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公开(公告)号：US20190111002A1
公开(公告)日：2019-04-18
申请号：US16091071
申请日：2017-04-04
Applicant: UNIVERSIDADE DE SANTIAGO DE COMPOSTELA , UNIVERSIDAD DEL PAIS VASCO - EUSKAL HERRIKO UNIBERTSITATEA (UPV/EHU)
Inventor： Alejandro SÁNCHEZ BARREIRO , Inés FERNÁNDEZ PIÑEIRO , Iker BADIOLA , Joana MÁRQUEZ
IPC: A61K9/51 , A61K31/7105
Abstract: The invention relates to a nanoparticle comprising: (i) between 60 wt.-% and 99 wt.-% sorbitan ester, relative to the total weight of the nanoparticle; (ii) a positively charged substance; and (iii) a miRNA. The invention also relates to the methods for producing same and to the uses thereof, particularly for therapeutic uses, such as cancer treatment.
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公开(公告)号：US20180258473A1
公开(公告)日：2018-09-13
申请号：US15755485
申请日：2016-10-10
Applicant: ADMINISTRACION GENERAL DE LA COMUNIDAD AUTONOMA DE EUSKADI , UNIVERSIDAD DEL PAIS VASCO/EUSKAL HERRIKO UNIBERTSITATEA , BASQUE CENTER FOR MACROMOLECULAR DESIGN AND ENGINEERING, POLYMAT FUNDAZIOA
Inventor： Charles Henderson Lawrie , Lourdes Basabe-Desmonts , Thomas Schäfer , Luis Manuel Liz Marzán , Wolfgang Johann Parak
IPC: C12Q1/6823 , B01L3/00 , C12Q1/6827
CPC classification number: C12Q1/6823 , B01L3/502707 , B01L3/502761 , B82Y30/00 , C12Q1/6827 , C12Q2523/313 , C12Q2527/101 , C12Q2527/107 , C12Q2537/125 , C12Q2563/155 , C12Q2563/159 , C12Q2565/113 , C12Q2565/519 , C12Q2600/156 , G01N33/542 , G01N33/54346 , C12Q2547/107
Abstract: The present invention provides a method for detecting the presence or absence of a target analyte in a test sample, comprising the steps: i) providing a plurality of detector nanoparticles comprising a first detector nanoparticle functionalised with a first probe specific for a first region of a target analyte and a second detector nanoparticle functionalised with a second probe specific for a second region of said target analyte; and ii) contacting said detector nanoparticles with a test sample under conditions suitable for the binding of the specific probes to the target analyte, wherein target analyte-induced agglomeration of the detector nanoparticles permits the release of a detectable signal means from a signal reservoir. Also provided are related devices and systems for performing the method of the invention.
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3.发明申请公开(公告)号：US20180050908A1
公开(公告)日：2018-02-22
申请号：US15553058
申请日：2016-02-19
Inventor： Alexander LÓPEZ URIONABARRENECHEA , Isabel DE MARCO RODRÍGUEZ , Blanca María CABALLERO IGLESIAS , Naia GASTELU OTAZUA , Ainhoa HERNÁNDEZ SÁINZ , Aitziber ADRADOS LÓPEZ DE VIÑASPRE , Jon SOLAR IRAZABAL
CPC classification number: C01B3/40 , B01D53/002 , B01D53/8668 , B01D2255/20753 , B01D2255/50 , B01J23/40 , B01J23/58 , B01J23/60 , B01J23/63 , B01J23/755 , B01J29/068 , B01J29/072 , B01J29/46 , B01J35/04 , B01J37/0201 , B01J37/0215 , B01J37/0246 , B01J37/0248 , B01J37/18 , B01J2229/186 , B29B17/02 , B29B17/04 , B29B2017/0496 , B29K2307/04 , C01B3/26 , C01B2203/0227 , C01B2203/0277 , C01B2203/1023 , C01B2203/1058 , C01B2203/1082 , C10B53/07 , C10K1/20 , C10K1/32 , C10K1/34
Abstract: A method for treating vapours generated during the pyrolysis of carbon fibre composites, such as production waste generated by the producers or composites of carbon fibre at the end of the service life thereof, includes, passing the vapours through a reactor which is at a high temperature and contains a solid material filler (solid bed), for example CSi, and optionally also a solid catalyst having an acid and/or reforming function, preferably both, for example a transition metal supported on an acid substrate, such as Ni on zeolite. Following the condensation of the vapours resulting from the treatment, an improved aqueous liquid phase, a minimum or non-existent organic fraction and a gaseous phase of increased added value are obtained.
