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公开(公告)号：US20100285109A1
公开(公告)日：2010-11-11
申请号：US12678692
申请日：2008-09-19
IPC分类号： A61K9/127 , C07K14/40 , C07H21/04 , C12N15/63 , C12N5/10 , A61K39/00 , A61K38/16 , A61K31/7088 , C12Q1/04 , C12Q1/68 , A61P31/10
CPC分类号： A61K39/0002 , A61K38/00 , C12N9/6478 , C12Q1/68 , G01N33/573 , Y02A50/471 , Y02A50/473
摘要： The present invention relates to a truncated form of the secretory aspartyl proteinase 2 (Sap2), as well as to nucleic acid molecules encoding same. This truncated Sap2 polypeptide (tSap2) is surprisingly stable and devoid of enzymatic activity but retains full immunogenicity upon intravaginal administration and confers full protection against intravaginal challenge by the Candida fungus. The present invention further relates to compositions comprising tSap2 and to the use of tSap2 in the preparation of such compositions.
摘要翻译： 本发明涉及分泌型天冬氨酰蛋白酶2（Sap2）的截短形式，以及编码其的核酸分子。 这种截短的Sap2多肽（tSap2）出人意料地稳定，没有酶活性，但在阴道内施用时保留完全的免疫原性，并且赋予针对假丝酵母真菌的阴道内攻击的完全保护。 本发明还涉及包含tSap2的组合物和tSap2在制备这些组合物中的用途。
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公开(公告)号：US20090202622A1
公开(公告)日：2009-08-13
申请号：US12281256
申请日：2007-03-02
CPC分类号： A61K9/1272 , A61K9/0019 , A61K9/0043 , A61K9/127 , A61K9/1271 , A61K39/12 , A61K39/21 , A61K2039/54 , A61K2039/545 , A61K2039/55555 , A61K2039/6018 , A61K2039/6075 , C07K14/005 , C12N2740/16122 , C12N2740/16134
摘要： The present invention relates to a virosome-like vesicle comprising at least a gp41-derived antigen or an analogue thereof, said gp41-derived antigen being located to the external surface of and/or encapsulated inside said vesicle and being in a convenient configuration for conferring said virosome-like vesicle with an ability to induce an immune response against a gp41 protein or a human immunodeficiency virus (HIV).
摘要翻译： 本发明涉及包含至少gp41衍生的抗原或其类似物的病毒颗粒样囊泡，所述gp41衍生的抗原位于所述囊泡的外表面和/或包封在囊泡内，并且处于方便的构型，以赋予 所述病毒颗粒样囊泡具有诱导针对gp41蛋白或人类免疫缺陷病毒（HIV）的免疫应答的能力。
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公开(公告)号：US20080268028A1
公开(公告)日：2008-10-30
申请号：US11823713
申请日：2007-06-28
申请人： Rinaldo Zurbriggen , Mario Amacker , Silvia Rasi
发明人： Rinaldo Zurbriggen , Mario Amacker , Silvia Rasi
IPC分类号： A61K9/127
CPC分类号： A61K47/28 , A61K9/1272 , A61K9/19 , A61K31/704 , A61K39/015 , A61K39/12 , A61K39/145 , A61K2039/5258 , A61K2039/55555 , A61K2039/70 , C12N2760/16134 , C12N2760/16142 , C12N2760/16234
摘要： The present invention relates to biologically active compositions and methods for the lyophilization and reconstruction of virosomes comprising special membrane compositions. These compositions are essential to the invention and provide superior freeze-drying stress-resistance for the virosomes of the invention.
摘要翻译： 本发明涉及包含特殊膜组合物的病毒颗粒的冻干和重建的生物活性组合物和方法。 这些组合物对于本发明是必需的，并且为本发明的病毒体提供优异的抗冻干应激性。
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公开(公告)号：US09216156B2
公开(公告)日：2015-12-22
申请号：US12281256
申请日：2007-03-02
CPC分类号： A61K9/1272 , A61K9/0019 , A61K9/0043 , A61K9/127 , A61K9/1271 , A61K39/12 , A61K39/21 , A61K2039/54 , A61K2039/545 , A61K2039/55555 , A61K2039/6018 , A61K2039/6075 , C07K14/005 , C12N2740/16122 , C12N2740/16134
摘要： The present invention relates to a virosome-like vesicle comprising at least a gp41-derived antigen or an analogue thereof, said gp41-derived antigen being located to the external surface of and/or encapsulated inside said vesicle and being in a convenient configuration for conferring said virosome-like vesicle with an ability to induce an immune response against a gp41 protein or a human immunodeficiency virus (HIV).
摘要翻译： 本发明涉及包含至少gp41衍生的抗原或其类似物的病毒颗粒样囊泡，所述gp41衍生的抗原位于所述囊泡的外表面和/或包封在囊泡内，并且处于方便的构型，以赋予 所述病毒颗粒样囊泡具有诱导针对gp41蛋白或人类免疫缺陷病毒（HIV）的免疫应答的能力。
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公开(公告)号：US20140193445A1
公开(公告)日：2014-07-10
申请号：US14219163
申请日：2014-03-19
IPC分类号： A61K39/00 , G01N33/573 , C12Q1/68
CPC分类号： A61K39/0002 , A61K38/00 , C12N9/6478 , C12Q1/68 , G01N33/573 , Y02A50/471 , Y02A50/473
摘要： The present invention relates to an isolated truncated form of the secretory aspartyl proteinase 2, as well as to nucleic acid molecules encoding same. The present invention also relates to a composition comprising an isolated truncated form of the secretory aspartyl proteinase 2, as well as to nucleic acid molecules encoding same.
