公开(公告)号：US20240358309A1

公开(公告)日：2024-10-31

申请号：US18765737

申请日：2024-07-08

Applicant: WUHAN NEURACOM TECHNOLOGY DEVELOPMENT CO., LTD.

Inventor： Li HUANG ,  Cheng HUANG ,  Kai LI ,  Moutao LI

IPC: A61B5/294

CPC classification number: A61B5/294

Abstract: A neural interface circuit for bidirectional signal transmission includes at least one electrode configured to collect a neural signal and receive an excitation signal. The neural interface circuit can transmit signals bidirectionally. On the one hand, neural signals can be collected through electrodes, and on the other hand, excitation signals can be received through electrodes. The excitation signals can achieve the purpose of researching or intervening treatment.

公开(公告)号：US20240358279A1

公开(公告)日：2024-10-31

申请号：US18771659

申请日：2024-07-12

Applicant: BLINK DEVICE LLC

Inventor： Justin HULVERSHORN ,  Karl SCHMIDT ,  Tyler HART

IPC: A61B5/11 ,  A61B5/00 ,  A61B5/24 ,  A61B5/294 ,  A61B5/296 ,  A61B5/305 ,  A61B5/388 ,  A61B5/389 ,  A61B5/395 ,  A61N1/04 ,  G16H10/60 ,  G16H50/20

CPC classification number: A61B5/1106 ,  A61B5/24 ,  A61B5/296 ,  A61B5/305 ,  A61B5/388 ,  A61B5/389 ,  A61B5/395 ,  A61B5/6824 ,  A61B5/6826 ,  A61B5/6833 ,  A61B5/685 ,  A61B5/7217 ,  A61B5/294 ,  A61B2560/0238 ,  A61B2562/0219 ,  A61N1/0456 ,  G16H10/60 ,  G16H50/20

Abstract: Neuromuscular monitoring is described that uses a novel lead assembly and a monitor that can select the appropriate electrodes on the lead assembly and calibrate the stimulation signals applied to the patient through the lead assembly. The monitoring can also set a noise floor value to reduce the likelihood of an erroneous train of four ratio.

公开(公告)号：US20240197235A1

公开(公告)日：2024-06-20

申请号：US18188980

申请日：2022-08-09

Applicant: Neurokinesis Corp.

Inventor： Josh Shachar

IPC: A61B5/367 ,  A61B5/00 ,  A61B5/20 ,  A61B5/287 ,  A61B5/294 ,  A61B5/35 ,  A61B5/388

CPC classification number: A61B5/367 ,  A61B5/0006 ,  A61B5/0017 ,  A61B5/201 ,  A61B5/287 ,  A61B5/294 ,  A61B5/35 ,  A61B5/388 ,  A61B5/4836 ,  A61B5/686 ,  A61B5/7203 ,  A61B2562/0209

Abstract: With respect to the methodology of using the Huygens sensing array, the invention includes an improvement in a method of sensing biopotentials in tissue including the steps of: providing a Huygens sensor array; and sensing a native electrical biopotential signal using at least one electrode on a catheter with an amplifier circuit placed on the inner surface of the at least one electrode in the Huygens sensor array to generate a well-formed waveform of the biopotential showing clear electrical properties indicative of the tissue with a SFDR of at least 24.9 dB and SNR of at least −13 dB. In one embodiment the tissue is cardiac tissue and the biopotential signal sensed by the Huygens sensing array is a native cardiac waveform. In one embodiment the sensed biopotential signal is a manifestation of underlying electrochemical activity sensed by the Huygens sensing array of a biological substrate corresponding to the tissue.

