公开(公告)号：US20140234350A1

公开(公告)日：2014-08-21

申请号：US14181276

申请日：2014-02-14

申请人： Cedars-Sinai Medical Center ,  ImmunoCellular Therapeutics Ltd.

发明人： John S. Yu ,  Zhenhua Li ,  Sandra Orsulic ,  Beth Y. Karlan ,  James G. Bender

IPC分类号： A61K39/385 ,  A61K39/00 ,  A61K45/06

CPC分类号： A61K39/0011 ,  A61K31/675 ,  A61K45/06 ,  A61K2039/5154 ,  A61K2039/585 ,  A61K2039/70 ,  C12N5/0639 ,  C12N2501/11 ,  C12N2501/22 ,  C12N2501/2304 ,  C12N2501/2313 ,  C12N2501/25 ,  C12N2501/48 ,  C12N2501/50 ,  C12N2501/599 ,  C12N2501/727 ,  C12N2501/998 ,  C12N2506/115

摘要： Compositions of multipeptide vaccines including tumor associated antigens, compositions of antigen presenting cell (e.g., dendritic cell) based vaccines presenting epitopes from tumor associated antigens, and methods of making same, are provided herein. Also, disclosed are methods for treating ovarian cancers using such vaccines.

摘要翻译： 本文提供了多肽疫苗的组合物，包括肿瘤相关抗原，呈递来自肿瘤相关抗原的表位的抗原呈递细胞（例如树突状细胞）疫苗的组合物及其制备方法。 还公开了使用这种疫苗治疗卵巢癌的方法。

公开(公告)号：US20240277761A1

公开(公告)日：2024-08-22

申请号：US18580524

申请日：2022-07-15

申请人： The Regents of the University of California

发明人： Dan S. Kaufman ,  Somayeh Pouyanfard ,  Tatiana Kisseleva

IPC分类号： A61K35/15 ,  A61P1/16 ,  C12N5/0786

CPC分类号： A61K35/15 ,  A61P1/16 ,  C12N5/0645 ,  C12N2501/2304 ,  C12N2501/2313 ,  C12N2501/24 ,  C12N2506/45

摘要： Compositions, methods of treatment for liver disease such as liver fibrosis, compositions, and methods for the manufacture thereof, comprising a plurality of macrophages derived from human induced pluripotent stem cells (iPSCs), wherein the macrophages are polarized to a pro-inflammatory M1 phenotype and/or an anti-inflammatory M2 phenotype. Administration reduces fibrogenic gene expression and liver disease associated histological markers. The M1 macrophages express elevated CD80, TNF-α and IL-6. The M2 macrophages express elevated CD206, CCL17, and CCL22.

公开(公告)号：US20240228958A1

公开(公告)日：2024-07-11

申请号：US18026419

申请日：2021-09-08

申请人： Ji-seop SHIN ,  Woo-seop SHIN

发明人： Ji-seop SHIN ,  Woo-seop SHIN

IPC分类号： C12N5/0783 ,  C07K14/54 ,  C07K16/28

CPC分类号： C12N5/0636 ,  C07K14/54 ,  C07K14/5434 ,  C07K14/5443 ,  C07K16/2803 ,  C07K16/2809 ,  C07K16/2812 ,  C07K16/2818 ,  C07K16/283 ,  C12N5/0646 ,  C12N2501/2313 ,  C12N2501/2315 ,  C12N2501/2318 ,  C12N2501/39 ,  C12N2501/515 ,  C12N2501/599

摘要： An immune cell proliferation activation kit includes a first unit including a T cell stimulating substance, and a second unit including a steroidal agent. The kit suppresses regulatory T cells (Treg) during immune cell culture to allow any one of natural killer cells (NK cells) and T cells from among immune cells to efficiently proliferate, and efficiently amplifies and activates immune cells for a long period of time.

