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公开(公告)号：US20140371295A1
公开(公告)日：2014-12-18
申请号：US14338378
申请日：2014-07-23
申请人： Harrisvaccines, Inc.
发明人： John Dustin Loy , Lyric Colleen Bartholomay , Delbert Linn Harris , Ed Scura , Kurt Iver Kamrud
IPC分类号： C12N15/113
CPC分类号： C12N15/1131 , A61K39/12 , A61K39/135 , A61K39/145 , A61K2039/5256 , A61K2039/552 , C07K14/005 , C12N15/111 , C12N15/86 , C12N2310/111 , C12N2310/14 , C12N2320/32 , C12N2710/18022 , C12N2710/18034 , C12N2720/00022 , C12N2720/00034 , C12N2760/16122 , C12N2760/16134 , C12N2770/10022 , C12N2770/10034 , C12N2770/32122 , C12N2770/32134 , C12N2770/36143 , Y02A50/492
摘要： Compositions and methods of protecting aquatic invertebrates from disease is shown. In one embodiment, dsRNA or antisense RNA to a nucleic acid molecule of the disease-causing microorganism is prepared and delivered to the animal. In another embodiment, a nucleic acid molecule of the disease-causing microorganism is delivered to the animal. In another embodiment, the RNA or nucleic acid molecule is delivered to the animal by replicon particle. In a further embodiment, the protective molecule is delivered to the digestive tract of the animal. Protection from disease is obtained.
摘要翻译： 显示了保护水生无脊椎动物免受疾病的组合和方法。 在一个实施方案中，制备并产生对致病微生物的核酸分子的dsRNA或反义RNA并将其递送至动物。 在另一个实施方案中，将致病微生物的核酸分子递送至动物。 在另一个实施方案中，通过复制子颗粒将RNA或核酸分子递送至动物。 在另一个实施方案中，保护性分子被递送到动物的消化道。 获得防治疾病。
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公开(公告)号：US10004797B2
公开(公告)日：2018-06-26
申请号：US13657895
申请日：2012-10-23
申请人： Harrisvaccines, Inc.
发明人： Delbert Linn Harris , Matthew Erdman , Kurt Iver Kamrud , Jonathan Fowler Smith , John Dustin Loy , Lyric Colleen Bartholomay , Ed Scura
IPC分类号： A61K39/00 , C12N15/86 , C07K14/005 , C12N7/00 , A61K39/145 , A61K39/12 , A61K39/135 , C12N15/11 , C12N15/113 , C12Q1/70
CPC分类号： A61K39/145 , A61K39/0013 , A61K39/12 , A61K39/135 , A61K2039/53 , A61K2039/552 , C07K14/005 , C12N7/00 , C12N15/111 , C12N15/1131 , C12N15/86 , C12N2310/111 , C12N2310/14 , C12N2320/32 , C12N2710/18022 , C12N2710/18034 , C12N2720/00022 , C12N2720/00034 , C12N2720/12143 , C12N2760/16034 , C12N2760/16122 , C12N2760/16134 , C12N2770/10022 , C12N2770/10034 , C12N2770/32122 , C12N2770/32134 , C12N2770/36143 , C12Q1/701
摘要： A method of quickly producing a vaccine for a biotype of pathogenic microorganism is described, where a nucleic acid molecule or fragment thereof is obtained from a biological sample from an animal exposed to the microorganism, a protective molecule is prepared based on the nucleic acid molecule of interest or fragment thereof, and administered to an animal which has been or is as risk of being exposed to the microorganism. A protective response to the biotype of the microorganism is obtained in the animal.
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公开(公告)号：US20130064839A1
公开(公告)日：2013-03-14
申请号：US13657895
申请日：2012-10-23
申请人： Harrisvaccines, Inc.
