公开(公告)号：US10207126B2

公开(公告)日：2019-02-19

申请号：US12463463

申请日：2009-05-11

Applicant: Maria Benson

Inventor： Maria Benson

IPC: A61N5/00 ,  A61N5/10 ,  A61M25/00 ,  A61M25/01 ,  A61M25/10 ,  A61B90/00

Abstract: Systems and methods that facilitate visualization and identification of lumens of a multi-lumen brachytherapy device are disclosed. In one embodiment, visualization and identification can be attained by modifying a feature of at least one of the lumens relative to the other lumens. The feature may include a marking on the lumen, a diameter of the lumen or a composition of the lumen. In an additional embodiment, for brachytherapy devices in which multiple lumens are coupled to a distal end point such as a rigid connection member, visualization and identification of the lumens can be attained by modifying a feature of the rigid connection member. It will be readily appreciated that visualization and identification can be further enhanced through a combination of two or more of the techniques described herein.

公开(公告)号：US20140057347A1

公开(公告)日：2014-02-27

申请号：US14068158

申请日：2013-10-31

Applicant: CYTYC CORPORATION

Inventor： Roy Ostgaard ,  Theodore S. Geiselman

IPC: C12Q1/24

CPC classification number: G01N1/30 ,  B01L3/50825 ,  B01L3/5453 ,  B01L2200/025 ,  B01L2300/042 ,  C12Q1/24 ,  G01N1/2813 ,  G01N1/312 ,  G01N2035/00752 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/113332 ,  Y10T436/114165 ,  Y10T436/114998

Abstract: An automated system for preparing a plurality of cytological specimens from a plurality of fluid samples in vials includes an apparatus for collecting a monolayer of cells from each sample and transferring the cells to a microscope slide for fixing, staining, and inspection. The system includes a first loading station for receiving the sample vials, a second loading station for receiving consumables such as filter membranes, a slide dispenser, and an unloading area for removing completed specimen slides. To maintain one-to-one correlation between the samples and specimens produced therefrom, the system includes a subsystem for identifying each sample and permanently marking each slide with corresponding indicia prior to transferring the specimen thereto.

Abstract translation: 用于从小瓶中的多个流体样品制备多个细胞学标本的自动化系统包括用于从每个样品收集单层细胞并将细胞转移到用于固定，染色和检查的显微镜载玻片的装置。 该系统包括用于接收样品瓶的第一装载站，用于接收消耗品的第二装载站，例如过滤膜，滑动分配器和用于移除已完成的标本载玻片的卸载区域。 为了保持样品和样品之间的一对一相关性，系统包括一个子系统，用于识别每个样品，并在将样本转移到其前的同时用相应的标记永久地标记每个载玻片。

公开(公告)号：US08372581B2

公开(公告)日：2013-02-12

申请号：US13081826

申请日：2011-04-07

Applicant: Robert O. Hussa ,  Mark Fischer-Colbrie ,  Jerome P. Lapointe ,  Simon Shorter ,  Andrew Senyei

Inventor： Robert O. Hussa ,  Mark Fischer-Colbrie ,  Jerome P. Lapointe ,  Simon Shorter ,  Andrew Senyei

IPC: C12Q1/00 ,  G01N33/53

CPC classification number: G01N33/689 ,  B01L3/5023 ,  B82Y5/00 ,  B82Y10/00 ,  B82Y30/00 ,  C07K16/18 ,  C07K16/30 ,  C12Q1/6834 ,  C12Q1/6883 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  G01N33/564 ,  G01N33/57476 ,  G01N33/6887 ,  G01N2333/471 ,  G01N2333/78 ,  G01N2500/00 ,  G01N2800/36 ,  G01N2800/368

Abstract: Methods and products for the detection of oncofetal fibronectin indicating molecules in samples are provided. Methods for imaging of oncofetal fibronectin are provided. In some methods provided herein, the sample is treated with a reagent and/or contacted with a non-specific binder. Provided are methods for testing subjects to ascertain health and disease status and to assess the risk of developing a disease or condition. Methods for detecting the presence of oncofetal fibronectin indicating molecules by a variety of methods such as immunoassays and mass spectrometry also are provided. Methods and products for detection of oncofetal fibronection for selection of concepti are provided.

