公开(公告)号：US20170158735A1

公开(公告)日：2017-06-08

申请号：US15213039

申请日：2016-07-18

Applicant: "IVIX" Ltd.

Inventor： Nikolay Fedorovich MYASOEDOV ,  Lyudmila Alexandrovna Andreeva ,  Dmitriy Viktorovich Golikov

IPC: C07K7/06

CPC classification number: C07K7/06 ,  A61K38/00 ,  A61K38/08 ,  C07K5/0802 ,  C07K5/1002 ,  C07K5/1013 ,  Y02A50/473

Abstract: The invention relates to peptides with the following general formula: A-Thr-Lys-Pro-B-C-D-X, where: A—0, Met, Met (O), Thr, Ala, His, Phe, Lys, Gly B—0, Gly, Asp, Trp, Gln, Asn, Tyr, Pro, Arg C—0, Arg, Phe, Tyr, Gly, His, Pro, Lys D—0, Val, Gly, Tyr, Trp, Phe, His X—OH, OCH3, NH2, where 0 is no amino acid residue, provided that if A≠0, then B and/or C and/or D≠0, if B≠0, then C and/or D≠0, excluding the peptides Phe-Thr-Lys-Pro-Gly (SEQ ID NO: 1), Thr-Lys-Pro-Pro-Arg (SEQ ID NO: 2), Thr-Lys-Pro-Arg-Gly (SEQ ID NO: 3).

公开(公告)号：US20170157196A1

公开(公告)日：2017-06-08

申请号：US15239708

申请日：2016-08-17

Applicant: HELIX BIOMEDIX, INC.

Inventor： Scott M. Harris ,  Timothy J. Falla ,  Lijuan Zhang

IPC: A61K38/07 ,  C07K5/117 ,  C07K5/103 ,  A61K9/00 ,  A61K9/06

CPC classification number: A61K38/07 ,  A61K8/64 ,  A61K9/0014 ,  A61K9/06 ,  A61K38/00 ,  A61K2121/00 ,  A61K2300/00 ,  A61Q19/00 ,  A61Q19/08 ,  C07K5/1002 ,  C07K5/1008 ,  C07K5/1024 ,  C07K14/78

Abstract: Short biologically active tetrapeptides are disclosed that are comprised of the sequences GxxG and PxxP where G (glycine) and P (proline) are maintained and x is a variable amino acid. The peptides can be used singly or in combination to stimulate production of extracellular matrix proteins in skin. A rapid, low-cost method of producing heterogenous formulations of tetrapeptides is disclosed.

公开(公告)号：US20170007696A1

公开(公告)日：2017-01-12

申请号：US15115385

申请日：2014-05-29

Applicant: Brandeis University ,  Boston Children's Hospital

Inventor： Fan ZHAO ,  Jingyu LI ,  Hongbo R. LUO ,  Bing XU

IPC: A61K39/39 ,  C07K5/10 ,  C07K7/06 ,  C07K7/08 ,  C07K14/00 ,  A61K9/06 ,  A61K38/07 ,  A61K38/08 ,  A61K38/10 ,  A61K38/16 ,  A61K9/00 ,  C07K5/08 ,  A61K38/06

CPC classification number: A61K39/39 ,  A01N37/46 ,  A61K9/0019 ,  A61K9/06 ,  A61K38/00 ,  A61K38/06 ,  A61K38/07 ,  A61K38/08 ,  A61K38/10 ,  A61K38/16 ,  A61K45/06 ,  A61K2039/55516 ,  A61K2039/572 ,  A61K2039/575 ,  C07K5/0802 ,  C07K5/1002 ,  C07K7/06 ,  C07K7/08 ,  C07K14/00 ,  C07K14/001 ,  C07K2319/00 ,  Y02A50/478 ,  A01N25/04 ,  A01N25/34

Abstract: The invention relates to the application of peptides that can self-assemble to form supramolecular nanofibrils and hydrogels, hydrogel compositions containing the self-assembled supramolecular nanofibrils, and methods of uses and making the hydrogel compositions.

