公开(公告)号：US11965152B2

公开(公告)日：2024-04-23

申请号：US16783275

申请日：2020-02-06

申请人： Lonza Ltd.

发明人： Thaddaeus Webster ,  Carrie Mason ,  Tristan Wilkins

IPC分类号： C12M1/34 ,  B01F23/45 ,  B01J19/00 ,  B01F101/22

CPC分类号： C12M41/26 ,  B01F23/45 ,  B01J19/0086 ,  C12M1/3407 ,  C12M1/3453 ,  C12M41/12 ,  B01F2101/22 ,  Y10T436/108331

摘要： The monitoring and control of bioprocesses is provided. More particularly, the present disclosure is directed to formulating buffer products from multiple buffer solutions for feeding the different operations occurring within a bioprocess line. As the buffer product is being formulated, the buffer product is tested for conductivity, refractive index, and optionally pH. The conductivity measurements are used in conjunction with refractive index measurements to ensure that the buffer product not only has the correct concentration of ions but also has the correct concentration of components. A controller can be used to make automatic adjustments to the buffer product should any of the measured parameters fall outside a preset range.

公开(公告)号：US20180201892A1

公开(公告)日：2018-07-19

申请号：US15753091

申请日：2016-08-19

申请人： TOKYO ELECTRON LIMITED ,  TOCALO CO., LTD.

发明人： Shinichi GOMI ,  Kenichi KAGAWA ,  Yusuke YODA ,  Shinya MIKI ,  Tatsuya HAMAGUCHI

IPC分类号： C12M1/12 ,  C12M1/32 ,  C12M1/00 ,  C12M1/34 ,  C12Q1/04 ,  G01N21/03

CPC分类号： C12M25/14 ,  C12M1/3453 ,  C12M23/00 ,  C12M23/10 ,  C12M23/12 ,  C12M23/20 ,  C12M41/36 ,  C12N5/0696 ,  C12Q1/04 ,  C12Q1/045 ,  G01N21/0303 ,  G01N2021/0378 ,  G02B21/14 ,  G02B21/34

摘要： The purpose of the present invention is to provide a culture container capable of preventing a concave meniscus without using a jig. In order to achieve this purpose, the present invention provides a culture container (1A) provided with: a base (3) having a concave portion (4); and a water-repellent layer (5) formed on an outer edge region (411) of the bottom (41) of the concave portion (4) and the inner circumferential surface (42) of the concave portion (4). One of the surfaces of the water-repellent layer (5) is exposed to the space in the concave portion (4).

公开(公告)号：US20170038289A1

公开(公告)日：2017-02-09

申请号：US15224675

申请日：2016-08-01

申请人： Pukyong National University Industry-University Cooperation Foundation

发明人： Yongwook LEE ,  Junghwan OH ,  Hyunwook KANG ,  Seungyun NAM ,  Youngmog KIM ,  Junhyeog JEONG

IPC分类号： G01N15/14 ,  G02B6/32 ,  G02B6/27

CPC分类号： G02B6/32 ,  C12M1/3453 ,  G01N15/06 ,  G01N2015/0065 ,  G02B6/2706

摘要： An apparatus for discriminating bacteria types using optical scattering patterns is disclosed. The apparatus includes an optical fiber for transferring light emitted from a light source, a lens for controlling a width of the light received from the optical fiber, a linear polarizer for transmitting the light passing through the lens and a bacterial colony, and a capturing unit for capturing an optical scattering pattern of the light transmitted through the linear polarizer.

摘要翻译： 公开了一种使用光散射图案辨别细菌类型的装置。 该装置包括用于传送从光源发射的光的光纤，用于控制从光纤接收的光的宽度的透镜，用于透射通过透镜的光的线性偏振器和细菌菌落，以及捕获单元 用于捕获透射通过线偏振器的光的光学散射图案。

公开(公告)号：US12098415B2

公开(公告)日：2024-09-24

申请号：US18449087

申请日：2023-08-14

申请人： International Business Machines Corporation

发明人： Amos Cahan ,  Guy M. Cohen ,  Theodore G. van Kessel ,  Sufi Zafar

IPC分类号： G01N27/02 ,  C12M1/00 ,  C12M1/12 ,  C12M1/18 ,  C12M1/34 ,  C12M3/00 ,  C12Q1/02 ,  C12Q1/18 ,  G01N15/06 ,  G01N21/59 ,  G01N27/04

CPC分类号： C12Q1/02 ,  C12M1/18 ,  C12M1/3453 ,  C12M3/00 ,  C12M23/34 ,  C12M25/14 ,  C12M31/02 ,  C12M41/36 ,  C12Q1/18 ,  G01N15/0656 ,  G01N21/59 ,  G01N27/04 ,  C12N2533/76 ,  G01N27/02 ,  G01N2201/08

摘要： A structure for culturing cells includes growth medium regions on a surface of the structure. Each of the growth medium regions includes a growth medium surface configured to receive and promote growth in a cell that is being cultured. The structure includes a non-growth medium. The non-growth medium includes a non-growth medium surface configured to receive the cell that is being cultured.