Abstract translation: 提供了检测样品中表达分子的支原体纤连蛋白的方法和产品。 提供了成骨纤维连接蛋白成像方法。 在本文提供的一些方法中，用试剂处理样品和/或与非特异性粘合剂接触。 提供了测试受试者以确定健康和疾病状态并评估发展疾病或病症的风险的方法。 还提供了通过各种方法如免疫测定和质谱法检测指示分子的成纤维细胞蛋白的存在的方法。 提供了用于检测骨髓纤维连接以选择概念的方法和产品。

公开(公告)号：US08321136B2

公开(公告)日：2012-11-27

申请号：US10794334

申请日：2004-03-05

Applicant: Kam Lin Wong ,  Louise Isenstein ,  David Zahniser

Inventor： Kam Lin Wong ,  Louise Isenstein ,  David Zahniser

IPC: G01N33/48 ,  G06K9/00

CPC classification number: G06K9/00147 ,  G01N15/1475 ,  G06T7/0012 ,  G06T2207/10056 ,  G06T2207/30004 ,  G06T2207/30024

Abstract: The present invention relates to a method and system for classifying biological specimen. A number of objects of interest are identified in a biological specimen. The nuclear area and nuclear integrated optical density for each object of interest in the specimen are measured and used for generating a scatter plot. The specimen is classified as normal or suspicious based on the distribution of points within the scatter plot.

Abstract translation: 本发明涉及一种用于分类生物样本的方法和系统。 在生物样本中识别出许多感兴趣的物体。 测量样品中感兴趣的每个物体的核面积和核集成光密度，并用于产生散点图。 根据分散图中点的分布，将样本分类为正常或可疑。

公开(公告)号：US08231619B2

公开(公告)日：2012-07-31

申请号：US12692057

申请日：2010-01-22

Applicant: David Callaghan ,  Matthew LaPlaca ,  Jeffrey Model ,  Mark Putnam ,  James Duronio

Inventor： David Callaghan ,  Matthew LaPlaca ,  Jeffrey Model ,  Mark Putnam ,  James Duronio

IPC: A61B18/12

CPC classification number: A61F6/225 ,  A61B17/12022 ,  A61B17/12031 ,  A61B17/12159 ,  A61B18/1206 ,  A61B18/1492 ,  A61B2017/00898 ,  A61B2017/1205 ,  A61B2018/00083 ,  A61B2018/00196 ,  A61B2018/00875

Abstract: Sterilization devices and methods for deploying porous implants within the fallopian tubes are disclosed. The devices include a catheter component including an external electrode sheath containing at least two deployable implants and a positioning member. Sliding the external sheath proximally disposes the implants within the fallopian tubes, while sliding both the positioning member and external electrode sheath distally reloads a second implant into the external electrode sheath. The devices further includes a handle component, which houses a chassis, external electrode sheath carrier, reciprocating shaft, positioning member carrier and first and second engaging members. The reciprocating shaft may be operated by a motor to slide distally and proximally along a long axis. The reciprocating shaft, external electrode sheath and its carrier, upon selective actuation, move together proportionally to deploy and reload the implants to facilitate occlusion of the fallopian tubes and complete sterilization.