摘要翻译： 本发明涉及分离的天冬氨酰蛋白酶2的截短形式，以及编码其的核酸分子。 本发明还涉及包含分离的截短形式的分泌型天冬氨酰蛋白酶2以及与其编码的核酸分子的组合物。
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公开(公告)号：US20140072616A1
公开(公告)日：2014-03-13
申请号：US13962613
申请日：2013-08-08
申请人： Pevion Biotech Ltd.
发明人： Rinaldo Zurbriggen , Mario Amacker , Silvia Rasi
IPC分类号： A61K47/28 , A61K9/127 , A61K31/704 , A61K39/145
CPC分类号： A61K47/28 , A61K9/1272 , A61K9/19 , A61K31/704 , A61K39/015 , A61K39/12 , A61K39/145 , A61K2039/5258 , A61K2039/55555 , A61K2039/70 , C12N2760/16134 , C12N2760/16142 , C12N2760/16234
摘要： The present invention relates to biologically active compositions and methods for the lyophilization and reconstruction of virosomes comprising special membrane compositions. These compositions are essential to the invention and provide superior freeze-drying stress-resistance for the virosomes of the invention.
摘要翻译： 本发明涉及包含特殊膜组合物的病毒颗粒的冻干和重建的生物活性组合物和方法。 这些组合物对于本发明是必需的，并且为本发明的病毒体提供优异的抗冻干应激性。
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7.发明申请High-Efficiency Fusogenic Vesicles, Methods of Producing Them, and Pharmaceutical Compositions Containing Them 审中-公开高效率Fusogenic囊泡，其生产方法和含有它们的药物组合物公开(公告)号：US20090280163A1
公开(公告)日：2009-11-12
申请号：US12029454
申请日：2008-02-11
IPC分类号： A61K9/127 , A61K31/7105 , A61K31/711
CPC分类号： A61K9/1272 , A61K9/1271 , Y10S977/799 , Y10S977/80 , Y10S977/801 , Y10S977/802 , Y10S977/803 , Y10S977/804 , Y10S977/805 , Y10S977/808
摘要： The present invention relates to novel fusogenic vesicles as highly efficient and versatile encapsulation systems for delivering a substance of choice, such as nucleic acids, proteins, peptides, antigens, pharmaceutical drugs and cosmetic agents to cells and tissues.
摘要翻译： 本发明涉及新颖的融合囊泡作为用于向细胞和组织递送所选择的物质（例如核酸，蛋白质，肽，抗原，药物和化妆品）的高效和通用的包封系统。
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公开(公告)号：US08496962B2
公开(公告)日：2013-07-30
申请号：US12086315
申请日：2006-12-15
申请人： Rinaldo Zurbriggen , Andreas Kammer
发明人： Rinaldo Zurbriggen , Andreas Kammer
IPC分类号： A61K9/127
CPC分类号： A61K39/39 , A61K39/12 , A61K39/145 , A61K2039/5258 , A61K2039/55555 , C12N7/00 , C12N2760/16123 , C12N2760/16134
摘要： The present invention relates to a novel adjuvant system that generates an efficient immune response against antigens of various origins while reducing the risk of toxic side effects attendant to the use of known adjuvants. The novel adjuvant of the present invention comprises virosomes and allows antigenic molecules to be bound to or encapsulated in a variety of delivery vehicles which are easier to prepare for virosomes.
摘要翻译： 本发明涉及一种新的佐剂系统，该系统可以降低针对各种来源的抗原的有效免疫应答，同时降低伴随使用已知佐剂的毒副作用的风险。 本发明的新型佐剂包含病毒颗粒，并使抗原分子结合或封装在易于制备病毒颗粒的各种递送载体中。
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公开(公告)号：US20100015214A1
公开(公告)日：2010-01-21
申请号：US12086315
申请日：2006-12-15
申请人： Rinaldo Zurbriggen , Andreas Kammer
发明人： Rinaldo Zurbriggen , Andreas Kammer
CPC分类号： A61K39/39 , A61K39/12 , A61K39/145 , A61K2039/5258 , A61K2039/55555 , C12N7/00 , C12N2760/16123 , C12N2760/16134
摘要： The present invention relates to a novel adjuvant system that generates an efficient immune response against antigens of various origins while reducing the risk of toxic side effects attendant to the use of known adjuvants. The novel adjuvant of the present invention comprises virosomes and allows antigenic molecules to be bound to or encapsulated in a variety of delivery vehicles which are easier to prepare for virosomes.
摘要翻译： 本发明涉及一种新的佐剂系统，该系统可以降低针对各种来源的抗原的有效免疫应答，同时降低伴随使用已知佐剂的毒副作用的风险。 本发明的新型佐剂包含病毒颗粒，并使抗原分子结合或封装在易于制备病毒颗粒的各种递送载体中。
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公开(公告)号：US07378495B2
公开(公告)日：2008-05-27
申请号：US10691125
申请日：2003-10-21
IPC分类号： C71K1/00
CPC分类号： A61K39/0005 , A61K39/00 , A61K39/0011 , A61K2039/5258 , A61K2039/53 , A61K2039/55555 , C07K14/635
摘要： Compositions comprising PTH-rP peptides, combinations thereof, and multiepitope PTH-rP peptides, vectors for their delivery to antigen presenting cells, as well as methods are provided which are useful in the immunotherapy of parathyroid hormone related peptide expressing malignancies.
摘要翻译： 提供了包含PTH-rP肽，其组合和多表位PTH-rP肽的组合物，用于递送至抗原呈递细胞的载体，以及可用于表达甲状旁腺激素相关肽的恶性肿瘤的免疫治疗的方法。
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