Abstract translation: 本发明涉及能够自组装形成超分子纳米原纤维和水凝胶的肽的应用，含有自组装超分子纳米原纤维的水凝胶组合物，以及使用和制备水凝胶组合物的方法。

公开(公告)号：US20150111837A1

公开(公告)日：2015-04-23

申请号：US14388080

申请日：2013-05-28

Applicant: "IVIX' Ltd.

Inventor： Nikolay Fedorovich Myasoedov ,  Lyudmila Alexandrovna Andreeva ,  Dmitriy Viktorovich Golikov

IPC: C07K7/06 ,  C07K5/10 ,  C07K5/08

CPC classification number: C07K7/06 ,  A61K38/00 ,  A61K38/08 ,  C07K5/0802 ,  C07K5/1002 ,  C07K5/1013 ,  Y02A50/473

Abstract: The invention relates to the field of biochemistry and concerns of recombinant method for production of peptides and the resulting peptides. In particular, the invention relates to peptides with the following general formula: A-Thr-Lys-Pro-B-C-D-X, where: A—0, Met, Met (O), Thr, Ala, His, Phe, Lys, Gly B—0, Gly, Asp, Trp, Gin, Asn, Tyr, Pro, Arg C—0, Arg, Phe, Tyr, Gly, His, Pro, Lys D—0, Val, Gly, Tyr, Trp, Phe, His X—OH, OCH3, NH2, where 0 is no amino acid residue, provided that if A≠0, then B and/or C and/or D≠0, if B≠0, then C and/or D≠0, excluding the peptides Phe-Thr-Lys-Pro-Gly, Thr-Lys-Pro-Pro-Arg, Thr-Lys-Pro-Arg-Gly.

Abstract translation: 本发明涉及生物化学领域和关于生产肽和所得肽的重组方法的关注。 特别地，本发明涉及具有以下通式的肽：A-Thr-Lys-Pro-BCDX，其中：A-0，Met，Met（O），Thr，Ala，His，Phe，Lys，Gly B- 0，Gly，Asp，Trp，Gin，Asn，Tyr，Pro，Arg C-0，Arg，Phe，Tyr，Gly，His，Pro，Lys D-0，Val，Gly，Tyr，Trp，Phe，His X -OH，OCH 3，NH 2，其中0不是氨基酸残基，条件是如果A≠0，则B和/或C和/或D≠0，如果B≠0，则C和/或D≠0，不包括 肽Phe-Thr-Lys-Pro-Gly，Thr-Lys-Pro-Pro-Arg，Thr-Lys-Pro-Arg-Gly。

公开(公告)号：US20140066380A1

公开(公告)日：2014-03-06

申请号：US13961782

申请日：2013-08-07

Applicant: HELIX BIOMEDIX, INC.

Inventor： Scott M. HARRIS ,  Timothy J. FALLA ,  Lijuan ZHANG

IPC: C07K5/10

CPC classification number: A61K38/07 ,  A61K8/64 ,  A61K9/0014 ,  A61K9/06 ,  A61K38/00 ,  A61K2121/00 ,  A61K2300/00 ,  A61Q19/00 ,  A61Q19/08 ,  C07K5/1002 ,  C07K5/1008 ,  C07K5/1024 ,  C07K14/78

Abstract: Short biologically active tetrapeptides are disclosed that are comprised of the sequences GxxG and PxxP where G (glycine) and P (proline) are maintained and x is a variable amino acid. The peptides can be used singly or in combination to stimulate production of extracellular matrix proteins in skin. A rapid, low-cost method of producing heterogenous formulations of tetrapeptides is disclosed.