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4.发明授权Catalyst-free methods of forming polyurethanes from pentafluorophenyl carbonates 有权从五氟苯基碳酸酯形成聚氨酯的无催化剂方法公开(公告)号：US09062160B1
公开(公告)日：2015-06-23
申请号：US14162222
申请日：2014-01-23
Applicant: International Business Machines Corporation , Agency For Science, Technology and Research , Universidad del Pais Vasco/Euskal Herriko Unibertsitatea
Inventor： Julian M. W. Chan , Daniel J. Coady , Amanda C. Engler , Jeannette M. Garcia , James L. Hedrick , Zhan Yuin Ong , Haritz Sardon , Yi Yan Yang
CPC classification number: C08G71/04 , C08G65/007 , C08G73/02 , C08G73/0206
Abstract: One catalyst-free method of forming a polyurethane comprises forming a first emulsion comprising a first monomer, a surfactant, a water immiscible organic solvent, and water. The first monomer comprises two or more pentafluorophenyl carbonate groups. The first emulsion is combined with an aqueous mixture containing a second monomer comprising two or more nucleophilic amine groups, thereby forming a second emulsion. The first and second monomers of the second emulsion are allowed to react by interfacial polymerization, thereby forming a polyurethane. The polyurethane can have a number average molecular weight (Mn) of about 30000 to about 80000. The method is compatible with introducing pendant functionality into the polyurethane by way of cyclic carbonate precursors to the first monomer.
Abstract translation: 形成聚氨酯的一种无催化剂的方法包括形成包含第一单体，表面活性剂，与水不混溶的有机溶剂和水的第一乳液。 第一单体包含两个或多个五氟苯基碳酸酯基团。 将第一乳液与含有包含两个或多个亲核胺基团的第二单体的含水混合物组合，从而形成第二乳液。 通过界面聚合使第二乳液的第一和第二单体反应，由此形成聚氨酯。 聚氨酯的数均分子量（Mn）可以为约30000至约80000.该方法与通过环状碳酸酯前体向第一单体引入侧链官能团相容。
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公开(公告)号：US12104015B2
公开(公告)日：2024-10-01
申请号：US17053562
申请日：2019-05-10
Applicant: UNIVERSIDAD DEL PAIS VASCO/EUSKAL HERRIKO UNIBERTSITATEA , BASQUE CENTER FOR MACROMOLECULAR DESIGN AND ENGINEERING, POLYMAT FUNDAZIOA
Inventor： David Mecerreyes Molero , Andere Basterretxea Gorostiza , Elena Gabirondo Amenabar , Haritz Sardon Muguruza
CPC classification number: C08G65/34 , B01J31/0225 , B01J31/0251 , B01J31/0298
Abstract: A method for the preparation of polyethers is provided, the method using a protic ionic salt formed by the combination of a Bronsted acid and a Bronsted base, as well as to the polyethers obtained using the method.
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Patent Agency Ranking
公开(公告)号：US11988595B2
公开(公告)日：2024-05-21
申请号：US17059915
申请日：2019-05-31
Inventor： Thomas Schafer , Iliane Rafaniello
CPC classification number: G01N17/008 , B01D61/145 , B01D65/02 , B01D65/109 , C02F1/008 , C02F1/444 , B01D2321/16 , C02F2303/14 , C02F2303/16 , C02F2303/20
Abstract: A method for the detection and monitoring of surface fouling from the nanoscale as a predictive or real-time monitoring tool is provided. Also provided are devices for carrying out the method, and to uses of the method, in particular for optimising cleaning procedures of devices or components thereof fouled by flows of foulant.
