公开(公告)号：US20240218458A1

公开(公告)日：2024-07-04

申请号：US18332359

申请日：2023-06-09

申请人： University of Maryland, Baltimore ,  University of Maryland, Baltimore County ,  The Penn State Research Foundation

发明人： Dipanjan Pan ,  Parikshit Moitra ,  Ketan Dighe

IPC分类号： C12Q1/689 ,  C12N9/22 ,  C12N15/11

CPC分类号： C12Q1/689 ,  C12N9/22 ,  C12N15/11 ,  C12N2310/20

摘要： The present invention provides methods of detecting the presence or absence of nucleic acid from Chlamydia trachomatis and the presence or absence of nucleic acid from Neisseria gonorrhoeae in a sample from a subject using CRISPR nucleases and crRNAs specific for Chlamydia trachomatis and Neisseria gonorrhoeae nucleic acid, kits for carrying out the methods and methods of treating subjects infected with Chlamydia trachomatis and/or Neisseria gonorrhoeae.

公开(公告)号：US20230323488A1

公开(公告)日：2023-10-12

申请号：US18298540

申请日：2023-04-11

申请人： University of Maryland, Baltimore County ,  University of Maryland, Baltimore

发明人： Govind RAO ,  Xudong GE ,  Douglas D. FREY ,  Sai Sathish RAMAMURTHY ,  Dipanjan PAN

IPC分类号： C12Q1/70 ,  C12Q1/6844 ,  G01N33/569 ,  G01N1/40 ,  B01L3/00 ,  G01N33/543

CPC分类号： C12Q1/701 ,  C12Q1/6844 ,  G01N33/56983 ,  G01N1/40 ,  B01L3/502761 ,  G01N33/54386 ,  G01N2333/165 ,  B01L2200/0652 ,  B01L2200/16

摘要： The present invention relates to the use of a condensate collector such as portable or stationary dehumidifier placed in a defined testing space or area and used as a readily available and affordable tool to collect airborne virus particles in collected condensate from the testing atmosphere in the defined testing space or area, wherein the collected condensate is analyzed for virus biomarkers to identify viruses, such as SARS-CoV-2 or mutants or variants thereof, in the testing atmosphere.

公开(公告)号：US20230248939A1

公开(公告)日：2023-08-10

申请号：US18167475

申请日：2023-02-10

申请人： UNIVERSITY OF MARYLAND, BALTIMORE ,  University of Maryland Medical System Corporation ,  The Feinstein Institutes for Medical Research

发明人： Bartley P. Griffith ,  Zhongjun Wu ,  Chetan Pasrija ,  Aakash Yogesh Shah ,  Zachary Kon

IPC分类号： A61M25/00 ,  A61M1/00 ,  A61M39/02

CPC分类号： A61M25/0026 ,  A61M1/84 ,  A61M39/0247

摘要： A modular cannula for drainage and return of fluids from and to a body, such as the body of a patient, is adjustable to enable an operator to achieve desired flow characteristics during such fluid drainage and return procedures. The modular, dual-lumen cannula system has an outer drainage cannula and an inner return cannula that is moveable with respect to the outer drainage cannula. By enabling movement of the inner return cannula with respect to the outer drainage cannula, a distance between return outlet ports at the distal end of the return cannula and drainage ports at the distal end of the drainage cannula may be manually adjusted. Such adjustable distance allows for optimal positioning of both the drainage and return ports that are particularly adapted to an individual patient’s physiology, in turn enabling optimal fluid flow characteristics to be achieved regardless of that patient physiology.

公开(公告)号：US20220395371A9

公开(公告)日：2022-12-15

申请号：US17584157

申请日：2022-01-25

申请人： University of Maryland, Baltimore ,  University of Maryland Medical System LLC

发明人： James Gammie ,  Rachael Quinn ,  Chetan Pasrija

IPC分类号： A61F2/24 ,  A61L27/36

摘要： The present invention provides devices for treating functional mitral regurgitation and methods of use thereof. The devices translocate a subject's mitral valve in an apical direction. The devices thereby treat mitral regurgitation while preserving a subject's original mitral valve and chordae tendinae.

公开(公告)号：US20220227845A1

公开(公告)日：2022-07-21

申请号：US17285956

申请日：2019-10-18

申请人： University of Maryland, College Park ,  University of Maryland, Baltimore ,  The United States of America, as Represented by the Secretary, Department of Health and Human Servic ,  International AIDS Vaccine Initiative

发明人： Yuxing Li ,  James Steinhardt ,  Javier Guenaga ,  John R. Mascola ,  Tae-Wook Chun ,  Susan Moir ,  Chi-I Chiang

IPC分类号： C07K16/10 ,  A61P31/18 ,  A61K39/42 ,  A61K45/06

摘要： The present invention provides a multispecific anti-HIV antibody that binds to multiple epitopes on HIV envelope protein, wherein the antibody comprises: i. an amino acid sequence that binds to a V1/V2 apex glycan epitope; ii. an amino acid sequence that binds to a V3-base glycan region epitope; iii. an amino acid sequence that binds to a CD4 binding site (CD4bs) epitope; iv. an amino acid sequence that binds to a gp120/gp41 interface epitope; and v. an amino acid sequence that binds to a membrane proximal external region (MPER) epitope.

