公开(公告)号：US20230142987A1

公开(公告)日：2023-05-11

申请号：US17919564

申请日：2021-04-19

Applicant: DUOGENIC STEMCELLS CORPORATION

Inventor： Hong-Lin SU ,  Ching-I SHEN ,  Fu-Hui WANG ,  Chia-Ying HSIEH ,  Masataka KIYOKAWA

IPC: C12N5/0786 ,  A61K35/15

CPC classification number: C12N5/0645 ,  A61K35/15 ,  C12N2501/15 ,  C12N2501/22 ,  C12N2501/2304 ,  C12N2501/231 ,  C12N2501/2313 ,  C12N2502/115 ,  C12N2533/52

Abstract: The present invention provides modified monocytes, modified macrophages, pharmaceutical compositions comprising the modified monocytes or modified macrophages described herein and at least one pharmaceutically acceptable carrier or excipient. Uses of the modified monocytes or the modified macrophages for the treatment of musculoskeletal diseases and inducing cartilage formation are provided. Also disclosed herein are in vitro culture methods for generating the modified macrophages.