公开(公告)号：US07923438B2

公开(公告)日：2011-04-12

申请号：US12366695

申请日：2009-02-06

Applicant: Gerhard Seibert ,  Luigi Toti ,  Joachim Wink

Inventor： Gerhard Seibert ,  Luigi Toti ,  Joachim Wink

IPC: A61K31/665

CPC classification number: A61K31/665

Abstract: The invention relates to the use of a compound of the formula (I) for the treatment of bacterial infections caused by mycobacteria, nocardia or corynebacteria, wherein E is phosphorus; X1, X2 and X3 are oxygen; and R1 and R2 are as defined in the specification.

Abstract translation: 本发明涉及式（I）化合物用于治疗由分枝杆菌，诺卡氏菌或棒状杆菌引起的细菌感染的用途，其中E是磷; X1，X2和X3是氧; R1和R2如说明书中所定义。

公开(公告)号：US06242424B1

公开(公告)日：2001-06-05

申请号：US08348815

申请日：1994-11-28

Applicant: Günther Riess ,  Gerhard Seibert ,  Udo Hedtmann

Inventor： Günther Riess ,  Gerhard Seibert ,  Udo Hedtmann

IPC: A61K3170

CPC classification number: A61K31/70 ,  A61K45/06

Abstract: Moenomycin and its derivatives are suitable for the production of pharmaceuticals for the treatment of gastric ulcers and for the control of Helicobacter pylori.

Abstract translation: 霉菌素及其衍生物适用于生产用于治疗胃溃疡和用于控制幽门螺杆菌的药物。

公开(公告)号：US5252472A

公开(公告)日：1993-10-12

申请号：US832314

申请日：1992-02-07

Applicant: Susanne Grabley ,  Joachim Wink ,  Klaus Kuhlein ,  Gerhard Seibert ,  Klaus Hutter ,  Hermann Uhr ,  Axel Zeeck

Inventor： Susanne Grabley ,  Joachim Wink ,  Klaus Kuhlein ,  Gerhard Seibert ,  Klaus Hutter ,  Hermann Uhr ,  Axel Zeeck

IPC: C07D307/33 ,  C07D307/42 ,  C07H7/02 ,  C07H13/10 ,  C12P17/04 ,  C12P19/44

CPC classification number: C07D307/33 ,  C07D307/42 ,  C07H13/10 ,  C07H7/02 ,  C12P17/04

Abstract: It is possible with the aid of various Streptomycetes species to prepare new compounds having a furan or lactone structure. These compounds have a pharmacological, especially antibiotic, action.

Abstract translation: 借助各种链霉菌种可以制备具有呋喃或内酯结构的新化合物。 这些化合物具有药理学特别是抗生素的作用。

公开(公告)号：US5128370A

公开(公告)日：1992-07-07

申请号：US325810

申请日：1989-03-20

Applicant: Susanne Grabley ,  Joachim Wink ,  Klaus Kuhlein ,  Gerhard Seibert ,  Klaus Hutter ,  Hermann Uhr ,  Axel Zeeck

Inventor： Susanne Grabley ,  Joachim Wink ,  Klaus Kuhlein ,  Gerhard Seibert ,  Klaus Hutter ,  Hermann Uhr ,  Axel Zeeck

IPC: C07D307/33 ,  C07D307/42 ,  C07H7/02 ,  C07H13/10 ,  C12N1/20 ,  C12P17/04 ,  C12P19/58 ,  C12R1/465

CPC classification number: C07D307/33 ,  C07D307/42 ,  C07H13/10 ,  C07H7/02 ,  C12P17/04 ,  Y10S435/886

Abstract: New furans and lactones from streptomycetes, a process for the preparation thereof, and the use thereof.It is possible with the aid of various streptomycetes species to prepared new compounds having a furan or lactone structure. These compounds have a pharmacological, especially antibiotic, action.