公开(公告)号：US11364333B2

公开(公告)日：2022-06-21

申请号：US16754382

申请日：2018-10-10

申请人： UNIVERSITY OF MARYLAND, BALTIMORE ,  UNIVERSITY OF MARYLAND MEDICAL SYSTEM, LLC

发明人： Zachary Kon ,  Mehrdad Ghoreishi ,  Chetan Pasrija ,  Bartley Griffith ,  Gregory Bittle

IPC分类号： A61M1/36 ,  A61M25/00

摘要： Disclosed herein is a bidirectional intravascular cannula, or catheter, that is configured to provide and return blood in a patient bidirectionally. The bidirectional intravascular cannula is configured to reduce or obviate the need for a second cannula, such as currently available unidirectional cannulae, to be placed in a second or opposite direction of flow. Users would include cardiac surgeons, intensivists, vascular surgeons, ER doctors, IR doctors and cardiologist who use peripheral cannulation for ECLS or cardiopulmonary bypass. The cannula allows continued flow to a patient's limb even with the cannula proximally in the vessel. The cannula further allows larger size cannula to be placed without the need for additional distal catheter placement.

公开(公告)号：US11259925B2

公开(公告)日：2022-03-01

申请号：US16888322

申请日：2020-05-29

申请人： University of Maryland, Baltimore ,  University of Maryland Medical System LLC

发明人： James Gammie ,  Rachael Quinn ,  Chetan Pasrija

IPC分类号： A61F2/24 ,  A61L27/36

摘要： The present invention provides devices for treating functional mitral regurgitation and methods of use thereof. The devices translocate a subject's mitral valve in an apical direction. The devices thereby treat mitral regurgitation while preserving a subject's original mitral valve and chordae tendinae.

公开(公告)号：US20210346582A1

公开(公告)日：2021-11-11

申请号：US17308567

申请日：2021-05-05

申请人： University of Maryland, Baltimore ,  University of Maryland, College Park

发明人： Joseph Friedberg ,  Hosam Fathy ,  Jin-Oh Hahn ,  Mahsa Doosthosseini ,  Majid Aroom ,  Kevin Aroom

IPC分类号： A61M1/28 ,  A61M1/36

摘要： Systems and methods for gas exchange in a patient are provided that use an external circuit to cause oxygenation perfusion in a patient's body cavity (such as the abdomen) using an inert chemical (e.g., perfluorocarbon), independent of the lungs. The external circuit includes components configured to control properties of the chemical, including temperature, flow rate, pressure, oxygenation percentage, carbon dioxide percentage. The system also includes safety features to reduce the likelihood of injury to the patient. Each of the safety features and chemical properties can be controlled by a healthcare worker, such as a physician, nurse, or emergency operator, for a particular patient.

公开(公告)号：US20210259738A1

公开(公告)日：2021-08-26

申请号：US17315729

申请日：2021-05-10

申请人： University of Maryland, Baltimore ,  University of Maryland Medical System LLC ,  Protaryx Medical Inc.

发明人： James S. GAMMIE ,  Philip J. HAARSTAD ,  David BLAESER ,  Ryan BAUER ,  Stephen ROLLER ,  Rachael QUINN ,  Chetan PASRIJA ,  Edwin HLAVKA

IPC分类号： A61B17/34

摘要： In some embodiments, a method includes a shaft having a side catheter guide attached thereto via a guide coupler into an inferior vena cava and a superior vena cava such that the guide coupler is disposed in a right atrium, and applying a distal force to a proximal portion of the side catheter guide such that a distal end of the side catheter guide deflects laterally about the guide coupler towards a septum. The method further includes extending a side catheter that is disposed within the side catheter guide distally from the side catheter guide towards and into contact with the septum. The method further includes, with the side catheter in contact with the septum, extending a septum penetrator that is slidably disposed within the side catheter distally from the side catheter such that the septum penetrator pierces the septum.

公开(公告)号：US11045224B2

公开(公告)日：2021-06-29

申请号：US16858015

申请日：2020-04-24

申请人： University of Maryland, Baltimore ,  University of Maryland Medical System LLC ,  Protaryx Medical Inc.

发明人： James S. Gammie ,  Philip J. Haarstad ,  David Blaeser ,  Ryan Bauer ,  Stephen Roller ,  Rachael Quinn ,  Chetan Pasrija ,  Edwin Hlavka

IPC分类号： A61B17/34 ,  A61B17/00

摘要： In some embodiments, a method includes a shaft having a side catheter guide attached thereto via a guide coupler into an inferior vena cava and a superior vena cava such that the guide coupler is disposed in a right atrium, and applying a distal force to a proximal portion of the side catheter guide such that a distal end of the side catheter guide deflects laterally about the guide coupler towards a septum. The method further includes extending a side catheter that is disposed within the side catheter guide distally from the side catheter guide towards and into contact with the septum. The method further includes, with the side catheter in contact with the septum, extending a septum penetrator that is slidably disposed within the side catheter distally from the side catheter such that the septum penetrator pierces the septum.