公开(公告)号：US11833160B2

公开(公告)日：2023-12-05

申请号：US16958429

申请日：2018-12-28

Applicant: UNIVERSIDAD DEL PAIS VASCO/EUSKAL HERRIKO UNIBERTSITATEA ,  ADMINISTRACION GENERAL DE LA COMUNIDAD AUTONOMA DE EUSKADI ,  FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE (IDIBELL) ,  UNIVERSIDAD DE SALAMANCA

Inventor： Jesus Maria Banales Asurmendi ,  Luis Bujanda Fernandez De Pierola ,  Alvaro Santos Laso ,  Fernando Pedro Cossio Mora ,  Ivan Rivilla De La Cruz ,  Francisco Javier Caballero Camino ,  Manel Esteller Badosa ,  Jose Juan Garcia Marin

IPC: A61K31/58 ,  A61K31/575

CPC classification number: A61K31/58 ,  A61K31/575

Abstract: The present invention relates to compounds derived from ursodeoxycholic acid of formula (I), to methods for obtaining same, as well as the use thereof in the treatment of polycystic diseases, particularly autosomal dominant polycystic liver disease, autosomal dominant polycystic kidney disease, or autosomal recessive polycystic kidney disease.

公开(公告)号：US20200317625A1

公开(公告)日：2020-10-08

申请号：US16304041

申请日：2017-05-23

Applicant: UNIVERSIDAD DEL PAIS VASCO ,  ADMINISTRACION GENERAL DE LA COMUNIDAD AUTONOMA DE EUSKADI

Inventor： Ainara VALLEJO ILLARRAMENDI ,  Adolfo Jose LOPEZ DE MUNAIN ARREGI ,  Pablo FERRON CELMA ,  Jesus Maria AIZPURUA IPARRAGUIRRE ,  Aitziber IRASTORZA EPELDE ,  Jose Ignacio MIRANDA MURUA ,  Ivan TORAL OJEDA ,  Garazi ALDANONDO ARISTIZABAL

IPC: C07D249/04 ,  A61P21/00 ,  A61P9/04

Abstract: The present invention relates to 1,2,3-triazoles of formula: useful for improving or restoring the intracellular calcium homeostasis and RyR-calstabin binding function in human and animal cells. The present invention also relates to methods for synthesizing said compounds, to pharmaceutical compositions containing them, and to the use thereof for preventing or treating skeletal muscle, heart and nervous system disorders.

公开(公告)号：US20180258473A1

公开(公告)日：2018-09-13

申请号：US15755485

申请日：2016-10-10

Applicant: ADMINISTRACION GENERAL DE LA COMUNIDAD AUTONOMA DE EUSKADI ,  UNIVERSIDAD DEL PAIS VASCO/EUSKAL HERRIKO UNIBERTSITATEA ,  BASQUE CENTER FOR MACROMOLECULAR DESIGN AND ENGINEERING, POLYMAT FUNDAZIOA

Inventor： Charles Henderson Lawrie ,  Lourdes Basabe-Desmonts ,  Thomas Schäfer ,  Luis Manuel Liz Marzán ,  Wolfgang Johann Parak

IPC: C12Q1/6823 ,  B01L3/00 ,  C12Q1/6827

CPC classification number: C12Q1/6823 ,  B01L3/502707 ,  B01L3/502761 ,  B82Y30/00 ,  C12Q1/6827 ,  C12Q2523/313 ,  C12Q2527/101 ,  C12Q2527/107 ,  C12Q2537/125 ,  C12Q2563/155 ,  C12Q2563/159 ,  C12Q2565/113 ,  C12Q2565/519 ,  C12Q2600/156 ,  G01N33/542 ,  G01N33/54346 ,  C12Q2547/107

Abstract: The present invention provides a method for detecting the presence or absence of a target analyte in a test sample, comprising the steps: i) providing a plurality of detector nanoparticles comprising a first detector nanoparticle functionalised with a first probe specific for a first region of a target analyte and a second detector nanoparticle functionalised with a second probe specific for a second region of said target analyte; and ii) contacting said detector nanoparticles with a test sample under conditions suitable for the binding of the specific probes to the target analyte, wherein target analyte-induced agglomeration of the detector nanoparticles permits the release of a detectable signal means from a signal reservoir. Also provided are related devices and systems for performing the method of the invention.

