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202 条记录 (耗时 0.039 秒)

    Macromolecule delivery to nanowells
    3.
    发明授权
    Macromolecule delivery to nanowells 有权

    公开(公告)号：US10550423B2

    公开(公告)日：2020-02-04

    申请号：US15797982

    申请日：2017-10-30

    申请人： IBIS BIOSCIENCES, INC.

    发明人： Phillip N. Gray

    IPC分类号： C12Q1/6806 ,  C12Q1/6869

    摘要： Provided herein is technology relating to depositing and/or placing a macromolecule at a desired site for an assay and particularly, but not exclusively, to methods and systems for transporting a macromolecule such as a protein, a nucleic acid, or a protein:nucleic acid complex to an assay site, such as the bottom of a nanopore, a nanowell, or a zero mode waveguide.

    DNA sequencing
    5.
    发明授权
    DNA sequencing 有权

    公开(公告)号：US10202642B2

    公开(公告)日：2019-02-12

    申请号：US14398267

    申请日：2013-05-02

    申请人： IBIS BIOSCIENCES, INC.

    发明人： Mark W. Eshoo

    IPC分类号： C12Q1/68 ,  C12Q1/6869

    摘要： Provided herein is technology relating to sequencing nucleic acids and particularly, but not exclusively, to methods, compositions, systems, and kits for sequencing a nucleic acid using a degenerate two-base code. Particular embodiments provide: 1) that the two-base degenerate code relates a first element to a base comprising adenine (A) or guanine (G) and a second element to a base comprising cytosine (C) or thymine (T); 2) that the two-base degenerate code relates a first element to a base comprising A or C and a second element to a base comprising G or T; and 3) that the two-base degenerate code relates a first element to a base comprising G or C and a second element to a base comprising A or T.

    Macromolecule positioning by electrical potential
    6.
    发明授权
    Macromolecule positioning by electrical potential 有权

    公开(公告)号：US10150993B2

    公开(公告)日：2018-12-11

    申请号：US14367789

    申请日：2012-12-21

    申请人： IBIS BIOSCIENCES, INC.

    发明人： Mark A. Hayden

    IPC分类号： C12Q1/6869 ,  C12Q1/6874 ,  B01L3/00 ,  G01N27/447

    摘要： Provided herein is technology relating to depositing and/or placing a macromolecule at a desired site for an assay and particularly, but not exclusively, to methods and systems for placing or guiding a macromolecule such as a protein, a nucleic acid, or a protein: nucleic acid complex to an assay site, such as near a nanopore, a nanowell, or a zero mode waveguide.

    Capture primers and capture sequence linked solid supports for molecular diagnostic tests
    7.
    发明授权
    Capture primers and capture sequence linked solid supports for molecular diagnostic tests 有权

    公开(公告)号：US10119164B2

    公开(公告)日：2018-11-06

    申请号：US15237284

    申请日：2016-08-15

    申请人： IBIS BIOSCIENCES, INC.

    发明人： Mark A. Hayden

    IPC分类号： C12Q1/68 ,  G06F19/22 ,  C12Q1/6869 ,  C12Q1/686

    摘要： The present invention provides systems, methods, and compositions for performing molecular tests. In particular, the present invention provides methods, compositions and systems for generating target sequence-linked solid supports (e.g., beads) using a solid support linked to a plurality of capture sequences and capture primers composed of a 3′ target-specific portion and a 5′ capture sequence portion. In certain embodiments, the target sequence linked solid support is used in sequencing methods (e.g., pyrosequencing, zero-mode waveguide type sequencing, nanopore sequencing, etc.) to determine the sequence of the target sequence (e.g., in order to detect the identity of a target nucleic acid in sample).

    Methods for concurrent identification and quantification of an unknown bioagent
    9.
    发明授权
    Methods for concurrent identification and quantification of an unknown bioagent 有权
    同时鉴定和量化未知生物标签的方法

    公开(公告)号：US09447462B2

    公开(公告)日：2016-09-20

    申请号：US14164559

    申请日：2014-01-27

    申请人： Ibis Biosciences, Inc.

    发明人： David J. Ecker ,  Rangarajan Sampath ,  Lawrence B. Blyn ,  Steven A. Hofstadler ,  Thomas A. Hall

    IPC分类号： C12Q1/68 ,  C12P19/34 ,  C07H21/04

    CPC分类号： C12Q1/6851 ,  C07H21/04 ,  C12Q1/6872 ,  C12Q2545/101

    摘要： The present invention provides methods for the quantification of an unknown bioagent in a sample by amplification of nucleic acid of the bioagent, and concurrent amplification of a known quantity of a calibration polynucleotide from which are obtained a bioagent identifying amplicon and a calibration amplicon. Upon molecular mass analysis, mass and abundance data are obtained. The identity of the bioagent is then determined from the molecular mass of the bioagent identifying amplicon and the quantity of the identified bioagent in the sample is determined from the abundance data of the bioagent identifying amplicon and the abundance data of the calibration amplicon.

    摘要翻译： 本发明提供了通过扩增生物标记的核酸来定量样品中的未知生物标签的方法，以及同时扩增已知量的校准多核苷酸，从中获得了鉴定扩增子的生物标志物和校准扩增子。 通过分子质量分析，获得质量和丰度数据。 然后根据鉴定扩增子的生物标志物的分子量确定生物标签的身份，并从鉴定扩增子的生物标志物的丰度数据和校准扩增子的丰度数据确定样品中鉴定的生物标记物的量。