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    IMMUNOASSAY OF S-ADENOSYLMETHIONINE IN PERSONALIZED MEDICINE AND HEALTH OR CANCER EVALUATION
    2.
    发明申请
    IMMUNOASSAY OF S-ADENOSYLMETHIONINE IN PERSONALIZED MEDICINE AND HEALTH OR CANCER EVALUATION 有权
    S-ADENOSYLMETHIONINE在个体化医学中的免疫和健康或癌症评估

    公开(公告)号：US20150268231A1

    公开(公告)日：2015-09-24

    申请号：US14457099

    申请日：2014-08-11

    申请人： Xiujuan Hao ,  Isaac A. Angres

    发明人： Xiujuan Hao ,  Isaac A. Angres

    IPC分类号： G01N33/53 ,  G01N33/564 ,  G01N33/574 ,  C07H19/16 ,  C07K16/44

    CPC分类号： G01N33/57484 ,  C07D473/02 ,  C07D493/04 ,  C07D519/00 ,  C07H19/16 ,  C07K16/44 ,  C07K2317/20 ,  C07K2317/33 ,  G01N2800/7033

    摘要： The invention provides a method of detecting the presence or absence of a disease in a patient wherein said disease is accompanied by deficient levels of S-adenosylmethionine comprising: identifying a patient that is suspected of having said disease or is at risk of having said disease; obtaining a biological sample from said patient; determining the level of S-adenosylmethionine in said biological sample using an antibody derived from a hapten analog of S-adenosylmethionine; and correlating the level of S-adenosylmethionine in said biological sample with the presence, absence, or severity of said disease. The invention also provides methods for measuring SAH which is used to determine the methylation index (ratio of SAM/SAH) in biological fluids which is indicative of the health status of an individual. Additionally, the invention includes test strips which are useful for determining S-adenosylmethionine and S-adenosylhomocysteine.

    摘要翻译： 本发明提供了一种检测患者疾病存在或不存在的方法，其中所述疾病伴随有S-腺苷甲硫氨酸水平不足的疾病，其包括：鉴定疑似患有该疾病或有风险患有该疾病的患者; 从所述患者获得生物样品; 使用衍生自S-腺苷甲硫氨酸的半抗原类似物的抗体测定所述生物样品中S-腺苷甲硫氨酸的水平; 并将所述生物样品中S-腺苷甲硫氨酸的水平与所述疾病的存在，不存在或严重性相关联。 本发明还提供了用于测量SAH的方法，其用于确定生物流体中的甲基化指数（SAM / SAH的比例），其指示个体的健康状况。 此外，本发明包括可用于测定S-腺苷甲硫氨酸和S-腺苷高半胱氨酸的测试条。

    Inhibitors of NEDD8-activating enzyme
    6.
    发明授权
    Inhibitors of NEDD8-activating enzyme 有权
    NEDD8活化酶抑制剂

    公开(公告)号：US08809356B2

    公开(公告)日：2014-08-19

    申请号：US13592389

    申请日：2012-08-23

    申请人： Ashley Sue McCarron ,  Todd B. Sells ,  Matthew Stirling ,  Stephen G. Stroud

    发明人： Ashley Sue McCarron ,  Todd B. Sells ,  Matthew Stirling ,  Stephen G. Stroud

    IPC分类号： C07D239/47

    CPC分类号： C07D239/47 ,  C07D239/46 ,  C07D473/02

    摘要： Disclosed are chemical entities which are inhibitors of Nedd8-activating enzyme (NAE), namely, the compound {(1S,2S,4R)-4-[(6-{[(1R,2S)-5-chloro-2-methoxy-2,3-dihydro-1H-inden-1-yl]amino}pyrimidin-4-yl)oxy]-2-hydroxycyclopentyl}methyl sulfamate and pharmaceutically acceptable salts thereof; solid state forms thereof; and prodrugs thereof. Also disclosed are methods of using the chemical entities to treat disorders such as cancer.

    摘要翻译： 公开了作为Nedd8活化酶（NAE）抑制剂的化学实体，即化合物{（1S，2S，4R）-4 - [（6 - {[（1R，2S）-5-氯-2-甲氧基 -2,3-二氢-1H-茚-1-基]氨基}嘧啶-4-基）氧基] -2-羟基环戊基}甲基氨基磺酸酯及其药学上可接受的盐; 其固态形式; 及其前体药物。 还公开了使用化学实体来治疗诸如癌症的疾病的方法。