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1.Use of sulfonyl-substituted 2-sulfonylaminobenzoic acid N-phenylamides in the treatment of pain 有权
Title translation: 使用磺酰基取代的2-磺酰基氨基苯甲酸N-苯基酰胺治疗疼痛公开(公告)号:US20110021505A1
公开(公告)日:2011-01-27
申请号:US12749986
申请日:2010-03-30
Applicant: Karl RUDOLPHI , Martin MICHAELIS , Hans GUEHRING
Inventor: Karl RUDOLPHI , Martin MICHAELIS , Hans GUEHRING
IPC: A61K31/55 , A61K31/54 , A61K31/5375 , A61K31/5377 , A61K31/495 , A61K31/18 , A61K31/445 , A61K31/426 , A61K31/40 , A61K31/44 , A61K31/541 , A61K31/4436 , A61K31/4439 , A61K31/4725 , A61K31/454 , A61K31/4035 , A61P29/00
CPC classification number: A61K31/18 , A61K31/195 , A61K31/635
Abstract: The present invention relates to the use of sulfonyl-substituted 2-sulfonylaminobenzoic acid N-phenylamides of the formula I, wherein A and R1 to R6 have the meanings indicated in the claims, for treating pain and for manufacturing a medicament for the treatment of pain.
Abstract translation: 本发明涉及式I的磺酰基取代的2-磺酰基氨基苯甲酸N-苯基酰胺,其中A和R 1至R 6具有权利要求中所示的含义,用于治疗疼痛和制备用于治疗疼痛的药物 。
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公开(公告)号:US20090069358A1
公开(公告)日:2009-03-12
申请号:US12266018
申请日:2008-11-06
Applicant: Martin MICHAELIS , Olaf RITZELER , Gerhard JAEHNE , Karl RUDOLPHI , Gerd GEISSLINGER , Hans-Georg SCHAIBLE
Inventor: Martin MICHAELIS , Olaf RITZELER , Gerhard JAEHNE , Karl RUDOLPHI , Gerd GEISSLINGER , Hans-Georg SCHAIBLE
IPC: A61K31/506
CPC classification number: A61K31/404 , A61K31/4184 , A61K31/4245 , A61K31/444
Abstract: The present invention relates to the use of IκB-kinase Inhibitors and methods for the prophylaxis and therapy for treating pain comprising administering such compounds.
Abstract translation: 本发明涉及IkappaB激酶抑制剂的用途和用于预防和治疗疼痛的方法,包括施用这些化合物。
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3.METHOD FOR ALLEVIATING PAIN USING SPHINGOSINE-1-PHOSPHATE AND RELATED COMPOUNDS, AND ASSAYS FOR IDENTIFYING SUCH COMPOUNDS 有权
Title translation: 使用磷脂酸1-磷酸盐及其相关化合物治疗疼痛的方法,以及鉴定这些化合物的方法公开(公告)号:US20100137257A1
公开(公告)日:2010-06-03
申请号:US12696250
申请日:2010-01-29
Applicant: Martin MICHAELIS , Gerd GEISSLINGER , Klaus SCHOLICH
Inventor: Martin MICHAELIS , Gerd GEISSLINGER , Klaus SCHOLICH
CPC classification number: A61K31/661 , A61K31/685 , C07F9/113 , G01N33/5008 , G01N33/5023 , G01N33/5058 , G01N33/6896 , G01N33/92 , G01N2333/988 , G01N2500/02 , G01N2500/04 , G01N2500/10
Abstract: Methods for alleviating pain comprising administering to a subject sphingosine-1-phosphate, functional fragments and derivatives thereof, and other compounds, and assays for identifying such compounds.
Abstract translation: 减轻疼痛的方法包括向受试者施用鞘氨醇-1-磷酸,其功能片段及其衍生物和其它化合物,以及用于鉴定这些化合物的测定法。
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4.METHOD FOR ALLEVIATING PAIN USING PROTEIN ASSOCIATED WITH MYC AND RELATED COMPOUNDS, AND ASSAYS FOR IDENTIFYING SUCH COMPOUNDS 审中-公开
Title translation: 使用与MYC及相关化合物相关的蛋白质进行疼痛评估的方法,以及用于鉴别这些化合物的方法公开(公告)号:US20110105405A1
公开(公告)日:2011-05-05
申请号:US12897057
申请日:2010-10-04
Applicant: Martin MICHAELIS , Gerd GEISSLINGER , Klaus SCHOLICH , Irmgard TEGEDER
Inventor: Martin MICHAELIS , Gerd GEISSLINGER , Klaus SCHOLICH , Irmgard TEGEDER
CPC classification number: A61K38/1709 , G01N2800/2842
Abstract: Use of PAM or functional fragments or derivatives thereof for the preparation of pharmaceutical compounds.
Abstract translation: PAM或其功能片段或其衍生物用于制备药物化合物的用途。
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