公开(公告)号：US20230405118A1

公开(公告)日：2023-12-21

申请号：US18251060

申请日：2021-10-29

申请人： THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION

发明人： Alejandro VILLAGRA ,  Satish NOONEPALLE ,  Maria del Mar Gracia HERNANDEZ

IPC分类号： A61K39/00 ,  C12N5/0786 ,  A61K35/15 ,  A61K45/06

CPC分类号： A61K39/4614 ,  C12N5/0645 ,  A61K39/464495 ,  A61K39/464491 ,  A61K39/464486 ,  A61K39/464488 ,  A61K39/46449 ,  A61K39/464482 ,  A61K39/464481 ,  A61K39/46447 ,  A61K39/464456 ,  A61K39/464451 ,  A61K39/4644 ,  A61K35/15 ,  A61K45/06 ,  C12N2501/2304 ,  C12N2501/2313 ,  A61K2039/5154

摘要： The present disclosure provides signal transducer and activator of transcription (STAT)-activated macrophages, compositions comprising STAT-activated macrophages, methods of making STAT-activated macrophages, and methods of treating diseases, e.g., cancer, by administering a therapeutically effective amount of STAT-activated macrophages.

公开(公告)号：US20230142987A1

公开(公告)日：2023-05-11

申请号：US17919564

申请日：2021-04-19

申请人： DUOGENIC STEMCELLS CORPORATION

发明人： Hong-Lin SU ,  Ching-I SHEN ,  Fu-Hui WANG ,  Chia-Ying HSIEH ,  Masataka KIYOKAWA

IPC分类号： C12N5/0786 ,  A61K35/15

CPC分类号： C12N5/0645 ,  A61K35/15 ,  C12N2501/15 ,  C12N2501/22 ,  C12N2501/2304 ,  C12N2501/231 ,  C12N2501/2313 ,  C12N2502/115 ,  C12N2533/52

摘要： The present invention provides modified monocytes, modified macrophages, pharmaceutical compositions comprising the modified monocytes or modified macrophages described herein and at least one pharmaceutically acceptable carrier or excipient. Uses of the modified monocytes or the modified macrophages for the treatment of musculoskeletal diseases and inducing cartilage formation are provided. Also disclosed herein are in vitro culture methods for generating the modified macrophages.

公开(公告)号：US20230233613A1

公开(公告)日：2023-07-27

申请号：US17963219

申请日：2022-10-11

申请人： Gwo Xi Stem Cell Applied Technology Co., Ltd.

发明人： Po-Cheng Lin ,  Pi-Chun Huang ,  Chia-Hsin Lee ,  Ming-Hsi Chuang ,  Chun-Hung Chen ,  Chao-Liang Chang ,  Kai-Ling Zhang ,  Yi-Chun Lin ,  Yu-Chen Tsai ,  Peggy Leh Jiunn Wong ,  Ruei-Yue Liang

IPC分类号： A61K35/28 ,  A61K9/00 ,  C12N5/0789

CPC分类号： A61K35/28 ,  A61K9/0085 ,  A61K9/0019 ,  C12N5/0647 ,  C12N2501/10 ,  C12N2502/1382 ,  C12N2501/2304 ,  C12N2501/2313

摘要： The present invention provides a pharmaceutical composition for treating chronic stroke, involving injection via brain into the cranium of a patient having chronic stroke for six months or more; the pharmaceutical composition is a suspension at least comprising TS stem cells, an active synergistic component and a growth factor, wherein the expression level of CD34 and CD45 of the TS stem cells is 10% or less, and the expression level of CD90 and CD105 is 90% or more; the active synergistic component is an extracellular vesicle; the growth factor is at least one selected from the group consisting of HGF, G-CSF, Fractalkine, IP-10, EGF, IL-1α, IL-1β, IL-4, IL-5, IL-13, IFNγ, TGFα and sCD40L. The present invention overcomes the limitations of previous cell therapy and provides a cell-based preparation that is clinically safe and therapeutically effective for chronic cerebral stroke.

公开(公告)号：US20230227781A1

公开(公告)日：2023-07-20

申请号：US17927786

申请日：2021-05-27

申请人： The University Court of The University of Edinburgh

发明人： Stuart Forbes ,  Lara Campana ,  Benjamin Dwyer ,  John Campbell ,  Alasdair Fraser

IPC分类号： C12N5/0786 ,  A61K35/15

CPC分类号： C12N5/0645 ,  A61K35/15 ,  C12N2506/115 ,  C12N2501/22 ,  C12N2501/2304 ,  C12N2501/231 ,  C12N2501/2313 ,  C12N2501/24

摘要： The improved 4-5 day, optionally 3-5 day GMP-compliant in-vitro method enables the production of macrophages from monocytes that benefits from a shorter cell culture time, fewer interventions whilst maintaining the desired characteristics of the human macrophages. The present invention describes a method wherein the monocytes are cultured in medium comprising one or more growth actors to stimulate macrophages with a pro-regenerative phenotype. The method described herein is xeno-free, serum-free and GMP compliant. In addition, further disclosed are macrophages produced according to the present invention and the use of said macrophages in the treatment of liver diseases, such as liver cirrhosis.

