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公开(公告)号：US20080233054A1
公开(公告)日：2008-09-25
申请号：US11836041
申请日：2007-08-08
CPC分类号： A61K8/42 , A61K6/0017 , A61K6/0035 , A61K8/0241 , A61K8/19 , A61K8/44 , A61K2800/59 , A61Q11/00 , Y10S514/835
摘要： The present invention relates to compositions and methods for calcifying dental tissue, e.g., preventing or treating dental hypersensitivity. An oral composition of arginine bicarbonate and calcium carbonate promotes the formation of dentinal tubule plugs aided by combining calcium and phosphate in the fluid. In a specific example, an arginine bicarbonate/calcium carbonate mixture blocked dentinal tubules in a model system. In addition to treating dentinal sensitivity, the compositions and methods of the invention provide for calcifying exposed tooth pulp, calcifying the base or all of a pit or fissure in a tooth, and treating a carious lesion.
摘要翻译： 本发明涉及用于钙化牙组织的组合物和方法，例如预防或治疗牙齿超敏反应。 精氨酸碳酸氢盐和碳酸钙的口服组合物促进通过在流体中混合钙和磷酸盐辅助的牙质小管塞的形成。 在具体实例中，精氨酸碳酸氢盐/碳酸钙混合物在模型系统中封闭牙质小管。 除了治疗牙质敏感性之外，本发明的组合物和方法提供钙化暴露的牙髓，钙化基底或全部牙齿中的凹坑或裂缝，以及治疗龋损。
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公开(公告)号：US06524558B2
公开(公告)日：2003-02-25
申请号：US09940723
申请日：2001-08-27
IPC分类号： A61K716
CPC分类号： A61K8/42 , A61K6/0017 , A61K6/0035 , A61K8/0241 , A61K8/19 , A61K8/44 , A61K2800/59 , A61Q11/00 , Y10S514/835
摘要： The present invention relates to compositions and methods for calcifying dental tissue, e.g., preventing or treating dental hypersensitivity. An oral composition of arginine bicarbonate and calcium carbonate promotes the formation of dentinal tubule plugs aided by combining calcium and phosphate in the fluid. In a specific example, an arginine bicarbonate/calcium carbonate mixture blocked dentinal tubules in a model system. In addition to treating dentinal sensitivity, the compositions and methods of the invention provide for calcifying exposed tooth pulp, calcifying the base or all of a pit or fissure in a tooth, and treating a carious lesion.
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公开(公告)号：US20120027828A1
公开(公告)日：2012-02-02
申请号：US13250412
申请日：2011-09-30
CPC分类号： A61K8/42 , A61K6/0017 , A61K6/0035 , A61K8/0241 , A61K8/19 , A61K8/44 , A61K2800/59 , A61Q11/00 , Y10S514/835
摘要： The present invention relates to compositions and methods for calcifying dental tissue, e.g., preventing or treating dental hypersensitivity. An oral composition of arginine bicarbonate and calcium carbonate promotes the formation of dentinal tubule plugs aided by combining calcium and phosphate in the fluid. In a specific example, an arginine bicarbonate/calcium carbonate mixture blocked dentinal tubules in a model system. In addition to treating dentinal sensitivity, the compositions and methods of the invention provide for calcifying exposed tooth pulp, calcifying the base or all of a pit or fissure in a tooth, and treating a carious lesion.
摘要翻译： 本发明涉及用于钙化牙组织的组合物和方法，例如预防或治疗牙齿超敏反应。 精氨酸碳酸氢盐和碳酸钙的口服组合物促进通过在流体中混合钙和磷酸盐辅助的牙质小管塞的形成。 在具体实例中，精氨酸碳酸氢盐/碳酸钙混合物在模型系统中封闭牙质小管。 除了治疗牙质敏感性之外，本发明的组合物和方法提供钙化暴露的牙髓，钙化基底或全部牙齿中的凹坑或裂缝，以及治疗龋损。
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公开(公告)号：US06436370B1
公开(公告)日：2002-08-20
申请号：US09504264
申请日：2000-02-15
IPC分类号： A61K716
CPC分类号： A61K8/42 , A61K6/0017 , A61K6/0035 , A61K8/0241 , A61K8/19 , A61K8/44 , A61K2800/59 , A61Q11/00 , Y10S514/835
摘要： The present invention relates to compositions and methods for calcifying dental tissue, e.g., preventing or treating dental hypersensitivity. An oral composition of arginine bicarbonate and calcium carbonate promotes the formation of dentinal tubule plugs aided by combining calcium and phosphate in the fluid. In a specific example, an arginine bicarbonate/calcium carbonate mixture blocked dentinal tubules in a model system. In addition to treating dentinal sensitivity, the compositions and methods of the invention provide for calcifying exposed tooth pulp, calcifying the base or all of a pit or fissure in a tooth, and treating a carious lesion.
摘要翻译： 本发明涉及用于钙化牙组织的组合物和方法，例如预防或治疗牙齿超敏反应。 精氨酸碳酸氢盐和碳酸钙的口服组合物促进通过在流体中混合钙和磷酸盐辅助的牙质小管塞的形成。 在具体实例中，精氨酸碳酸氢盐/碳酸钙混合物在模型系统中封闭牙质小管。 除了治疗牙质敏感性之外，本发明的组合物和方法提供钙化暴露的牙髓，钙化基底或全部牙齿中的凹坑或裂缝，以及治疗龋损。
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