摘要:
Disclosed is a continuous process for separating or extracting proteins from a low grade mixture of a protein of interest, other proteins, impurities, and salts in a continuous simulated moving bed separation process. The invention provides for direct extraction of heme protein and plant protein from a crude mixture of such proteins, other proteins, impurities and salts using the chromatographic technique of simulated moving bed (SMB) continuous chromatography. The SMB process combines the steps of feed loading, adsorbent washing, product elution, adsorbent regeneration, and adsorbent equilibration. The novel strong anion exchange resin adsorbent is a quaternary amine cross-linked microcellulose wherein the microcellulose is cross-linked with epichlorohydrin and the quaternary amine is 2,3-epoxypropyltrimethyl-ammonium chloride which exhibits selective adsorption of proteins and complete regeneration. Purified protein separated in this manner may provide human health benefits by providing greater medicinal and nutrition opportunities from low quality protein sources.
摘要:
The present invention relates to a process for simulated moving bed (SMB) adsorption and separation with a reduced number of control valves, comprising separating the feedstocks comprising isomers by SMB adsorption, said SMB comprising m beds of adsorbent, each of which is equipped with grids, each of the grids being equipped with the materials charging and discharging pipeline of the bed, the materials charged into and discharged from SMB at least comprising adsorption feedstocks, desorbent, extract, raffinate and the flushing liquids charged from different beds, wherein the to extract is enriched with the target product; there are at least two streams of said flushing liquid selected from any one of the adsorption feedstock, desorbent, extract and raffinate; there are altogether n streams of materials charged to and discharged from the SMB, wherein there are s types of materials having the same composition and flow direction; p sets of on-off valves are used to control n streams of materials is charged to and discharged from the beds of adsorbent, wherein at least one group of materials composed of two streams of materials having the composition and flow direction is controlled by one set of valves, with s≦p
摘要翻译:本发明涉及一种具有减少数量的控制阀的模拟移动床(SMB)吸附和分离方法,包括通过SMB吸附分离包含异构体的原料,所述SMB包括多个吸附剂床,每个床装有栅格 每个网格配备有床的材料充放电管线,至少包含吸附原料,解吸剂,提取物,提余液和从不同床装入的冲洗液体的SMB中排出的材料,其中提取 富含目标产品; 从吸附原料,解吸剂,萃取液和萃余液中的任一种中选出至少两股所述冲洗液; 总共有N条物料流充入和排出SMB,其中有类型的材料具有相同的组成和流动方向; p组开关阀用于控制n个物料流从吸附剂床排出并排出,其中由具有组成和流动方向的两股材料组成的至少一组材料由一组控制 阀门,s≦̸ p
摘要:
A process for separating a product from a multicomponent feedstream to an adsorption apparatus or system is described. The apparatus or system may comprise a moving-bed or a simulated moving-bed adsorption means. The product comprises at least one organic compound, such as an aryl compound with alkyl substitutes. In embodiments the conduits used to supply the feedstream to the apparatus or system are flushed with media of multiple grades. The improvement is a more efficient use of the desorbent. In embodiments the process achieves improvements in one or more of efficiency of adsorption separation, capacity of adsorption apparatus systems, and purity of product attainable by adsorption process.
摘要:
A process to increase the capacity of the adsorbent in a normal paraffin adsorption separation system is presented. A tertiary flush stream is used to improve the capacity of the simulated moving bed system by flushing residual raffinate from the feed transfer line. The flushing removes residual raffinate containing desorbent that competes with the adsorption of normal paraffins from the feedstream. The flush stream is a material that will displace fluid in the column, but will not enter the pores of the adsorbent.
摘要:
A simulated moving bed flushing apparatus and its use are described. The adsorber comprises a plurality of beds (10, 11) of adsorbent, each bed being connected to a distribution means (5) comprising two fluid distribution lines (2,1,) the first distribution line (2) of each distribution means being connected to at least one inlet (7) for feed and to at least one raffmate outlet (8), the other line 1 being connected to at least one solvent inlet (3) and to at least one extract outlet (4), each inlet and outlet comprising an on-off valve (7a, 8a, 3a, 4a), the first distribution line (2) comprising a flushing valve (9), and all of the flushing valves (9) relating to all of the distribution lines (2) are connected to means (100, 102) for circulating a fluid to be displaced. FIG. 1 to be published.
摘要:
This is a separation process employing a column of adsorbent which is divided sequentially into at least three zones, adsorption, purification and desorption zones. A net fluid flow is maintained through the column with the adsorbent moving actually or in a simulated manner countercurrent with respect to the fluid. The feedstock contains the components to be separated with one component being more selectively adsorbed in the adsorption zone by the adsorbent than the other components. A desorbent fluid effects desorption of the more selectively adsorbed component in the desorption zone, however, if carried over into the adsorption zone with the moving adsorbent the desorbent impedes adsorption. The process employs a flush stream introduced at the upstream boundary of the desorption zone, with the desorbent introduced between the upstream and downstream boundaries of that zone, which flushes the desorbent from the adsorbent prior to its movement into the adsorption zone.
摘要:
Disclosed is a continuous process for separating or extracting proteins from a low grade mixture of a protein of interest, other proteins, impurities, and salts in a continuous simulated moving bed separation process. The invention provides for direct extraction of heme protein and plant protein from a crude mixture of such proteins, other proteins, impurities and salts using the chromatographic technique of simulated moving bed (SMB) continuous chromatography. The SMB process combines the steps of feed loading, adsorbent washing, product elution, adsorbent regeneration, and adsorbent equilibration. The novel strong anion exchange resin adsorbent is a quaternary amine cross-linked microcellulose wherein the microcellulose is cross-linked with epichlorohydrin and the quaternary amine is 2,3-epoxypropyltrimethyl-ammonium chloride which exhibits selective adsorption of proteins and complete regeneration. Purified protein separated in this manner may provide human health benefits by providing greater medicinal and nutrition opportunities from low quality protein sources.
摘要:
Disclosed is a continuous process for separating or extracting proteins from a low grade mixture of a protein of interest, other proteins, impurities, and salts in a continuous simulated moving bed separation process. The invention provides for direct extraction of heme protein and plant protein from a crude mixture of such proteins, other proteins, impurities and salts using the chromatographic technique of simulated moving bed (SMB) continuous chromatography. The SMB process combines the steps of feed loading, adsorbent washing, product elution, adsorbent regeneration, and adsorbent equilibration. The novel strong anion exchange resin adsorbent is a quaternary amine cross-linked microcellulose wherein the microcellulose is cross-linked with epichlorohydrin and the quaternary amine is 2,3-epoxypropyltrimethyl-ammonium chloride which exhibits selective adsorption of proteins and complete regeneration. Purified protein separated in this manner may provide human health benefits by providing greater medicinal and nutrition opportunities from low quality protein sources.
摘要:
Purge fluid from a vessel head in an adsorption process is distributed to recovery processes according to the purity of product contained in the fluid. Extract-rich fluid thus is routed directly to recovery of the extract product. Distribution preferably is determined by internal positioning of feed, desorbent and product streams in the adsorption vessel.