公开(公告)号：US20160201036A1

公开(公告)日：2016-07-14

申请号：US15072971

申请日：2016-03-17

申请人： Commence Bio, Inc.

发明人： Aline BETANCOURT

IPC分类号： C12N5/0775

CPC分类号： C12N5/0043 ,  A61K35/28 ,  A61K2035/124 ,  C12N5/0662 ,  C12N5/0663 ,  C12N5/0668 ,  C12N2500/02 ,  C12N2500/92 ,  C12N2501/00 ,  C12N2501/052 ,  C12N2501/14 ,  C12N2501/22 ,  C12N2501/2304 ,  C12N2501/2313 ,  C12N2501/24 ,  C12N2501/25 ,  C12N2501/58 ,  C12N2501/599 ,  C12N2501/90 ,  C12N2501/999

摘要： Novel MSC stem-cell culture and therapy methods and culture medium compositions for the purpose of inducing, activating, or priming discrete uniform cell phenotypes to selectively promote or suppress inflammation and immunity, yielding polarized, primed, activated, or induced cells used in cell-based therapy.

公开(公告)号：US20160194602A1

公开(公告)日：2016-07-07

申请号：US15072943

申请日：2016-03-17

申请人： Commence Bio, Inc.

发明人： Aline BETANCOURT

IPC分类号： C12N5/00 ,  C12N5/0775

CPC分类号： C12N5/0043 ,  A61K35/28 ,  A61K2035/124 ,  C12N5/0662 ,  C12N5/0663 ,  C12N5/0668 ,  C12N2500/02 ,  C12N2500/92 ,  C12N2501/00 ,  C12N2501/052 ,  C12N2501/14 ,  C12N2501/22 ,  C12N2501/2304 ,  C12N2501/2313 ,  C12N2501/24 ,  C12N2501/25 ,  C12N2501/58 ,  C12N2501/599 ,  C12N2501/90 ,  C12N2501/999

摘要： Novel MSC stem-cell culture and therapy methods and culture medium compositions for the purpose of inducing, activating, or priming discrete uniform cell phenotypes to selectively promote or suppress inflammation and immunity, yielding polarized, primed, activated, or induced cells used in cell-based therapy.

摘要翻译： 新型MSC干细胞培养和治疗方法和培养基组合物，用于诱导，激活或引发离散的均匀细胞表型以选择性地促进或抑制炎症和免疫，产生用于细胞周期的极化的，引发的，活化的或诱导的细胞， 基于治疗。

公开(公告)号：US09321994B1

公开(公告)日：2016-04-26

申请号：US14720603

申请日：2015-05-22

申请人： WibiWorks Therapeutics, Inc.

发明人： Aline Betancourt

IPC分类号： A61K35/28 ,  C12N5/0775

CPC分类号： C12N5/0043 ,  A61K35/28 ,  A61K2035/124 ,  C12N5/0662 ,  C12N5/0663 ,  C12N5/0668 ,  C12N2500/02 ,  C12N2500/92 ,  C12N2501/00 ,  C12N2501/052 ,  C12N2501/14 ,  C12N2501/22 ,  C12N2501/2304 ,  C12N2501/2313 ,  C12N2501/24 ,  C12N2501/25 ,  C12N2501/58 ,  C12N2501/599 ,  C12N2501/90 ,  C12N2501/999

摘要： Novel MSC stem-cell culture and therapy methods and culture medium compositions for the purpose of inducing, activating, or priming discrete uniform cell phenotypes to selectively promote or suppress inflammation and immunity, yielding polarized, primed, activated, or induced cells used in cell-based therapy.

摘要翻译： 新型MSC干细胞培养和治疗方法和培养基组合物，用于诱导，激活或引发离散的均匀细胞表型以选择性地促进或抑制炎症和免疫，产生用于细胞周期的极化的，引发的，活化的或诱导的细胞， 基于治疗。