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    BOND-SELECTIVE FULL-FIELD OPTICAL COHERENCE TOMOGRAPHY
    4.
    发明申请
    BOND-SELECTIVE FULL-FIELD OPTICAL COHERENCE TOMOGRAPHY 有权

    公开(公告)号：US20250012557A1

    公开(公告)日：2025-01-09

    申请号：US18761623

    申请日：2024-07-02

    Applicant: Trustees of Boston University

    Inventor： Ji-Xin Cheng ,  Haonan Zong ,  Celalettin Yurdakul ,  M. Selim Ünlü

    IPC: G01B9/02091

    Abstract: A wide-field bond-selective optical coherence tomography (OCT) system and method for imaging a sample includes generating infrared light and directing the infrared light onto the sample to selectively heat the sample. Probe light is also directed onto the sample. A first actuator provides sample depth scanning with respect to a first objective in a reference arm of the system, and a second actuator provides sample depth scanning with respect to a second objective in a sample arm of the system. A detection system receives scattered probe light reflected from the sample. A change in the received probe light from the sample that is indicative of absorption of infrared light.

    Production of red blood cells and platelets from stem cells
    5.
    发明授权
    Production of red blood cells and platelets from stem cells 有权

    公开(公告)号：US12173320B2

    公开(公告)日：2024-12-24

    申请号：US17407349

    申请日：2021-08-20

    Applicant: BOSTON MEDICAL CENTER CORPORATION ,  TRUSTEES OF BOSTON UNIVERSITY

    Inventor： George J. Murphy ,  David H. Sherr ,  Sarah S. Rozelle ,  Brenden W. Smith

    IPC: C12N5/0789 ,  A61K31/404 ,  A61K31/655 ,  A61K35/18 ,  A61K35/19 ,  A61K45/06 ,  C12N5/078 ,  G01N33/50 ,  G01N33/80 ,  G01N33/86 ,  A61K35/12

    Abstract: This disclosure provides methods of making a megakaryocyte-erythroid progenitor cell (MEP), comprising differentiating a MEP precursor cell into a MEP in culture in the presence of an aryl hydrocarbon receptor (AhR) modulator. In some embodiments the AhR modulator is an AhR antagonist. In some embodiments the AhR modulator is an AhR agonist. In some embodiments the methods comprise culturing MEP precursor cells in the presence of an AHR antagonist and then culturing MEP precursor cells in the presence of an AHR agonist. In some embodiments the stem cell is a pluripotent stem cell. In some embodiments the MEP co-expresses CD41 and CD235. In some embodiments the number of MEPs produced in the culture increases exponentially. Methods of making a red blood cell (RBC) by culturing a MEP in the presence of an AhR modulator are also provided. Methods of making a megakaryocyte and/or a platelet, comprising culturing a MEP in the presence of an AhR modulator are also provided. In some embodiments the AhR modulator is an AhR antagonist. This disclosure also provides compositions comprising at least 1 million MEPs per ml and compositions in which at least 50% of the cells are MEPs, among other things.

    SEMI-CUSTOM ACCELERATOR DEVICE FOR BOOTSTRAPPABLE FULLY HOMOMORPHIC ENCRYPTION
    6.
    发明申请
    SEMI-CUSTOM ACCELERATOR DEVICE FOR BOOTSTRAPPABLE FULLY HOMOMORPHIC ENCRYPTION 有权

    公开(公告)号：US20240421971A1

    公开(公告)日：2024-12-19

    申请号：US18742330

    申请日：2024-06-13

    Applicant: Trustees of Boston University

    Inventor： Rashmi S. Agrawal ,  Ajay J. Joshi

    IPC: H04L9/00

    Abstract: An FPGA-based accelerator for bootstrappable fully homomorphic encryption (FHE) employs (1) acceleration of scalar arithmetic operations using a multi-word approach for efficient utilization of standard-width components (multipliers/adders) on custom-width operands; (2) a performant, shift-based modular reduction technique that avoids the need for expensive multipliers; (3) an improved datapath for an expensive Key Switch operation; and (4) an efficient organization of on-chip memory for storing custom-width operands and supplying them at high bandwidth to computation units.

    Dark-field mid-infrared photothermal microscopy
    7.
    发明授权
    Dark-field mid-infrared photothermal microscopy 有权

    公开(公告)号：US12147022B2

    公开(公告)日：2024-11-19

    申请号：US18205152

    申请日：2023-06-02

    Applicant: Trustees of Boston University

    Inventor： Ji-Xin Cheng ,  Celalettin Yurdakul ,  Haonan Zong ,  M. Selim Ünlü

    IPC: G02B21/16 ,  G02B21/02 ,  G02B21/36

    Abstract: Microscopic analysis of a sample includes a system using dark-field illumination. A mid-IR optical source generates a mid-infrared beam, which is directed onto the sample to induce a temperature change by absorption of the mid-infrared beam. A visible light source generates a light illuminating the sample on a substrate and creating a scattered field and a reflected field along a collection path of the system. A pupil mask is positioned along the collection path to block the reflected field while allowing the scattered field to pass therethrough. A camera is positioned at an end of the collection path to collect the scattered field and generate a dark-field image of the sample.

    Inhibitors of aortic carboxypeptidase-like protein (ACLP)
    9.
    发明授权
    Inhibitors of aortic carboxypeptidase-like protein (ACLP) 有权

    公开(公告)号：US12139542B2

    公开(公告)日：2024-11-12

    申请号：US15313257

    申请日：2015-05-27

    Applicant: TRUSTEES OF BOSTON UNIVERSITY

    Inventor： Matthew D. Layne ,  Kathleen E. Tumelty ,  Robert Lafyatis

    IPC: C07K16/28 ,  A61K38/16

    Abstract: The present invention generally relates to the field of treatment of fibroproliferative diseases and disorders and cancer. Embodiments of the present invention generally relate to compostions, methods and kits comprising an inhibitor of a portion of the N-terminal pro-fibrotic domain (PFD) of Aortic Carboxypeptidase-Like Protein (ACLP), and in some embodiments, in combination with an inhibitor of the discoidin (DS) domain of ACLP, for use in methods for the treatment of fibroproliferative diseases and cancer, and inhibition of ACLP-mediated activation of a member of the TGFβ receptor superfamily.

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