Abstract translation: 公开了用于在输卵管内部署多孔植入物的灭菌装置和方法。 所述装置包括导管部件，该导管部件包括包含至少两个可展开植入物的外部电极护套和定位部件。 将外部护套向近侧滑动，将植入物放置在输卵管内，同时使定位构件和外部电极护套两侧滑动将第二植入物再次加载到外部电极护套中。 这些装置还包括手柄部件，其容纳底盘，外部电极护套托架，往复运动轴，定位构件托架以及第一和第二接合构件。 往复轴可以由马达操作，以沿长轴向远侧和近侧滑动。 往复运动轴，外部电极护套及其载体在选择性致动时，按比例移动，以部署和重新装载植入物，以便于输卵管的闭塞和完全消毒。

公开(公告)号：US08174763B2

公开(公告)日：2012-05-08

申请号：US12335390

申请日：2008-12-15

Applicant: Patrick Guiney ,  Douglas A. Tenney

Inventor： Patrick Guiney ,  Douglas A. Tenney

IPC: G02B21/26

CPC classification number: G02B21/26 ,  G02B21/367

Abstract: Methods and systems for scanning a cytological specimen carried by a slide. Movement or positioning of a motorized stage of an automated screening system may be controlled manually by a user such that the user controls movement, e.g., controlling speed, position, and/or timing, of the motorized stage along a first scan line to controllably scan a first portion of the specimen along the scan line. The user may then index the motorized stage from the first scan line to the next scan line and manually control movement of the stage along the second scan line to controllably scan another portion of the specimen. Stage indexing may also be automatic such that the user does not control or initiate indexing.

Abstract translation: 用于扫描载玻片携带的细胞学标本的方法和系统。 自动化筛选系统的机动台的移动或定位可以由用户手动控制，使得用户控制电动台沿着第一扫描线的运动，例如控制速度，位置和/或定时，以可控地扫描 沿着扫描线的样品的第一部分。 然后用户可以将电动台从第一扫描线索引到下一扫描线，并且手动地控制台沿着第二扫描线的移动，以可控地扫描样本的另一部分。 阶段索引也可以是自动的，使得用户不控制或启动索引。

公开(公告)号：US08163565B2

公开(公告)日：2012-04-24

申请号：US11297701

申请日：2005-12-08

Applicant: Patrick McCormick ,  James Linder

Inventor： Patrick McCormick ,  James Linder

IPC: G01N33/00

CPC classification number: G01N31/22 ,  Y10T436/108331 ,  Y10T436/2525

Abstract: The invention relates to a cell fixative that can be used in the preparation of slides for investigation by microscopy techniques. In particular the present invention provides a cell fixative that contains a light curable mounting medium.

Abstract translation: 本发明涉及可用于制备幻灯片以用于通过显微技术研究的细胞固定剂。 特别地，本发明提供了一种含有可光固化的固定介质的细胞固定剂。

公开(公告)号：US08137289B2

公开(公告)日：2012-03-20

申请号：US12717566

申请日：2010-03-04

Applicant: Hal Watts ,  Robert Sakal

Inventor： Hal Watts ,  Robert Sakal

IPC: A61B5/00 ,  G01N1/00 ,  G01N1/12

CPC classification number: B01L3/0272 ,  A61B10/0096 ,  B01L3/50825 ,  B01L2200/0605 ,  B01L2200/141 ,  B01L2300/042 ,  B01L2300/047 ,  B01L2300/049 ,  B01L2400/0633

Abstract: Sample vials and methods of processing the sample vials are provided. The sample vial comprises a vial container, a sample collection chamber within the vial container, a vial cap configured to be mated with the vial container to enclose the collection chamber, an aliquot chamber, which may be carried by the vial cap or the vial container, and a valve mechanism for selectively sealing and unsealing the aliquot chamber from the collection chamber. The method may comprise flowing an aliquot of the sample from the collection chamber while the sample within the collection chamber is isolated from an environment exterior to the vial, sealing the aliquot chamber from the collection chamber to isolate the aliquot sample from the remaining sample portion, and transferring at least some of the remaining sample portion from the collection chamber to a microscope slide while the aliquot chamber is sealed from the collection chamber. The method further comprises reserving the slide for cytological screening of the sample, and reserving the aliquot sample for deoxynucleic acid (DNA) testing.