Abstract translation: 来自链霉菌的新呋喃和内酯，其制备方法及其用途。 借助各种链霉菌种可以制备具有呋喃或内酯结构的新化合物。 这些化合物具有药理学特别是抗生素的作用。

公开(公告)号：US5091382A

公开(公告)日：1992-02-25

申请号：US552058

申请日：1990-07-13

Applicant: Friedhelm Adam ,  Walter Durckheimer ,  Karl-Heinz Scheunemann ,  Dieter Isert ,  Gerhard Seibert

Inventor： Friedhelm Adam ,  Walter Durckheimer ,  Karl-Heinz Scheunemann ,  Dieter Isert ,  Gerhard Seibert

IPC: A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D277/36 ,  C07D277/56 ,  C07D501/00 ,  C07D501/36

CPC classification number: C07D277/56 ,  C07D277/36 ,  C07D501/00

Abstract: Cephalosporin derivatives of the general formula ##STR1## pharmaceutical preparations active against bacterial infections which contain such cephalosporin derivatives, processes for the preparation of the cephalosporin derivatives, use of the cephalosporin derivatives for the preparation of a pharmaceutical for combating bacterial infections, and starting products for the preparation of cephalosporin derivatives.

Abstract translation: 具有通式的头孢菌素衍生物，其含有这种头孢菌素衍生物的细菌感染活性的药物制剂，头孢菌素衍生物的制备方法，头孢菌素衍生物用于制备抗菌细菌感染药物，以及起始产品 头孢菌素衍生物的制备。

公开(公告)号：US4456199A

公开(公告)日：1984-06-26

申请号：US276288

申请日：1981-06-22

Applicant: Gerhard Seibert

Inventor： Gerhard Seibert

IPC: B65H54/04 ,  B65H54/28 ,  B66D1/38

CPC classification number: B65H54/2875 ,  B65H2553/42

Abstract: A control device for obtaining a uniform or even winding is provided for a winding machine for winding strand-shaped winding material, and includes a first measurement device which detects the position of the last winding to have been wound in each instance, a second measuring device for detecting the relative position of a spool with respect to a strand guide, and a computer for controlling the feed drive for the relative reciprocating traversing movement between the spool and the strand guide.

Abstract translation: 提供了一种用于获得均匀或均匀绕组的控制装置，用于缠绕线状绕组材料的绕线机，并且包括：第一测量装置，其检测在每种情况下卷绕的最后一个绕组的位置;第二测量装置 用于检测线轴相对于线引导件的相对位置;以及计算机，用于控制进给驱动器以用于卷轴和线引导件之间的相对往复运动。

公开(公告)号：US06077830A

公开(公告)日：2000-06-20

申请号：US36683

申请日：1998-03-09

Applicant: Laszlo Vertesy ,  Michael Kurz ,  Astrid Markus ,  Gerhard Seibert

Inventor： Laszlo Vertesy ,  Michael Kurz ,  Astrid Markus ,  Gerhard Seibert

IPC: C07H13/12 ,  A61K31/70 ,  A61K31/702 ,  A61K31/7024 ,  A61K31/7135 ,  A61P1/00 ,  A61P1/04 ,  A61P31/04 ,  C07F9/94 ,  C07H21/00

CPC classification number: A61K31/70

Abstract: The present invention relates to bismuth salts of antibiotics of the moenomycin group, processes for their preparation, their use and pharmaceuticals comprising such salts. The salts according to the invention contain antibiotics of the moenomycin group which are so-called phosphoglycolipid antibiotics and which are present individually or as a mixture, or derivatives thereof, and bismuth in defined stoichiometric ratios. They are outstandingly suitable, in particular, for controlling Helicobacter pylori and, thus, for example, for the therapy and prophylaxis of gastric disorders.