公开(公告)号：US20230147433A1

公开(公告)日：2023-05-11

申请号：US17920419

申请日：2020-05-04

Applicant: Synergia Medical

Inventor： Pascal Doguet ,  Aurore Nieuwenhuys ,  Yohan Botquin ,  Jérôme Garnier

IPC: A61N1/08 ,  A61B5/00 ,  A61B5/294 ,  A61N1/372

CPC classification number: A61N1/08 ,  A61B5/6822 ,  A61B5/0017 ,  A61B5/294 ,  A61N1/37223 ,  A61N1/37247

Abstract: A kit-of-parts for visualizing by a magnetic resonance imaging (MRI) technique including a functional magnetic resonance imaging (fMRI) technique, regions of a central nervous system of a patient having an implanted active implantable medical device (AIMD) is provided. The kit-of-parts is provided and includes:



the AIMD, which can be used exposed to the electromagnetic conditions for MR-images acquisition,
an external processing unit for controlling the AIMD,
an optical communication lead for establishing a two-way optical communication between the AIMD and
an external communication unit which is controlled by the external processing unit.




A patient having an implanted AIMD can be treated in a conventional MR-device for imaging, e.g., a brain region. The other elements of the kit-of-parts allow controlling the functions of the AIMD and following any effects of a stimulation on the brain region thus imaged.

公开(公告)号：US12059248B2

公开(公告)日：2024-08-13

申请号：US16339163

申请日：2017-10-13

Applicant: BLINK DEVICE LLC

Inventor： Justin Hulvershorn ,  Karl Schmidt ,  Tyler Hart

IPC: A61B5/05 ,  A61B5/00 ,  A61B5/11 ,  A61B5/24 ,  A61B5/296 ,  A61B5/305 ,  A61B5/388 ,  A61B5/389 ,  A61B5/395 ,  A61N1/00 ,  A61B5/294 ,  A61N1/04 ,  G16H10/60 ,  G16H50/20

CPC classification number: A61B5/1106 ,  A61B5/24 ,  A61B5/296 ,  A61B5/305 ,  A61B5/388 ,  A61B5/389 ,  A61B5/395 ,  A61B5/6824 ,  A61B5/6826 ,  A61B5/6833 ,  A61B5/685 ,  A61B5/7217 ,  A61B5/294 ,  A61B2560/0238 ,  A61B2562/0219 ,  A61N1/0456 ,  G16H10/60 ,  G16H50/20

Abstract: Neuromuscular monitoring is described that uses a novel lead assembly and a monitor that can select the appropriate electrodes on the lead assembly and calibrate the stimulation signals applied to the patient through the lead assembly. The monitoring can also set a noise floor value to reduce the likelihood of an erroneous train of four calculations. The present system can automatically sense train of four response of a patient and reduce the likelihood of false train of four indications.

公开(公告)号：US20240099632A1

公开(公告)日：2024-03-28

申请号：US18038458

申请日：2021-12-01

Applicant: CHECKPOINT SURGICAL, INC.

Inventor： Ben Cottrill ,  Eric R. Walker

IPC: A61B5/294 ,  A61B5/00 ,  A61B5/388

CPC classification number: A61B5/294 ,  A61B5/388 ,  A61B5/6848

Abstract: An electrical stimulation system includes a stimulation device. The stimulation device may generate electrical stimulation in a stimulation pattern. Sensors may detect evoked potential. The electrical stimulation system may determine whether the evoked potential is a result of the electrical stimulation based at least in part on the stimulation pattern.

公开(公告)号：US20240041376A1

公开(公告)日：2024-02-08

申请号：US18455535

申请日：2023-08-24

Applicant: President and Fellows of Harvard College

Inventor： Jia Liu ,  Paul Claude Henri Le Floch ,  Hao Sheng

IPC: A61B5/268 ,  C09D171/02 ,  C08L27/12 ,  A61B5/294 ,  A61B5/388

CPC classification number: A61B5/268 ,  C09D171/02 ,  C08L27/12 ,  A61B5/294 ,  A61B5/388 ,  C08L2203/202 ,  A61B2562/125 ,  A61B2562/164

Abstract: Articles and devices comprising fluorinated elastomers, as well as methods of preparing fluorinated elastomers, are generally described. In some cases, such fluorinated elastomers can be used for sensing neural activity, e.g., by encapsulating electronic circuits, or other applications. Furthermore, according to certain embodiments, polymers can, surprisingly, be directly deposited onto layers comprising low molecular weight fluorinated elastomers, e.g., without swelling in the presence of certain solvents. Some embodiments are generally directed to devices and methods for treating fluorinated elastomers and subsequently depositing material onto the treated fluorinated elastomers. This may allow the fabrication and patterning of multilayered articles comprising fluorinated elastomers.

