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公开(公告)号：US20160188790A1
公开(公告)日：2016-06-30
申请号：US14900829
申请日：2014-07-08
IPC分类号： G06F19/16 , G06F19/12 , C12Q1/02 , C07K14/005 , C12N7/00
CPC分类号： G06F19/16 , C07K14/005 , C07K14/14 , C07K2319/42 , C07K2319/50 , C07K2319/70 , C07K2319/73 , C07K2319/735 , C12N7/00 , C12N2720/12321 , C12N2720/12323 , C12N2720/12351 , C12Q1/02 , G06F19/12
摘要： The present invention relates to the use of rotavirus particles for displaying a heterologous protein, alone or in complex with another molecule. The invention further relates to methods that employ these modified rotavirus particles to rapidly determine the structure of the heterologous protein or the complex using cryo-electron microscopy (cryo-EM). The invention also relates to a method of immunising a patient, wherein said method comprises administering to the patient the modified rotavirus particles of the invention.
摘要翻译： 本发明涉及轮状病毒颗粒在单独或与另一种分子复合物中显示异源蛋白质的用途。 本发明还涉及使用这些修饰轮状病毒颗粒使用低温电子显微镜（cryo-EM）快速确定异源蛋白质或复合物的结构的方法。 本发明还涉及免疫患者的方法，其中所述方法包括向患者施用本发明的修饰轮状病毒颗粒。
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公开(公告)号：US09243299B2
公开(公告)日：2016-01-26
申请号：US13582739
申请日：2011-03-04
申请人： Bernhard Roth
发明人： Bernhard Roth
IPC分类号： C07H21/04 , C12Q1/70 , A61K39/15 , C07K14/005 , C07K7/06 , C07K7/08 , C07K14/14 , G01N33/68 , A61K39/12 , A61K39/00
CPC分类号： C12Q1/701 , A61K39/00 , A61K39/12 , A61K39/15 , C07K7/06 , C07K7/08 , C07K14/005 , C07K14/14 , C12N2720/12322 , C12N2720/12334 , C12Q1/70 , G01N33/6893
摘要： The invention relates to a newly identified avian rotavirus D VP6 nucleotide sequence and uses thereof.
摘要翻译： 本发明涉及新鉴定的禽类轮状病毒D VP6核苷酸序列及其用途。
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公开(公告)号：US11707516B2
公开(公告)日：2023-07-25
申请号：US16336735
申请日：2017-09-26
申请人： Osaka University
发明人： Takeshi Kobayashi , Yuta Kanai
摘要： Provided is a method for producing an artificial recombinant virus of the family Reoviridae, the method comprising the steps of:
(1) introducing a FAST protein expression vector and/or a capping enzyme expression vector into host cells;
(2) introducing a vector containing expression cassettes for individual RNA genome segments of a virus or introducing a set of single-stranded RNA transcripts from the expression cassettes into host cells; and
(3) culturing the host cells.
The method of the present invention allows more efficient production of an artificial recombinant virus of the family Reoviridae as compared with conventional methods and allows artificial recombinant rotavirus production without using a helper virus.-
公开(公告)号：US20130216567A1
公开(公告)日：2013-08-22
申请号：US13582739
申请日：2011-03-04
申请人： Bernhard Roth
发明人： Bernhard Roth
CPC分类号： C12Q1/701 , A61K39/00 , A61K39/12 , A61K39/15 , C07K7/06 , C07K7/08 , C07K14/005 , C07K14/14 , C12N2720/12322 , C12N2720/12334 , C12Q1/70 , G01N33/6893
摘要： The invention relates to a newly identified avian rotavirus D VP6 nucleotide sequence and uses thereof.
摘要翻译： 本发明涉及新鉴定的禽类轮状病毒D VP6核苷酸序列及其用途。
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公开(公告)号：US09566320B2
公开(公告)日：2017-02-14
申请号：US14494812
申请日：2014-09-24
IPC分类号： A61K39/00 , A61K39/002 , A61K39/385 , A61K39/38 , A61K38/00 , C07K2/00 , C07K4/00 , C07K5/00 , C07K7/00 , C07K14/00 , C07K16/00 , C07K17/00 , A61K39/005 , C07K14/14 , C07K14/445
CPC分类号： A61K39/005 , A61K38/00 , A61K39/00 , A61K39/0011 , A61K2039/545 , A61K2039/55505 , A61K2039/55516 , A61K2039/575 , C07K14/14 , C07K14/445 , Y02A50/414
摘要： Use of synthetic peptides derived from Trypanosoma cruzi antigens and their use in vaccination against trypomastigote infection and Chagas disease. T. cruzi uses several surface proteins to invade the host. In their role of protection, the surface protients ensure the targeting and invasion of specific cells or tissues. A conserved region in the family of mucin-associated surface proteins (MASP) was used to analyze the expression of MASP at different points of invasion and proved to be important for host cell invasion, thus suggesting MASP as a candidate for vaccine development. A synthetic peptide, MASPsyn, was studied and showed efficacy in stimulating antibody and cytokine production necessary for resistance against the parasite.
