公开(公告)号：US20120108649A1

公开(公告)日：2012-05-03

申请号：US13277066

申请日：2011-10-19

申请人： John Dustin Loy ,  Lyric Colleen Bartolomay ,  Delbert Linn Harris ,  Ed Scura ,  Kurt Iver Kamrud

发明人： John Dustin Loy ,  Lyric Colleen Bartolomay ,  Delbert Linn Harris ,  Ed Scura ,  Kurt Iver Kamrud

IPC分类号： A61K31/713 ,  A61P31/14 ,  C07H21/04 ,  C07H21/02 ,  A61K31/7088 ,  A61P31/20

CPC分类号： C12N15/1131 ,  A61K39/12 ,  A61K39/135 ,  A61K39/145 ,  A61K2039/5256 ,  A61K2039/552 ,  C07K14/005 ,  C12N15/111 ,  C12N15/86 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2320/32 ,  C12N2710/18022 ,  C12N2710/18034 ,  C12N2720/00022 ,  C12N2720/00034 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2770/10022 ,  C12N2770/10034 ,  C12N2770/32122 ,  C12N2770/32134 ,  C12N2770/36143 ,  Y02A50/492

摘要： Compositions and methods of protecting aquatic invertebrates from disease is shown. In one embodiment, dsRNA or antisense RNA to a nucleic acid molecule of the disease-causing microorganism is prepared and delivered to the animal. In another embodiment, a nucleic acid molecule of the disease-causing microorganism is delivered to the animal. In another embodiment, the RNA or nucleic acid molecule is delivered to the animal by replicon particle. In a further embodiment, the protective molecule is delivered to the digestive tract of the animal. Protection from disease is obtained.

摘要翻译： 显示了保护水生无脊椎动物免受疾病的组合和方法。 在一个实施方案中，制备并产生对致病微生物的核酸分子的dsRNA或反义RNA并将其递送至动物。 在另一个实施方案中，将致病微生物的核酸分子递送至动物。 在另一个实施方案中，通过复制子颗粒将RNA或核酸分子递送至动物。 在另一个实施方案中，保护性分子被递送到动物的消化道。 获得防治疾病。

公开(公告)号：US10004797B2

公开(公告)日：2018-06-26

申请号：US13657895

申请日：2012-10-23

申请人： Harrisvaccines, Inc.

发明人： Delbert Linn Harris ,  Matthew Erdman ,  Kurt Iver Kamrud ,  Jonathan Fowler Smith ,  John Dustin Loy ,  Lyric Colleen Bartholomay ,  Ed Scura

IPC分类号： A61K39/00 ,  C12N15/86 ,  C07K14/005 ,  C12N7/00 ,  A61K39/145 ,  A61K39/12 ,  A61K39/135 ,  C12N15/11 ,  C12N15/113 ,  C12Q1/70

CPC分类号： A61K39/145 ,  A61K39/0013 ,  A61K39/12 ,  A61K39/135 ,  A61K2039/53 ,  A61K2039/552 ,  C07K14/005 ,  C12N7/00 ,  C12N15/111 ,  C12N15/1131 ,  C12N15/86 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2320/32 ,  C12N2710/18022 ,  C12N2710/18034 ,  C12N2720/00022 ,  C12N2720/00034 ,  C12N2720/12143 ,  C12N2760/16034 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2770/10022 ,  C12N2770/10034 ,  C12N2770/32122 ,  C12N2770/32134 ,  C12N2770/36143 ,  C12Q1/701

摘要： A method of quickly producing a vaccine for a biotype of pathogenic microorganism is described, where a nucleic acid molecule or fragment thereof is obtained from a biological sample from an animal exposed to the microorganism, a protective molecule is prepared based on the nucleic acid molecule of interest or fragment thereof, and administered to an animal which has been or is as risk of being exposed to the microorganism. A protective response to the biotype of the microorganism is obtained in the animal.

公开(公告)号：US20130064839A1

公开(公告)日：2013-03-14

申请号：US13657895

申请日：2012-10-23

申请人： Harrisvaccines, Inc.