公开(公告)号：US11813466B2

公开(公告)日：2023-11-14

申请号：US17157433

申请日：2021-01-25

Applicant: Medtronic, Inc.

Inventor： Lilian Kornet ,  Richard Cornelussen ,  Berthold Stegemann

IPC: A61N1/375 ,  A61N1/37 ,  A61B5/388 ,  A61B5/294

CPC classification number: A61N1/37512 ,  A61B5/294 ,  A61B5/388 ,  A61N1/3702 ,  A61N1/3756

Abstract: Devices and methods are described herein for treating cardiac conditions using electrical stimulation delivered to and sensing nerve activity from one or both of the AV node and nerve tissue innervating the AV node using one or more neural electrodes positioned in a location within the triangle of Koch of the right atrium.

公开(公告)号：US20230321443A1

公开(公告)日：2023-10-12

申请号：US18188339

申请日：2023-03-22

Applicant: Saluda Medical Pty Ltd

Inventor： Dean Michael Karantonis ,  Daniel John Parker ,  Ian Cameron Gould

IPC: A61N1/36 ,  A61B5/294 ,  G06F17/18

CPC classification number: A61N1/36139 ,  A61B5/294 ,  A61N1/37235 ,  G06F17/18 ,  A61N1/36157

Abstract: Disclosed is a method of computing a probability distribution of the suitability of measurement electrode configurations for a neuromodulation device. The method comprises: computing the probability distribution of suitability of measurement electrode configurations from: a predetermined stimulus program vector of the neuromodulation device; and prior patient data. Also disclosed is an automated method of setting a measurement electrode configuration for a neuromodulation device configured to deliver a neural stimulus to a neural pathway of a patient. The method comprises: obtaining an initial measurement electrode configuration for a predetermined stimulus program vector from a prior probability distribution of suitability of measurement electrode configurations; delivering a plurality of neural stimuli of different stimulus intensities to the neural pathway according to the stimulus program vector; measuring intensities of neural responses evoked by the neural stimuli using a current measurement electrode configuration; computing one or more quality measures of the evoked neural responses using the measured neural response intensities and the respective stimulus intensities; refining the probability distribution of suitability of measurement electrode configurations using the one or more quality measures; and obtaining a new measurement electrode configuration for the predetermined stimulus program vector using the refined probability distribution of suitability of measurement electrode configurations.

公开(公告)号：US20240350064A1

公开(公告)日：2024-10-24

申请号：US18651145

申请日：2024-04-30

Applicant: Retropsoas Technologies, LLC

Inventor： Nicholas POULOS ,  James CUPP

IPC: A61B5/294 ,  A61B5/251 ,  A61B5/263

CPC classification number: A61B5/294 ,  A61B5/251 ,  A61B5/263

Abstract: An electrode assembly (preferably in the form of a nerve cuff) comprises a base with first and second arms extending from opposite sides of the base, and which, in combination, define an arc. First and second electrically conductive electrodes extend along the inner surface of the first and second arms. Each electrode can comprise a single length of foil can or can comprise multiple discrete foil segments. The foils are electrically isolated from each other. Electrical wires, which are in electrical communication with the each of the foils, extend from the nerve cuff and are adapted to be electrically connected to a signal monitor. When the nerve cuff is applied to a nerve, the foils, in combination, substantially surround the nerve, with the first and second electrodes being on opposite sides of the nerve from each other. Also disclosed is a method of using the nerve cuff to monitor a nerve during a lumbar spinal surgery while the patient is anesthetized and paralyzed.