公开(公告)号：US20170029361A1

公开(公告)日：2017-02-02

申请号：US15293507

申请日：2016-10-14

Applicant: Nippon Soda Co., Ltd.

Inventor： Hiroki Inoue ,  Yuzuru Sakata ,  Shinichi Kobayashi ,  Yoshikazu Ito ,  Takashi Kitayama

IPC: C07C205/12 ,  C07C17/06 ,  C07C201/08

CPC classification number: C07C209/74 ,  C07C17/00 ,  C07C17/06 ,  C07C17/12 ,  C07C201/08 ,  C07C201/14 ,  C07C205/12 ,  C07C209/32 ,  C07C211/52 ,  C07C25/13

Abstract: The present invention provides a halogenated aniline represented by formula (I) (wherein each of X1 and X2 independently represents a chlorine atom, a bromine atom or an iodine atom), a method for producing the halogenated aniline, and other aspects.

Abstract translation: 本发明提供由式（I）表示的卤代苯胺（其中，X 1和X 2各自独立地表示氯原子，溴原子或碘原子），卤代苯胺的制造方法等。

公开(公告)号：US20160251328A1

公开(公告)日：2016-09-01

申请号：US15148716

申请日：2016-05-06

Applicant: OKINAWA INSTITUTE OF SCIENCE AND TECHNOLOGY SCHOOL CORPORATION

Inventor： Pandurang V. CHOUTHAIWALE ,  Fujie TANAKA

IPC: C07D309/28

CPC classification number: C07D309/28 ,  C07C201/14 ,  C07C205/55 ,  C07C2601/14 ,  C07D241/44 ,  C07D243/02 ,  C07D307/54 ,  C07D309/30 ,  C07D317/30 ,  C07D407/04

Abstract: Disclosed is a process for preparing dihydro-2H-pyran derivatives of formula I: wherein R1 and R2 are defined herein. The process of the invention provides the compound of formula I in concise cascade reactions and in one pot. The compound of formulae I prepared by the process of the invention and its further transformed derivatives are useful for making pharmaceutical composition for the treatment of proliferative diseases.

公开(公告)号：US20160167031A1

公开(公告)日：2016-06-16

申请号：US14901456

申请日：2014-06-25

Applicant: COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH

Inventor： Ankush Venkatrao BIRADAR ,  Shubhangi Bhalchandra UMBARKAR ,  Mohan Keraba DONGARE

IPC: B01J31/02 ,  C07D301/12 ,  C07C201/14 ,  B01J37/08

CPC classification number: B01J31/0237 ,  B01J21/18 ,  B01J31/0205 ,  B01J31/0225 ,  B01J31/08 ,  B01J31/10 ,  B01J35/002 ,  B01J35/08 ,  B01J37/0209 ,  B01J37/084 ,  B01J2231/342 ,  B01J2231/4205 ,  B01J2231/72 ,  C01B32/05 ,  C07C201/14 ,  C07D301/12

Abstract: Disclosed herein is a simple process for functionalization/grafting of carbon microspheres obtained from bagasse with various active functional groups onto it and use of the same as catalyst for various organic reactions, having very high selectivity and conversion rate.

Abstract translation: 本文公开了一种简单的方法，用于将从具有各种活性官能团的蔗渣获得的碳微球官能化/接枝到其上，并将其用作各种有机反应的催化剂，具有非常高的选择性和转化率。

公开(公告)号：US20150246896A1

公开(公告)日：2015-09-03

申请号：US14431945

申请日：2013-10-10

Applicant: OKINAWA INSTITUTE OF SCIENCE AND TECHNOLOGY SCHOOL CORPORATION

Inventor： Pandurang V. Chouthaiwale ,  Fujie Tanaka

IPC: C07D309/28 ,  C07D407/04 ,  C07D307/54 ,  C07D241/44 ,  C07D317/30 ,  C07C205/55 ,  C07D243/02

CPC classification number: C07D309/28 ,  C07C201/14 ,  C07C205/55 ,  C07C2601/14 ,  C07D241/44 ,  C07D243/02 ,  C07D307/54 ,  C07D309/30 ,  C07D317/30 ,  C07D407/04

Abstract: Disclosed is a process for preparing dihydro-2H-pyran derivatives of formula I: wherein R1 and R2 are defined herein. The process of the invention provides the compound of formula I in concise cascade reactions and in one pot. The compound of formulae I prepared by the process of the invention and its further transformed derivatives are useful for making pharmaceutical composition for the treatment of proliferative diseases.

