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公开(公告)号：US20190256817A1
公开(公告)日：2019-08-22
申请号：US16347104
申请日：2017-11-03
发明人： Steven C. Gebhart , Robert W. McClellan , Nicholas C. Trotta , Nancy L. Allbritton , Peter Joseph Attayek , Paul Michael Armistead
摘要： Embodiments of the disclosed subject matter provide an automated method and system to isolate and collect cells using computerized analysis of images of cells and their surroundings obtained from a digital imaging device or system. Embodiments of the disclosed subject matter make use of a “microwell array,” which can comprise a formed, elastomeric grid of indentations or “wells.” Many, most, or all of the wells in a microwell array can contain a releasable, microfabricated element, which can be referred to as a “raft.” Embodiments of the disclosed subject matter provide a system and method for cell collection that includes computerized identification and collection of rafts with isolated single cells or a specific group or groups of cells, eliminating the need for continuous human identification and selection.
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公开(公告)号：US12103003B2
公开(公告)日：2024-10-01
申请号：US17048153
申请日：2019-11-05
IPC分类号： B01L3/00
CPC分类号： B01L3/502761 , B01L2200/0668 , B01L2300/0816 , B01L2300/0819 , B01L2300/0829 , B01L2300/1827 , B01L2400/043
摘要： Analysis systems with a housing having a chamber sized and configured to receive at least one microfluidic device. The systems also include an optic system coupled to the housing in optical communication with the at least one microfluidic device, a controller coupled to the optic system, a heat source coupled to the optic system and thermally coupled to the at least one microfluidic device held in the housing, and a sub-array selection module in communication with the controller. The sub-array selection module is configured to select a sub-set of sets of microwells of at least one fluid channel of the microfluidic device for imaging by the optic system after a reaction step (e.g., one thermocycle) during an assay.
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公开(公告)号：US20240197830A1
公开(公告)日：2024-06-20
申请号：US18419845
申请日：2024-01-23
申请人： University of Pittsburgh - Of the Commonwealth System of Higher Education , Tuskegee University , The University of North Carolina at Chapel Hill , The United Government as represented by the Department of Veterans Affairs
发明人： Cecelia C. Yates-Binder , Jesse Jaynes , Monte S. Willis , Richard J. Bodnar , Zariel I. Johnson
CPC分类号： A61K38/195 , A61P9/10 , A61P35/00 , C07K7/02 , C12N15/113 , C12N15/62 , C12N15/86
摘要： Interferon-γ-inducible protein 10 (IP-10) peptides, IP-10 peptide variants and in silico designed C-X-C chemokine receptor 3 (CXCR3) peptide agonists are described. The small peptides can be used for inhibiting pathological tissue remodeling and treating fibrosis in a subject, such as a subject with fibrosis of the heart, lung, liver, kidney or skin. The peptide agonists can also be used to treat cardiovascular disease, including myocardial infarction and ischemia-reperfusion injury. Also described are in silico designed peptide antagonists that bind CXCR3 or ligands of CXCR3. These antagonist peptides block CXCR3 signaling by disrupting interaction of CXCR3 with its ligand. Antagonist peptides can be used, for example, to treat myocarditis and atherosclerosis. In additional embodiments agonists and antagonists of CXCR4 are disclosed.
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公开(公告)号：US20240197637A1
公开(公告)日：2024-06-20
申请号：US18287093
申请日：2022-04-13
IPC分类号： A61K9/16 , A61K31/537 , A61K31/573 , A61K31/7105 , A61K45/06 , A61P19/02
CPC分类号： A61K9/1647 , A61K31/537 , A61K31/573 , A61K31/7105 , A61K45/06 , A61P19/02
摘要： The present invention relates to drug-delivery compositions comprising microparticles with the shape of a prism comprising at least one polymer and at least one CCR2 inhibitor. Preferably said composition is for the treatment of local chronic inflammation diseases, such as osteoarthritis.