Abstract translation: 提供样品瓶和处理样品瓶的方法。 样品瓶包括小瓶容器，小瓶容器内的样品收集室，构造成与小瓶容器配合以封闭收集室的小瓶盖，等分试样室，其可以由小瓶盖或小瓶容器 以及用于从收集室选择性地密封和开封等分试样室的阀机构。 该方法可以包括使来自收集室的样品的等分试样流动，同时收集室内的样品与小瓶外部的环境隔离，将等分试样室从收集室密封以将等分试样与剩余样品部分隔离， 以及将所述剩余样品部分中的至少一部分从所述收集室转移到显微镜载玻片，同时所述等分试样室与所述收集室密封。 该方法还包括保留用于样品的细胞学筛选的载玻片，并保留等分试样以进行脱氧核酸（DNA）测试。

公开(公告)号：US07881532B2

公开(公告)日：2011-02-01

申请号：US12712023

申请日：2010-02-24

Applicant: Michael Zahniser

Inventor： Michael Zahniser

IPC: G06K9/34 ,  G06K9/46

CPC classification number: G06K9/0014 ,  G06K9/342 ,  G06T7/12 ,  G06T2207/10072 ,  G06T2207/30024

Abstract: An improved image segmentation algorithm is provided that identifies each object in an image. Pixels of the image are sorted based on a range of attribute values of the image. These pixels are then added to a labeling image one by one starting with an extreme point in the range of attribute values. Features are calculated for each object located and these features are matched with pre-defined acceptance criteria. If there is a match, the object is output to an output image. The steps of adding pixels to the image, evaluating the features of the resulting objects and outputting the objects are repeated until a stopping point is reached.

Abstract translation: 提供了一种改进的图像分割算法，其识别图像中的每个对象。 基于图像的属性值的范围对图像的像素进行排序。 然后将这些像素逐个添加到标签图像，从属性值范围的极值点开始。 为每个定位的对象计算特征，这些特征与预定义的接受标准相匹配。 如果有匹配，则将对象输出到输出图像。 将像素添加到图像，评估结果对象的特征和输出对象的步骤被重复，直到达到停止点。

公开(公告)号：US07866209B2

公开(公告)日：2011-01-11

申请号：US12333814

申请日：2008-12-12

Applicant: Douglas A. Tenney

Inventor： Douglas A. Tenney

IPC: G01F23/00 ,  G01F23/28

CPC classification number: G01F23/296 ,  C12M33/04 ,  G01F23/14 ,  G01F23/292 ,  G01N2035/1025 ,  G05D9/12 ,  Y10T137/0396 ,  Y10T137/7287

Abstract: A biological specimen collection and transfer system, including a biological sample container configured for storing a biological fluid sample, a vacuum source, a specimen filter having an interior chamber and an opening in communication with the chamber, and a fluid level regulator configured to determine a fluid level in the biological sample container and to dispense a fluid into the container if the determined fluid level is less than a desired fluid level. The fluid level regulator includes a fluid level monitor, a fluid dispenser, and a controller in communication with the fluid level monitor and the fluid dispenser, wherein the fluid level monitor includes a sound source configured to emit sound towards a surface of the fluid sample, and a sound detector configured to measure sound reflected from the surface of the fluid sample, wherein the controller determines the fluid level based at least in part on a measurement of reflected sound emitted from the sound source.

Abstract translation: 一种生物标本收集和转移系统，包括构造成存储生物流体样品的生物样本容器，真空源，具有内室的样品过滤器和与室连通的开口;以及液位调节器，其被配置为确定 如果所确定的液体水平低于期望的液体水平，则在生物样品容器中的液体水平并且将流体分配到容器中。 液位调节器包括液位监视器，流体分配器和与液位监视器和流体分配器连通的控制器，其中液位监视器包括配置成朝向流体样本的表面发出声音的声源， 以及声音检测器，被配置为测量从所述流体样品的表面反射的声音，其中所述控制器至少部分地基于从所述声源发射的反射声音的测量来确定所述液体水平。