发明人： Delbert Linn Harris , Matthew Erdman , Kurt Iver Kamrud , Jonathan Fowler Smith , John Dustin Loy , Lyric Colleen Bartholomay , Ed Scura
CPC分类号： A61K39/145 , A61K39/0013 , A61K39/12 , A61K39/135 , A61K2039/53 , A61K2039/552 , C07K14/005 , C12N7/00 , C12N15/111 , C12N15/1131 , C12N15/86 , C12N2310/111 , C12N2310/14 , C12N2320/32 , C12N2710/18022 , C12N2710/18034 , C12N2720/00022 , C12N2720/00034 , C12N2720/12143 , C12N2760/16034 , C12N2760/16122 , C12N2760/16134 , C12N2770/10022 , C12N2770/10034 , C12N2770/32122 , C12N2770/32134 , C12N2770/36143 , C12Q1/701
摘要： A method of quickly producing a vaccine for a biotype of pathogenic microorganism is described, where a nucleic acid molecule or fragment thereof is obtained from a biological sample from an animal exposed to the microorganism, a protective molecule is prepared based on the nucleic acid molecule of interest or fragment thereof, and administered to an animal which has been or is as risk of being exposed to the microorganism. A protective response to the biotype of the microorganism is obtained in the animal.
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公开(公告)号：US08822427B2
公开(公告)日：2014-09-02
申请号：US13657898
申请日：2012-10-23
申请人： Harrisvaccines, Inc.
发明人： John Dustin Loy , Lyric Colleen Bartholomay , Delbert Linn Harris , Ed Scura , Kurt Iver Kamrud
IPC分类号： A61K31/70 , C07H21/02 , C07H21/04 , C12N15/11 , A61K39/12 , A61K39/145 , A61K39/135 , C12N15/113 , C12N15/86 , C07K14/005 , C12Q1/68 , A61K39/00
CPC分类号： A61K39/145 , A61K39/12 , A61K39/135 , A61K2039/54 , A61K2039/552 , C07K14/005 , C12N15/111 , C12N15/1131 , C12N15/86 , C12N2310/111 , C12N2310/14 , C12N2320/32 , C12N2710/18022 , C12N2710/18034 , C12N2720/00022 , C12N2720/00034 , C12N2760/16122 , C12N2760/16134 , C12N2770/10022 , C12N2770/10034 , C12N2770/32122 , C12N2770/32134 , C12N2770/36143
摘要： Compositions and methods of protecting aquatic invertebrates from disease is shown. In one embodiment, dsRNA or antisense RNA to a nucleic acid molecule of the disease-causing microorganism is prepared and delivered to the animal. In another embodiment, a nucleic acid molecule of the disease-causing microorganism is delivered to the animal. In another embodiment, the RNA or nucleic acid molecule is delivered to the animal by replicon particle. In a further embodiment, the protective molecule is delivered to the digestive tract of the animal. Protection from disease is obtained.
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公开(公告)号：US20130045223A1
公开(公告)日：2013-02-21
申请号：US13657898
申请日：2012-10-23
申请人： Harrisvaccines, Inc.
发明人： John Dustin Loy , Lyric Colleen Bartholomay , Delbert Linn Harris , Ed Scura , Kurt Iver Kamrud
IPC分类号： A61K31/713 , A61K31/7088 , A61P37/04 , C07H1/00 , A61K39/00 , C12Q1/70 , A61P31/14
CPC分类号： A61K39/145 , A61K39/12 , A61K39/135 , A61K2039/54 , A61K2039/552 , C07K14/005 , C12N15/111 , C12N15/1131 , C12N15/86 , C12N2310/111 , C12N2310/14 , C12N2320/32 , C12N2710/18022 , C12N2710/18034 , C12N2720/00022 , C12N2720/00034 , C12N2760/16122 , C12N2760/16134 , C12N2770/10022 , C12N2770/10034 , C12N2770/32122 , C12N2770/32134 , C12N2770/36143
摘要： Compositions and methods of protecting aquatic invertebrates from disease is shown. In one embodiment, dsRNA or antisense RNA to a nucleic acid molecule of the disease-causing microorganism is prepared and delivered to the animal. In another embodiment, a nucleic acid molecule of the disease-causing microorganism is delivered to the animal. In another embodiment, the RNA or nucleic acid molecule is delivered to the animal by replicon particle. In a further embodiment, the protective molecule is delivered to the digestive tract of the animal. Protection from disease is obtained.
