/or prophylaxis of at least one further disease-causing organism for swine. Moreover, the present invention also relates to a kit that comprises an immunological agent effective for reducing the incidence of or lessening the severity of PPE caused by L. intracellularis, and one or more immunological active components effective in treatment and/or prophylaxis of at least one further disease-causing organism for swine.
Abstract translation: 本发明提供了组合疫苗，其包含有效降低由细胞内源性细胞因子引起的PPE的严重程度的发生率或降低的免疫学试剂，以及一种或多种有效治疗和/或预防至少一种其它疾病的免疫活性成分， 引起猪的生物体。 此外，本发明还涉及一种试剂盒，其包含有效降低由细胞内源性细胞因子引起的PPE的严重程度的发生率或降低的免疫学试剂，以及一种或多种有效治疗和/或预防的免疫活性成分 一种另外一种导致猪致病的生物体。
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公开(公告)号：US20140341947A1
公开(公告)日：2014-11-20
申请号：US14447694
申请日：2014-07-31
Applicant: Jeremy KROLL , Mike ROOF
Inventor： Jeremy KROLL , Mike ROOF
IPC: A61K39/295
CPC classification number: A61K39/105 , A61K35/74 , A61K39/0241 , A61K39/0275 , A61K39/12 , A61K39/295 , A61K39/39 , A61K2039/521 , A61K2039/522 , A61K2039/525 , A61K2039/542 , A61K2039/55 , A61K2039/552 , A61K2039/55566 , A61K2039/70 , C12N7/00 , C12N2750/10034 , Y02A50/482 , Y10S424/825
Abstract: The present invention provides combination vaccines that comprise an immunological agent effective for reducing the incidence of or lessening the severity of PPE caused by L. intracellularis, and one or more immunological active components effective in treatment and/or prophylaxis of at least one further disease-causing organism for swine. Moreover, the present invention also relates to a kit that comprises an immunological agent effective for reducing the incidence of or lessening the severity of PPE caused by L. intracellularis, and one or more immunological active components effective in treatment and/or prophylaxis of at least one further disease-causing organism for swine.
Abstract translation: 本发明提供了组合疫苗，其包含有效降低由细胞内源性细胞因子引起的PPE的严重程度的发生率或降低的免疫学试剂，以及一种或多种有效治疗和/或预防至少一种其它疾病的免疫活性成分， 引起猪的生物体。 此外，本发明还涉及一种试剂盒，其包含有效降低由细胞内源性细胞因子引起的PPE的严重程度的发生率或降低的免疫学试剂，以及一种或多种有效治疗和/或预防的免疫活性成分 一种另外一种导致猪致病的生物体。
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公开(公告)号：US08470336B2
公开(公告)日：2013-06-25
申请号：US11750458
申请日：2007-05-18
Applicant: Jeremy Kroll
Inventor： Jeremy Kroll
IPC: A61K39/02
CPC classification number: A61K39/105 , A61K2039/521 , A61K2039/522 , A61K2039/55 , A61K2039/552
Abstract: The present invention provides a method of vaccinating a young animal against L. intracellularis infection comprising the step of administering to an animal an effective dose of L. intracellularis antigen. It also provides a method of vaccinating an animal, preferably a young animal, having anti-L. intracellularis antibodies or is exposed to anti-L. intracellularis antibodies. In particular, those anti-L.intracellularis antibodies are maternally derived antibodies.
Abstract translation: 本发明提供了一种针对细胞内感染细胞内感染疫苗接种幼体动物的方法，包括向动物施用有效剂量的细胞内抗原的步骤。 它还提供了一种接种具有抗-L的动物，优选年轻动物的方法。 细胞内抗体或暴露于抗L。 细胞内抗体。 特别地，这些抗细胞纤维蛋白酶抗体是母体衍生的抗体。
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