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公开(公告)号：US20240190949A1
公开(公告)日：2024-06-13
申请号：US18412245
申请日：2024-01-12
发明人： Nancy Demore , Cam Patterson
CPC分类号： C07K16/18 , A61P35/00 , C07K16/2818 , C07K16/3015 , C07K16/303 , A61K2039/505 , C07K2317/24
摘要： The present disclosure provides humanized antibodies and antigen-binding fragments thereof that specifically bind to SFRP2 and compositions comprising such humanized antibodies or antigen-binding fragments thereof. In some aspects, the humanized antibodies or antigen-binding fragments can be used to treat diseases or conditions associated with increased SFRP2, such as cancer. In some aspects, the antibodies or antigen-binding fragments can be used to treat osteosarcoma.
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公开(公告)号：US11993627B2
公开(公告)日：2024-05-28
申请号：US16625342
申请日：2018-07-03
CPC分类号： C07H3/06 , C07H11/00 , C08B37/0063 , C08B37/0069 , C12N9/1048 , C12N9/13 , C12P19/26
摘要： Methods of synthesizing chondroitin sulfate oligosaccharides are provided. Enzymatic schematic approaches to synthesizing structurally defined homogenous chondroitin sulfate oligosaccharides at high yields are provided. Synthetic chondroitin sulfate oligosaccharides ranging from 3-mers to 15-mers are provided.
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7.发明公开公开(公告)号：US20240156737A1
公开(公告)日：2024-05-16
申请号：US18391998
申请日：2023-12-21
发明人： Martina Kovarova , Soumya Rahima Benhabbour , J. Victor Garcia-Martinez , Panita Maturavongsadit
CPC分类号： A61K9/204 , A61K9/0024 , A61K9/2095 , A61K45/06
摘要： Disclosed herein are polymeric implants and controlled release drug delivery systems to provide high drug loading and long-acting drug release. Provided herein are methods for making the same. Methods of administering pharmacologically active agents via the disclosed polymeric implants and controlled release drug delivery systems are also provided.
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公开(公告)号：US20240101973A1
公开(公告)日：2024-03-28
申请号：US18184198
申请日：2023-03-15
发明人： Darrel W. Stafford , Tao Li
IPC分类号： C12N9/04 , C12N9/50 , C12N9/64 , C12N9/88 , C12Q1/6883
CPC分类号： C12N9/0006 , C12N9/50 , C12N9/64 , C12N9/88 , C12Q1/6883 , C12Y101/04001 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172 , C12Y304/21006 , C12Y401/0109
摘要： The present invention relates to methods and compositions for improving the productivity of recombinant vitamin K dependent protein expression in host cells.
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公开(公告)号：US20240099984A1
公开(公告)日：2024-03-28
申请号：US17769042
申请日：2020-10-15
CPC分类号： A61K9/7007 , A61K9/0034 , A61K31/167 , A61K47/38 , A61K47/42 , A61P29/00
摘要： Provided are biodissolvable films for localized treatment of a disorder of the female genital tract. The biodissolvable films are made of polymers forming a film suitable for application to a tissue of a female genital tract, where the film has a mucoadhesive property. Such films further include an active ingredient integrated and/or loaded into the biodissolvable film. Methods of treating inflammatory, atrophic and/or irritative disorders, including Vestibulodynia (VBD), are also provided.
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10.发明授权公开(公告)号：US11920042B2
公开(公告)日：2024-03-05
申请号：US17422842
申请日：2020-01-14
发明人： Jinsong Huang , Guang Yang , Wuqiang Wu
IPC分类号： C09D11/033 , C03C17/34 , C03C17/42 , H10K30/88
CPC分类号： C09D11/033 , C03C17/3447 , C03C17/42 , H10K30/88
摘要： Described herein is an ink solution, comprising: i. a composition having the formula ABX3; ii. a compound having the formula NH2—R1—NH2; and iii. a solvent. Methods for producing polycrystalline perovskite films using the ink solutions described herein in a fast blading process and the use of the films in photoactive and photovoltaic applications are additionally described.
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