公开(公告)号：US20230390308A1

公开(公告)日：2023-12-07

申请号：US18353525

申请日：2023-07-17

Applicant: UNIVERSIDAD DEL PAIS VASCO/EUSKAL HERRIKO UNIBERTSITATEA ,  ADMINISTRACION GENERAL DE LA COMUNIDAD AUTONOMA DE EUSKADI ,  FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE (IDIBELL) ,  UNIVERSIDAD DE SALAMANCA

Inventor： Jesus Maria BANALES ASURMENDI ,  Luis BUJANDA FERNANDEZ DE PIEROLA ,  Alvaro SANTOS LASO ,  Fernando Pedro COSSIO MORA ,  Ivan RIVILLA DE LA CRUZ ,  Francisco Javier CABALLERO CAMINO ,  Manel ESTELLER BADOSA ,  Jose Juan GARCIA MARIN

IPC: A61K31/58 ,  A61K31/575

CPC classification number: A61K31/58 ,  A61K31/575

Abstract: Compounds derived from ursodeoxycholic acid of formula (I) and to methods for obtaining same, as well as the use thereof in the treatment of polycystic diseases, particularly autosomal dominant polycystic liver disease, autosomal dominant polycystic kidney disease, or autosomal recessive polycystic kidney disease.

公开(公告)号：US11377427B2

公开(公告)日：2022-07-05

申请号：US16304041

申请日：2017-05-23

Applicant: UNIVERSIDAD DEL PAIS VASCO ,  ADMINISTRACION GENERAL DE LA COMUNIDAD AUTONOMA DE EUSKADI

Inventor： Ainara Vallejo Illarramendi ,  Adolfo Jose Lopez De Munain Arregi ,  Pablo Ferron Celma ,  Jesus Maria Aizpurua Iparraguirre ,  Aitziber Irastorza Epelde ,  Jose Ignacio Miranda Murua ,  Ivan Toral Ojeda ,  Garazi Aldanondo Aristizabal

IPC: C07D249/04 ,  A61P21/00 ,  A61P9/04 ,  A61K9/00

Abstract: The present invention relates to 1,2,3-triazoles of formula: useful for improving or restoring the intracellular calcium homeostasis and RyR-calstabin binding function in human and animal cells. The present invention also relates to methods for synthesizing said compounds, to pharmaceutical compositions containing them, and to the use thereof for preventing or treating skeletal muscle, heart and nervous system disorders.

公开(公告)号：US20210137946A1

公开(公告)日：2021-05-13

申请号：US16958429

申请日：2018-12-28

Applicant: UNIVERSIDAD DEL PAIS VASCO/EUSKAL HERRIKO UNIBERTSITATEA ,  ADMINISTRACION GENERAL DE LA COMUNIDAD AUTONOMA DE EUSKADI ,  FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE (IDIBELL) ,  UNIVERSIDAD DE SALAMANCA

Inventor： Jesus Maria BANALES ASURMENDI ,  Luis BUJANDA FERNANDEZ DE PIEROLA ,  Alvaro SANTOS LASO ,  Fernando Pedro COSSIO MORA ,  Ivan RIVILLA DE LA CRUZ ,  Francisco Javier CABALLERO CAMINO ,  Manel ESTELLER BADOSA ,  Jose Juan GARCIA MARIN

IPC: A61K31/58 ,  A61K31/575

Abstract: The present invention relates to compounds derived from ursodeoxycholic acid of formula (I), to methods for obtaining same, as well as the use thereof in the treatment of polycystic diseases, particularly autosomal dominant polycystic liver disease, autosomal dominant polycystic kidney disease, or autosomal recessive polycystic kidney disease.

公开(公告)号：US20150141882A1

公开(公告)日：2015-05-21

申请号：US14335430

申请日：2014-07-18

Applicant: SIBEL, S.A. ,  ADMINISTRACION GENERAL DE LA COMUNIDAD AUTONOMA DE EUSKADI

Inventor： Daniel OREJA PUERTO ,  Jordi RIGAU RIGAU ,  Joaquin J. DURAN CANTOLLA

IPC: A61F5/56 ,  A61H11/00 ,  A61H23/02

CPC classification number: A61F5/56 ,  A61H11/00 ,  A61H23/0263 ,  A61H2201/501 ,  A61H2201/5064 ,  A61H2201/5084 ,  A61H2205/02 ,  A61H2230/625

Abstract: The invention relates to an improved cranial device with a rotary inclination detector, including a container box which can be secured to the cranium of sleeping person and which contains an electric motor and an eccentric counterweight coupled thereto, forming a vibrator. The device also includes a battery or a battery holder for at least one battery, which is provided with two axially opposed projecting contacts or studs. The container box is provided with inclined formations with dielectric properties, on which the battery or battery holder can roll by means of the studs thereof, and two electric contacts on which the inclined formations terminate, such that, when the battery holder is placed on the electric contacts, the motor circuit is closed, thereby activating the vibrator.

Abstract translation: 本发明涉及一种具有旋转倾斜检测器的改进的颅面装置，其包括可固定到睡眠者的颅骨的容器箱，其包含电动机和耦合到其上的偏心配重，形成振动器。 该装置还包括用于至少一个电池的电池或电池保持器，其设置有两个轴向相对的突出触头或螺柱。 容器箱设置有具有介电特性的倾斜结构，电池或电池座可以借助它的螺柱滚动，两个电触点在其上倾斜结构终止，使得当电池座放置在 电触点，电机电路闭合，从而激活振动器。