Abstract translation: 公开了由保持G（甘氨酸）和P（脯氨酸）并且x是可变氨基酸的序列GxxG和PxxP组成的短生物活性四肽。 肽可单独使用或组合使用以刺激皮肤中细胞外基质蛋白的产生。 公开了生产四肽的异源制剂的快速，低成本的方法。

公开(公告)号：US08110658B2

公开(公告)日：2012-02-07

申请号：US11811876

申请日：2007-06-12

Applicant: Scott M. Harris ,  Timothy J. Falla ,  Lijuan Zhang

Inventor： Scott M. Harris ,  Timothy J. Falla ,  Lijuan Zhang

IPC: C07K5/10

CPC classification number: A61K38/07 ,  A61K8/64 ,  A61K9/0014 ,  A61K9/06 ,  A61K38/00 ,  A61K2121/00 ,  A61K2300/00 ,  A61Q19/00 ,  A61Q19/08 ,  C07K5/1002 ,  C07K5/1008 ,  C07K5/1024 ,  C07K14/78

Abstract: Short biologically active tetrapeptides are disclosed that are comprised of the sequences GxxG and PxxP where G (glycine) and P (proline) are maintained and x is a variable amino acid. The peptides can be used singly or in combination to stimulate production of extracellular matrix proteins in skin. A rapid, low-cost method of producing heterogenous formulations of tetrapeptides is disclosed.

Abstract translation: 公开了由保持G（甘氨酸）和P（脯氨酸）并且x是可变氨基酸的序列GxxG和PxxP组成的短生物活性四肽。 肽可单独使用或组合使用以刺激皮肤中细胞外基质蛋白的产生。 公开了生产四肽的异源制剂的快速，低成本的方法。

公开(公告)号：US09839665B2

公开(公告)日：2017-12-12

申请号：US15041712

申请日：2016-02-11

Applicant: Merck Patent GmbH

Inventor： Markus Klein ,  Christos Tsaklakidis ,  Hans Guehring ,  Birgitta Leuthner

IPC: C07K5/10 ,  A61K38/08 ,  C07K5/02 ,  A61K38/06 ,  A61K38/07 ,  A61K45/06 ,  C07K5/087 ,  C07K5/103 ,  A61K38/05 ,  C07K1/107 ,  C07K5/062 ,  C07K5/083 ,  C07K5/117 ,  C07K7/06

CPC classification number: A61K38/08 ,  A61K38/05 ,  A61K38/06 ,  A61K38/07 ,  A61K45/06 ,  C07K1/1075 ,  C07K5/0205 ,  C07K5/06043 ,  C07K5/0808 ,  C07K5/0812 ,  C07K5/1002 ,  C07K5/101 ,  C07K5/1024 ,  C07K7/06

Abstract: The present invention relates to compounds of the formula (I) and in particular medicaments comprising at least one compound of the formula (I) for use in the treatment and/or prophylaxis of physiological and/or pathophysiological states in the triggering of which cathepsin D is involved, in particular for use in the treatment and/or prophylaxis of arthrosis, traumatic cartilage injuries, arthritis, pain, allodynia or hyperalgesia.

公开(公告)号：US09345742B2

公开(公告)日：2016-05-24

申请号：US13983848

申请日：2012-01-09

Applicant: Markus Klein ,  Christos Tsaklakidis ,  Hans Guehring ,  Brigitta Leuthner

Inventor： Markus Klein ,  Christos Tsaklakidis ,  Hans Guehring ,  Brigitta Leuthner

IPC: C07K5/10 ,  A61K38/08 ,  C07K5/02 ,  A61K38/06 ,  A61K38/07 ,  A61K45/06 ,  C07K5/087 ,  C07K5/103

CPC classification number: A61K38/08 ,  A61K38/05 ,  A61K38/06 ,  A61K38/07 ,  A61K45/06 ,  C07K1/1075 ,  C07K5/0205 ,  C07K5/06043 ,  C07K5/0808 ,  C07K5/0812 ,  C07K5/1002 ,  C07K5/101 ,  C07K5/1024 ,  C07K7/06

Abstract: The present invention relates to compounds of the formula (I) and in particular medicaments comprising at least one compound of the formula (I) for use in the treatment and/or prophylaxis of physiological and/or pathophysiological states in the triggering of which cathepsin D is involved, in particular for use in the treatment and/or prophylaxis of arthrosis, traumatic cartilage injuries, arthritis, pain, allodynia or hyperalgesia.