摘要翻译： 显示了保护水生无脊椎动物免受疾病的组合和方法。 在一个实施方案中，制备并产生对致病微生物的核酸分子的dsRNA或反义RNA并将其递送至动物。 在另一个实施方案中，将致病微生物的核酸分子递送至动物。 在另一个实施方案中，通过复制子颗粒将RNA或核酸分子递送至动物。 在另一个实施方案中，保护性分子被递送到动物的消化道。 获得防治疾病。
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公开(公告)号：US09650634B2
公开(公告)日：2017-05-16
申请号：US14338378
申请日：2014-07-23
申请人： Harrisvaccines, Inc.
发明人： John Dustin Loy , Lyric Colleen Bartholomay , Delbert Linn Harris , Ed Scura , Kurt Iver Kamrud
IPC分类号： C07H21/02 , C07H21/04 , C12Q1/68 , C12N15/113 , A61K39/12 , A61K39/135 , A61K39/145 , C07K14/005 , C12N15/11 , C12N15/86 , C12N5/00 , A61K39/00
CPC分类号： C12N15/1131 , A61K39/12 , A61K39/135 , A61K39/145 , A61K2039/5256 , A61K2039/552 , C07K14/005 , C12N15/111 , C12N15/86 , C12N2310/111 , C12N2310/14 , C12N2320/32 , C12N2710/18022 , C12N2710/18034 , C12N2720/00022 , C12N2720/00034 , C12N2760/16122 , C12N2760/16134 , C12N2770/10022 , C12N2770/10034 , C12N2770/32122 , C12N2770/32134 , C12N2770/36143 , Y02A50/492
摘要： Compositions and methods of protecting aquatic invertebrates from disease is shown. In one embodiment, dsRNA or antisense RNA to a nucleic acid molecule of the disease-causing microorganism is prepared and delivered to the animal. In another embodiment, a nucleic acid molecule of the disease-causing microorganism is delivered to the animal. In another embodiment, the RNA or nucleic acid molecule is delivered to the animal by replicon particle. In a further embodiment, the protective molecule is delivered to the digestive tract of the animal. Protection from disease is obtained.
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公开(公告)号：US20130122025A1
公开(公告)日：2013-05-16
申请号：US13736184
申请日：2013-01-08
申请人： Harrisvaccines, Inc.
发明人： Delbert Linn Harris , Matthew Erdman , Kurt Iver Kamrud , Jonathan Fowler Smith , John Dustin Loy , Lyric Colleen Bartholomay , Ed Scura
IPC分类号： A61K39/00
CPC分类号： A61K39/145 , A61K39/0013 , A61K39/12 , A61K39/135 , A61K2039/53 , A61K2039/552 , C07K14/005 , C12N7/00 , C12N15/111 , C12N15/1131 , C12N15/86 , C12N2310/111 , C12N2310/14 , C12N2320/32 , C12N2710/18022 , C12N2710/18034 , C12N2720/00022 , C12N2720/00034 , C12N2720/12143 , C12N2760/16034 , C12N2760/16122 , C12N2760/16134 , C12N2770/10022 , C12N2770/10034 , C12N2770/32122 , C12N2770/32134 , C12N2770/36143 , C12Q1/701
摘要： A method of quickly producing a vaccine for a biotype of pathogenic microorganism is described, where a nucleic acid molecule or fragment thereof is obtained from a biological sample from an animal exposed to the microorganism, a protective molecule is prepared based on the nucleic acid molecule of interest or fragment thereof, and administered to an animal which has been or is as risk of being exposed to the microorganism. A protective response to the biotype of the microorganism is obtained in the animal.
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