-
1.发明授权Use of sulfonyl-substituted 2-sulfonylaminobenzoic acid N-phenylamides in the treatment of pain 有权使用磺酰基取代的2-磺酰基氨基苯甲酸N-苯基酰胺治疗疼痛公开(公告)号：US08518998B2
公开(公告)日：2013-08-27
申请号：US12749986
申请日：2010-03-30
Applicant: Karl Rudolphi , Martin Michaelis , Hans Guehring
Inventor： Karl Rudolphi , Martin Michaelis , Hans Guehring
IPC: A01N41/06 , A61K31/18 , C07C303/00 , C07C307/00 , C07C309/00 , C07C311/00
CPC classification number: A61K31/18 , A61K31/195 , A61K31/635
Abstract: The present invention relates to the use of sulfonyl-substituted 2-sulfonylaminobenzoic acid N-phenylamides of the formula I, wherein A and R1 to R6 have the meanings indicated in the claims, for treating pain and for manufacturing a medicament for the treatment of pain.
Abstract translation: 本发明涉及式I的磺酰基取代的2-磺酰基氨基苯甲酸N-苯基酰胺，其中A和R 1至R 6具有权利要求中所示的含义，用于治疗疼痛和制备用于治疗疼痛的药物 。
-
公开(公告)号：US20130316955A1
公开(公告)日：2013-11-28
申请号：US13983848
申请日：2012-01-09
Applicant: Markus Klein , Christos Tsaklakidis , Hans Guehring , Brigitta Leuthner
Inventor： Markus Klein , Christos Tsaklakidis , Hans Guehring , Brigitta Leuthner
CPC classification number: A61K38/08 , A61K38/05 , A61K38/06 , A61K38/07 , A61K45/06 , C07K1/1075 , C07K5/0205 , C07K5/06043 , C07K5/0808 , C07K5/0812 , C07K5/1002 , C07K5/101 , C07K5/1024 , C07K7/06
Abstract: The present invention relates to compounds of the formula (I) and in particular medicaments comprising at least one compound of the formula (I) for use in the treatment and/or prophylaxis of physiological and/or pathophysiological states in the triggering of which cathepsin D is involved, in particular for use in the treatment and/or prophylaxis of arthrosis, traumatic cartilage injuries, arthritis, pain, allodynia or hyperalgesia.
Abstract translation: 本发明涉及式（I）化合物，特别是包含至少一种式（I）化合物的药物，其用于治疗和/或预防触发组织蛋白酶D的生理和/或病理生理状态 涉及，特别是用于治疗和/或预防关节炎，创伤性软骨损伤，关节炎，疼痛，异常性疼痛或痛觉过敏。
-
Patent Agency Ranking
3.发明申请Use of sulfonyl-substituted 2-sulfonylaminobenzoic acid N-phenylamides in the treatment of pain 有权使用磺酰基取代的2-磺酰基氨基苯甲酸N-苯基酰胺治疗疼痛公开(公告)号：US20110021505A1
公开(公告)日：2011-01-27
申请号：US12749986
申请日：2010-03-30
Applicant: Karl RUDOLPHI , Martin MICHAELIS , Hans GUEHRING
Inventor： Karl RUDOLPHI , Martin MICHAELIS , Hans GUEHRING
IPC: A61K31/55 , A61K31/54 , A61K31/5375 , A61K31/5377 , A61K31/495 , A61K31/18 , A61K31/445 , A61K31/426 , A61K31/40 , A61K31/44 , A61K31/541 , A61K31/4436 , A61K31/4439 , A61K31/4725 , A61K31/454 , A61K31/4035 , A61P29/00
CPC classification number: A61K31/18 , A61K31/195 , A61K31/635
Abstract: The present invention relates to the use of sulfonyl-substituted 2-sulfonylaminobenzoic acid N-phenylamides of the formula I, wherein A and R1 to R6 have the meanings indicated in the claims, for treating pain and for manufacturing a medicament for the treatment of pain.
Abstract translation: 本发明涉及式I的磺酰基取代的2-磺酰基氨基苯甲酸N-苯基酰胺，其中A和R 1至R 6具有权利要求中所示的含义，用于治疗疼痛和制备用于治疗疼痛的药物 。
-
公开(公告)号：US09345742B2
公开(公告)日：2016-05-24
申请号：US13983848
申请日：2012-01-09
Applicant: Markus Klein , Christos Tsaklakidis , Hans Guehring , Brigitta Leuthner
Inventor： Markus Klein , Christos Tsaklakidis , Hans Guehring , Brigitta Leuthner
CPC classification number: A61K38/08 , A61K38/05 , A61K38/06 , A61K38/07 , A61K45/06 , C07K1/1075 , C07K5/0205 , C07K5/06043 , C07K5/0808 , C07K5/0812 , C07K5/1002 , C07K5/101 , C07K5/1024 , C07K7/06
Abstract: The present invention relates to compounds of the formula (I) and in particular medicaments comprising at least one compound of the formula (I) for use in the treatment and/or prophylaxis of physiological and/or pathophysiological states in the triggering of which cathepsin D is involved, in particular for use in the treatment and/or prophylaxis of arthrosis, traumatic cartilage injuries, arthritis, pain, allodynia or hyperalgesia.
