公开(公告)号：US20230390308A1

公开(公告)日：2023-12-07

申请号：US18353525

申请日：2023-07-17

Applicant: UNIVERSIDAD DEL PAIS VASCO/EUSKAL HERRIKO UNIBERTSITATEA ,  ADMINISTRACION GENERAL DE LA COMUNIDAD AUTONOMA DE EUSKADI ,  FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE (IDIBELL) ,  UNIVERSIDAD DE SALAMANCA

Inventor： Jesus Maria BANALES ASURMENDI ,  Luis BUJANDA FERNANDEZ DE PIEROLA ,  Alvaro SANTOS LASO ,  Fernando Pedro COSSIO MORA ,  Ivan RIVILLA DE LA CRUZ ,  Francisco Javier CABALLERO CAMINO ,  Manel ESTELLER BADOSA ,  Jose Juan GARCIA MARIN

IPC: A61K31/58 ,  A61K31/575

CPC classification number: A61K31/58 ,  A61K31/575

Abstract: Compounds derived from ursodeoxycholic acid of formula (I) and to methods for obtaining same, as well as the use thereof in the treatment of polycystic diseases, particularly autosomal dominant polycystic liver disease, autosomal dominant polycystic kidney disease, or autosomal recessive polycystic kidney disease.

公开(公告)号：US20220407279A1

公开(公告)日：2022-12-22

申请号：US17787096

申请日：2020-12-16

Applicant: UNIVERSIDAD DE SALAMANCA ,  SPHERE ULTRAFAST PHOTONICS, S.L.

Inventor： Iñigo Juan SOLA LARRAÑAGA ,  Benjamín ALONSO FERNÁNDEZ

IPC: H01S3/00 ,  G01J11/00 ,  G01J3/45

Abstract: The method comprises A method includes steps for creating at least two replicas of an input pulse to be characterised, varying the relative amplitude of the two replicas within a range, creating a nonlinear signal at each case of said amplitude variation, measuring the spectra of the nonlinear signals and recovering the spectral amplitude and phase of the input pulse with a proper algorithm. The system includes a replicator for creating at least two replicas of the input pulse and varying their relative amplitude within a range of relative amplitudes, a nonlinear medium, which obtains a nonlinear signal for each relative amplitude, and an analyzer, associated to the nonlinear signal for measuring and characterising spectrally each nonlinear signal.

公开(公告)号：US20210137946A1

公开(公告)日：2021-05-13

申请号：US16958429

申请日：2018-12-28

Applicant: UNIVERSIDAD DEL PAIS VASCO/EUSKAL HERRIKO UNIBERTSITATEA ,  ADMINISTRACION GENERAL DE LA COMUNIDAD AUTONOMA DE EUSKADI ,  FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE (IDIBELL) ,  UNIVERSIDAD DE SALAMANCA

Inventor： Jesus Maria BANALES ASURMENDI ,  Luis BUJANDA FERNANDEZ DE PIEROLA ,  Alvaro SANTOS LASO ,  Fernando Pedro COSSIO MORA ,  Ivan RIVILLA DE LA CRUZ ,  Francisco Javier CABALLERO CAMINO ,  Manel ESTELLER BADOSA ,  Jose Juan GARCIA MARIN

IPC: A61K31/58 ,  A61K31/575

Abstract: The present invention relates to compounds derived from ursodeoxycholic acid of formula (I), to methods for obtaining same, as well as the use thereof in the treatment of polycystic diseases, particularly autosomal dominant polycystic liver disease, autosomal dominant polycystic kidney disease, or autosomal recessive polycystic kidney disease.

公开(公告)号：US09746472B2

公开(公告)日：2017-08-29

申请号：US13557543

申请日：2012-07-25

Applicant: José Alberto Orfao De Matos Correia E Vale

Inventor： José Alberto Orfao De Matos Correia E Vale

IPC: G01N33/574

CPC classification number: G01N33/57407 ,  G01N33/57488

Abstract: This invention relates to methods to detect the presence of cancer infiltration of the Central Nervous System (CNS) based on the detection of soluble proteins, preferably, in cerebrospinal fluid samples and vitreous fluid. The invention also relates to kits to perform the methods of the invention.