Abstract translation: 本发明涉及霉霉素组的抗生素铋盐，其制备方法及其用途和包含这些盐的药物。 根据本发明的盐含有呼伦霉素基团的抗生素，它是所谓的磷脂糖抗生素，它们单独存在或作为其混合物或其衍生物，以及定义化学计量比的铋。 它们特别适用于控制幽门螺杆菌，因此例如用于治疗和预防胃疾病。

公开(公告)号：US6018940A

公开(公告)日：2000-02-01

申请号：US23704

申请日：1998-02-13

Applicant: Gerhard Seibert

Inventor： Gerhard Seibert

IPC: D07B3/00 ,  H01B13/02 ,  D01H5/00

CPC classification number: H01B13/0257 ,  D07B3/005

Abstract: A device for producing cable stranding from stranding elements (1) with changing direction of lay between stranding pulley (3) driven with alternating direction of rotation and stationary inlet pulley (5) on the wire inlet side with holes (8) to hold individual wires (1) to be stranded has several storage pulleys (4) likewise provided with holes (8). Storage pulleys (4) are pivotally mounted in machine frame (17). There is one drive (6) only for stranding pulley (3) and there is torsionally elastic connection (7,9,11,14,16) between stranding pulley (3) and storage pulleys (4), via which storage pulleys (4) are driven.

Abstract translation: 一种用于从绞合元件（1）产生电缆绞合的装置，其具有沿着旋转方向驱动的绞合滑轮（3）和线路入口侧的固定入口滑轮（5）之间的变化的铺设方向，具有孔（8）以保持单根线 （1）具有几个同样设置有孔（8）的存储带轮（4）。 存储滑轮（4）可枢转地安装在机架（17）中。 只有一个驱动器（6）用于绞合滑轮（3），并且在绞合滑轮（3）和存储滑轮（4）之间存在扭转弹性连接（7,9,11,14,16），存储滑轮（4） ）被驱动。

公开(公告)号：US5561060A

公开(公告)日：1996-10-01

申请号：US420638

申请日：1995-04-12

Applicant: Joachim Wink ,  Susanne Grabley ,  Gerhard Seibert ,  Klaus Hutter ,  Axel Zeeck

Inventor： Joachim Wink ,  Susanne Grabley ,  Gerhard Seibert ,  Klaus Hutter ,  Axel Zeeck

IPC: A61K31/365 ,  A61P31/04 ,  C07D313/00 ,  C12N1/14 ,  C12P17/08 ,  C12P17/18 ,  C12R1/80

CPC classification number: C12R1/80 ,  C07D313/00 ,  C12P17/08 ,  C12P17/181 ,  Y10S435/911 ,  Y10S435/933

Abstract: Penicillium cultures capable of producing 10-member ring lactones.It is possible with the aid of Penicillium strains to prepare new 10-membered ring lactones having a pharmacological action.

Abstract translation: 能够产生10元环内酯的青霉培养物。 借助于青霉菌菌株可以制备具有药理作用的新的10元环内酯。

公开(公告)号：US5206405A

公开(公告)日：1993-04-27

申请号：US927886

申请日：1992-08-11

Applicant: Werner Aretz ,  Dirk Bottger ,  Gerhard Seibert ,  Alois Tumulka ,  Peter Welzel ,  Kurt Hobert

Inventor： Werner Aretz ,  Dirk Bottger ,  Gerhard Seibert ,  Alois Tumulka ,  Peter Welzel ,  Kurt Hobert

IPC: C07C59/125 ,  C07C59/60 ,  C07F9/09 ,  C07F9/655 ,  C07H13/12 ,  C12N9/16 ,  C12P7/42 ,  C12P19/26 ,  C12P19/44

CPC classification number: C07H13/12 ,  C07C59/125 ,  C07C59/60 ,  C07F9/091 ,  C07F9/6552 ,  C12N9/16 ,  C12P19/26 ,  C12P19/44 ,  C12P7/42 ,  C12R1/07

Abstract: A new Bacillus species and the appropriate enzymes obtained therefrom can be used to break down phosphoglycolipid antibiotics. The breakdown products of moenomycins display antibiotic activity or can be used as building blocks for the synthetic preparation of transglycosylase inhibitors.

Abstract translation: 可以使用新的芽孢杆菌种类和由其获得的合适的酶来分解磷脂糖抗生素。 莫内霉素的分解产物显示抗生素活性，或可用作合成制备转糖基酶抑制剂的结构单元。