摘要翻译： 使用衍生自锥虫克氏锥虫抗原的合成肽及其在针对锥虫病感染和恰加斯病的疫苗接种中的用途。 克鲁日使用几种表面蛋白侵入宿主。 在保护的作用下，表面质量保证特定细胞或组织的靶向和侵袭。 粘蛋白相关表面蛋白家族（MASP）的保守区域用于分析不同入侵点的MASP表达，并被证明对宿主细胞侵袭具有重要意义，从而提示MASP作为疫苗开发的候选者。 研究了合成肽MASPsyn，并且显示出在刺激抵抗寄生虫所必需的抗体和细胞因子产生方面的功效。
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公开(公告)号：US20150086583A1
公开(公告)日：2015-03-26
申请号：US14494812
申请日：2014-09-24
IPC分类号： A61K39/005
CPC分类号： A61K39/005 , A61K38/00 , A61K39/00 , A61K39/0011 , A61K2039/545 , A61K2039/55505 , A61K2039/55516 , A61K2039/575 , C07K14/14 , C07K14/445 , Y02A50/414
摘要： Use of synthetic peptides derived from Trypanosoma cruzi antigens and their use in vaccination against trypomastigote infection and Chagas disease. T. cruzi uses several surface proteins to invade the host. In their role of protection, the surface protients ensure the targeting and invasion of specific cells or tissues. A conserved region in the family of mucin-associated surface proteins (MASP) was used to analyze the expression of MASP at different points of invasion and proved to be important for host cell invasion, thus suggesting MASP as a candidate for vaccine development. A synthetic peptide, MASPsyn, was studied and showed efficacy in stimulating antibody and cytokine production necessary for resistance against the parasite.
摘要翻译： 使用衍生自锥虫克氏锥虫抗原的合成肽及其在针对锥虫病感染和恰加斯病的疫苗接种中的应用。 克鲁日使用几种表面蛋白侵入宿主。 在保护的作用下，表面质量保证特定细胞或组织的靶向和侵袭。 粘蛋白相关表面蛋白家族（MASP）的保守区域用于分析不同入侵点的MASP表达，并被证明对宿主细胞侵袭具有重要意义，从而提示MASP作为疫苗开发的候选者。 研究了合成肽MASPsyn，并且显示出在刺激抵抗寄生虫所必需的抗体和细胞因子产生方面的功效。
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公开(公告)号：US09249195B2
公开(公告)日：2016-02-02
申请号：US13639564
申请日：2011-04-04
CPC分类号： C07K14/14 , A61K39/12 , A61K39/21 , A61K2039/5256 , C07K14/005 , C07K2319/40 , C12N2720/12222 , C12N2720/12243 , C12N2740/16122 , C12N2740/16134
摘要： The present invention provides for modified reoviruses that carry α-helical epitopes from a variety of pathogens, as well as methods of using such modified reoviruses to generate immune responses against those epitopes in hosts.
摘要翻译： 本发明提供了携带来自各种病原体的α-螺旋表位的修饰的呼肠孤病毒，以及使用这种修饰的呼肠孤病毒来产生针对宿主中那些表位的免疫应答的方法。
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公开(公告)号：US20130259887A1
公开(公告)日：2013-10-03
申请号：US13639564
申请日：2011-04-04
IPC分类号： C07K14/14
CPC分类号： C07K14/14 , A61K39/12 , A61K39/21 , A61K2039/5256 , C07K14/005 , C07K2319/40 , C12N2720/12222 , C12N2720/12243 , C12N2740/16122 , C12N2740/16134
摘要： The present invention provides for modified reoviruses that carry α-helical epitopes from a variety of pathogens, as well as methods of using such modified reoviruses to generate immune responses against those epitopes in hosts.
摘要翻译： 本发明提供了携带来自各种病原体的α-螺旋表位的修饰的呼肠孤病毒，以及使用这种修饰的呼肠孤病毒来产生针对宿主中那些表位的免疫应答的方法。
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公开(公告)号：US12109262B2
公开(公告)日：2024-10-08
申请号：US17805419
申请日：2022-06-03
申请人： Osaka University
发明人： Takeshi Kobayashi , Yuta Kanai
摘要： Provided is a method for producing an artificial recombinant virus of the family Reoviridae, the method comprising the steps of:
(1) introducing a FAST protein expression vector and/or a capping enzyme expression vector into host cells;
(2) introducing a vector containing expression cassettes for individual RNA genome segments of a virus or introducing a set of single-stranded RNA transcripts from the expression cassettes into host cells; and
(3) culturing the host cells.
The method of the present invention allows more efficient production of an artificial recombinant virus of the family Reoviridae as compared with conventional methods and allows artificial recombinant rotavirus production without using a helper virus.-
公开(公告)号：US20230218684A1
公开(公告)日：2023-07-13
申请号：US17995069
申请日：2021-03-29
发明人： Rodolphe Barrangou , Gregg A. Dean
IPC分类号： A61K35/744 , C12N1/20 , C12N15/74 , C07K14/165 , A61P31/14 , C07K14/14
CPC分类号： A61K35/744 , C12N1/20 , C12N15/746 , C07K14/165 , A61P31/14 , C07K14/14 , A61K2039/523
摘要： The present disclosure provides materials and methods related to engineered bacteria for use in vaccines. In particular, the present disclosure provides novel compositions and methods for generating vaccine compositions comprising bacteria (e.g., Lactobacillus) engineered to express immunogenic polypeptides and immunogenicity-enhancing adjuvant polypeptides to treat and/or prevent infection from a pathogenic organism (e.g., coronavirus).
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