公开(公告)号：US11779637B2

公开(公告)日：2023-10-10

申请号：US16606993

申请日：2018-04-23

Applicant: NANTCELL, INC.

Inventor： Kayvan Niazi

IPC: A61K39/00 ,  A61K39/39 ,  A61P35/00 ,  C07K14/705 ,  C12N15/70 ,  C12N15/861 ,  C12N15/81

CPC classification number: A61K39/001102 ,  A61K39/39 ,  A61P35/00 ,  C07K14/70596 ,  C12N15/70 ,  C12N15/81 ,  C12N15/861 ,  A61K2039/51 ,  A61K2039/523 ,  A61K2039/5256 ,  A61K2039/53 ,  A61K2039/585 ,  C12N2710/10011 ,  C12N2710/10021 ,  C12N2710/10043 ,  C12N2799/022

Abstract: Systems and methods are presented that allow for selection of tumor neoepitopes that are then used to generate recombinant nucleic acids that encode one or more polytopes that are optimized for proper trafficking and processing. In preferred methods, the polytopes are encoded in a plasmid and/or a viral expression system for use as a therapeutic agent.

公开(公告)号：US20180305665A1

公开(公告)日：2018-10-25

申请号：US15769872

申请日：2016-10-19

Applicant: The Catholic University of Korea Industry-Academic Cooperation Foundation

Inventor： Seok Goo CHO ,  Nayoun KIM ,  Jung-Yeon LIM ,  Keon-Il IM ,  Young-Sun NAM

IPC: C12N5/0783 ,  A61K39/235 ,  A61K35/17 ,  C07K16/24

CPC classification number: C12N5/0636 ,  A61K35/14 ,  A61K35/17 ,  A61K39/235 ,  A61K2039/5156 ,  A61K2039/5158 ,  C07K14/005 ,  C07K16/246 ,  C07K16/28 ,  C12N2510/00 ,  C12N2710/10011 ,  C12N2710/16111 ,  Y02A50/467

Abstract: The present invention relates to a method for inducing and proliferating target virus antigen-specific dual activated T cells, and can produce target virus antigen-specific dual activated T cells by treating monocytes, which are isolated from peripheral blood, with a cytokine and a virus antigen peptide mixture and culturing the same.

公开(公告)号：US20230323395A1

公开(公告)日：2023-10-12

申请号：US18066537

申请日：2022-12-15

Applicant: Homology Medicines, Inc.

Inventor： Marissa Stanvick ,  Richard Gilmore ,  Divya Tsiros

IPC: C12N15/86

CPC classification number: C12N15/86 ,  C12N2710/10011 ,  C12N2750/14141

Abstract: Provided herein are methods for the production of recombinant adeno-associated virus (rAAV) particles. These methods are particularly useful for the large-scale production of AAV particles.

公开(公告)号：US20180080045A1

公开(公告)日：2018-03-22

申请号：US15706898

申请日：2017-09-18

Applicant: Boehringer Ingelheim Vetmedica GmbH

Inventor： Andreas GALLEI ,  Ramesh KOUKUNTLA ,  Robert Barry MANDELL ,  Alice MUNDT ,  Kristina REHMET ,  Eric Martin VAUGHN

IPC: C12N15/86 ,  A61K39/155 ,  A61K39/205

CPC classification number: C12N15/86 ,  A61K39/12 ,  A61K39/155 ,  A61K39/205 ,  A61K39/295 ,  A61K48/00 ,  A61K2039/5256 ,  A61K2039/545 ,  A61K2039/552 ,  A61P31/14 ,  A61P31/20 ,  A61P31/22 ,  C12N2710/00 ,  C12N2710/10011 ,  C12N2710/10041 ,  C12N2710/10044 ,  C12N2710/10051 ,  C12N2710/10343 ,  C12N2710/10371 ,  C12N2710/16734 ,  C12N2710/16743 ,  C12N2750/14334 ,  C12N2760/18434 ,  C12N2760/18534 ,  C12N2760/18634 ,  C12N2760/20134 ,  C12N2760/20171 ,  C12N2830/60

Abstract: The present invention relates to the field of CAdV vector vaccines, and especially to promoters suitable to express target antigens from such vector vaccines. Disclosed and claimed are recombinant canine adenoviruses, methods of making them, uses for them (including in immunological, immunogenic, vaccine or therapeutic compositions, or, as a vector for cloning, replicating or expressing DNA and methods of using the compositions and vector), expression products from them, and uses for the expression products. Additionally, disclosed and claimed are truncated EHV4 promoters, expression cassettes containing the promoters, and recombinant viruses and plasmids containing the promoters or expression cassettes.

公开(公告)号：US20030138808A1

公开(公告)日：2003-07-24

申请号：US10225568

申请日：2002-08-20

Inventor： John J.L. Simard ,  Xiang-Dong Lei ,  David C. Diamond

IPC: C12Q001/68 ,  C07H021/04

CPC classification number: G01N33/68 ,  A61K38/00 ,  A61K39/00 ,  A61K39/0011 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/57 ,  C07H21/04 ,  C07K14/47 ,  C07K14/4748 ,  C07K2319/00 ,  C12N9/0059 ,  C12N15/74 ,  C12N15/85 ,  C12N2710/10011 ,  C12N2710/22011 ,  C12N2710/24011 ,  C12N2720/12011 ,  C12N2730/10111 ,  C12N2840/203

Abstract: The invention provides a nucleic acid construct encoding a housekeeping epitope derived from an antigen associated with a target cell. The construct can further include a second sequence encoding a housekeeping epitope or an immune epitope. The construct can be used as a vaccine against numerous kinds of target cells, including neoplastic cells and cells infected with an intracellular virus.

Abstract translation: 本发明提供了编码源自与靶细胞相关的抗原的护理表位的核酸构建体。 该构建体可以进一步包括编码持续保护表位或免疫表位的第二序列。 该构建体可以用作针对多种靶细胞的疫苗，包括肿瘤细胞和感染了细胞内病毒的细胞。