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    System and method for acceleration of image reconstruction
    2.
    发明授权
    System and method for acceleration of image reconstruction 有权
    用于加速图像重建的系统和方法

    公开(公告)号：US08687869B2

    公开(公告)日：2014-04-01

    申请号：US12095662

    申请日：2006-11-30

    申请人： Jerome Z. Liang ,  Zigang Wang

    发明人： Jerome Z. Liang ,  Zigang Wang

    IPC分类号： G06K9/00

    CPC分类号： G06T11/006 ,  G06T2211/424

    摘要： A method for reconstructing an image from emission data includes generating a compressed point-spread function matrix, generating an accumulated attenuation factor; and performing at least one image projection operation on an image matrix of the emission data using the compressed point-spread function matrix and the accumulated attenuation factor. The image projection operation can include rotating an image matrix and an exponential attenuation map to align with a selected viewing angle. An accumulated attenuation image is then generated from the rotated image matrix and rotated exponential attenuation map and a projection image is generated for each voxel by multiplying the accumulated attenuation image and point spread function matrix for each voxel. The rotating and multiplying operations can be performed on a graphics processing unit, which may be found in a commercially available video processing card, which are specifically designed to efficiently perform such operations.

    摘要翻译： 一种从发射数据重建图像的方法，包括生成压缩点扩散函数矩阵，产生累积衰减因子; 以及使用压缩的点扩散函数矩阵和累积的衰减因子对发射数据的图像矩阵执行至少一个图像投影操作。 图像投影操作可以包括旋转图像矩阵和指数衰减图以与选择的视角对准。 然后从旋转的图像矩阵生成累积的衰减图像并旋转指数衰减图，并且通过将累积的衰减图像和每个体素的点扩散函数矩阵相乘，为每个体素生成投影图像。 旋转和乘法运算可以在图形处理单元上执行，该图形处理单元可以在市售的视频处理卡中找到，其专门用于有效地执行这种操作。

    Nanosphere/microsphere delivery system for the treatment of spinal cord injury
    4.
    发明申请
    Nanosphere/microsphere delivery system for the treatment of spinal cord injury 审中-公开
    纳米球/微球输送系统治疗脊髓损伤

    公开(公告)号：US20070116697A1

    公开(公告)日：2007-05-24

    申请号：US11452721

    申请日：2006-06-14

    申请人： Donna Osterhout ,  Julie Hasenwinkel ,  Dennis Stelzner

    发明人： Donna Osterhout ,  Julie Hasenwinkel ,  Dennis Stelzner

    IPC分类号： A61K38/47 ,  A61K9/14

    CPC分类号： A61K9/0019 ,  A61K9/1647 ,  A61K9/5153 ,  A61K38/51

    摘要： A formulation including injectable biodegradable nanospheres and/or microspheres as a delivery system for chondroitinase ABC (cABC) or a functional derivative of cABC to treat acute and chronic spinal chord injury in a mammal having the same is provided. The biodegradable nanosphere/microsphere formulation releases cABC or a functional derivative of cABC in a time-released manner at the site of the spinal cord injury. cABC infusion can promote axon regrowth and some behavioral recovery. The nanospheres and/or microspheres provided herein include cABC or a functional derivative of cABC loaded within and/or on a biodegradable polymer matrix. In some embodiments of the present invention, the surface of the biodegradable polymer matrix can be modified to target a specific scar site. In addition to providing a nanosphere formulation that include polymeric incorporated cABC, a method of treating a mammal having a spinal cord injury is also provided.

    摘要翻译： 提供了包含可注射的可生物降解的纳米球和/或微球作为软骨素酶ABC（cABC）的递送系统或cABC的功能性衍生物，用于治疗哺乳动物中的急性和慢性脊髓和弦损伤的制剂。 可生物降解的纳米球/微球体制剂在脊髓损伤部位以释放时间的方式释放cABC或cABC的功能衍生物。 cABC输注可以促进轴突再生和一些行为恢复。 本文提供的纳米球和/或微球包括cABC或负载在生物可降解聚合物基质内和/或上的cABC的功能性衍生物。 在本发明的一些实施方案中，生物可降解聚合物基质的表面可以被修饰以靶向特定的瘢痕部位。 除了提供包括聚合物掺入的cABC的纳米球配方之外，还提供了治疗具有脊髓损伤的哺乳动物的方法。

    DENTAL ANTI-HYPERSENSITIVITY COMPOSITION AND METHOD
    6.
    发明申请
    DENTAL ANTI-HYPERSENSITIVITY COMPOSITION AND METHOD 审中-公开
    牙齿抗高血压组合物和方法

    公开(公告)号：US20080233054A1

    公开(公告)日：2008-09-25

    申请号：US11836041

    申请日：2007-08-08

    申请人： Israel Kleinberg ,  Ana Marie Acevedo ,  Robi Chatterjee

    发明人： Israel Kleinberg ,  Ana Marie Acevedo ,  Robi Chatterjee

    IPC分类号： A61K8/43 ,  A61K8/55 ,  A61K9/68 ,  A23L1/30 ,  A23L1/236

    CPC分类号： A61K8/42 ,  A61K6/0017 ,  A61K6/0035 ,  A61K8/0241 ,  A61K8/19 ,  A61K8/44 ,  A61K2800/59 ,  A61Q11/00 ,  Y10S514/835

    摘要： The present invention relates to compositions and methods for calcifying dental tissue, e.g., preventing or treating dental hypersensitivity. An oral composition of arginine bicarbonate and calcium carbonate promotes the formation of dentinal tubule plugs aided by combining calcium and phosphate in the fluid. In a specific example, an arginine bicarbonate/calcium carbonate mixture blocked dentinal tubules in a model system. In addition to treating dentinal sensitivity, the compositions and methods of the invention provide for calcifying exposed tooth pulp, calcifying the base or all of a pit or fissure in a tooth, and treating a carious lesion.

    摘要翻译： 本发明涉及用于钙化牙组织的组合物和方法，例如预防或治疗牙齿超敏反应。 精氨酸碳酸氢盐和碳酸钙的口服组合物促进通过在流体中混合钙和磷酸盐辅助的牙质小管塞的形成。 在具体实例中，精氨酸碳酸氢盐/碳酸钙混合物在模型系统中封闭牙质小管。 除了治疗牙质敏感性之外，本发明的组合物和方法提供钙化暴露的牙髓，钙化基底或全部牙齿中的凹坑或裂缝，以及治疗龋损。