公开(公告)号：US3919425A

公开(公告)日：1975-11-11

申请号：US33694673

申请日：1973-03-01

Applicant: MILES LAB

Inventor： VIDRIO HORACIO

IPC: A61K31/505 ,  A61K31/305

CPC classification number: A61K31/505

Abstract: WHEREIN R1 is hydrogen or halogen, R2 is hydrogen or methyl, E is oxygen or sulfur, R3 is hydrogen or halogen, and n has a value of from 1 to 6, produce vasodilation in animals.

Certain 3-substituted-2,4(1H,3H)-di-oxo-quinazoline and 3substituted-2-thio-4-oxo(1H,3H)-quinazoline derivatives and pharmaceutically acceptable acid addition salts thereof having the formula

Abstract translation: 某些具有式WHEREIN的3-取代-2,4（1H，3H） - 二氧代 - 喹唑啉和3-取代-2-硫代-4-氧代（1H，3H） - 喹唑啉衍生物及其药学上可接受的酸加成盐 R1为氢或卤素，R2为氢或甲基，E为氧或硫，R3为氢或卤素，n为1至6，在动物中产生血管舒张。

公开(公告)号：US3918435A

公开(公告)日：1975-11-11

申请号：US43622374

申请日：1974-01-24

Applicant: MILES LAB

Inventor： BEALL GLENN LEE ,  WHITE FRED K

IPC: A61M35/00 ,  A61B10/00 ,  A61B10/02 ,  A61F13/38 ,  A61F13/40 ,  B01L99/00 ,  C12M1/30 ,  G01N1/02

CPC classification number: A61B10/02 ,  A61B10/0096 ,  A61F13/38 ,  A61M35/006 ,  B01L3/5029 ,  B01L2200/141 ,  B01L2300/047 ,  B01L2300/123 ,  B01L2400/0478 ,  B01L2400/0481 ,  G01N2001/028

Abstract: Transport swab tube apparatus is described capable of storing and transporting to a clinical laboratory a swab containing a microorganism sample and a suitable preservative medium. The apparatus comprises in combination an outer tube container having a removable sealing cap, a hollow tubular swab member having a bibulous swab material at one end and a liquid storage receptacle at its other end, and wherein the liquid storage receptacle and the swab member are supported by the removable sealing cap. When the cap is placed on and seals the tube container, the swab member is supported within the tube container so that the bibulous swab material does not touch the walls or end of the tube container. When desired, the liquid in the liquid storage receptacle can flow through the hollow swab member and contact the swab material.

Abstract translation: 描述了能够将包含微生物样品和合适的防腐介质的棉签存储并运送到临床实验室的运输拭子管装置。 该装置组合包括具有可移除密封帽的外管容器，在一端具有吸水拭子材料的中空管状拭子构件和在其另一端处的液体储存容器，并且其中液体储存容器和拭子构件被支撑 通过可拆卸的密封盖。 当盖子被放置并密封管容器时，拭子构件被支撑在管容器内，使得吸收的拭子材料不接触管容器的壁或端部。 当需要时，液体储存容器中的液体可以流过中空拭子构件并接触拭子材料。

公开(公告)号：US3912393A

公开(公告)日：1975-10-14

申请号：US35381273

申请日：1973-04-23

Applicant: MILES LAB

Inventor： HOSSOM MILES G ,  JOHNSON KEITH R

IPC: G01N1/38 ,  G01N21/47 ,  G01N21/51 ,  G01N1/00

CPC classification number: G01N21/51 ,  G01N1/38 ,  G01N21/47 ,  Y10T436/25625

Abstract: Methods and apparatus for measuring and adjusting the concentration of a solution to a standard concentration or a multiple thereof are provided in accordance with the invention by detecting the concentration of a solution and producing an electrical signal representative of the detected concentration. The electrical signal produced is compared with a reference value and diluent is delivered to the solution at a rate governed by the magnitude of the difference between the electrical signal produced and the reference value until the concentration of the solution is adjusted to substantially the same concentration of a standard solution. A measurement of the concentration of the solution is indicated by an appropriately calibrated meter.

公开(公告)号：US3900576A

公开(公告)日：1975-08-19

申请号：US29011572

申请日：1972-09-18

Applicant: MILES LAB

Inventor： SCHULZ ARTHUR AUGUST

IPC: A23L13/00 ,  A23J3/00 ,  A23J3/22 ,  A23L13/40 ,  A23L13/60 ,  A22C11/00

CPC classification number: A23J3/227 ,  A23L13/424 ,  A23L13/426

Abstract: Meat emulsions, such as those suitable for the production of frankfurters and poultry or fish products, can be extended by the addition of an aqueous mixture of vegetable protein fiber, vegetable protein isolate, albumen, vegetable protein concentrate, edible whey, emulsifier, non-fat dried milk solids, gluten or an aqueous flour slurry, and salt. Appropriate amounts of seasoning, vitamins and minerals can also be present. The resulting extended emulsion mixture when cooked produces a final product which is equal to or superior to the prior art all-meat products.

公开(公告)号：US3882234A

公开(公告)日：1975-05-06

申请号：US45745574

申请日：1974-04-03

Applicant: MILES LAB

Inventor： HAVERA HERBERT JOHN ,  STRYCKER WALLACE GLENN

IPC: C07D233/74 ,  A61K15/12

CPC classification number: C07D233/74 ,  Y10S514/821

Abstract: N-(2-diethylamino)ethyl- Alpha -(5,5-diphenylhydantoin-3yl)acetamide and nontoxic salts thereof exhibit antiarrhythmic activity in mammals.