Abstract translation: 本发明涉及式（I）化合物，特别是包含至少一种式（I）化合物的药物，其用于治疗和/或预防触发组织蛋白酶D的生理和/或病理生理状态 涉及，特别是用于治疗和/或预防关节炎，创伤性软骨损伤，关节炎，疼痛，异常性疼痛或痛觉过敏。
-
公开(公告)号：US08476222B2
公开(公告)日：2013-07-02
申请号：US12417307
申请日：2009-04-02
Applicant: Gerhard Seibert , László Vértesy , Joachim Wink , Irvin Winkler , Mark Broenstrup , Holger Hoffmann , Hans Guehring , Luigi Toti , Roderich Süssmuth , George M. Sheldrick , Kathrin Meindl
Inventor： Gerhard Seibert , László Vértesy , Joachim Wink , Irvin Winkler , Mark Broenstrup , Holger Hoffmann , Hans Guehring , Luigi Toti , Roderich Süssmuth , George M. Sheldrick , Kathrin Meindl
Abstract: The disclosure relates to a compound of the formula (I) wherein R1 is H, C(O)—(C1-C6)alkyl or C(O)—O—(C1-C6)alkyl; R2 is OH, NH2, NH—(C1-C6)alkyl, NH—(C1-C4)alkylene-phenyl or NH—(C1-C4)alkylene-pyridyl; R3 and R4 are independently of each other H or OH, or R3 and R4 together are ═O; and m and n are independently of one another 0, 1 or 2; in any stereochemical form, or a mixture of any stereochemical forms in any ratio, or a physiologically acceptable salt thereof, obtainable from Actinomadura namibiensis (DSM 6313), and its use for the treatment of bacterial infections, viral infections and/or pain, and pharmaceutical composition comprising it.
Abstract translation: 本发明涉及式（I）化合物，其中R 1是H，C（O） - （C 1 -C 6）烷基或C（O）-O-（C 1 -C 6）烷基; R2是OH，NH2，NH-（C1-C6）烷基，NH-（C1-C4）亚烷基 - 苯基或NH-（C1-C4）亚烷基 - 吡啶基; R3和R4彼此独立地为H或OH，或R3和R4一起为= O; m和n彼此独立地为0,1或2; 任何立体化学形式，或任何比例的任何立体化学形式的混合物，或其生理学上可接受的盐，可从放线杆菌素（DSM 6313）获得，以及其用于治疗细菌感染，病毒感染和/或疼痛的用途，以及 包含它的药物组合物。
-
公开(公告)号：US20090298904A1
公开(公告)日：2009-12-03
申请号：US12417307
申请日：2009-04-02
Applicant: Gerhard Seibert , László Vértesy , Joachim Wink , Irvin Winkler , Mark Broenstrup , Holger Hoffmann , Hans Guehring , Luigi Toti , Roderich Süssmuth , George M. Sheldrick , Kathrin Meindl
Inventor： Gerhard Seibert , László Vértesy , Joachim Wink , Irvin Winkler , Mark Broenstrup , Holger Hoffmann , Hans Guehring , Luigi Toti , Roderich Süssmuth , George M. Sheldrick , Kathrin Meindl
IPC: A61K31/40 , C07D513/18 , C12P17/18
Abstract: The disclosure relates to a compound of the formula (I) wherein m and n are independently of one another 0, 1 or 2, obtainable from Actinomadura namibiensis (DSM 6313), its use for the treatment of bacterial infections, viral infections and/or pain, and pharmaceutical composition comprising it.
Abstract translation: 本公开涉及式（I）的化合物，其中m和n彼此独立地为0,1或2，可从放线菌素（DSM 6313）获得，其用于治疗细菌感染，病毒感染和/或 疼痛和包含它的药物组合物。
-
7.发明申请公开(公告)号：US20110144001A1
公开(公告)日：2011-06-16
申请号：US12895106
申请日：2010-09-30
Applicant: Mark BROENSTRUP , Hans GUEHRING , Holger HOFFMANN , Joachim WINK , Roderich SUESSMUTH , Timo SCHMIEDERER
Inventor： Mark BROENSTRUP , Hans GUEHRING , Holger HOFFMANN , Joachim WINK , Roderich SUESSMUTH , Timo SCHMIEDERER
Abstract: The invention refers to so-called Labyrinthopeptin derivatives of the formula (I) wherein {A}, {B}, {C}, R1-R6, m and n are as defined herein, obtainable from microorganism strain Actinomadura namibiensis (DSM 6313), its use for the treatment of bacterial infections, viral infections and/or pain, a pharmaceutical composition comprising it, prepro-Labyrinthopeptin, pro-Labyrinthopeptin, and DNA coding for prepro-Labyrinthopeptin and pro-Labyrinthopeptin.
Abstract translation: 本发明涉及可从微生物菌株放线菌（Actinomadura namibiensis）（DSM 6313）获得的所谓的式（I）的赖氨维内肽衍生物，其中{A}，{B}，{C}，R1-R6，m和n如本文所定义 ，其用于治疗细菌感染，病毒感染和/或疼痛的药物组合物，包含其的药物组合物，前体Labyrinthopeptin，前Labyrinthopeptin和编码前LabLinhopeptin和亲Labyrinthopeptin的DNA。
-
-
-
-
-
-
Search Results
7
records
(took 0.013 seconds)