Abstract translation: 公开了制备式I的二氢-2H-吡喃衍生物的方法：其中R 1和R 2在本文中定义。 本发明的方法在简单的级联反应中和一锅中提供式I化合物。 通过本发明方法制备的式I化合物及其进一步转化的衍生物可用于制备用于治疗增殖性疾病的药物组合物。

公开(公告)号：US06610889B2

公开(公告)日：2003-08-26

申请号：US09999802

申请日：2001-10-31

Applicant: Barry M. Trost ,  Hisanaka Ito

Inventor： Barry M. Trost ,  Hisanaka Ito

IPC: C07C4572

CPC classification number: C07C45/64 ,  B01J23/06 ,  B01J31/1805 ,  B01J31/182 ,  B01J2231/342 ,  B01J2231/345 ,  B01J2231/40 ,  B01J2531/20 ,  B01J2531/22 ,  B01J2531/23 ,  B01J2531/26 ,  B01J2531/27 ,  C07B53/00 ,  C07B2200/07 ,  C07C45/72 ,  C07C45/74 ,  C07C201/12 ,  C07C201/14 ,  C07C269/06 ,  C07C2601/14 ,  C07D207/09 ,  C07C49/83 ,  C07C271/16 ,  C07C205/15 ,  C07C205/16 ,  C07C205/30 ,  C07C205/32 ,  C07C205/14 ,  C07C205/26

Abstract: Methods and compositions are provided for the direct catalytic asymmetric aldol reaction of aldehydes with donor molecules selected from ketones and nitroalkyl compounds. The reactions employ as catalyst a Group 2A or Group 2B metal complex of a ligand of formula I, as defined further herein.

公开(公告)号：US06476280B1

公开(公告)日：2002-11-05

申请号：US10042627

申请日：2002-01-11

Applicant: Michael E. Sitzmann

Inventor： Michael E. Sitzmann

IPC: C07C20500

CPC classification number: C07C201/14 ,  C07C205/06

Abstract: The present invention is a method for synthesizing polynitropolyphenyls, and more particularly 2,2′,2″,4,4′,4″,6,6′,6″-nonanitroterphenyl (NONA), that employs only a dihalotrinitrobenzene as a starting material. The general method comprises reacting copper dust with dihalo-trinitrobenzene to form a dihalo-polynitropolyphenyl product. This product is then reduced through a high-yield conversion by heating it within a solvent with a reagent capable of providing a source of iodide and a proton source.

Abstract translation: 本发明是一种合成多苯基聚苯基的方法，特别是仅使用二卤代硝基苯的2,2'，2“，4,4”，4“，6,6'，6” - 壬基三苯基（NONA） 作为起始材料。 一般方法包括使铜粉与二卤代三硝基苯反应以形成二卤代多硝基苯基产物。 然后通过在能够提供碘源和质子源的试剂的溶剂内加热产物，通过高产率转化来还原该产物。

公开(公告)号：US4533776A

公开(公告)日：1985-08-06

申请号：US575649

申请日：1984-02-01

Applicant: Bernd Baasner ,  Hermann Hagemann ,  Erich Klauke

Inventor： Bernd Baasner ,  Hermann Hagemann ,  Erich Klauke

IPC: C07C67/00 ,  C07C201/00 ,  C07C201/14 ,  C07C205/08 ,  C07C205/10 ,  C07C79/12

CPC classification number: C07C205/08 ,  C07C201/14 ,  C07C205/10 ,  C07C2101/14

Abstract: In the preparation of an .alpha.-fluorinated nitroalkane of the formula ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are identical or different and individually represent hydrogen, fluorine, chlorine, bromine, alkyl, halogenoalkyl or cycloalkyl, orR.sup.1 and R.sup.3 have the meaning indicated andR.sup.2 and R.sup.4 together represent an alkylene group having 3-6 carbon atoms,by conjugated nitrofluorination of the corresponding olefin of the formula ##STR2## the improvement which comprises employing about 1.1 mols of hydrogen fluoride and 1 to 2 mols of nitric acid per mol of olefin and carrying out the reaction in the presence of an agent which binds water, e.g. chlorosulphonic acid, fluorosulphonic acid, sulphur trioxide, sulphur dioxide, thionyl chloride, thionyl fluoride, sulfuryl chloride or sulfuryl fluoride. The end products, some of which are known, are useful as intermediates in synthesizing herbicides.

