公开(公告)号：US07923438B2

公开(公告)日：2011-04-12

申请号：US12366695

申请日：2009-02-06

Applicant: Gerhard Seibert ,  Luigi Toti ,  Joachim Wink

Inventor： Gerhard Seibert ,  Luigi Toti ,  Joachim Wink

IPC: A61K31/665

CPC classification number: A61K31/665

Abstract: The invention relates to the use of a compound of the formula (I) for the treatment of bacterial infections caused by mycobacteria, nocardia or corynebacteria, wherein E is phosphorus; X1, X2 and X3 are oxygen; and R1 and R2 are as defined in the specification.

Abstract translation: 本发明涉及式（I）化合物用于治疗由分枝杆菌，诺卡氏菌或棒状杆菌引起的细菌感染的用途，其中E是磷; X1，X2和X3是氧; R1和R2如说明书中所定义。

公开(公告)号：US06242424B1

公开(公告)日：2001-06-05

申请号：US08348815

申请日：1994-11-28

Applicant: Günther Riess ,  Gerhard Seibert ,  Udo Hedtmann

Inventor： Günther Riess ,  Gerhard Seibert ,  Udo Hedtmann

IPC: A61K3170

CPC classification number: A61K31/70 ,  A61K45/06

Abstract: Moenomycin and its derivatives are suitable for the production of pharmaceuticals for the treatment of gastric ulcers and for the control of Helicobacter pylori.

Abstract translation: 霉菌素及其衍生物适用于生产用于治疗胃溃疡和用于控制幽门螺杆菌的药物。

公开(公告)号：US5252472A

公开(公告)日：1993-10-12

申请号：US832314

申请日：1992-02-07

Applicant: Susanne Grabley ,  Joachim Wink ,  Klaus Kuhlein ,  Gerhard Seibert ,  Klaus Hutter ,  Hermann Uhr ,  Axel Zeeck

Inventor： Susanne Grabley ,  Joachim Wink ,  Klaus Kuhlein ,  Gerhard Seibert ,  Klaus Hutter ,  Hermann Uhr ,  Axel Zeeck

IPC: C07D307/33 ,  C07D307/42 ,  C07H7/02 ,  C07H13/10 ,  C12P17/04 ,  C12P19/44

CPC classification number: C07D307/33 ,  C07D307/42 ,  C07H13/10 ,  C07H7/02 ,  C12P17/04

Abstract: It is possible with the aid of various Streptomycetes species to prepare new compounds having a furan or lactone structure. These compounds have a pharmacological, especially antibiotic, action.

Abstract translation: 借助各种链霉菌种可以制备具有呋喃或内酯结构的新化合物。 这些化合物具有药理学特别是抗生素的作用。

公开(公告)号：US5128370A

公开(公告)日：1992-07-07

申请号：US325810

申请日：1989-03-20

Applicant: Susanne Grabley ,  Joachim Wink ,  Klaus Kuhlein ,  Gerhard Seibert ,  Klaus Hutter ,  Hermann Uhr ,  Axel Zeeck

Inventor： Susanne Grabley ,  Joachim Wink ,  Klaus Kuhlein ,  Gerhard Seibert ,  Klaus Hutter ,  Hermann Uhr ,  Axel Zeeck

IPC: C07D307/33 ,  C07D307/42 ,  C07H7/02 ,  C07H13/10 ,  C12N1/20 ,  C12P17/04 ,  C12P19/58 ,  C12R1/465

CPC classification number: C07D307/33 ,  C07D307/42 ,  C07H13/10 ,  C07H7/02 ,  C12P17/04 ,  Y10S435/886

Abstract: New furans and lactones from streptomycetes, a process for the preparation thereof, and the use thereof.It is possible with the aid of various streptomycetes species to prepared new compounds having a furan or lactone structure. These compounds have a pharmacological, especially antibiotic, action.