发明人： Delbert Linn Harris ,  Matthew Erdman ,  Kurt Iver Kamrud ,  Jonathan Fowler Smith ,  John Dustin Loy ,  Lyric Colleen Bartholomay ,  Ed Scura

IPC分类号： A61K39/00 ,  A61P31/00 ,  A61K31/713 ,  A61P37/04 ,  C12Q1/70 ,  C12Q1/68

CPC分类号： A61K39/145 ,  A61K39/0013 ,  A61K39/12 ,  A61K39/135 ,  A61K2039/53 ,  A61K2039/552 ,  C07K14/005 ,  C12N7/00 ,  C12N15/111 ,  C12N15/1131 ,  C12N15/86 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2320/32 ,  C12N2710/18022 ,  C12N2710/18034 ,  C12N2720/00022 ,  C12N2720/00034 ,  C12N2720/12143 ,  C12N2760/16034 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2770/10022 ,  C12N2770/10034 ,  C12N2770/32122 ,  C12N2770/32134 ,  C12N2770/36143 ,  C12Q1/701

摘要： A method of quickly producing a vaccine for a biotype of pathogenic microorganism is described, where a nucleic acid molecule or fragment thereof is obtained from a biological sample from an animal exposed to the microorganism, a protective molecule is prepared based on the nucleic acid molecule of interest or fragment thereof, and administered to an animal which has been or is as risk of being exposed to the microorganism. A protective response to the biotype of the microorganism is obtained in the animal.

公开(公告)号：US20130045223A1

公开(公告)日：2013-02-21

申请号：US13657898

申请日：2012-10-23

申请人： Harrisvaccines, Inc.

发明人： John Dustin Loy ,  Lyric Colleen Bartholomay ,  Delbert Linn Harris ,  Ed Scura ,  Kurt Iver Kamrud

IPC分类号： A61K31/713 ,  A61K31/7088 ,  A61P37/04 ,  C07H1/00 ,  A61K39/00 ,  C12Q1/70 ,  A61P31/14

CPC分类号： A61K39/145 ,  A61K39/12 ,  A61K39/135 ,  A61K2039/54 ,  A61K2039/552 ,  C07K14/005 ,  C12N15/111 ,  C12N15/1131 ,  C12N15/86 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2320/32 ,  C12N2710/18022 ,  C12N2710/18034 ,  C12N2720/00022 ,  C12N2720/00034 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2770/10022 ,  C12N2770/10034 ,  C12N2770/32122 ,  C12N2770/32134 ,  C12N2770/36143

摘要： Compositions and methods of protecting aquatic invertebrates from disease is shown. In one embodiment, dsRNA or antisense RNA to a nucleic acid molecule of the disease-causing microorganism is prepared and delivered to the animal. In another embodiment, a nucleic acid molecule of the disease-causing microorganism is delivered to the animal. In another embodiment, the RNA or nucleic acid molecule is delivered to the animal by replicon particle. In a further embodiment, the protective molecule is delivered to the digestive tract of the animal. Protection from disease is obtained.

摘要翻译： 显示了保护水生无脊椎动物免受疾病的组合和方法。 在一个实施方案中，制备并产生对致病微生物的核酸分子的dsRNA或反义RNA并将其递送至动物。 在另一个实施方案中，将致病微生物的核酸分子递送至动物。 在另一个实施方案中，通过复制子颗粒将RNA或核酸分子递送至动物。 在另一个实施方案中，保护性分子被递送到动物的消化道。 获得防治疾病。

公开(公告)号：US09650634B2

公开(公告)日：2017-05-16

申请号：US14338378

申请日：2014-07-23

申请人： Harrisvaccines, Inc.

发明人： John Dustin Loy ,  Lyric Colleen Bartholomay ,  Delbert Linn Harris ,  Ed Scura ,  Kurt Iver Kamrud

IPC分类号： C07H21/02 ,  C07H21/04 ,  C12Q1/68 ,  C12N15/113 ,  A61K39/12 ,  A61K39/135 ,  A61K39/145 ,  C07K14/005 ,  C12N15/11 ,  C12N15/86 ,  C12N5/00 ,  A61K39/00

CPC分类号： C12N15/1131 ,  A61K39/12 ,  A61K39/135 ,  A61K39/145 ,  A61K2039/5256 ,  A61K2039/552 ,  C07K14/005 ,  C12N15/111 ,  C12N15/86 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2320/32 ,  C12N2710/18022 ,  C12N2710/18034 ,  C12N2720/00022 ,  C12N2720/00034 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2770/10022 ,  C12N2770/10034 ,  C12N2770/32122 ,  C12N2770/32134 ,  C12N2770/36143 ,  Y02A50/492