Abstract translation: N-（2-二乙氨基）乙基-α-（5,5-二苯基乙内酰脲-3-基）乙酰胺及其无毒盐在哺乳动物中表现出抗心律失常活性。

公开(公告)号：US3882225A

公开(公告)日：1975-05-06

申请号：US78246768

申请日：1968-12-09

Applicant: MILES LAB

Inventor： PATEL VIRENDRA ,  FETTER MARION COOK ,  NAND SHRADHA

IPC: G01N33/554 ,  G01N31/00 ,  G01N31/02 ,  G01N33/10

CPC classification number: G01N33/554

Abstract: Immunological reagents capable of direct agglutination with antigens are prepared by pre-polymerizing the antibody to form an aggregate and then coupling this aggregate to a microbial cell carrier particle with a chemical coupling agent. The prepolymerization of the antibody can be accomplished by the use of the same or another coupling agent. The use of the microbial cell carrier particle allows the reagents formed to be used as immunological indicator particles in slide tests which permit a quick read-out of test results. The reagent formed may be prepared and shipped in dry form and then reconstituted with liquid for use.

Abstract translation: 通过使抗体预聚合形成骨料，然后用化学偶联剂将该骨料与微生物细胞载体颗粒偶联，可制备能够与抗原直接凝集的免疫试剂。 抗体的预聚合可以通过使用相同或另一种偶联剂来实现。 微生物细胞载体颗粒的使用允许所形成的试剂用作滑动试验中的免疫指示剂颗粒，其允许快速读出测试结果。 所形成的试剂可以制备并以干燥形式运输，然后用液体重构使用。

公开(公告)号：US3879393A

公开(公告)日：1975-04-22

申请号：US37127773

申请日：1973-06-18

Applicant: MILES LAB

Inventor： HAVERA HERBERT JOHN

IPC: C07D401/06 ,  C07D51/48

CPC classification number: C07D401/06 ,  Y10S514/929

Abstract: The disclosed derivatives of 1,3-disubstituted 2,4 (1H,3H)quinazolinediones produce vasodilation in experimental animals. The 1,3-disubstitutions include, among others, 1(alky(alkylamino))-, 1-(alkylpiperidyl)-, 3-(alkyl(alkylamino))-, 3-(alkyl(4-phenyl-1-piperidyl)-, and 3-(alkyl(4-phenyl-1piperazinyl))-moieties. In the latter two substituents the phenyl group optionally is substituted with halogeno or loweralkyl groups. Additionally, the compounds optionally are substituted at carbon atoms 5 through 8 of the quinazolinedione nucleus with halogeno, nitro, alkoxy, and alkylamido substituents.

Abstract translation: 公开的1,3-二取代的2,4（1H，3H） - 喹唑啉二酮的衍生物在实验动物中产生血管舒张。 1,3-二取代基包括1- [烷基（烷基氨基）] - ，1-（烷基哌啶基） - ，3- [烷基（烷基氨基）] - ，3- [烷基（4-苯基-1-哌啶基 ] - 和3- [烷基（4-苯基-1-哌嗪基）] - 部分，在后两个取代基中，苯基任选被卤代或低级烷基取代。另外，化合物任选地在碳原子5 8具有卤代，硝基，烷氧基和烷基酰氨基取代基的喹唑啉二酮核。

公开(公告)号：US3856649A

公开(公告)日：1974-12-24

申请号：US34199973

申请日：1973-03-16

Applicant: MILES LAB

Inventor： GENSHAW M ,  SMITH M

IPC: G01N27/333 ,  G01N27/30

CPC classification number: G01N27/3335

Abstract: A solid state electrode for use in determining ion concentration in an aqueous solution. The electrode comprises an electrically conductive inner element with a salt disposed on a surface portion thereof having as a cation a cation form of the element and also having an anion, a hydrophilic layer in intimate contact with the salt and including a water soluble salt of said anion and a hydrophobic layer in intimate contact with the hydrophilic layer whereby the hydrophilic layer is shielded from contact with the ion-containing aqueous solution. This electrode may function as a reference electrode as well as an electrode for identifying specific ions.

Abstract translation: 用于测定水溶液中离子浓度的固态电极。 所述电极包括导电内部元件，其具有盐，其设置在其表面部分上，其具有作为所述元件的阳离子形式的阳离子，并且还具有阴离子，与所述盐紧密接触的亲水层，并且包含所述 阴离子和与亲水层紧密接触的疏水层，从而使亲水层不被与含离子的水溶液接触。 该电极可以用作参考电极以及用于识别特定离子的电极。

公开(公告)号：US3843710A

公开(公告)日：1974-10-22

申请号：US33280573

申请日：1973-02-15

Applicant: MILES LAB

Inventor： BUCKLER R ,  HARTZLER H

IPC: C07K1/00 ,  C07C121/78

CPC classification number: C07K1/006 ,  Y10S514/869

Abstract: Certain substituted Beta -arylamidoacrylic acids and a method of preparing them are disclosed. These compounds are useful as antiinflammatory and diuretic agents.

公开(公告)号：US3836667A

公开(公告)日：1974-09-17

申请号：US34274173

申请日：1973-03-19

Applicant: MILES LAB

Inventor： OSWALD H ,  WARREN B

IPC: A61K31/19 ,  A61K31/557 ,  A61K27/00

CPC classification number: A61K31/557 ,  A61K31/19

Abstract: THE INVENTION RELATES TO THE USE OF PROSTAGLANDIN A1 AS A BRONCHODILATING AGENT; THE PROSTAGLANDIN CAN BE USED IN PARTICULAR IN ALLEVIATING THE SYMPTOMS OF STATUS ASTHMATICUS BY INJECTION.