知搜-全球专利检索

  1. 登录
  2. 注册

搜索结果

37 条记录 (耗时 0.034 秒)

    Microorganisms transformed with Ig-Like polypeptide and uses thereof
    6.
    发明申请
    Microorganisms transformed with Ig-Like polypeptide and uses thereof 审中-公开
    用Ig-样多肽转化的微生物及其用途

    公开(公告)号：US20030186908A1

    公开(公告)日：2003-10-02

    申请号：US10277471

    申请日：2002-10-22

    申请人： Gavish-Galilee Bio Applications Ltd.

    发明人： Martin Goldway

    IPC分类号： A61K048/00

    CPC分类号： C07K16/1228 ,  A61K35/12 ,  A61K48/00 ,  A61K2035/11 ,  A61K2039/505 ,  A61K2039/5156 ,  A61K2039/523 ,  C07K2317/622

    摘要： The present invention relates to a composition for conferring to a subject, immunity against a gastrointestinal (GI) pathogen, particularly Salmonella. The composition of the invention comprises as an active ingredient at least one microorganism transformed with at least one vector comprising a nucleic acid sequence coding for an immunoglobulin-like polypeptide having specific binding affinity for said pathogen. The invention further relates to the single-chain variable fragment (ScFv) antibody molecule having affinity for Salmonella species, used by the invention and to methods for the treatment of infections of gastrointestinal enteropathogenic bacteria in a subject.

    摘要翻译： 本发明涉及给予受试者的组合物，对胃肠（GI）病原体，特别是沙门氏菌的免疫。 本发明的组合物包含作为活性成分的至少一种由至少一种载体转化的微生物，所述载体包含编码对所述病原体具有特异性结合亲和力的免疫球蛋白样多肽的核酸序列。 本发明进一步涉及本发明使用的对沙门氏菌属具有亲和力的单链可变片段（ScFv）抗体分子，以及治疗受试者胃肠道肠病原菌感染的方法。

    GENETICALLY REPROGRAMMED TREGS EXPRESSING CARS
    8.
    发明申请
    GENETICALLY REPROGRAMMED TREGS EXPRESSING CARS 有权

    公开(公告)号：US20220186232A1

    公开(公告)日：2022-06-16

    申请号：US17598208

    申请日：2020-03-26

    申请人： Gavish-Galilee Bio Applications Ltd.

    发明人： Gideon Gross ,  Hadas Weinstein-Marom ,  Sarah Pozner ,  Amit Kroner

    IPC分类号： C12N15/62 ,  A61P1/00 ,  C07K14/54 ,  C07K14/725 ,  C07K16/12

    摘要： Nucleic acid molecules comprising a nucleotide sequence encoding an activating chimeric antigen receptor (aCARs) are provided, said aCARs comprising (i) an extracellular binding-domain specifically binding an antigen selected from an antigen of the commensal gut microflora and a self-cell surface antigen specific to the lamina propria (LP) or submucosa of the gastrointestinal tract; (ii) a transmembrane domain; (iii) an intracellular domain including at least one signal transduction element that activates and/or co-stimulates a T cell; and optionally (iv) a stalk region linking the extracellular domain and the transmembrane domain. Compositions and vectors comprising the nucleic acid molecules encoding the aCAR as well as methods for preparing regulatory T cells comprising the vectors and expressing the aCARs are further provided as are methods for treating or preventing a disease, disorder or condition manifested in excessive activity of the immune system in a subject, comprising administering to said subject the mammalian Treg expressing on its surface an aCAR. The regulatory T cells optionally express a membrane-bound homodimeric IL-10 conferring a stable Tr1 phenotype.

    SYSTEM FOR TREATMENT OF POLLUTED EFFLUENTS
    9.
    发明申请
    SYSTEM FOR TREATMENT OF POLLUTED EFFLUENTS 有权

    公开(公告)号：US20210292206A1

    公开(公告)日：2021-09-23

    申请号：US17339432

    申请日：2021-06-04

    申请人： GAVISH-GALILEE BIO APPLICATIONS LTD.

    发明人： Giora RYTWO ,  Gonen DASKAL

    IPC分类号： C02F9/00 ,  C02F1/00 ,  B01D65/02 ,  B01D61/14 ,  B01D61/18 ,  B01D61/22 ,  B01D69/02

    摘要： A system for treatment of a polluted effluent includes an outer chamber and a computerized control system. The system is configured to treat an effluent/catalyst mixture that includes the polluted effluent in admixture with a purification slurry. The slurry includes particles of one or more catalysts and/or organoclays. The treatment of the effluent/catalyst mixture is carried out by contact between the particles of the catalysts and/or organoclays and the polluted effluent to mineralize or degrade pollutants in the polluted effluent.