Abstract translation: 来自链霉菌的新呋喃和内酯，其制备方法及其用途。 借助各种链霉菌种可以制备具有呋喃或内酯结构的新化合物。 这些化合物具有药理学特别是抗生素的作用。

公开(公告)号：US5091382A

公开(公告)日：1992-02-25

申请号：US552058

申请日：1990-07-13

Applicant: Friedhelm Adam ,  Walter Durckheimer ,  Karl-Heinz Scheunemann ,  Dieter Isert ,  Gerhard Seibert

Inventor： Friedhelm Adam ,  Walter Durckheimer ,  Karl-Heinz Scheunemann ,  Dieter Isert ,  Gerhard Seibert

IPC: A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D277/36 ,  C07D277/56 ,  C07D501/00 ,  C07D501/36

CPC classification number: C07D277/56 ,  C07D277/36 ,  C07D501/00

Abstract: Cephalosporin derivatives of the general formula ##STR1## pharmaceutical preparations active against bacterial infections which contain such cephalosporin derivatives, processes for the preparation of the cephalosporin derivatives, use of the cephalosporin derivatives for the preparation of a pharmaceutical for combating bacterial infections, and starting products for the preparation of cephalosporin derivatives.

Abstract translation: 具有通式的头孢菌素衍生物，其含有这种头孢菌素衍生物的细菌感染活性的药物制剂，头孢菌素衍生物的制备方法，头孢菌素衍生物用于制备抗菌细菌感染药物，以及起始产品 头孢菌素衍生物的制备。

公开(公告)号：US4456199A

公开(公告)日：1984-06-26

申请号：US276288

申请日：1981-06-22

Applicant: Gerhard Seibert

Inventor： Gerhard Seibert

IPC: B65H54/04 ,  B65H54/28 ,  B66D1/38

CPC classification number: B65H54/2875 ,  B65H2553/42

Abstract: A control device for obtaining a uniform or even winding is provided for a winding machine for winding strand-shaped winding material, and includes a first measurement device which detects the position of the last winding to have been wound in each instance, a second measuring device for detecting the relative position of a spool with respect to a strand guide, and a computer for controlling the feed drive for the relative reciprocating traversing movement between the spool and the strand guide.

Abstract translation: 提供了一种用于获得均匀或均匀绕组的控制装置，用于缠绕线状绕组材料的绕线机，并且包括：第一测量装置，其检测在每种情况下卷绕的最后一个绕组的位置;第二测量装置 用于检测线轴相对于线引导件的相对位置;以及计算机，用于控制进给驱动器以用于卷轴和线引导件之间的相对往复运动。

公开(公告)号：US20050134008A1

公开(公告)日：2005-06-23

申请号：US11018882

申请日：2004-12-20

Applicant: Ralf Salameh ,  Gerhard Seibert

Inventor： Ralf Salameh ,  Gerhard Seibert

IPC: F16J15/06 ,  F16J15/08 ,  F16J15/12 ,  F16J3/00

CPC classification number: F16J15/127 ,  F16J15/062 ,  F16J15/0818 ,  F16J15/122 ,  F16J2015/0856

Abstract: Process for creating one or more sealed chambers between flat supporting elements interlinked by studs in a gasket, such that the studs are thinner than the cross-section of the supporting elements and have staggered, facing embossed areas, and such that each of the sealed chambers is situated toward the margins of the supporting elements.

Abstract translation: 用于在由垫片中的螺柱相互连接的平坦支撑元件之间形成一个或多个密封室的工艺，使得螺柱比支撑元件的横截面更薄并且具有交错的面对的压花区域，并且使得每个密封室 位于支撑元件的边缘。

公开(公告)号：US06194383B1

公开(公告)日：2001-02-27

申请号：US08811843

申请日：1997-03-05

Applicant: Peter Hammann ,  Johannes Meiwes ,  Gerhard Seibert ,  László Vertesy ,  Joachim Wink ,  Astrid Markus