Abstract translation: 在制备其中R 1，R 2，R 3和R 4相同或不同并且各自表示氢，氟，氯，溴，烷基，卤代烷基或环烷基的式（Ia）的α-氟化硝基烷烃或R1和R3具有 所表示的含义，R2和R4一起表示具有3-6个碳原子的亚烷基，通过共轭硝基氟化相应的式“烯烃”烯烃，其改进包括使用约1.1摩尔氟化氢和1至2摩尔硝酸 酸/每摩尔烯烃，并在结合水的试剂存在下进行反应，例如 氯磺酸，氟磺酸，三氧化硫，二氧化硫，亚硫酰氯，亚硫酰氟，磺酰氯或硫酰氟。 其中一些已知的最终产物可用作合成除草剂的中间体。

公开(公告)号：US4342701A

公开(公告)日：1982-08-03

申请号：US123870

申请日：1980-02-22

Applicant: Werner Steinbeck ,  Gunter Gehrke

Inventor： Werner Steinbeck ,  Gunter Gehrke

IPC: C07C201/08 ,  C07C67/00 ,  C07C201/00 ,  C07C205/47 ,  C07C205/48 ,  C07C49/74

CPC classification number: C07C201/08 ,  C07C201/14 ,  C07C2103/24

Abstract: 95-99% pure 4,5-dinitro-1,8-dihydroxyanthraquinone which is essentially free from by-products is obtained by "direct nitration" of 1,8-dihydroxyanthraquinones or 1,8-dimethoxyanthraquinones if the concentrations of acid are chosen such that, when the nitration reaction and, if appropriate, the saponification reaction have ended, an 80-100% strength sulphuric acid is present, or such a sulphuric acid concentration is established by adding water, and the 4,5-dinitro-1,8-dihydroxyanthraquinone which crystallizes out is separated off.

Abstract translation: 如果选择酸的浓度，则通过“直接硝化”1,8-二羟基蒽醌或1,8-二甲氧基蒽醌获得基本上不含副产物的95-99％纯的4,5-二硝基-1,8-二羟基蒽醌 使得当硝化反应和（如果合适的话）皂化反应已经结束时，存在80-100％的强度硫酸，或者通过加入水来建立这样的硫酸浓度，并且将4,5-dinitro-1 分离出结晶出的8-二羟基蒽醌。

公开(公告)号：US4319059A

公开(公告)日：1982-03-09

申请号：US153360

申请日：1980-05-27

Applicant: Nobuyuki Ishibe

Inventor： Nobuyuki Ishibe

IPC: C07C76/02 ,  C07C79/04

CPC classification number: C07C201/14

Abstract: A process for making nitroalkanes in which an alpha-bromoalkanoic acid is reacted with an alkali metal nitrite, e.g. NaNO.sub.2, in the presence of the magnesium ion (Mg.sup.++) in an aprotic solvent to form a chelate. Neutralization of the chelate with a mineral acid produces a nitroalkane having one less carbon atom than the reactant bromoalkanoic acid.

Abstract translation: 制备硝基烷烃的方法，其中α-溴链烷酸与碱金属亚硝酸盐反应。 NaNO 2，在非质子溶剂中在镁离子（Mg ++）存在下形成螯合物。 螯合物与无机酸的中和产生比反应物溴链烷酸少一碳原子的硝基烷烃。

公开(公告)号：US3859354A

公开(公告)日：1975-01-07

申请号：US31796972

申请日：1972-12-26

Applicant: LILLY CO ELI

Inventor： BOOHER RICHARD N ,  POHLAND ALBERT

IPC: C07C213/02 ,  C07C67/00 ,  C07C205/16 ,  C07C205/42 ,  C07C213/00 ,  C07C215/20 ,  C07C215/28 ,  C07C217/10 ,  C07C219/06 ,  C07C219/22 ,  C07C85/00

CPC classification number: C07C201/12 ,  C07C201/14 ,  C07C213/02 ,  C07C215/28 ,  C07C219/18 ,  C07C205/16 ,  C07C205/40

Abstract: 1-Methyl-3,3-diphenyl-4-hydroxyhexylamine, its salts and O-acyl derivatives, are prepared via a novel nitro intermediate formed by the neutral permanganate oxidation of normethadol or of a noracymethadol.