知搜-全球专利检索

  1. Login
  2. Sign Up

Search Results

1509 records (took 0.118 seconds)

    METHOD FOR THE GENERATION OF OUTER RADIAL GLIAL (ORG) CELLS
    1.
    发明申请
    METHOD FOR THE GENERATION OF OUTER RADIAL GLIAL (ORG) CELLS 有权

    公开(公告)号：US20250066723A1

    公开(公告)日：2025-02-27

    申请号：US18843203

    申请日：2023-03-02

    Applicant: MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. ,  RAMOT AT TEL-AVIV UNIVERSITY LTD.

    Inventor： Yechiel ELKABETZ ,  Naresh MUTUKULA ,  Sneha ARORA ,  Daniel ROSEBROCK

    IPC: C12N5/079 ,  C12N5/0793

    Abstract: The present invention relates to a method for the generation of outer radial glial (oRG) cells of the outer sub-ventricular (oSVZ)-like region in cerebral organoids comprising (a) culturing primate stem cells in a primate stem cell medium until about day 6, thereby inducing the formation of embryonic bodies; (b) culturing the embryonic bodies as obtained in step (a) in a neural induction medium until about day 11, thereby inducing the formation of organoids; wherein an inhibitor of TGF-β, an inhibitor of BMP and an inhibitor of WNT is present from about day 2 until about day 11; (c) embedding the organoids as obtained after steps (a) and (b) and if they display a size of at least 300 μm into a hydrogel that mimics the extracellular matrix (ECM), preferably Matrigel and culturing the organoids in a cerebral differentiation medium at least until about day 40, preferably at least until about day 60 and most preferably at least until about day 80, thereby obtaining cerebral organoids with oRG cells in oSVZ-like regions, wherein the organoids in step (c) are subjected to agitation from about day 15 onward, preferably by using an orbital shaker or a spinning bioreactor; and (d) optionally isolating one or more oRG cells from the oSVZ-like region.

    TMS PROTOCOL AND ASSESSMENT
    2.
    发明申请
    TMS PROTOCOL AND ASSESSMENT 有权

    公开(公告)号：US20250061999A1

    公开(公告)日：2025-02-20

    申请号：US18719323

    申请日：2022-12-13

    Applicant: Mor Research Applications Ltd. ,  Ramot at Tel-Aviv University Ltd.

    Inventor： Amir GLIK ,  Miriam FURST-YUST ,  Felix BENNINGER

    IPC: G16H20/40 ,  A61N2/00 ,  A61N2/02

    Abstract: A system which can be used for carrying out a method for determining an efficacy of a transcranial magnetic stimulation (TMS) treatment, including: delivering TMS to a patient using a TMS protocol in a TMS treatment session; recording EEG signals before and after the delivering during the treatment session; recording EEG signals after completion of the treatment session; analyzing the recorded EEG signals to generate values of one or more EEG parameters; determining an acute effect and an intermediate effect of the TMS protocol on a brain state of the patient based on a change in values of the one or more EEG parameters; determining an efficacy of the TMS protocol based on the determined acute effect and the intermediate effect.

    METHOD AND SYSTEM FOR VISUALIZATION OF THE STRUCTURE OF BIOLOGICAL CELLS
    3.
    发明申请
    METHOD AND SYSTEM FOR VISUALIZATION OF THE STRUCTURE OF BIOLOGICAL CELLS 有权

    公开(公告)号：US20250052664A1

    公开(公告)日：2025-02-13

    申请号：US18717651

    申请日：2022-12-14

    Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

    Inventor： Natan Tzvi SHAKED

    IPC: G01N15/14 ,  G01N15/10 ,  G01N15/1434 ,  G03H1/00 ,  G03H1/04 ,  G06V10/82

    Abstract: Some embodiments relate to a data analysis system is presented for inspecting unstained biological cells during fast flow. The data analysis system comprises: a data input utility, and data processor. The data input utility receives raw measured data comprising measured data pieces corresponding to a stream of raw data containing wavefront acquisitions collected from said unstained biological cell under inspection being obtained from the unstained biological cell during the fast flow. The data processor and analyzer is configured and operable to apply to said raw measured data real time processing by a trained neural network model and extract cell-related data.

    USE OF ADNF POLYPEPTIDES IN THERAPY
    6.
    发明申请
    USE OF ADNF POLYPEPTIDES IN THERAPY 有权

    公开(公告)号：US20250032580A1

    公开(公告)日：2025-01-30

    申请号：US18552263

    申请日：2022-03-25

    Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

    Inventor： Illana GOZES

    IPC: A61K38/18 ,  A61P25/28 ,  G01N33/68

    Abstract: Uses of ADNF polypeptides in therapy are provided. Accordingly, there is provided a method of treating a disease associated with visual evoked potential impairment and/or speech impairment that is not due to vocal disturbance and in which the subject suffers from the visual evoked potential impairment and/or speech impairment, the method comprising administering to the subject a therapeutically effective amount of an ADNF polypeptide, wherein said ADNF polypeptide has a neurotrophic/neuroprotective activity in an in vitro cortical neuron culture assay.

    Method and system for subcutaneous sensing
    7.
    发明授权
    Method and system for subcutaneous sensing 有权

    公开(公告)号：US12201452B2

    公开(公告)日：2025-01-21

    申请号：US16326385

    申请日：2017-08-22

    Applicant: Ramot at Tel-Aviv University Ltd.

    Inventor： Fernando Patolsky ,  Vadim Krivitsky ,  Omri Heifler ,  Marina Zverzhinetsky

    IPC: A61B5/00 ,  A61B5/145 ,  A61B5/1473 ,  A61B5/1486 ,  A61B5/1495 ,  A61M37/00

    Abstract: A system for monitoring at least presence of a bioanalyte. The system comprises: a substrate having a skin contact surface, a microneedle outwardly protruding from the skin contact surface, a sensing complex positioned in the microneedle, and a circuit attached to the substrate. The sensing complex can comprise a nanostructure modified by a functional moiety covalently attached thereto, and an affinity moiety effective to react specifically with the bioanalyte to produce a reaction product. The circuit can apply voltage to the nanostructure and monitor changes in an electrical property of the nanostructure responsively to reaction between the reaction product and the functional moiety.

Patent Agency Ranking