Inventor： Peter Hammann ,  Johannes Meiwes ,  Gerhard Seibert ,  László Vertesy ,  Joachim Wink ,  Astrid Markus

IPC: A61K3800

CPC classification number: C07K7/60 ,  A61K38/00 ,  Y10S435/827

Abstract: The invention relates to lipopeptides with very homologous amino-acid sequences but different fatty acid residues (lipid portion) which are synthesized by Actinoplanes sp. during fermentation and are released into the culture medium, to a process for isolating the lipopeptides from the culture medium and purifying them, to the use of the lipopeptides as pharmacologically active substances, in particular against Gram-positive bacteria, and to Actinoplanes sp. DSM 7358 for producing the abovementioned lipopeptides.

Abstract translation: 本发明涉及具有非常同源的氨基酸序列但不同脂肪酸残基（脂质部分）的脂肽，其由Actinoplanes sp。 在发酵过程中释放到培养基中，从分离来自培养基中的脂肽并纯化它们的方法，使用脂肽作为药理活性物质，特别是抗革兰氏阳性细菌，以及使用Actinoplanes sp。 DSM 7358用于生产上述脂肽。

公开(公告)号：US5506140A

公开(公告)日：1996-04-09

申请号：US403575

申请日：1995-03-14

Applicant: Werner Aretz ,  Dirk Bottger ,  Gerhard Seibert ,  Alois Tumulka ,  Peter Welzel ,  Kurt Hobert

Inventor： Werner Aretz ,  Dirk Bottger ,  Gerhard Seibert ,  Alois Tumulka ,  Peter Welzel ,  Kurt Hobert

IPC: C07C59/125 ,  C07C59/60 ,  C07F9/09 ,  C07F9/655 ,  C07H13/12 ,  C12N9/16 ,  C12P7/42 ,  C12P19/26 ,  C12P19/44 ,  C12N1/20

CPC classification number: C07H13/12 ,  C07C59/125 ,  C07C59/60 ,  C07F9/091 ,  C07F9/6552 ,  C12N9/16 ,  C12P19/26 ,  C12P19/44 ,  C12P7/42 ,  C12R1/07 ,  Y10S435/832

Abstract: A new Bacillus species and the appropriate enzymes obtained therefrom can be used to break down phosphoglycolipid antibiotics. The breakdown products of moenomycins display antibiotic activity or can be used as building blocks for the synthetic preparation of transglycosylase inhibitors.

Abstract translation: 可以使用新的芽孢杆菌种类和由其获得的合适的酶来分解磷脂糖抗生素。 莫内霉素的分解产物显示抗生素活性，或可用作合成制备转糖基酶抑制剂的结构单元。

公开(公告)号：US5306717A

公开(公告)日：1994-04-26

申请号：US924598

申请日：1992-07-24

Applicant: Friedhelm Adam ,  Walter Durckheimer ,  Gerd Fischer ,  Burkhard Mencke ,  Gerhard Seibert ,  Dieter Isert ,  Norbert Klesel

Inventor： Friedhelm Adam ,  Walter Durckheimer ,  Gerd Fischer ,  Burkhard Mencke ,  Gerhard Seibert ,  Dieter Isert ,  Norbert Klesel

IPC: A61K20060101 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D20060101 ,  C07D501/00 ,  C07D501/04 ,  C07D501/06 ,  C07D501/22 ,  C07D501/34 ,  C07D501/46

CPC classification number: C07D501/34

Abstract: Cephalosporin derivatives of the general formula ##STR1## pharmaceutical preparations which are active against bacterial infections and contain such cephem derivatives, processes for the preparation of the cephem derivatives and the pharmaceutical preparations and the use of the cephem derivatives for combating bacterial infections.

Abstract translation: 具有抗细菌感染和含有此类头孢烯衍生物的通式为“IMAGE”+ TR 的药物制剂的头孢菌素衍生物，头孢烯衍生物和药物制剂的制备方法以及头孢烯衍生物用于对抗细菌 感染。