公开(公告)号：US20170043162A1

公开(公告)日：2017-02-16

申请号：US15303798

申请日：2015-04-28

Applicant: UNIVERSIDAD DE SALAMANCA

Inventor： Enrique Alejandro Lopez-Poveda

IPC: A61N1/36 ,  H04R25/00

Abstract: This document mainly discloses a method and a device for sound enhancement, both aspects of the invention hereby described are directed to cochlear implants. The method for sound enhancement and the sound enhancement device comprising a component adapted to carry out said method are based on processing the envelope for frequency bands of the acoustic signal captured, said amplification is directed to the gain value of the amplification according to an amplitude of an output signal of the other sound processor.

Abstract translation: 该文献主要公开了一种用于声音增强的方法和装置，其中描述的本发明的两个方面都针对人工耳蜗。 用于声音增强的方法和包括适于执行所述方法的部件的声音增强装置基于对所捕获的声信号的频带的包络进行处理，所述放大根据幅度的幅度来指向放大的增益值 另一个声音处理器的输出信号。

公开(公告)号：US20120220480A1

公开(公告)日：2012-08-30

申请号：US13388506

申请日：2010-07-19

Applicant: Yaremi Quiros Luis ,  Laura Ferreira Redondo ,  Sandra M. Sancho Martínez ,  José M. Gonzalez De Buitrago Arriero ,  Francisco J. Lopez Hernandez ,  José M. Lopez Novoa ,  Omar Garcia Sanchez

Inventor： Yaremi Quiros Luis ,  Laura Ferreira Redondo ,  Sandra M. Sancho Martínez ,  José M. Gonzalez De Buitrago Arriero ,  Francisco J. Lopez Hernandez ,  José M. Lopez Novoa ,  Omar Garcia Sanchez

IPC: C40B30/04 ,  G01N33/566

CPC classification number: G01N33/6893 ,  G01N2800/347 ,  G01N2800/50 ,  G01N2800/60

Abstract: The invention relates to a method for determining the presence of renal damage in an individual and also to a method for detecting one or several proteins selected from the list comprising Reg3B, fetuin B, Ras-related GTP-binding protein A serine protease inhibitor A3L, subunit 1 of COP9, gamma subunit of ATP synthase, gelsolin, ribonuclease UK114, aminoacylase 1A, alpha-enolase, keratin 5, parvalbumin alpha, ribonuclease 4 or serine protease inhibitor A3K. The renal damage may be acute renal failure. Said renal pathologies may be caused by the administration of a nephrotoxic agent, wherein the nephrotoxic agent may be an aminoglycoside antibiotic such as gentamicin, or cisplatin. The invention also provides means to differentiate the renal damage or renal failure induced by gentamicin from that induced by cisplatin, through the biochemical analysis of the urinary level of Reg3B and/or gelsolin, or fragments thereof.

Abstract translation: 本发明涉及一种用于确定个体中肾损伤的存在的方法，还涉及用于检测选自包含Reg3B，胎球蛋白B，Ras相关GTP结合蛋白A丝氨酸蛋白酶抑制剂A3L的一种或多种蛋白质的方法， COP9的亚基1，ATP合成酶的γ亚基，凝溶胶蛋白，核糖核酸酶UK114，氨基酰化酶1A，α-烯醇化酶，角蛋白5，小白蛋白α，核糖核酸酶4或丝氨酸蛋白酶抑制剂A3K。 肾损伤可能是急性肾衰竭。 所述肾脏病变可以由施用肾毒性剂引起，其中所述肾毒性剂可以是氨基糖苷类抗生素如庆大霉素或顺铂。 本发明还提供了通过Reg3B和/或凝溶胶蛋白或其片段的尿液水平的生物化学分析来区分由庆大霉素诱导的肾损伤或肾衰竭与顺铂诱导的手段。