摘要： Compositions and methods of protecting aquatic invertebrates from disease is shown. In one embodiment, dsRNA or antisense RNA to a nucleic acid molecule of the disease-causing microorganism is prepared and delivered to the animal. In another embodiment, a nucleic acid molecule of the disease-causing microorganism is delivered to the animal. In another embodiment, the RNA or nucleic acid molecule is delivered to the animal by replicon particle. In a further embodiment, the protective molecule is delivered to the digestive tract of the animal. Protection from disease is obtained.

公开(公告)号：US20130122025A1

公开(公告)日：2013-05-16

申请号：US13736184

申请日：2013-01-08

申请人： Harrisvaccines, Inc.

发明人： Delbert Linn Harris ,  Matthew Erdman ,  Kurt Iver Kamrud ,  Jonathan Fowler Smith ,  John Dustin Loy ,  Lyric Colleen Bartholomay ,  Ed Scura

IPC分类号： A61K39/00

CPC分类号： A61K39/145 ,  A61K39/0013 ,  A61K39/12 ,  A61K39/135 ,  A61K2039/53 ,  A61K2039/552 ,  C07K14/005 ,  C12N7/00 ,  C12N15/111 ,  C12N15/1131 ,  C12N15/86 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2320/32 ,  C12N2710/18022 ,  C12N2710/18034 ,  C12N2720/00022 ,  C12N2720/00034 ,  C12N2720/12143 ,  C12N2760/16034 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2770/10022 ,  C12N2770/10034 ,  C12N2770/32122 ,  C12N2770/32134 ,  C12N2770/36143 ,  C12Q1/701

摘要： A method of quickly producing a vaccine for a biotype of pathogenic microorganism is described, where a nucleic acid molecule or fragment thereof is obtained from a biological sample from an animal exposed to the microorganism, a protective molecule is prepared based on the nucleic acid molecule of interest or fragment thereof, and administered to an animal which has been or is as risk of being exposed to the microorganism. A protective response to the biotype of the microorganism is obtained in the animal.

公开(公告)号：US20120107355A1

公开(公告)日：2012-05-03

申请号：US13277076

申请日：2011-10-19

申请人： Delbert Linn Harris ,  Matthew Erdman ,  Kurt Iver Kamrud ,  Jonathan Smith ,  John Dustin Loy ,  Lyric Colleen Bartholomay ,  Ed Scura

发明人： Delbert Linn Harris ,  Matthew Erdman ,  Kurt Iver Kamrud ,  Jonathan Smith ,  John Dustin Loy ,  Lyric Colleen Bartholomay ,  Ed Scura

IPC分类号： A61K39/145 ,  A61K39/135 ,  C12Q1/04 ,  C12N7/00 ,  C12Q1/70 ,  C07H21/02 ,  C07H1/00 ,  C12P21/00 ,  C12Q1/68 ,  C12P19/34 ,  A61K39/12 ,  C07H21/04

CPC分类号： C12N15/1131 ,  A61K39/12 ,  A61K39/135 ,  A61K39/145 ,  A61K2039/5256 ,  A61K2039/552 ,  C07K14/005 ,  C12N15/111 ,  C12N15/86 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2320/32 ,  C12N2710/18022 ,  C12N2710/18034 ,  C12N2720/00022 ,  C12N2720/00034 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2770/10022 ,  C12N2770/10034 ,  C12N2770/32122 ,  C12N2770/32134 ,  C12N2770/36143

摘要： A method of quickly producing a vaccine for a biotype of pathogenic microorganism is described, where a nucleic acid molecule or fragment thereof is obtained from a biological sample from an animal exposed to the microorganism, a protective molecule is prepared based on the nucleic acid molecule of interest or fragment thereof, and administered to an animal which has been or is as risk of being exposed to the microorganism. A protective response to the biotype of the microorganism is obtained in the animal.

摘要翻译： 描述了一种快速生产病原微生物生物型疫苗的方法，其中核酸分子或其片段是从暴露于微生物的动物的生物样品获得的，基于核酸分子的 利益或其片段，并且施用于已经或具有暴露于微生物的风险的动物。 在动物中获得对微生物生物型的保护性反应。