Abstract translation: 本发明涉及式（I）化合物，特别是包含至少一种式（I）化合物的药物，其用于治疗和/或预防触发组织蛋白酶D的生理和/或病理生理状态 涉及，特别是用于治疗和/或预防关节炎，创伤性软骨损伤，关节炎，疼痛，异常性疼痛或痛觉过敏。

公开(公告)号：US20070155657A1

公开(公告)日：2007-07-05

申请号：US11633899

申请日：2006-12-04

Applicant: Yoshitane Kojima ,  Hiromu Sakurai ,  Yutaka Yoshikawa

Inventor： Yoshitane Kojima ,  Hiromu Sakurai ,  Yutaka Yoshikawa

IPC: A61K31/555 ,  A61K31/315

CPC classification number: C07K5/1002 ,  A61K31/315 ,  A61K31/341 ,  A61K31/555 ,  A61K38/00 ,  C07C51/412 ,  C07C229/76 ,  C07D307/58 ,  C07K5/06008 ,  C07K5/08 ,  C07K5/0802 ,  C07C59/08

Abstract: A zinc(II) complex which is lowly toxic, has high insulin-like activity, and is effectively usable as a hypoglycemic agent for the prevention or treatment of diabetes; a hypoglycemic agent containing the complex; a medicinal preparation which contains the complex and is useful as a preventive/remedy for diabetes; and a food containing the complex, such as a health food or supplementary health food. The hypoglycemic agent contains an organic zinc(II) complex having as a ligand a compound selected among aminoalkylpyridines, bis-optically active amino acids, bisaminoalkylcarboxylic acids, oligopeptides, oligopseudopeptides, di-substituted aminocarboxylic acids, α- and β-hydroxycarboxylic acids, vitamins, glutamine derivatives, etc.

公开(公告)号：US06797461B2

公开(公告)日：2004-09-28

申请号：US09955639

申请日：2001-09-19

Applicant: Andrew L. Niles ,  Mary Haak-Frendscho ,  Jennifer L. Harris ,  Charles S. Craik

Inventor： Andrew L. Niles ,  Mary Haak-Frendscho ,  Jennifer L. Harris ,  Charles S. Craik

IPC: C12Q100

CPC classification number: C07K5/1002 ,  C07K5/101 ,  C07K5/1013 ,  C07K5/1024

Abstract: The invention is directed to synthetic polypeptide substrates for tryptase enzymes and assays for tryptase activity that utilize the synthetic polypeptide substrates. The preferred synthetic polypeptide substrates are tetramers of the formula P4-P3-P2-P1, wherein the substrate is selected from the group consisting of P-R-N-K (SEQ. ID. NO: 2), P-K-N-K (SEQ. ID. NO: 3), P-R-N-R (SEQ. ID. NO: 4), P-K-N-R (SEQ. ID. NO: 5), P-A-N-K (SEQ. ID. NO: 6), and P-R-T-K (SEQ. ID. NO: 7).

Abstract translation: 本发明涉及用于类胰蛋白酶的合成多肽底物和利用合成多肽底物的类胰蛋白酶活性的测定。 优选的合成多肽底物是式P4-P3-P2-P1的四聚体，其中底物选自PRNK（SEQ ID NO：2），PKNK（SEQ ID NO：3）， PRNR（SEQ ID NO：4），PKNR（SEQ ID NO：5），PANK（SEQ ID NO：6）和PRTK（SEQ ID NO：7）。