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公开(公告)号：US20230390308A1
公开(公告)日：2023-12-07
申请号：US18353525
申请日：2023-07-17
Applicant: UNIVERSIDAD DEL PAIS VASCO/EUSKAL HERRIKO UNIBERTSITATEA , ADMINISTRACION GENERAL DE LA COMUNIDAD AUTONOMA DE EUSKADI , FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE (IDIBELL) , UNIVERSIDAD DE SALAMANCA
Inventor： Jesus Maria BANALES ASURMENDI , Luis BUJANDA FERNANDEZ DE PIEROLA , Alvaro SANTOS LASO , Fernando Pedro COSSIO MORA , Ivan RIVILLA DE LA CRUZ , Francisco Javier CABALLERO CAMINO , Manel ESTELLER BADOSA , Jose Juan GARCIA MARIN
IPC: A61K31/58 , A61K31/575
CPC classification number: A61K31/58 , A61K31/575
Abstract: Compounds derived from ursodeoxycholic acid of formula (I) and to methods for obtaining same, as well as the use thereof in the treatment of polycystic diseases, particularly autosomal dominant polycystic liver disease, autosomal dominant polycystic kidney disease, or autosomal recessive polycystic kidney disease.
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公开(公告)号：US20210137946A1
公开(公告)日：2021-05-13
申请号：US16958429
申请日：2018-12-28
Applicant: UNIVERSIDAD DEL PAIS VASCO/EUSKAL HERRIKO UNIBERTSITATEA , ADMINISTRACION GENERAL DE LA COMUNIDAD AUTONOMA DE EUSKADI , FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE (IDIBELL) , UNIVERSIDAD DE SALAMANCA
Inventor： Jesus Maria BANALES ASURMENDI , Luis BUJANDA FERNANDEZ DE PIEROLA , Alvaro SANTOS LASO , Fernando Pedro COSSIO MORA , Ivan RIVILLA DE LA CRUZ , Francisco Javier CABALLERO CAMINO , Manel ESTELLER BADOSA , Jose Juan GARCIA MARIN
IPC: A61K31/58 , A61K31/575
Abstract: The present invention relates to compounds derived from ursodeoxycholic acid of formula (I), to methods for obtaining same, as well as the use thereof in the treatment of polycystic diseases, particularly autosomal dominant polycystic liver disease, autosomal dominant polycystic kidney disease, or autosomal recessive polycystic kidney disease.
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公开(公告)号：US20190271675A1
公开(公告)日：2019-09-05
申请号：US16345001
申请日：2017-10-26
Inventor： Fernando BENITO LÓPEZ , Janire SAEZ CASTAÑO
Abstract: An ion gel including a hydrogel in an ionic liquid, and a reactive system that changes colour upon reaction with the nitrite and a microfluidic device having a substrate with calibration reservoirs that are separated from one another and include an ion gel, a calibration reservoir of the hydrogel in the ionic liquid, a reservoir for holding a sample to be analysed, connected to a measuring reservoir including an ion gel via a microfluidic channel with a reducing agent, and a measuring reservoir including an ion gel of the invention where a sample to be analysed is held and methods for producing the ion gel and the device, as well as a method for colorimetrically determining and detecting nitrite and nitrate in contaminated water using the ion gel and the device.
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公开(公告)号：US20190160618A1
公开(公告)日：2019-05-30
申请号：US16305006
申请日：2017-05-11
Applicant: UNIVERSIDAD DEL PAIS VASCO - EUSKAL HERRIKO UNIBERTSITATEA (UPV/EHU) , FUNDACIÓN TECNALIA RESEARCH & INNOVATION
Inventor： Octavio Manuel PEREIRA NETO , Adrián RODRÍGUEZ EZQUERRO , López De Lacalle Marcaide LUIS , Franck Andrés GIROT MATA , Mariluz PENALVA OSCOZ , Rivero Rastrero MARIA ASUNCIÓN
IPC: B23Q11/10
Abstract: A device for cooling and lubricating a tool during a chip removal machining process, which includes: a first subsystem for cryogenic cooling that includes: a first entry configured to introduce CO2 in liquid state in a first conduit of the device; a first exit configured to supply CO2 in liquid state from a second conduit of the device; a third conduit located between the first and second conduit; and means for preventing the formation of dry ice in the first, second and third conduits; and a second subsystem for lubrication that includes means for supplying micro-particles of a cutting oil in liquid state; wherein the first subsystem and second subsystem are independent from each other, and wherein the first subsystem and second subsystem are configured to act either simultaneously or either one alone. Method of operation of the device.
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