公开(公告)号：US09791630B2

公开(公告)日：2017-10-17

申请号：US15224675

申请日：2016-08-01

申请人： Pukyong National University Industry-University Cooperation Foundation

发明人： Yongwook Lee ,  Junghwan Oh ,  Hyunwook Kang ,  Seungyun Nam ,  Youngmog Kim ,  Junhyeog Jeong

IPC分类号： G01N21/00 ,  G02B6/32 ,  G02B6/27 ,  G01N15/06 ,  C12M1/34 ,  G01N15/00

CPC分类号： G02B6/32 ,  C12M1/3453 ,  G01N15/06 ,  G01N2015/0065 ,  G02B6/2706

摘要： An apparatus for discriminating bacteria types using optical scattering patterns is disclosed. The apparatus includes an optical fiber for transferring light emitted from a light source, a lens for controlling a width of the light received from the optical fiber, a linear polarizer for transmitting the light passing through the lens and a bacterial colony, and a capturing unit for capturing an optical scattering pattern of the light transmitted through the linear polarizer.

公开(公告)号：US20230392178A1

公开(公告)日：2023-12-07

申请号：US18449087

申请日：2023-08-14

申请人： International Business Machines Corporation

发明人： Amos Cahan ,  Guy M. Cohen ,  Theodore G. van Kessel ,  Sufi Zafar

IPC分类号： C12Q1/02 ,  C12Q1/18 ,  G01N21/59 ,  G01N27/04 ,  G01N15/06 ,  C12M1/12 ,  C12M1/34 ,  C12M1/00 ,  C12M3/00 ,  C12M1/18

CPC分类号： C12Q1/02 ,  C12Q1/18 ,  G01N21/59 ,  G01N27/04 ,  G01N15/0656 ,  C12M25/14 ,  C12M41/36 ,  C12M1/3453 ,  C12M23/34 ,  C12M3/00 ,  C12M1/18 ,  C12M31/02 ,  G01N2201/08 ,  C12N2533/76 ,  G01N27/02

摘要： A structure for culturing cells includes growth medium regions on a surface of the structure. Each of the growth medium regions includes a growth medium surface configured to receive and promote growth in a cell that is being cultured. The structure includes a non-growth medium. The non-growth medium includes a non-growth medium surface configured to receive the cell that is being cultured.

公开(公告)号：US11781166B2

公开(公告)日：2023-10-10

申请号：US17708387

申请日：2022-03-30

申请人： International Business Machines Corporation

发明人： Amos Cahan ,  Guy M. Cohen ,  Theodore G. van Kessel ,  Sufi Zafar

IPC分类号： G01N27/02 ,  C12Q1/02 ,  C12Q1/18 ,  G01N21/59 ,  G01N27/04 ,  G01N15/06 ,  C12M1/12 ,  C12M1/34 ,  C12M1/00 ,  C12M3/00 ,  C12M1/18

CPC分类号： C12Q1/02 ,  C12M1/18 ,  C12M1/3453 ,  C12M3/00 ,  C12M23/34 ,  C12M25/14 ,  C12M31/02 ,  C12M41/36 ,  C12Q1/18 ,  G01N15/0656 ,  G01N21/59 ,  G01N27/04 ,  C12N2533/76 ,  G01N27/02 ,  G01N2201/08

摘要： A structure for culturing cells includes growth medium regions on a surface of the structure. Each of the growth medium regions includes a growth medium surface configured to receive and promote growth in a cell that is being cultured. The structure includes a non-growth medium. The non-growth medium includes a non-growth medium surface configured to receive the cell that is being cultured.

公开(公告)号：US20180105779A1

公开(公告)日：2018-04-19

申请号：US15569195

申请日：2016-04-29

申请人： University of Virginia Patent Foundation

发明人： Jason A. Papin ,  Bonnie V. Dougherty ,  Alisha Mae Geldert ,  Kevin P. Seitter

IPC分类号： C12M1/34 ,  G01N21/17 ,  G01N21/51

CPC分类号： C12M1/3453 ,  C12M23/08 ,  C12M41/30 ,  C12M41/36 ,  C12M41/46 ,  G01N21/1717 ,  G01N21/51 ,  G01N21/59 ,  G01N2021/1744

摘要： An apparatus and related method for determining the optical density and/or change in optical density of a reaction mixture in an agitated vessel or container. The apparatus may include at least one electromagnetic emitter configured to pass radiation through the reaction mixture to at least one receptor, whereby the receptor receives the transmitted or scattered light, while the reaction mixture is subjected to shaking. The emitters may have an interchangeable association with the vessel or container and/or the receptors may have an interchangeable association with the vessel or container. Further, a processor may be provided to receive the transmitted or scattered light data and filter to eliminate or reduce the effect of the frequency at which the reaction mixture is shaken. The processor analyzes the filtered data to provide the optical density and/or change in optical density of the reaction mixture.