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    Cytotoxic T Lymphocyte Inducing Immunogens For Prevention Treatment and Diagnosis of Dengue Virus Infection
    1.
    发明申请
    Cytotoxic T Lymphocyte Inducing Immunogens For Prevention Treatment and Diagnosis of Dengue Virus Infection 审中-公开

    公开(公告)号：US20190106462A1

    公开(公告)日：2019-04-11

    申请号：US16163162

    申请日：2018-10-17

    申请人： Emergex Vaccines Holdings Limited

    发明人： Ramila Philip

    IPC分类号： C07K14/005 ,  A61K38/19

    CPC分类号： C07K14/005 ,  A61K38/017 ,  A61K38/19 ,  A61K39/12 ,  A61K2039/55522 ,  C12N2770/24134 ,  Y02A50/386

    摘要： Dengue Fever (DF) and Dengue Hemorrhagic Fever (DHR) are significant global public health problems and understanding the overall immune response to infection will contribute to appropriate management of the disease and its potentially severe complications. Live attenuated and subunit vaccine candidates, which are under clinical evaluation, induce primarily an antibody response to the virus and minimal cross-reactive T cell responses. Currently, there are no available tools to assess protective T cell responses during infection or post vaccination. The present invention incorporates immunoproteomics to uncover novel HLA-A2 specific epitopes derived from Dengue Virus (DV)-infected cells. These epitopes are conserved with epitope-specific CTLs cross-reacting against all four DV serotypes. These epitopes have potential as new informational and diagnostic tools to characterize T cell immunity in Dengue virus (DV) infection, and serves as a universal vaccine candidate complementary to current vaccines.

    Method of Use of Activated Functional Proteins to Improve Animal Health
    3.
    发明申请
    Method of Use of Activated Functional Proteins to Improve Animal Health 审中-公开
    使用活化功能蛋白改善动物健康的方法

    公开(公告)号：US20130345113A1

    公开(公告)日：2013-12-26

    申请号：US13182018

    申请日：2011-07-13

    申请人： Ronald E. Strohbehn

    发明人： Ronald E. Strohbehn

    IPC分类号： A61K38/00

    CPC分类号： A23K20/147 ,  A23K50/10 ,  A23K50/30 ,  A23K50/60 ,  A61K9/0017 ,  A61K9/0019 ,  A61K9/0053 ,  A61K38/00 ,  A61K38/017 ,  A61K38/018 ,  A61K38/1709 ,  A61K38/18 ,  A61K38/40 ,  A61K38/54

    摘要： It was found that feeding a composition including activated growth factor(s) increases feed to gain ratio, increases overall weight gain, reduces necessary antibiotic or electrolyte therapy and reduces mortality in animals. The composition is derived by first separating growth factor(s) from a source such as whey or blood, then subjecting the factor to an activation process, and then providing the activated growth factor to the animal. A feed additive comprising activated growth factors in appropriate amounts, shows results that are an improvement over standard therapies of supplementation. Application of activated growth factors may be by topical, injection or oral application.

    摘要翻译： 已经发现，喂食包含活性生长因子的组合物可增加饲料增重比，增加总体重量增加，减少必需的抗生素或电解质治疗并降低动物的死亡率。 通过首先从源（例如乳清或血液）分离生长因子，然后使因子进行活化过程，然后向动物提供活化的生长因子，从而产生组合物。 包含适当量的活化生长因子的饲料添加剂显示出比标准补充疗法改进的结果。 活化生长因子的应用可以通过局部，注射或口服施用。

    Heme-iron-enriched amino acid and a process for the preparation of heme-iron-enriched amino acid
    7.
    发明授权
    Heme-iron-enriched amino acid and a process for the preparation of heme-iron-enriched amino acid 失效
    血红素富集氨基酸和制备富含血红质铁的氨基酸的方法

    公开(公告)号：US4411915A

    公开(公告)日：1983-10-25

    申请号：US255218

    申请日：1981-04-18

    申请人： Caj Eriksson

    发明人： Caj Eriksson

    IPC分类号： A23J1/06 ,  A23J3/34 ,  A23L1/305 ,  A61K33/26 ,  A61K38/00 ,  A61K38/01 ,  A61K38/16 ,  C07K14/795 ,  C07K14/805 ,  C12P21/06

    CPC分类号： C07K14/805 ,  A23J3/345 ,  A23L33/18 ,  A61K38/017 ,  C07K14/795 ,  Y10S530/829 ,  Y10S530/83

    摘要： There is disclosed heme-iron-enriched amino acid preparation consisting of aggregates of heme-protein fragments with heme bonded to histidine groups present in the fragment and a method for preparing this amino acid preparation from heme-proteins, especially hemoglobin. The heme-protein in a manner known per se at first is hemolyzed and denaturated and subsequently split with the aid of proteolytic enzymes to the formation of one heme-iron-enriched and one fraction which does not contain heme-iron and separation of these fractions from each other. The amino acid preparation is suitable for iron enrichment of for instance foodstuffs and for use in pharmaceutical iron preparations.

    摘要翻译： 公开了含血红素富集的氨基酸制剂，其由血红素蛋白片段的聚集体组成，血红素与片段中存在的组氨酸基团键合，以及由血红素蛋白特别是血红蛋白制备该氨基酸制剂的方法。 首先已知本身已知的血红素蛋白质被溶血和变性，随后借助于蛋白水解酶分裂，形成一种不含血红素铁和一个不含血红素的部分，并分离这些级分 从彼此。 氨基酸制剂适用于铁的富集，例如食品和用于制药铁制剂。