公开(公告)号：US12104851B2

公开(公告)日：2024-10-01

申请号：US17624694

申请日：2020-07-02

Applicant: UNIVERSIDAD DE SALAMANCA

Inventor： Andrés Celestino García Montero ,  Alberto Orfao De Matos Correia E Vale ,  Francisco Javier García Palomo ,  Catia Daniela Quintas Faria ,  Roberto José García Martín ,  Maria Pérez Caro

IPC: F26B5/06 ,  F26B25/00

CPC classification number: F26B5/06 ,  F26B25/003

Abstract: The invention relates to a device and method for the simultaneous lyophilisation of a plurality of biological samples ensuring the traceability of said samples intended to be housed within coded containers (1); the device comprises a diffuser block (2) comprising a plurality of openings which define receptacles (21) to house the coded containers (1), wherein the diffuser block (2) further comprises a perimeter cavity (24) configured so that the alloy surrounding each receptacle (21) is similar in all the coded containers (1), enabling high thermal homogeneity, and the receptacles (21) have through openings defining an open bottom (23) to scan the coded containers (1). Likewise, the device further comprises a transfer lid (3) to ensure the position of each container (1) when it is transferred to the diffuser block (1) and back to the starting box (4).

公开(公告)号：US11919967B2

公开(公告)日：2024-03-05

申请号：US16636416

申请日：2018-08-03

Applicant: ALZHEIMUR 2012 S.L. ,  FUNDACIÓN UNIVERSITARIA SAN ANTONIO ,  IBSAL (INSTITUTO DE INVESTIGACIÓN BIOMEDICA DE SALAMANCA) ,  UNIVERSIDAD DE SALAMANCA

Inventor： Rogelio Gonzalez Sarmiento ,  Miguel Rodriguez Manotas ,  Javier Fernandez Mateos ,  Juan Carlos Gallar Ruiz ,  David Florenciano Gomez

IPC: C07K16/30 ,  C07K16/38 ,  A61K39/395 ,  A61K39/00

CPC classification number: C07K16/30 ,  C07K16/38 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/73

Abstract: An antibody or fragment thereof, against presenilin, and more specifically against the luminal loop 1 of presenilin, for use in the treatment of cancer, by way of administrating a therapeutically effective quantity of the antibody or a fragment thereof, or a pharmaceutical composition comprising thereof, to a subject who suffers from cancer.

公开(公告)号：US20230271008A1

公开(公告)日：2023-08-31

申请号：US18068822

申请日：2022-12-20

Applicant: Universidad de Salamanca

Inventor： Enrique Alejandro López-Poveda

IPC: A61N1/36 ,  A61N1/02 ,  A61N1/05

CPC classification number: A61N1/36038 ,  A61N1/025 ,  A61N1/0541 ,  A61N1/36167 ,  A61N1/36039

Abstract: A signal processing arrangement is described for signal processing in a bilateral hearing implant system. A channel compression module develops a inhibition-adjusted band pass signal for each band pass signal using a channel-specific dynamic inhibition adjustment based on a channel-normalized medial olivocochlear reflex model that reflects bandwidth energy for a corresponding contralateral band pass signal and bandwidth energy for a selected reference contralateral band pass signal.

公开(公告)号：US11035737B2

公开(公告)日：2021-06-15

申请号：US16615179

申请日：2018-06-26

Applicant: SPHERE ULTRAFAST PHOTONICS SL ,  UNIVERSIDAD DE SALAMANCA

Inventor： Benjamin Alonso Fernandez ,  Inigo Juan Sola Larranaga ,  Helder Manuel Paiva Rebelo Cerejo Crespo

IPC: G01J11/00 ,  G02F1/35

Abstract: The present application relates to a method and system for characterization and compression of ultrashort pulses. It is described a flexible self-calibrating dispersion-scan technique and respective system to characterize and compress ultrashort laser pulses over a broad range of pulse parameters, where previous knowledge of the amount of dispersion introduced for each position or step of the compressor is not required. The self-calibrating d-scan operation is based on the numerical retrieval of the spectral phase of the pulses using an optimization algorithm, where the spectral phase is treated as a multi-parameter unknown variable, and where the unknown dispersion of the dispersion scanning system is described by a theoretical model of its functional dependence on the compressor position.